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Items: 38


Recent Advances in ADAM17 Research: A Promising Target for Cancer and Inflammation.

Moss ML, Minond D.

Mediators Inflamm. 2017;2017:9673537. doi: 10.1155/2017/9673537. Epub 2017 Nov 2. Review.


Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide.

Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME.

PLoS One. 2017 Nov 16;12(11):e0187868. doi: 10.1371/journal.pone.0187868. eCollection 2017.


Clinical Implications of Compounds Designed to Inhibit ECM-Modifying Metalloproteinases.

Amar S, Minond D, Fields GB.

Proteomics. 2017 Dec;17(23-24). doi: 10.1002/pmic.201600389. Epub 2017 Sep 15. Review.


Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate.

Madoux F, Dreymuller D, Pettiloud JP, Santos R, Becker-Pauly C, Ludwig A, Fields GB, Bannister T, Spicer TP, Cudic M, Scampavia LD, Minond D.

Sci Rep. 2016 Dec 5;6(1):11. doi: 10.1038/s41598-016-0013-4.


An improved fluorescent substrate for assaying soluble and membrane-associated ADAM family member activities.

Moss ML, Minond D, Yoneyama T, Hansen HP, Vujanovic N, Rasmussen FH.

Anal Biochem. 2016 Aug 15;507:13-7. doi: 10.1016/j.ab.2016.05.001. Epub 2016 May 10.


Multicomponent assembly of 4-aza-podophyllotoxins: A fast entry to highly selective and potent anti-leukemic agents.

Jeedimalla N, Flint M, Smith L, Haces A, Minond D, Roche SP.

Eur J Med Chem. 2015 Dec 1;106:167-79. doi: 10.1016/j.ejmech.2015.10.009. Epub 2015 Oct 17.


SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fields GB, Minond D.

J Med Chem. 2015 Aug 13;58(15):5808-24. doi: 10.1021/acs.jmedchem.5b00354. Epub 2015 Aug 4.


Thermodynamic Switch in Binding of Adhesion/Growth Regulatory Human Galectin-3 to Tumor-Associated TF Antigen (CD176) and MUC1 Glycopeptides.

Rodriguez MC, Yegorova S, Pitteloud JP, Chavaroche AE, André S, Ardá A, Minond D, Jiménez-Barbero J, Gabius HJ, Cudic M.

Biochemistry. 2015 Jul 28;54(29):4462-74. doi: 10.1021/acs.biochem.5b00555. Epub 2015 Jul 20.


Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro.

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D.

J Med Chem. 2014 Nov 26;57(22):9598-611. doi: 10.1021/jm501284e. Epub 2014 Nov 11.


Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β.

Madoux F, Tredup C, Spicer TP, Scampavia L, Chase PS, Hodder PS, Fields GB, Becker-Pauly C, Minond D.

Biopolymers. 2014 Sep;102(5):396-406. doi: 10.1002/bip.22527.


AlphaLISA-based high-throughput screening assay to measure levels of soluble amyloid precursor protein α.

Wang H, Nefzi A, Fields GB, Lakshmana MK, Minond D.

Anal Biochem. 2014 Aug 15;459:24-30. doi: 10.1016/j.ab.2014.05.007. Epub 2014 May 20.


ML302, a Novel Beta-lactamase (BLA) Inhibitor.

Spicer T, Minond D, Enogieru I, Saldanha SA, Allais C, Liu Q, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2014 May 13].


Production of soluble Neprilysin by endothelial cells.

Kuruppu S, Rajapakse NW, Minond D, Smith AI.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):423-7. doi: 10.1016/j.bbrc.2014.01.158. Epub 2014 Feb 2.


Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis.

Onwuha-Ekpete L, Tack L, Knapinska A, Smith L, Kaushik G, Lavoi T, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Med Chem. 2014 Feb 27;57(4):1599-608. doi: 10.1021/jm4019542. Epub 2014 Feb 5.


Glycosylation of a disintegrin and metalloprotease 17 affects its activity and inhibition.

Chavaroche A, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

Anal Biochem. 2014 Mar 15;449:68-75. doi: 10.1016/j.ab.2013.12.018. Epub 2013 Dec 19.


RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain.

Palavicini JP, Wang H, Minond D, Bianchi E, Xu S, Lakshmana MK.

J Alzheimers Dis. 2014;39(4):727-40. doi: 10.3233/JAD-131550.


Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

Richard DJ, Lena R, Bannister T, Blake N, Pierceall WE, Carlson NE, Keller CE, Koenig M, He Y, Minond D, Mishra J, Cameron M, Spicer T, Hodder P, Cardone MH.

Bioorg Med Chem. 2013 Nov 1;21(21):6642-9. doi: 10.1016/j.bmc.2013.08.017. Epub 2013 Aug 15.


COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels.

Wang H, Dey D, Carrera I, Minond D, Bianchi E, Xu S, Lakshmana MK.

J Biol Chem. 2013 Sep 13;288(37):26668-77. doi: 10.1074/jbc.M113.476689. Epub 2013 Aug 7.


Activity of ADAM17 (a disintegrin and metalloprotease 17) is regulated by its noncatalytic domains and secondary structure of its substrates.

Stawikowska R, Cudic M, Giulianotti M, Houghten RA, Fields GB, Minond D.

J Biol Chem. 2013 Aug 2;288(31):22871-9. doi: 10.1074/jbc.M113.462267. Epub 2013 Jun 18.


ML311: A Small Molecule that Potently and Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis.

Bannister T, Koenig M, He Y, Mishra J, Spicer T, Minond D, Saldanha A, Mercer BA, Cameron M, Lena R, Carlson N, Richard D, Cardone M, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 Mar 14].


Development of an AlphaScreen assay for discovery of inhibitors of low-affinity glycan-lectin interactions.

Yegorova S, Chavaroche AE, Rodriguez MC, Minond D, Cudic M.

Anal Biochem. 2013 Aug 15;439(2):123-31. doi: 10.1016/j.ab.2013.04.028. Epub 2013 May 16.


Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine.

Hayes CD, Dey D, Palavicini JP, Wang H, Patkar KA, Minond D, Nefzi A, Lakshmana MK.

BMC Med. 2013 Mar 26;11:81. doi: 10.1186/1741-7015-11-81.


Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.

Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB.

J Biol Chem. 2012 Oct 19;287(43):36473-87. doi: 10.1074/jbc.M112.389114. Epub 2012 Aug 27.


Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR.

Bioorg Med Chem Lett. 2011 Dec 1;21(23):7180-4. doi: 10.1016/j.bmcl.2011.09.077. Epub 2011 Sep 22.


HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors.

Minond D, Saldanha SA, Spicer T, Qin L, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Nov 13 [updated 2011 May 5].


Probe Report for P97/cdc48 Inhibitors.

Brown SJ, Chou TF, Deshaies R, Roberts E, Guerrero M, Minond D, Mercer BA, Hodder P, Rosen HR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Mar 6 [updated 2010 Aug 6].


Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7.


NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies.

Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV.

ACS Med Chem Lett. 2010 Jul 8;1(4):150-154.


Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB.

J Biol Chem. 2009 Sep 4;284(36):24017-24. doi: 10.1074/jbc.M109.016873. Epub 2009 Jul 1.


Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries.

Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P.

Bioorg Med Chem. 2009 Jul 15;17(14):5027-37. doi: 10.1016/j.bmc.2009.05.070. Epub 2009 Jun 22.


Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors.

Lauer-Fields JL, Minond D, Brew K, Fields GB.

Methods Mol Biol. 2007;386:125-66. doi: 10.1007/978-1-59745-430-8_5.


High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.

Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB.

Bioorg Med Chem. 2009 Feb 1;17(3):990-1005. doi: 10.1016/j.bmc.2008.03.004. Epub 2008 Mar 6.


Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II).

Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P.

J Biomol Screen. 2008 Jan;13(1):17-28. doi: 10.1177/1087057107310806.


Differentiation of secreted and membrane-type matrix metalloproteinase activities based on substitutions and interruptions of triple-helical sequences.

Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Moss ML, Fields GB.

Biochemistry. 2007 Mar 27;46(12):3724-33. Epub 2007 Mar 6.


Substrate conformation modulates aggrecanase (ADAMTS-4) affinity and sequence specificity. Suggestion of a common topological specificity for functionally diverse proteases.

Lauer-Fields JL, Minond D, Sritharan T, Kashiwagi M, Nagase H, Fields GB.

J Biol Chem. 2007 Jan 5;282(1):142-50. Epub 2006 Nov 9.


The roles of substrate thermal stability and P2 and P1' subsite identity on matrix metalloproteinase triple-helical peptidase activity and collagen specificity.

Minond D, Lauer-Fields JL, Cudic M, Overall CM, Pei D, Brew K, Visse R, Nagase H, Fields GB.

J Biol Chem. 2006 Dec 15;281(50):38302-13. Epub 2006 Oct 25.


Matrix metalloproteinase triple-helical peptidase activities are differentially regulated by substrate stability.

Minond D, Lauer-Fields JL, Nagase H, Fields GB.

Biochemistry. 2004 Sep 14;43(36):11474-81.


Differential modulation of human melanoma cell metalloproteinase expression by alpha2beta1 integrin and CD44 triple-helical ligands derived from type IV collagen.

Baronas-Lowell D, Lauer-Fields JL, Borgia JA, Sferrazza GF, Al-Ghoul M, Minond D, Fields GB.

J Biol Chem. 2004 Oct 15;279(42):43503-13. Epub 2004 Aug 2.

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