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Items: 1 to 50 of 309

1.

Synthetic lethality in pancreatic cancer: discovery of a new RAD51-BRCA2 small molecule disruptor that inhibits homologous recombination and synergizes with olaparib.

Bagnolini G, Milano D, Manerba M, Schipani F, Ortega JA, Gioia D, Falchi F, Balboni A, Farabegoli F, De Franco F, Robertson J, Pellicciari R, Pallavicini I, Peri S, Minucci S, Girotto S, Di Stefano G, Roberti M, Cavalli A.

J Med Chem. 2020 Feb 10. doi: 10.1021/acs.jmedchem.9b01526. [Epub ahead of print]

PMID:
32037829
2.

Tranylcypromine-Based LSD1 Inhibitors: Structure-Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation.

Fioravanti R, Romanelli A, Mautone N, Di Bello E, Rovere A, Corinti D, Zwergel C, Valente S, Rotili D, Botrugno OA, Dessanti P, Vultaggio S, Vianello P, Cappa A, Binda C, Mattevi A, Minucci S, Mercurio C, Varasi M, Mai A.

ChemMedChem. 2020 Jan 31. doi: 10.1002/cmdc.201900730. [Epub ahead of print]

PMID:
32003940
3.

DAAM1 and PREP are involved in human spermatogenesis.

Venditti M, Fasano C, Minucci S, Serino I, Sinisi AA, Dale B, Di Matteo L.

Reprod Fertil Dev. 2020 Jan 24. doi: 10.1071/RD19172. [Epub ahead of print]

PMID:
31972124
4.

Study of expression of genes potentially responsible for reduced fitness in patients with myotonic dystrophy type 1 and identification of new biomarkers of testicular function.

Ergoli M, Venditti M, Picillo E, Minucci S, Politano L.

Mol Reprod Dev. 2020 Jan;87(1):45-52. doi: 10.1002/mrd.23307. Epub 2019 Dec 16.

PMID:
31840338
5.

Melatonin protects bone against cadmium-induced toxicity via activation of Wnt/β-catenin signaling pathway.

Knani L, Venditti M, Kechiche S, Banni M, Messaoudi I, Minucci S.

Toxicol Mech Methods. 2019 Dec 11:1-9. doi: 10.1080/15376516.2019.1701595. [Epub ahead of print]

PMID:
31809235
6.

Sexual and functional outcomes of prostate artery embolisation: A prospective long-term follow-up, large cohort study.

Al Rawashdah SF, Pastore AL, Velotti G, Fuschi A, Capone L, Suraci PP, Martoccia A, Saltarelli A, Minucci S, Falsaperla M, Al Salhi Y, Illiano E, Costantini E, Carbone A.

Int J Clin Pract. 2019 Nov 26:e13454. doi: 10.1111/ijcp.13454. [Epub ahead of print]

PMID:
31769906
7.

Preclinical models of breast cancer: Two-way shuttles for immune checkpoint inhibitors from and to patient bedside.

Abdel-Aziz AK, Saadeldin MK, D'Amico P, Orecchioni S, Bertolini F, Curigliano G, Minucci S.

Eur J Cancer. 2019 Nov;122:22-41. doi: 10.1016/j.ejca.2019.08.013. Epub 2019 Oct 10. Review.

PMID:
31606656
8.

Ex vivo lung cancer spheroids resemble treatment response of a patient with NSCLC to chemotherapy and immunotherapy: case report and translational study.

Di Liello R, Ciaramella V, Barra G, Venditti M, Della Corte CM, Papaccio F, Sparano F, Viscardi G, Iacovino ML, Minucci S, Fasano M, Ciardiello F, Morgillo F.

ESMO Open. 2019 Aug 19;4(4):e000536. doi: 10.1136/esmoopen-2019-000536. eCollection 2019.

9.

Tuning mTORC1 activity dictates the response of acute myeloid leukemia to LSD1 inhibition.

Abdel-Aziz AK, Pallavicini I, Ceccacci E, Meroni G, Saadeldin MK, Varasi M, Minucci S.

Haematologica. 2019 Sep 19. pii: haematol.2019.224501. doi: 10.3324/haematol.2019.224501. [Epub ahead of print]

10.

D-Asp upregulates PREP and GluA2/3 expressions and induces p-ERK1/2 and p-Akt in rat testis.

Santillo A, Venditti M, Minucci S, Chieffi Baccari G, Falvo S, Rosati L, Di Fiore MM.

Reproduction. 2019 Oct;158(4):357-367. doi: 10.1530/REP-19-0204.

PMID:
31398714
11.

Author Correction: Differential epigenetic reprogramming in response to specific endocrine therapies promotes cholesterol biosynthesis and cellular invasion.

Nguyen VTM, Barozzi I, Faronato M, Lombardo Y, Steel JH, Patel N, Darbre P, Castellano L, Győrffy B, Woodley L, Rodriguez-Meira A, Patten DK, Vircillo V, Periyasamy M, Ali S, Frige G, Minucci S, Coombes RC, Magnani L.

Nat Commun. 2019 Aug 6;10(1):3505. doi: 10.1038/s41467-019-11569-z.

12.

Comparing apples with oranges: Studying LSD1 inhibitors in cellular assays.

Abdel-Aziz AK, Minucci S.

Pharmacol Res. 2019 Aug;146:104345. doi: 10.1016/j.phrs.2019.104345. Epub 2019 Jul 8. No abstract available.

PMID:
31295569
13.

Expression pattern dysregulation of stress- and neuronal activity-related genes in response to prenatal stress paradigm in zebrafish larvae.

D'Agostino S, Testa M, Aliperti V, Venditti M, Minucci S, Aniello F, Donizetti A.

Cell Stress Chaperones. 2019 Sep;24(5):1005-1012. doi: 10.1007/s12192-019-01017-8. Epub 2019 Jun 18.

PMID:
31209726
14.

Study on PREP localization in mouse seminal vesicles and its possible involvement during regulated exocytosis.

Venditti M, Aniello F, Santillo A, Minucci S.

Zygote. 2019 Jun;27(3):160-165. doi: 10.1017/S0967199419000194. Epub 2019 May 7.

PMID:
31060637
15.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3β-MCL-1 Axis.

Elgendy M, Cirò M, Hosseini A, Weiszmann J, Mazzarella L, Ferrari E, Cazzoli R, Curigliano G, DeCensi A, Bonanni B, Budillon A, Pelicci PG, Janssens V, Ogris M, Baccarini M, Lanfrancone L, Weckwerth W, Foiani M, Minucci S.

Cancer Cell. 2019 May 13;35(5):798-815.e5. doi: 10.1016/j.ccell.2019.03.007. Epub 2019 Apr 25.

PMID:
31031016
16.

Identification of mutations associated with acquired resistance to sunitinib in renal cell cancer.

Elgendy M, Fusco JP, Segura V, Lozano MD, Minucci S, Echeveste JI, Gurpide A, Andueza M, Melero I, Sanmamed MF, Ruiz MR, Calvo A, Pascual JI, Velis JM, Miñana B, Valle RD, Pio R, Agorreta J, Abengozar M, Colecchia M, Brich S, Renne SL, Guruceaga E, Patiño-García A, Perez-Gracia JL.

Int J Cancer. 2019 Oct 1;145(7):1991-2001. doi: 10.1002/ijc.32256. Epub 2019 Mar 30.

PMID:
30848481
17.

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

Roberti M, Schipani F, Bagnolini G, Milano D, Giacomini E, Falchi F, Balboni A, Manerba M, Farabegoli F, De Franco F, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Girotto S, Pellicciari R, Cavalli A.

Eur J Med Chem. 2019 Mar 1;165:80-92. doi: 10.1016/j.ejmech.2019.01.008. Epub 2019 Jan 10.

PMID:
30660828
18.

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology.

Amatori S, Persico G, Paolicelli C, Hillje R, Sahnane N, Corini F, Furlan D, Luzi L, Minucci S, Giorgio M, Pelicci PG, Fanelli M.

Clin Epigenetics. 2018 Nov 16;10(1):143. doi: 10.1186/s13148-018-0576-y.

19.

Subcellular Localization of Prolyl Endopeptidase During the First Wave of Rat Spermatogenesis and in Rat and Human Sperm.

Venditti M, Minucci S.

J Histochem Cytochem. 2019 Apr;67(4):229-243. doi: 10.1369/0022155418810064. Epub 2018 Oct 31.

PMID:
30380361
20.

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors.

Milik SN, Abdel-Aziz AK, Lasheen DS, Serya RAT, Minucci S, Abouzid KAM.

Eur J Med Chem. 2018 Jul 15;155:316-336. doi: 10.1016/j.ejmech.2018.06.011. Epub 2018 Jun 6.

21.

Study of anti-Müllerian hormone levels in patients with Myotonic Dystrophy Type 1. Preliminary results.

Ergoli M, Venditti M, Dotolo R, Picillo E, Minucci S, Politano L.

Acta Myol. 2017 Dec 1;36(4):199-202. eCollection 2017 Dec.

22.

Extensive and systematic rewiring of histone post-translational modifications in cancer model systems.

Noberini R, Osti D, Miccolo C, Richichi C, Lupia M, Corleone G, Hong SP, Colombo P, Pollo B, Fornasari L, Pruneri G, Magnani L, Cavallaro U, Chiocca S, Minucci S, Pelicci G, Bonaldi T.

Nucleic Acids Res. 2018 May 4;46(8):3817-3832. doi: 10.1093/nar/gky224.

23.

First evidence of DAAM1 localization in mouse seminal vesicles and its possible involvement during regulated exocytosis.

Venditti M, Fasano C, Santillo A, Aniello F, Minucci S.

C R Biol. 2018 Apr;341(4):228-234. doi: 10.1016/j.crvi.2018.03.001. Epub 2018 Mar 21.

PMID:
29571963
24.

Corrigendum: From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

Abdel-Aziz AK, Abdel-Naim AB, Shouman S, Minucci S, Elgendy M.

Front Pharmacol. 2018 Feb 12;9:101. doi: 10.3389/fphar.2018.00101. eCollection 2018.

25.

Thyroid Autoimmunity: An Interplay of Factors.

Merrill SJ, Minucci SB.

Vitam Horm. 2018;106:129-145. doi: 10.1016/bs.vh.2017.07.001. Epub 2017 Sep 4. Review.

PMID:
29407432
26.

Temporal and spatial expression of insulin-like peptide (insl5a and insl5b) paralog genes during the embryogenesis of Danio rerio.

Venditti M, Donizetti A, Fiengo M, Fasano C, Santillo A, Aniello F, Minucci S.

J Exp Zool B Mol Dev Evol. 2018 Jan;330(1):33-40. doi: 10.1002/jez.b.22787. Epub 2018 Jan 10.

PMID:
29319231
27.

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

Dell'Aversana C, Giorgio C, D'Amato L, Lania G, Matarese F, Saeed S, Di Costanzo A, Belsito Petrizzi V, Ingenito C, Martens JHA, Pallavicini I, Minucci S, Carissimo A, Stunnenberg HG, Altucci L.

Leukemia. 2018 Feb;32(2):573. doi: 10.1038/leu.2017.310. Epub 2017 Dec 22.

PMID:
29271969
28.

Prothymosin alpha expression in the vertebrate testis: a comparative review.

Venditti M, Minucci S.

Zygote. 2017 Dec;25(6):760-770. doi: 10.1017/S096719941700065X. Epub 2017 Nov 27. Review.

PMID:
29173229
29.

From Resistance to Sensitivity: Insights and Implications of Biphasic Modulation of Autophagy by Sunitinib.

Abdel-Aziz AK, Abdel-Naim AB, Shouman S, Minucci S, Elgendy M.

Front Pharmacol. 2017 Oct 10;8:718. doi: 10.3389/fphar.2017.00718. eCollection 2017. Review. Erratum in: Front Pharmacol. 2018 Feb 12;9:101.

30.

Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis.

Trabanelli S, Chevalier MF, Martinez-Usatorre A, Gomez-Cadena A, Salomé B, Lecciso M, Salvestrini V, Verdeil G, Racle J, Papayannidis C, Morita H, Pizzitola I, Grandclément C, Bohner P, Bruni E, Girotra M, Pallavi R, Falvo P, Leibundgut EO, Baerlocher GM, Carlo-Stella C, Taurino D, Santoro A, Spinelli O, Rambaldi A, Giarin E, Basso G, Tresoldi C, Ciceri F, Gfeller D, Akdis CA, Mazzarella L, Minucci S, Pelicci PG, Marcenaro E, McKenzie ANJ, Vanhecke D, Coukos G, Mavilio D, Curti A, Derré L, Jandus C.

Nat Commun. 2017 Sep 19;8(1):593. doi: 10.1038/s41467-017-00678-2.

31.

Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors.

Falchi F, Giacomini E, Masini T, Boutard N, Di Ianni L, Manerba M, Farabegoli F, Rossini L, Robertson J, Minucci S, Pallavicini I, Di Stefano G, Roberti M, Pellicciari R, Cavalli A.

ACS Chem Biol. 2017 Oct 20;12(10):2491-2497. doi: 10.1021/acschembio.7b00707. Epub 2017 Sep 1.

PMID:
28841282
32.

Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.

Gerboth S, Frittoli E, Palamidessi A, Baltanas FC, Salek M, Rappsilber J, Giuliani C, Troglio F, Rolland Y, Pruneri G, Kreutmair S, Pallavicini I, Zobel M, Cinquanta M, Minucci S, Gomez C, Santos E, Illert AL, Scita G.

Leukemia. 2018 Mar;32(3):820-827. doi: 10.1038/leu.2017.267. Epub 2017 Aug 18.

33.

Novel potent inhibitors of the histone demethylase KDM1A (LSD1), orally active in a murine promyelocitic leukemia model.

Trifirò P, Cappa A, Brambillasca S, Botrugno OA, Cera MR, Zuffo RD, Dessanti P, Meroni G, Thaler F, Villa M, Minucci S, Mercurio C, Varasi M, Vianello P.

Future Med Chem. 2017 Jul;9(11):1161-1174. doi: 10.4155/fmc-2017-0003. Epub 2017 Jul 19.

PMID:
28722470
34.

Entinostat for the treatment of breast cancer.

Trapani D, Esposito A, Criscitiello C, Mazzarella L, Locatelli M, Minchella I, Minucci S, Curigliano G.

Expert Opin Investig Drugs. 2017 Aug;26(8):965-971. doi: 10.1080/13543784.2017.1353077. Epub 2017 Jul 24. Review.

35.

A comprehensive review of lysine-specific demethylase 1 and its roles in cancer.

Hosseini A, Minucci S.

Epigenomics. 2017 Aug;9(8):1123-1142. doi: 10.2217/epi-2017-0022. Epub 2017 Jul 12. Review.

PMID:
28699367
36.

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.

Ferrari E, Bruhn C, Peretti M, Cassani C, Carotenuto WV, Elgendy M, Shubassi G, Lucca C, Bermejo R, Varasi M, Minucci S, Longhese MP, Foiani M.

Mol Cell. 2017 Jul 20;67(2):266-281.e4. doi: 10.1016/j.molcel.2017.05.027. Epub 2017 Jun 22.

37.

Corrigendum: Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

Magnani L, Frigè G, Gadaleta RM, Corleone G, Fabris S, Kempe MH, Vershure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S.

Nat Genet. 2017 May 26;49(6):970. doi: 10.1038/ng0617-970b. No abstract available.

38.

Pharmacokinetic drug evaluation of ribociclib for the treatment of metastatic, hormone-positive breast cancer.

Curigliano G, Criscitiello C, Esposito A, Intra M, Minucci S.

Expert Opin Drug Metab Toxicol. 2017 May;13(5):575-581. doi: 10.1080/17425255.2017.1318848. Epub 2017 Apr 21. Review.

PMID:
28395543
39.

Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity.

Chemek M, Venditti M, Boughamoura S, Mimouna SB, Messaoudi I, Minucci S.

J Cell Physiol. 2018 Jan;233(1):630-640. doi: 10.1002/jcp.25923. Epub 2017 May 19.

PMID:
28332181
40.

miR-194-5p/BCLAF1 deregulation in AML tumorigenesis.

Dell'Aversana C, Giorgio C, D'Amato L, Lania G, Matarese F, Saeed S, Di Costanzo A, Belsito Petrizzi V, Ingenito C, Martens JHA, Pallavicini I, Minucci S, Carissimo A, Stunnenberg HG, Altucci L.

Leukemia. 2017 Nov;31(11):2315-2325. doi: 10.1038/leu.2017.64. Epub 2017 Feb 20. Erratum in: Leukemia. 2017 Dec 22;:.

41.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.

Vianello P, Sartori L, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Botrugno OA, Dessanti P, Minucci S, Vultaggio S, Zagarrí E, Varasi M, Mercurio C.

J Med Chem. 2017 Mar 9;60(5):1693-1715. doi: 10.1021/acs.jmedchem.6b01019. Epub 2017 Feb 27.

PMID:
28186757
42.

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration.

Sartori L, Mercurio C, Amigoni F, Cappa A, Fagá G, Fattori R, Legnaghi E, Ciossani G, Mattevi A, Meroni G, Moretti L, Cecatiello V, Pasqualato S, Romussi A, Thaler F, Trifiró P, Villa M, Vultaggio S, Botrugno OA, Dessanti P, Minucci S, Zagarrí E, Carettoni D, Iuzzolino L, Varasi M, Vianello P.

J Med Chem. 2017 Mar 9;60(5):1673-1692. doi: 10.1021/acs.jmedchem.6b01018. Epub 2017 Feb 27.

PMID:
28186755
43.

Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer.

Magnani L, Frige G, Gadaleta RM, Corleone G, Fabris S, Kempe MH, Verschure PJ, Barozzi I, Vircillo V, Hong SP, Perone Y, Saini M, Trumpp A, Viale G, Neri A, Ali S, Colleoni MA, Pruneri G, Minucci S.

Nat Genet. 2017 Mar;49(3):444-450. doi: 10.1038/ng.3773. Epub 2017 Jan 23. Erratum in: Nat Genet. 2017 May 26;49(6):970.

44.

HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia.

Mehdipour P, Santoro F, Botrugno OA, Romanenghi M, Pagliuca C, Matthews GM, Johnstone RW, Minucci S.

Leukemia. 2017 Apr;31(4):995-997. doi: 10.1038/leu.2017.3. Epub 2017 Jan 24. No abstract available.

PMID:
28074065
45.

Dual modulation of MCL-1 and mTOR determines the response to sunitinib.

Elgendy M, Abdel-Aziz AK, Renne SL, Bornaghi V, Procopio G, Colecchia M, Kanesvaran R, Toh CK, Bossi D, Pallavicini I, Perez-Gracia JL, Lozano MD, Giandomenico V, Mercurio C, Lanfrancone L, Fazio N, Nole F, Teh BT, Renne G, Minucci S.

J Clin Invest. 2017 Jan 3;127(1):153-168. doi: 10.1172/JCI84386. Epub 2016 Nov 28.

46.

PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL.

di Masi A, Cilli D, Berardinelli F, Talarico A, Pallavicini I, Pennisi R, Leone S, Antoccia A, Noguera NI, Lo-Coco F, Ascenzi P, Minucci S, Nervi C.

Cell Death Dis. 2016 Jul 28;7:e2308. doi: 10.1038/cddis.2016.115.

47.

Mass-spectrometry analysis of histone post-translational modifications in pathology tissue using the PAT-H-MS approach.

Noberini R, Pruneri G, Minucci S, Bonaldi T.

Data Brief. 2016 Feb 16;7:188-94. doi: 10.1016/j.dib.2016.02.028. eCollection 2016 Jun.

48.

c-Myc Modulation and Acetylation Is a Key HDAC Inhibitor Target in Cancer.

Nebbioso A, Carafa V, Conte M, Tambaro FP, Abbondanza C, Martens J, Nees M, Benedetti R, Pallavicini I, Minucci S, Garcia-Manero G, Iovino F, Lania G, Ingenito C, Belsito Petrizzi V, Stunnenberg HG, Altucci L.

Clin Cancer Res. 2017 May 15;23(10):2542-2555. doi: 10.1158/1078-0432.CCR-15-2388. Epub 2016 Jun 29.

49.

In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype.

Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L.

Cancer Discov. 2016 Jun;6(6):650-63. doi: 10.1158/2159-8290.CD-15-1200. Epub 2016 May 13.

50.

Self-renewal of tumor cells: epigenetic determinants of the cancer stem cell phenotype.

Ravasio R, Ceccacci E, Minucci S.

Curr Opin Genet Dev. 2016 Feb;36:92-9. doi: 10.1016/j.gde.2016.04.002. Epub 2016 May 7. Review.

PMID:
27153353

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