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A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function.

Chang A, Abderemane-Ali F, Hura GL, Rossen ND, Gate RE, Minor DL Jr.

Neuron. 2018 Feb 21;97(4):836-852.e6. doi: 10.1016/j.neuron.2018.01.035. Epub 2018 Feb 8.


Global versus local mechanisms of temperature sensing in ion channels.

Arrigoni C, Minor DL Jr.

Pflugers Arch. 2018 May;470(5):733-744. doi: 10.1007/s00424-017-2102-z. Epub 2018 Jan 17. Review.


Structural Basis for Activity and Specificity of an Anticoagulant Anti-FXIa Monoclonal Antibody and a Reversal Agent.

Ely LK, Lolicato M, David T, Lowe K, Kim YC, Samuel D, Bessette P, Garcia JL, Mikita T, Minor DL Jr, Coughlin SR.

Structure. 2018 Feb 6;26(2):187-198.e4. doi: 10.1016/j.str.2017.12.010. Epub 2018 Jan 11.


Cryo-EM structures of the TMEM16A calcium-activated chloride channel.

Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL Jr, Cheng Y, Jan LY.

Nature. 2017 Dec 21;552(7685):426-429. doi: 10.1038/nature25024. Epub 2017 Dec 13.


Channel surfing uncovers a dual-use transporter.

Minor DL Jr.

EMBO J. 2017 Nov 15;36(22):3272-3273. doi: 10.15252/embj.201798304. Epub 2017 Oct 19. No abstract available.


K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.

Lolicato M, Arrigoni C, Mori T, Sekioka Y, Bryant C, Clark KA, Minor DL Jr.

Nature. 2017 Jul 20;547(7663):364-368. doi: 10.1038/nature22988. Epub 2017 Jul 10.


Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL Jr.

ACS Chem Neurosci. 2017 Jun 21;8(6):1313-1326. doi: 10.1021/acschemneuro.6b00454. Epub 2017 Mar 17.


Unfolding of a Temperature-Sensitive Domain Controls Voltage-Gated Channel Activation.

Arrigoni C, Rohaim A, Shaya D, Findeisen F, Stein RA, Nurva SR, Mishra S, Mchaourab HS, Minor DL Jr.

Cell. 2016 Feb 25;164(5):922-36. doi: 10.1016/j.cell.2016.02.001.


Let It Go and Open Up, an Ensemble of Ion Channel Active States.

Minor DL Jr.

Cell. 2016 Feb 11;164(4):597-8. doi: 10.1016/j.cell.2016.01.037.


Insights into the molecular foundations of electrical excitation.

Gaudet R, Roux B, Minor DL Jr.

J Mol Biol. 2015 Jan 16;427(1):1-2. doi: 10.1016/j.jmb.2014.12.006. No abstract available.


Transmembrane helix straightening and buckling underlies activation of mechanosensitive and thermosensitive K(2P) channels.

Lolicato M, Riegelhaupt PM, Arrigoni C, Clark KA, Minor DL Jr.

Neuron. 2014 Dec 17;84(6):1198-212. doi: 10.1016/j.neuron.2014.11.017. Epub 2014 Dec 11.


Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.

Bagriantsev SN, Chatelain FC, Clark KA, Alagem N, Reuveny E, Minor DL Jr.

ACS Chem Neurosci. 2014 Sep 17;5(9):812-22. doi: 10.1021/cn5000698. Epub 2014 Jul 16.


Conduits of life's spark: a perspective on ion channel research since the birth of neuron.

Isacoff EY, Jan LY, Minor DL Jr.

Neuron. 2013 Oct 30;80(3):658-74. doi: 10.1016/j.neuron.2013.10.040. Review.


Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Shaya D, Findeisen F, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL Jr.

J Mol Biol. 2014 Jan 23;426(2):467-83. doi: 10.1016/j.jmb.2013.10.010. Epub 2013 Oct 10.


Apo states of calmodulin and CaBP1 control CaV1 voltage-gated calcium channel function through direct competition for the IQ domain.

Findeisen F, Rumpf CH, Minor DL Jr.

J Mol Biol. 2013 Sep 9;425(17):3217-34. doi: 10.1016/j.jmb.2013.06.024. Epub 2013 Jun 25.


A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels.

Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL Jr.

ACS Chem Biol. 2013 Aug 16;8(8):1841-51. doi: 10.1021/cb400289x. Epub 2013 Jun 17.


Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC).

Tien J, Lee HY, Minor DL Jr, Jan YN, Jan LY.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6352-7. doi: 10.1073/pnas.1303672110. Epub 2013 Apr 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5775.


Patch-clamp characterization of the MscS-like mechanosensitive channel from Silicibacter pomeroyi.

Petrov E, Palanivelu D, Constantine M, Rohde PR, Cox CD, Nomura T, Minor DL Jr, Martinac B.

Biophys J. 2013 Apr 2;104(7):1426-34. doi: 10.1016/j.bpj.2013.01.055.


Using yeast to study potassium channel function and interactions with small molecules.

Bagriantsev SN, Minor DL Jr.

Methods Mol Biol. 2013;995:31-42. doi: 10.1007/978-1-62703-345-9_3.


Structure of a Ca(2+)/CaM:Kv7.4 (KCNQ4) B-helix complex provides insight into M current modulation.

Xu Q, Chang A, Tolia A, Minor DL Jr.

J Mol Biol. 2013 Jan 23;425(2):378-94. doi: 10.1016/j.jmb.2012.11.023. Epub 2012 Nov 23.


Metabolic and thermal stimuli control K(2P)2.1 (TREK-1) through modular sensory and gating domains.

Bagriantsev SN, Clark KA, Minor DL Jr.

EMBO J. 2012 Aug 1;31(15):3297-308. doi: 10.1038/emboj.2012.171. Epub 2012 Jun 22.


A glutamate switch controls voltage-sensitive phosphatase function.

Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL Jr.

Nat Struct Mol Biol. 2012 May 6;19(6):633-41. doi: 10.1038/nsmb.2289.


Chemical informatics and target identification in a zebrafish phenotypic screen.

Laggner C, Kokel D, Setola V, Tolia A, Lin H, Irwin JJ, Keiser MJ, Cheung CY, Minor DL Jr, Roth BL, Peterson RT, Shoichet BK.

Nat Chem Biol. 2011 Dec 18;8(2):144-6. doi: 10.1038/nchembio.732.


Effect of dietary protein supplementation on blood pressure: a randomized, controlled trial.

He J, Wofford MR, Reynolds K, Chen J, Chen CS, Myers L, Minor DL, Elmer PJ, Jones DW, Whelton PK.

Circulation. 2011 Aug 2;124(5):589-95. doi: 10.1161/CIRCULATIONAHA.110.009159. Epub 2011 Jul 18.


Multiple modalities converge on a common gate to control K2P channel function.

Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL Jr.

EMBO J. 2011 Jul 15;30(17):3594-606. doi: 10.1038/emboj.2011.230.


Voltage-gated sodium channel (NaV) protein dissection creates a set of functional pore-only proteins.

Shaya D, Kreir M, Robbins RA, Wong S, Hammon J, Brüggemann A, Minor DL Jr.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12313-8. doi: 10.1073/pnas.1106811108. Epub 2011 Jul 11.


Calmodulin overexpression does not alter Cav1.2 function or oligomerization state.

Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL Jr.

Channels (Austin). 2011 Jul-Aug;5(4):320-4. doi: 10.4161/chan.5.4.16821. Epub 2011 Jul 1.


Progress in the structural understanding of voltage-gated calcium channel (CaV) function and modulation.

Minor DL Jr, Findeisen F.

Channels (Austin). 2010 Nov-Dec;4(6):459-74. doi: 10.4161/chan.4.6.12867. Review.


Structural basis for the differential effects of CaBP1 and calmodulin on Ca(V)1.2 calcium-dependent inactivation.

Findeisen F, Minor DL Jr.

Structure. 2010 Dec 8;18(12):1617-31. doi: 10.1016/j.str.2010.09.012.


Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL Jr.

EMBO J. 2010 Dec 1;29(23):3924-38. doi: 10.1038/emboj.2010.260. Epub 2010 Oct 15. Erratum in: EMBO J. 2010 Dec 1;29(23):4062.


Small molecule ion channel match making: a natural fit for new ASIC ligands.

Bagriantsev SN, Minor DL Jr.

Neuron. 2010 Oct 6;68(1):1-3. doi: 10.1016/j.neuron.2010.09.038.


Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP.

Kohout SC, Bell SC, Liu L, Xu Q, Minor DL Jr, Isacoff EY.

Nat Chem Biol. 2010 May;6(5):369-75. doi: 10.1038/nchembio.349. Epub 2010 Apr 4. Erratum in: Nat Chem Biol. 2010 Oct;6(10):782.


Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.

Chatelain FC, Gazzarrini S, Fujiwara Y, Arrigoni C, Domigan C, Ferrara G, Pantoja C, Thiel G, Moroni A, Minor DL Jr.

PLoS One. 2009 Oct 16;4(10):e7496. doi: 10.1371/journal.pone.0007496.


Searching for interesting channels: pairing selection and molecular evolution methods to study ion channel structure and function.

Minor DL Jr.

Mol Biosyst. 2009 Aug;5(8):802-10. doi: 10.1039/b901708a. Epub 2009 Jun 19. Review.


Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.

Findeisen F, Minor DL Jr.

J Gen Physiol. 2009 Mar;133(3):327-43. doi: 10.1085/jgp.200810143. Erratum in: J Gen Physiol. 2010 Feb;135(2) doi: 10.1085/jgp.200810143011310c.


A green fluorescent protein screen for identification of well-expressed membrane proteins from a cohort of extremophilic organisms.

Hammon J, Palanivelu DV, Chen J, Patel C, Minor DL Jr.

Protein Sci. 2009 Jan;18(1):121-33. doi: 10.1002/pro.18.


2007 annual progress report synopsis of the Center for Structures of Membrane Proteins.

Stroud RM, Choe S, Holton J, Kaback HR, Kwiatkowski W, Minor DL, Riek R, Sali A, Stahlberg H, Harries W.

J Struct Funct Genomics. 2009 Apr;10(2):193-208. doi: 10.1007/s10969-008-9058-3. Epub 2009 Jan 16.


Structures of CaV2 Ca2+/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation.

Kim EY, Rumpf CH, Fujiwara Y, Cooley ES, Van Petegem F, Minor DL Jr.

Structure. 2008 Oct 8;16(10):1455-67. doi: 10.1016/j.str.2008.07.010.


X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.

Fujiwara Y, Minor DL Jr.

J Mol Biol. 2008 Nov 21;383(4):854-70. doi: 10.1016/j.jmb.2008.08.059. Epub 2008 Aug 29.


Transmembrane domain length of viral K+ channels is a signal for mitochondria targeting.

Balss J, Papatheodorou P, Mehmel M, Baumeister D, Hertel B, Delaroque N, Chatelain FC, Minor DL Jr, Van Etten JL, Rassow J, Moroni A, Thiel G.

Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12313-8. doi: 10.1073/pnas.0805709105. Epub 2008 Aug 21.


Alanine-scanning mutagenesis defines a conserved energetic hotspot in the CaValpha1 AID-CaVbeta interaction site that is critical for channel modulation.

Van Petegem F, Duderstadt KE, Clark KA, Wang M, Minor DL Jr.

Structure. 2008 Feb;16(2):280-94. doi: 10.1016/j.str.2007.11.010.


Puzzle plugged by protein pore plasticity.

Minor DL Jr.

Mol Cell. 2007 May 25;26(4):459-60. No abstract available.


Structural insight into KCNQ (Kv7) channel assembly and channelopathy.

Howard RJ, Clark KA, Holton JM, Minor DL Jr.

Neuron. 2007 Mar 1;53(5):663-75.


Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer.

Pioletti M, Findeisen F, Hura GL, Minor DL Jr.

Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22.


The structural biology of voltage-gated calcium channel function and regulation.

Van Petegem F, Minor DL Jr.

Biochem Soc Trans. 2006 Nov;34(Pt 5):887-93.


Coiled coils direct assembly of a cold-activated TRP channel.

Tsuruda PR, Julius D, Minor DL Jr.

Neuron. 2006 Jul 20;51(2):201-12.


A sensitive channel family replete with sense and motion.

Minor DL Jr.

Nat Struct Mol Biol. 2006 May;13(5):388-90.


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