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Items: 32


The Connexin50D47A Mutant Causes Cataracts by Calcium Precipitation.

Berthoud VM, Gao J, Minogue PJ, Jara O, Mathias RT, Beyer EC.

Invest Ophthalmol Vis Sci. 2019 May 1;60(6):2336-2346. doi: 10.1167/iovs.18-26459.


Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.

Jara O, Minogue PJ, Berthoud VM, Beyer EC.

Exp Eye Res. 2018 Oct;175:192-198. doi: 10.1016/j.exer.2018.06.015. Epub 2018 Jun 18.


Disruption of the lens circulation causes calcium accumulation and precipitates in connexin mutant mice.

Gao J, Minogue PJ, Beyer EC, Mathias RT, Berthoud VM.

Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C492-C503. doi: 10.1152/ajpcell.00277.2017. Epub 2018 Jan 3.


Characterization of a variant of gap junction protein α8 identified in a family with hereditary cataract.

Kuo DS, Sokol JT, Minogue PJ, Berthoud VM, Slavotinek AM, Beyer EC, Gould DB.

PLoS One. 2017 Aug 21;12(8):e0183438. doi: 10.1371/journal.pone.0183438. eCollection 2017.


Physiological and Optical Alterations Precede the Appearance of Cataracts in Cx46fs380 Mice.

Minogue PJ, Gao J, Zoltoski RK, Novak LA, Mathias RT, Beyer EC, Berthoud VM.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4366–4374. doi: 10.1167/iovs.17-21684. Erratum in: Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4799.


The Cataract-linked Mutant Connexin50D47A Causes Endoplasmic Reticulum Stress in Mouse Lenses.

Berthoud VM, Minogue PJ, Lambert PA, Snabb JI, Beyer EC.

J Biol Chem. 2016 Aug 19;291(34):17569-78. doi: 10.1074/jbc.M115.707950. Epub 2016 Jun 17.


Connexin23 deletion does not affect lens transparency.

Berthoud VM, Minogue PJ, Snabb JI, Dzhashiashvili Y, Novak LA, Zoltoski RK, Popko B, Beyer EC.

Exp Eye Res. 2016 May;146:283-8. doi: 10.1016/j.exer.2016.03.025. Epub 2016 Mar 31.


The E368Q Mutant Allele of GJA8 is Associated with Congenital Cataracts with Intrafamilial Variation in a South Indian Family.

Senthil Kumar G, Dinesh Kumar K, Minogue PJ, Berthoud VM, Kannan R, Beyer EC, Santhiya ST.

Open Access J Ophthalmol. 2016;1(1). pii: 106. Epub 2016 Jul 28.


The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating.

Tong JJ, Minogue PJ, Kobeszko M, Beyer EC, Berthoud VM, Ebihara L.

J Membr Biol. 2015 Feb;248(1):145-55. doi: 10.1007/s00232-014-9752-y. Epub 2014 Nov 18.


Connexin46fs380 causes progressive cataracts.

Berthoud VM, Minogue PJ, Yu H, Snabb JI, Beyer EC.

Invest Ophthalmol Vis Sci. 2014 Aug 7;55(10):6639-48. doi: 10.1167/iovs.14-15012.


Roles and regulation of lens epithelial cell connexins.

Berthoud VM, Minogue PJ, Osmolak P, Snabb JI, Beyer EC.

FEBS Lett. 2014 Apr 17;588(8):1297-303. doi: 10.1016/j.febslet.2013.12.024. Epub 2014 Jan 14. Review.


Connexin50D47A decreases levels of fiber cell connexins and impairs lens fiber cell differentiation.

Berthoud VM, Minogue PJ, Yu H, Schroeder R, Snabb JI, Beyer EC.

Invest Ophthalmol Vis Sci. 2013 Nov 19;54(12):7614-22. doi: 10.1167/iovs.13-13188.


A connexin50 mutant, CX50fs, that causes cataracts is unstable, but is rescued by a proteasomal inhibitor.

Minogue PJ, Beyer EC, Berthoud VM.

J Biol Chem. 2013 Jul 12;288(28):20427-34. doi: 10.1074/jbc.M113.452847. Epub 2013 May 17.


An MIP/AQP0 mutation with impaired trafficking and function underlies an autosomal dominant congenital lamellar cataract.

Senthil Kumar G, Kyle JW, Minogue PJ, Dinesh Kumar K, Vasantha K, Berthoud VM, Beyer EC, Santhiya ST.

Exp Eye Res. 2013 May;110:136-41. doi: 10.1016/j.exer.2012.10.010. Epub 2012 Oct 29.


Removal of nitrogen and phosphorus by Eucalyptus and Populus at a tertiary treated municipal wastewater sprayfield.

Minogue PJ, Miwa M, Rockwood DL, Mackowiak CL.

Int J Phytoremediation. 2012 Dec;14(10):1010-23.


Cytoplasmic amino acids within the membrane interface region influence connexin oligomerization.

Smith TD, Mohankumar A, Minogue PJ, Beyer EC, Berthoud VM, Koval M.

J Membr Biol. 2012 Jun;245(5-6):221-30. doi: 10.1007/s00232-012-9443-5. Epub 2012 Jun 22.


Autophagy: a pathway that contributes to connexin degradation.

Lichtenstein A, Minogue PJ, Beyer EC, Berthoud VM.

J Cell Sci. 2011 Mar 15;124(Pt 6):910-20. doi: 10.1242/jcs.073072.


Different domains are critical for oligomerization compatibility of different connexins.

Martínez AD, Maripillán J, Acuña R, Minogue PJ, Berthoud VM, Beyer EC.

Biochem J. 2011 May 15;436(1):35-43. doi: 10.1042/BJ20110008.


Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50.

Tong JJ, Minogue PJ, Guo W, Chen TL, Beyer EC, Berthoud VM, Ebihara L.

Am J Physiol Cell Physiol. 2011 May;300(5):C1055-64. doi: 10.1152/ajpcell.00384.2010. Epub 2011 Jan 12.


The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation.

Graw J, Schmidt W, Minogue PJ, Rodriguez J, Tong JJ, Klopp N, Illig T, Ebihara L, Berthoud VM, Beyer EC.

Mol Vis. 2009 Sep 14;15:1881-5.


A mutant connexin50 with enhanced hemichannel function leads to cell death.

Minogue PJ, Tong JJ, Arora A, Russell-Eggitt I, Hunt DM, Moore AT, Ebihara L, Beyer EC, Berthoud VM.

Invest Ophthalmol Vis Sci. 2009 Dec;50(12):5837-45. doi: 10.1167/iovs.09-3759. Epub 2009 Aug 13.


The N terminus of connexin37 contains an alpha-helix that is required for channel function.

Kyle JW, Berthoud VM, Kurutz J, Minogue PJ, Greenspan M, Hanck DA, Beyer EC.

J Biol Chem. 2009 Jul 24;284(30):20418-27. doi: 10.1074/jbc.M109.016907. Epub 2009 May 28.


An intact connexin N-terminus is required for function but not gap junction formation.

Kyle JW, Minogue PJ, Thomas BC, Domowicz DA, Berthoud VM, Hanck DA, Beyer EC.

J Cell Sci. 2008 Aug 15;121(Pt 16):2744-50. doi: 10.1242/jcs.032482. Epub 2008 Jul 29.


Cataracts are caused by alterations of a critical N-terminal positive charge in connexin50.

Thomas BC, Minogue PJ, Valiunas V, Kanaporis G, Brink PR, Berthoud VM, Beyer EC.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2549-56. doi: 10.1167/iovs.07-1658. Epub 2008 Mar 7.


A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts.

Arora A, Minogue PJ, Liu X, Addison PK, Russel-Eggitt I, Webster AR, Hunt DM, Ebihara L, Beyer EC, Berthoud VM, Moore AT.

J Med Genet. 2008 Mar;45(3):155-60. Epub 2007 Nov 15.


Transgenic overexpression of connexin50 induces cataracts.

Chung J, Berthoud VM, Novak L, Zoltoski R, Heilbrunn B, Minogue PJ, Liu X, Ebihara L, Kuszak J, Beyer EC.

Exp Eye Res. 2007 Mar;84(3):513-28. Epub 2007 Jan 10.


A novel GJA8 mutation is associated with autosomal dominant lamellar pulverulent cataract: further evidence for gap junction dysfunction in human cataract.

Arora A, Minogue PJ, Liu X, Reddy MA, Ainsworth JR, Bhattacharya SS, Webster AR, Hunt DM, Ebihara L, Moore AT, Beyer EC, Berthoud VM.

J Med Genet. 2006 Jan;43(1):e2.


An aberrant sequence in a connexin46 mutant underlies congenital cataracts.

Minogue PJ, Liu X, Ebihara L, Beyer EC, Berthoud VM.

J Biol Chem. 2005 Dec 9;280(49):40788-95. Epub 2005 Oct 3.


Highly restricted pattern of connexin36 expression in chick somite development.

Berthoud VM, Singh R, Minogue PJ, Ragsdale CW, Beyer EC.

Anat Embryol (Berl). 2004 Nov;209(1):11-8.


Pathways for degradation of connexins and gap junctions.

Berthoud VM, Minogue PJ, Laing JG, Beyer EC.

Cardiovasc Res. 2004 May 1;62(2):256-67. Review.


An alpha-tocopherol dose response study in Paramecium tetraurelia.

Minogue PJ, Thomas JN.

Mech Ageing Dev. 2004 Jan;125(1):21-30.


Loss of function and impaired degradation of a cataract-associated mutant connexin50.

Berthoud VM, Minogue PJ, Guo J, Williamson EK, Xu X, Ebihara L, Beyer EC.

Eur J Cell Biol. 2003 May;82(5):209-21.

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