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Items: 1 to 50 of 145

1.

Depletion of Caveolin-1 in Type-2 Diabetes Model Induces Alzheimer's disease Pathology Precursors.

Bonds JA, Shetti A, Bheri A, Chen Z, Disoukey A, Tai L, Mao M, Head BP, Bonini MG, Haus JM, Minshall RD, Lazarov O.

J Neurosci. 2019 Sep 16. pii: 0730-19. doi: 10.1523/JNEUROSCI.0730-19.2019. [Epub ahead of print]

PMID:
31527120
2.

Injury-Induced Shedding of Extracellular Vesicles Depletes Endothelial Cells of Cav-1 (Caveolin-1) and Enables TGF-β (Transforming Growth Factor-β)-Dependent Pulmonary Arterial Hypertension.

Oliveira SDS, Chen J, Castellon M, Mao M, Raj JU, Comhair S, Erzurum S, Silva CLM, Machado RF, Bonini MG, Minshall RD.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1191-1202. doi: 10.1161/ATVBAHA.118.312038.

PMID:
30943774
3.

Echocardiographic assessment of right ventricular function in experimental pulmonary hypertension.

Zhu Z, Godana D, Li A, Rodriguez B, Gu C, Tang H, Minshall RD, Huang W, Chen J.

Pulm Circ. 2019 Apr-Jun;9(2):2045894019841987. doi: 10.1177/2045894019841987.

4.

Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.

5.

The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury.

Zhang Y, Wang L, Lv Y, Jiang C, Wu G, Dull RO, Minshall RD, Malik AB, Hu G.

J Immunol. 2019 Jan 1;202(1):194-206. doi: 10.4049/jimmunol.1800777. Epub 2018 Nov 19.

PMID:
30455398
6.

Caveolin and Endothelial NO Signaling.

Oliveira SDS, Minshall RD.

Curr Top Membr. 2018;82:257-279. doi: 10.1016/bs.ctm.2018.09.004. Epub 2018 Oct 15.

PMID:
30360781
7.

Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure.

DeLalio LJ, Keller AS, Chen J, Boyce AKJ, Artamonov MV, Askew-Page HR, Keller TCS 4th, Johnstone SR, Weaver RB, Good ME, Murphy SA, Best AK, Mintz EL, Penuela S, Greenwood IA, Machado RF, Somlyo AV, Swayne LA, Minshall RD, Isakson BE.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2065-2078. doi: 10.1161/ATVBAHA.118.311290.

8.

Reciprocal regulation of eNOS and caveolin-1 functions in endothelial cells.

Chen Z, D S Oliveira S, Zimnicka AM, Jiang Y, Sharma T, Chen S, Lazarov O, Bonini MG, Haus JM, Minshall RD.

Mol Biol Cell. 2018 May 15;29(10):1190-1202. doi: 10.1091/mbc.E17-01-0049. Epub 2018 Mar 22.

9.

ICAM-1 regulates macrophage polarization by suppressing MCP-1 expression via miR-124 upregulation.

Gu W, Yao L, Li L, Zhang J, Place AT, Minshall RD, Liu G.

Oncotarget. 2017 Dec 5;8(67):111882-111901. doi: 10.18632/oncotarget.22948. eCollection 2017 Dec 19.

10.

Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.

Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):64-75. doi: 10.1161/ATVBAHA.117.309907. Epub 2017 Oct 12.

11.

Nitric oxide donor [Ru(terpy)(bdq)NO]3+ induces uncoupling and phosphorylation of endothelial nitric oxide synthase promoting oxidant production.

Potje SR, Chen Z, Oliveira SDS, Bendhack LM, da Silva RS, Bonini MG, Antoniali C, Minshall RD.

Free Radic Biol Med. 2017 Nov;112:587-596. doi: 10.1016/j.freeradbiomed.2017.09.004. Epub 2017 Sep 9.

12.

Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction.

Yan M, Zhang X, Chen A, Gu W, Liu J, Ren X, Zhang J, Wu X, Place AT, Minshall RD, Liu G.

FASEB J. 2017 Nov;31(11):4759-4769. doi: 10.1096/fj.201700280R. Epub 2017 Jul 12.

13.

The nitric oxide donor RuBPY does not induce in vitro cross-tolerance with acetylcholine.

Paulo M, Grando MD, da Silva RS, Minshall RD, Bendhack LM.

Nitric Oxide. 2017 Sep 30;69:69-77. doi: 10.1016/j.niox.2017.05.004. Epub 2017 May 27.

PMID:
28559108
14.

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury.

Savio LEB, de Andrade Mello P, Figliuolo VR, de Avelar Almeida TF, Santana PT, Oliveira SDS, Silva CLM, Feldbrügge L, Csizmadia E, Minshall RD, Longhi MS, Wu Y, Robson SC, Coutinho-Silva R.

J Hepatol. 2017 Oct;67(4):716-726. doi: 10.1016/j.jhep.2017.05.021. Epub 2017 May 26.

15.

Aberrant caveolin-1-mediated Smad signaling and proliferation identified by analysis of adenine 474 deletion mutation (c.474delA) in patient fibroblasts: a new perspective on the mechanism of pulmonary hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 May 1;28(9):1177-1185. doi: 10.1091/mbc.E16-11-0790.

16.

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

PMID:
28428423
17.

Caveolin-1-mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype.

Portugal CC, Socodato R, Canedo T, Silva CM, Martins T, Coreixas VS, Loiola EC, Gess B, Röhr D, Santiago AR, Young P, Minshall RD, Paes-de-Carvalho R, Ambrósio AF, Relvas JB.

Sci Signal. 2017 Mar 28;10(472). pii: eaal2005. doi: 10.1126/scisignal.aal2005.

PMID:
28351945
18.

Aberrant Caveolin-1-Mediated Smad Signaling and Proliferation Identified by Analysis of Adenine 474 Deletion Mutation (c.474delA) in Patient Fibroblasts: A New Perspective in the Mechanism of Pulmonary Hypertension.

Marsboom G, Chen Z, Yuan Y, Zhang Y, Tiruppathi C, Loyd JE, Austin ED, Machado RF, Minshall RD, Rehman J, Malik AB.

Mol Biol Cell. 2017 Mar 15. pii: mbc.E16-06-0380. doi: 10.1091/mbc.E16-06-0380. [Epub ahead of print]

PMID:
28298490
19.

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.

Oliveira SDS, Castellon M, Chen J, Bonini MG, Gu X, Elliott MH, Machado RF, Minshall RD.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L760-L771. doi: 10.1152/ajplung.00484.2016. Epub 2017 Feb 10.

20.

Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.

Jiang C, Liu Z, Hu R, Bo L, Minshall RD, Malik AB, Hu G.

J Immunol. 2017 Feb 15;198(4):1660-1672. doi: 10.4049/jimmunol.1601495. Epub 2017 Jan 4.

21.

Hyperinsulinemia augments endothelin-1 protein expression and impairs vasodilation of human skeletal muscle arterioles.

Mahmoud AM, Szczurek MR, Blackburn BK, Mey JT, Chen Z, Robinson AT, Bian JT, Unterman TG, Minshall RD, Brown MD, Kirwan JP, Phillips SA, Haus JM.

Physiol Rep. 2016 Aug;4(16). pii: e12895. Epub 2016 Aug 22.

22.

Lysozyme and bilirubin bind to ACE and regulate its conformation and shedding.

Danilov SM, Lünsdorf H, Akinbi HT, Nesterovitch AB, Epshtein Y, Letsiou E, Kryukova OV, Piegeler T, Golukhova EZ, Schwartz DE, Dull RO, Minshall RD, Kost OA, Garcia JG.

Sci Rep. 2016 Oct 13;6:34913. doi: 10.1038/srep34913.

23.

Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells.

Jiang Y, Sverdlov MS, Toth PT, Huang LS, Du G, Liu Y, Natarajan V, Minshall RD.

J Biol Chem. 2016 Sep 23;291(39):20729-38. doi: 10.1074/jbc.M116.752485. Epub 2016 Aug 10.

24.

Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.

Coelho-Santos V, Socodato R, Portugal C, Leitão RA, Rito M, Barbosa M, Couraud PO, Romero IA, Weksler B, Minshall RD, Fontes-Ribeiro C, Summavielle T, Relvas JB, Silva AP.

Cell Mol Life Sci. 2016 Dec;73(24):4701-4716. Epub 2016 Jul 4.

PMID:
27376435
25.

Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae.

Zimnicka AM, Husain YS, Shajahan AN, Sverdlov M, Chaga O, Chen Z, Toth PT, Klomp J, Karginov AV, Tiruppathi C, Malik AB, Minshall RD.

Mol Biol Cell. 2016 Jul 1;27(13):2090-106. doi: 10.1091/mbc.E15-11-0756. Epub 2016 May 11.

26.

Rab11a Mediates Vascular Endothelial-Cadherin Recycling and Controls Endothelial Barrier Function.

Yan Z, Wang ZG, Segev N, Hu S, Minshall RD, Dull RO, Zhang M, Malik AB, Hu G.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):339-49. doi: 10.1161/ATVBAHA.115.306549. Epub 2015 Dec 10.

27.

Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.

Hart PC, Ratti BA, Mao M, Ansenberger-Fricano K, Shajahan-Haq AN, Tyner AL, Minshall RD, Bonini MG.

Oncotarget. 2016 Jan 5;7(1):308-22. doi: 10.18632/oncotarget.5687.

28.

Clinically relevant concentrations of lidocaine and ropivacaine inhibit TNFα-induced invasion of lung adenocarcinoma cells in vitro by blocking the activation of Akt and focal adhesion kinase.

Piegeler T, Schläpfer M, Dull RO, Schwartz DE, Borgeat A, Minshall RD, Beck-Schimmer B.

Br J Anaesth. 2015 Nov;115(5):784-91. doi: 10.1093/bja/aev341.

29.

NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1.

Baig MS, Zaichick SV, Mao M, de Abreu AL, Bakhshi FR, Hart PC, Saqib U, Deng J, Chatterjee S, Block ML, Vogel SM, Malik AB, Consolaro ME, Christman JW, Minshall RD, Gantner BN, Bonini MG.

J Exp Med. 2015 Sep 21;212(10):1725-38. doi: 10.1084/jem.20140654. Epub 2015 Aug 31.

30.

Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxaemia.

Urner M, Schläpfer M, Herrmann IK, Hasler M, Schimmer RR, Booy C, Roth Z'graggen B, Rehrauer H, Aigner F, Minshall RD, Stark WJ, Beck-Schimmer B.

Clin Exp Immunol. 2015 Sep;181(3):468-79. doi: 10.1111/cei.12648. Epub 2015 Jul 7.

31.

Propofol increases morbidity and mortality in a rat model of sepsis.

Schläpfer M, Piegeler T, Dull RO, Schwartz DE, Mao M, Bonini MG, Z'Graggen BR, Beck-Schimmer B, Minshall RD.

Crit Care. 2015 Feb 19;19:45. doi: 10.1186/s13054-015-0751-x.

32.

p120-catenin expressed in alveolar type II cells is essential for the regulation of lung innate immune response.

Chignalia AZ, Vogel SM, Reynolds AB, Mehta D, Dull RO, Minshall RD, Malik AB, Liu Y.

Am J Pathol. 2015 May;185(5):1251-63. doi: 10.1016/j.ajpath.2015.01.022. Epub 2015 Mar 13.

33.

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer.

Hart PC, Mao M, de Abreu AL, Ansenberger-Fricano K, Ekoue DN, Ganini D, Kajdacsy-Balla A, Diamond AM, Minshall RD, Consolaro ME, Santos JH, Bonini MG.

Nat Commun. 2015 Feb 5;6:6053. doi: 10.1038/ncomms7053.

34.

Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.

Tang H, Chen J, Fraidenburg DR, Song S, Sysol JR, Drennan AR, Offermanns S, Ye RD, Bonini MG, Minshall RD, Garcia JG, Machado RF, Makino A, Yuan JX.

Am J Physiol Lung Cell Mol Physiol. 2015 Jan 15;308(2):L208-20. doi: 10.1152/ajplung.00242.2014. Epub 2014 Nov 21.

35.

Nitroglycerin tolerance in caveolin-1 deficient mice.

Mao M, Varadarajan S, Fukai T, Bakhshi FR, Chernaya O, Dudley SC Jr, Minshall RD, Bonini MG.

PLoS One. 2014 Aug 26;9(8):e104101. doi: 10.1371/journal.pone.0104101. eCollection 2014.

36.

Ropivacaine attenuates endotoxin plus hyperinflation-mediated acute lung injury via inhibition of early-onset Src-dependent signaling.

Piegeler T, Dull RO, Hu G, Castellon M, Chignalia AZ, Koshy RG, Votta-Velis EG, Borgeat A, Schwartz DE, Beck-Schimmer B, Minshall RD.

BMC Anesthesiol. 2014 Jul 19;14:57. doi: 10.1186/1471-2253-14-57. eCollection 2014.

37.

Neurogenesis and inflammation after ischemic stroke: what is known and where we go from here.

Tobin MK, Bonds JA, Minshall RD, Pelligrino DA, Testai FD, Lazarov O.

J Cereb Blood Flow Metab. 2014 Oct;34(10):1573-84. doi: 10.1038/jcbfm.2014.130. Epub 2014 Jul 30. Review.

38.

Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol.

Han H, Rosenhouse-Dantsker A, Gnanasambandam R, Epshtein Y, Chen Z, Sachs F, Minshall RD, Levitan I.

J Physiol. 2014 Sep 15;592(18):4025-38. doi: 10.1113/jphysiol.2014.273177. Epub 2014 Jul 18.

39.

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.

Yang KC, Rutledge CA, Mao M, Bakhshi FR, Xie A, Liu H, Bonini MG, Patel HH, Minshall RD, Dudley SC Jr.

Circ Arrhythm Electrophysiol. 2014 Aug;7(4):701-10. doi: 10.1161/CIRCEP.113.001394. Epub 2014 Jul 13.

40.

Differential role for p120-catenin in regulation of TLR4 signaling in macrophages.

Yang Z, Sun D, Yan Z, Reynolds AB, Christman JW, Minshall RD, Malik AB, Zhang Y, Hu G.

J Immunol. 2014 Aug 15;193(4):1931-41. doi: 10.4049/jimmunol.1302863. Epub 2014 Jul 11.

41.

Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension.

Bakhshi FR, Mao M, Shajahan AN, Piegeler T, Chen Z, Chernaya O, Sharma T, Elliott WM, Szulcek R, Bogaard HJ, Comhair S, Erzurum S, van Nieuw Amerongen GP, Bonini MG, Minshall RD.

Pulm Circ. 2013 Dec;3(4):816-30. doi: 10.1086/674753.

42.

Behavioral heterogeneity of adult mouse lung epithelial progenitor cells.

Chernaya O, Shinin V, Liu Y, Minshall RD.

Stem Cells Dev. 2014 Nov 15;23(22):2744-57. doi: 10.1089/scd.2013.0631. Epub 2014 Aug 18.

43.

Deciphering the binding of caveolin-1 to client protein endothelial nitric-oxide synthase (eNOS): scaffolding subdomain identification, interaction modeling, and biological significance.

Trane AE, Pavlov D, Sharma A, Saqib U, Lau K, van Petegem F, Minshall RD, Roman LJ, Bernatchez PN.

J Biol Chem. 2014 May 9;289(19):13273-83. doi: 10.1074/jbc.M113.528695. Epub 2014 Mar 19.

44.

Endothelial barrier protection by local anesthetics: ropivacaine and lidocaine block tumor necrosis factor-α-induced endothelial cell Src activation.

Piegeler T, Votta-Velis EG, Bakhshi FR, Mao M, Carnegie G, Bonini MG, Schwartz DE, Borgeat A, Beck-Schimmer B, Minshall RD.

Anesthesiology. 2014 Jun;120(6):1414-28. doi: 10.1097/ALN.0000000000000174.

45.

Caveolin-1 Tyr14 phosphorylation induces interaction with TLR4 in endothelial cells and mediates MyD88-dependent signaling and sepsis-induced lung inflammation.

Jiao H, Zhang Y, Yan Z, Wang ZG, Liu G, Minshall RD, Malik AB, Hu G.

J Immunol. 2013 Dec 15;191(12):6191-9. doi: 10.4049/jimmunol.1300873. Epub 2013 Nov 15.

46.

Regional anaesthesia and cancer metastases: the implication of local anaesthetics.

Votta-Velis EG, Piegeler T, Minshall RD, Aguirre J, Beck-Schimmer B, Schwartz DE, Borgeat A.

Acta Anaesthesiol Scand. 2013 Nov;57(10):1211-29. doi: 10.1111/aas.12210. Review. Erratum in: Acta Anaesthesiol Scand. 2014 Feb;58(2):262.

PMID:
24134442
47.

G protein-dependent basal and evoked endothelial cell vWF secretion.

Rusu L, Andreeva A, Visintine DJ, Kim K, Vogel SM, Stojanovic-Terpo A, Chernaya O, Liu G, Bakhshi FR, Haberichter SL, Iwanari H, Kusano-Arai O, Suzuki N, Hamakubo T, Kozasa T, Cho J, Du X, Minshall RD.

Blood. 2014 Jan 16;123(3):442-50. doi: 10.1182/blood-2013-03-489351. Epub 2013 Sep 30.

48.

Optimization of isolated perfused/ventilated mouse lung to study hypoxic pulmonary vasoconstriction.

Yoo HY, Zeifman A, Ko EA, Smith KA, Chen J, Machado RF, Zhao YY, Minshall RD, Yuan JX.

Pulm Circ. 2013 Apr;3(2):396-405. doi: 10.4103/2045-8932.114776.

49.

Intravenous application of a primary sevoflurane metabolite improves outcome in murine septic peritonitis: first results.

Herrmann IK, Castellon M, Schwartz DE, Hasler M, Urner M, Hu G, Minshall RD, Beck-Schimmer B.

PLoS One. 2013 Aug 19;8(8):e72057. doi: 10.1371/journal.pone.0072057. eCollection 2013.

50.

Volatile anesthetics improve survival after cecal ligation and puncture.

Herrmann IK, Castellon M, Schwartz DE, Hasler M, Urner M, Hu G, Minshall RD, Beck-Schimmer B.

Anesthesiology. 2013 Oct;119(4):901-6. doi: 10.1097/ALN.0b013e3182a2a38c.

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