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Items: 44


Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y.

J Biol Chem. 2019 Jun 5. pii: jbc.RA119.008041. doi: 10.1074/jbc.RA119.008041. [Epub ahead of print]


Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD.

Geiger S, Ozay EI, Geumann U, Hereth MK, Magnusson T, Shanthalingam S, Hirsch D, Kälin S, Günther C, Osborne BA, Tew GN, Hermann FG, Minter LM.

Mol Ther. 2019 May 16. pii: S1525-0016(19)30221-7. doi: 10.1016/j.ymthe.2019.05.007. [Epub ahead of print]


Corrigendum: Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Hatfield S, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 May 3;10:935. doi: 10.3389/fimmu.2019.00935. eCollection 2019.


Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.

Wang W, Yang J, Edin ML, Wang Y, Luo Y, Wan D, Yang H, Song CQ, Xue W, Sanidad KZ, Song M, Bisbee HA, Bradbury JA, Nan G, Zhang J, Shih PB, Lee KSS, Minter LM, Kim D, Xiao H, Liu JY, Hammock BD, Zeldin DC, Zhang G.

Cancer Res. 2019 Apr 15;79(8):1822-1830. doi: 10.1158/0008-5472.CAN-18-3221. Epub 2019 Feb 25.


Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 Feb 7;10:162. doi: 10.3389/fimmu.2019.00162. eCollection 2019. Erratum in: Front Immunol. 2019 May 03;10:935.


Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease.

Ozay EI, Vijayaraghavan J, Gonzalez-Perez G, Shanthalingam S, Sherman HL, Garrigan DT Jr, Chandiran K, Torres JA, Osborne BA, Tew GN, Slukvin II, Macdonald RA, Kelly K, Minter LM.

Stem Cell Res. 2019 Mar;35:101401. doi: 10.1016/j.scr.2019.101401. Epub 2019 Feb 1.


Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways.

Hossain F, Sorrentino C, Ucar DA, Peng Y, Matossian M, Wyczechowska D, Crabtree J, Zabaleta J, Morello S, Del Valle L, Burow M, Collins-Burow B, Pannuti A, Minter LM, Golde TE, Osborne BA, Miele L.

Front Oncol. 2018 Dec 4;8:575. doi: 10.3389/fonc.2018.00575. eCollection 2018.


The Role of Cargo Binding Strength in Polymer-Mediated Intracellular Protein Delivery.

Posey ND, Hango CR, Minter LM, Tew GN.

Bioconjug Chem. 2018 Aug 15;29(8):2679-2690. doi: 10.1021/acs.bioconjchem.8b00363. Epub 2018 Aug 6.


Rotenone Treatment Reveals a Role for Electron Transport Complex I in the Subcellular Localization of Key Transcriptional Regulators During T Helper Cell Differentiation.

Ozay EI, Sherman HL, Mello V, Trombley G, Lerman A, Tew GN, Yadava N, Minter LM.

Front Immunol. 2018 Jun 7;9:1284. doi: 10.3389/fimmu.2018.01284. eCollection 2018.


Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.

Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L.

Front Immunol. 2018 Jun 4;9:1288. doi: 10.3389/fimmu.2018.01288. eCollection 2018. Review.


A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice.

Yang H, Wang W, Romano KA, Gu M, Sanidad KZ, Kim D, Yang J, Schmidt B, Panigrahy D, Pei R, Martin DA, Ozay EI, Wang Y, Song M, Bolling BW, Xiao H, Minter LM, Yang GY, Liu Z, Rey FE, Zhang G.

Sci Transl Med. 2018 May 30;10(443). pii: eaan4116. doi: 10.1126/scitranslmed.aan4116.


Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29.

Chandiran K, Lawlor R, Pannuti A, Perez GG, Srinivasan J, Golde TE, Miele L, Osborne BA, Minter LM.

Mol Immunol. 2018 Jul;99:191-198. doi: 10.1016/j.molimm.2018.05.002. Epub 2018 May 26.


Effects of Consumer Antimicrobials Benzalkonium Chloride, Benzethonium Chloride, and Chloroxylenol on Colonic Inflammation and Colitis-Associated Colon Tumorigenesis in Mice.

Sanidad KZ, Yang H, Wang W, Ozay EI, Yang J, Gu M, Karner E, Zhang J, Kim D, Minter LM, Xiao H, Zhang G.

Toxicol Sci. 2018 Jun 1;163(2):490-499. doi: 10.1093/toxsci/kfy045.


γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE.

EMBO Mol Med. 2017 Jul;9(7):950-966. doi: 10.15252/emmm.201607265.


ROMP- and RAFT-Based Guanidinium-Containing Polymers as Scaffolds for Protein Mimic Synthesis.

Sarapas JM, Backlund CM, deRonde BM, Minter LM, Tew GN.

Chemistry. 2017 May 17;23(28):6858-6863. doi: 10.1002/chem.201700423. Epub 2017 May 2.


Sequence segregation improves non-covalent protein delivery.

Sgolastra F, Backlund CM, Ilker Ozay E, deRonde BM, Minter LM, Tew GN.

J Control Release. 2017 May 28;254:131-136. doi: 10.1016/j.jconrel.2017.03.387. Epub 2017 Mar 29.


Intracellular Delivery of Anti-pPKCθ (Thr538) via Protein Transduction Domain Mimics for Immunomodulation.

Ozay EI, Gonzalez-Perez G, Torres JA, Vijayaraghavan J, Lawlor R, Sherman HL, Garrigan DT Jr, Burnside AS, Osborne BA, Tew GN, Minter LM.

Mol Ther. 2016 Dec;24(12):2118-2130. doi: 10.1038/mt.2016.177. Epub 2016 Sep 16.


Mapping Optimal Charge Density and Length of ROMP-Based PTDMs for siRNA Internalization.

Caffrey LM, deRonde BM, Minter LM, Tew GN.

Biomacromolecules. 2016 Oct 10;17(10):3205-3212. Epub 2016 Sep 21.


Optimal Hydrophobicity in Ring-Opening Metathesis Polymerization-Based Protein Mimics Required for siRNA Internalization.

deRonde BM, Posey ND, Otter R, Caffrey LM, Minter LM, Tew GN.

Biomacromolecules. 2016 Jun 13;17(6):1969-77. doi: 10.1021/acs.biomac.6b00138. Epub 2016 May 19.


Development of Guanidinium-Rich Protein Mimics for Efficient siRNA Delivery into Human T Cells.

deRonde BM, Torres JA, Minter LM, Tew GN.

Biomacromolecules. 2015 Oct 12;16(10):3172-9. doi: 10.1021/acs.biomac.5b00795. Epub 2015 Sep 14.


The Link between Autoimmunity and Lymphoma: Does NOTCH Signaling Play a Contributing Role?

Kuksin CA, Minter LM.

Front Oncol. 2015 Feb 24;5:51. doi: 10.3389/fonc.2015.00051. eCollection 2015. Review.


CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia.

Arieta Kuksin C, Gonzalez-Perez G, Minter LM.

Blood. 2015 Mar 26;125(13):2087-94. doi: 10.1182/blood-2014-08-594796. Epub 2015 Feb 3.


Evaluation of native bees as pollinators of cucurbit crops under floating row covers.

Minter LM, Bessin RT.

Environ Entomol. 2014 Oct;43(5):1354-63. doi: 10.1603/EN13076. Epub 2014 Aug 25.


NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome.

Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM.

Front Immunol. 2014 May 26;5:249. doi: 10.3389/fimmu.2014.00249. eCollection 2014.


Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.

Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA.

Front Immunol. 2014 Feb 12;5:54. doi: 10.3389/fimmu.2014.00054. eCollection 2014.


Importance of sequence specific hydrophobicity in synthetic protein transduction domain mimics.

Sgolastra F, Minter LM, Osborne BA, Tew GN.

Biomacromolecules. 2014 Mar 10;15(3):812-20. doi: 10.1021/bm401634r. Epub 2014 Feb 26.


Molecular identification of sand flies (Diptera: Psychodidae) in eastern North America by using PCR-RFLP.

Minter LM, Yu T, Florin DA, Nukmal N, Brown GC, Zhou X.

J Med Entomol. 2013 Jul;50(4):920-4.


Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia.

Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, Andrzejewski C Jr, Fauq AH, Golde TE, Miele L, Minter LM.

J Exp Med. 2013 Jul 1;210(7):1311-29. doi: 10.1084/jem.20112615. Epub 2013 Jun 3.


NOTCH signaling in immune-mediated bone marrow failure of aplastic anemia.

Minter LM.

Rare Dis. 2013 Nov 6;1:e26764. doi: 10.4161/rdis.26764. eCollection 2013.


Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells.

Tezgel AÖ, Gonzalez-Perez G, Telfer JC, Osborne BA, Minter LM, Tew GN.

Mol Ther. 2013 Jan;21(1):201-9. doi: 10.1038/mt.2012.209. Epub 2012 Oct 16.


Notch and the survival of regulatory T cells: location is everything!

Minter LM, Osborne BA.

Sci Signal. 2012 Jul 24;5(234):pe31. doi: 10.1126/scisignal.2003358.


Canonical and non-canonical Notch signaling in CD4⁺ T cells.

Minter LM, Osborne BA.

Curr Top Microbiol Immunol. 2012;360:99-114. doi: 10.1007/82_2012_233. Review.


Circadian activity of Lutzomyia shannoni (Diptera: Psychodidae) during late season population peaks.

Minter LM, Brown GC.

J Am Mosq Control Assoc. 2010 Dec;26(4):441-4.


Notch regulates cytolytic effector function in CD8+ T cells.

Cho OH, Shin HM, Miele L, Golde TE, Fauq A, Minter LM, Osborne BA.

J Immunol. 2009 Mar 15;182(6):3380-9. doi: 10.4049/jimmunol.0802598.


Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA.

Blood. 2009 Feb 19;113(8):1689-98. doi: 10.1182/blood-2008-03-147967. Epub 2008 Nov 10.


Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.

Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA.

Blood. 2008 Sep 1;112(5):1813-21. doi: 10.1182/blood-2008-03-144980. Epub 2008 Jun 11.


Notch signalling during peripheral T-cell activation and differentiation.

Osborne BA, Minter LM.

Nat Rev Immunol. 2007 Jan;7(1):64-75. Epub 2006 Dec 15. Review.


Notch1 augments NF-kappaB activity by facilitating its nuclear retention.

Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA.

EMBO J. 2006 Jan 11;25(1):129-38. Epub 2005 Dec 1.


Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21.

Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, Golde TE, Miller SD, Osborne BA.

Nat Immunol. 2005 Jul;6(7):680-8.


Cell death in the thymus--it' s all a matter of contacts.

Minter LM, Osborne BA.

Semin Immunol. 2003 Jun;15(3):135-44. Review.


Hormonal control of p53 and chemoprevention.

Jerry DJ, Minter LM, Becker KA, Blackburn AC.

Breast Cancer Res. 2002;4(3):91-4. Epub 2002 Mar 26. Review.


Epithelial cell cycling predicts p53 responsiveness to gamma-irradiation during post-natal mammary gland development.

Minter LM, Dickinson ES, Naber SP, Jerry DJ.

Development. 2002 Jun;129(12):2997-3008.

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