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Items: 28


Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.


Ghrelin acylation by ghrelin- O-acyltransferase can occur in healthy part of oncological liver in humans.

Germain N, Cuenco J, Ling Y, Minnion JS, Bageacu S, Grouselle D, Estour B, Galusca B.

Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G366-G371. doi: 10.1152/ajpgi.00143.2018. Epub 2018 Dec 21.


Oxyntomodulin analogue increases energy expenditure via the glucagon receptor.

Scott R, Minnion J, Tan T, Bloom SR.

Peptides. 2018 Jun;104:70-77. doi: 10.1016/j.peptides.2018.04.008. Epub 2018 Apr 20.


Differentiating constitutional thinness from anorexia nervosa in DSM 5 era.

Estour B, Marouani N, Sigaud T, Lang F, Fakra E, Ling Y, Diamondé A, Minnion JS, Galusca B, Germain N.

Psychoneuroendocrinology. 2017 Oct;84:94-100. doi: 10.1016/j.psyneuen.2017.06.015. Epub 2017 Jun 23.


The Effect of a Subcutaneous Infusion of GLP-1, OXM, and PYY on Energy Intake and Expenditure in Obese Volunteers.

Tan T, Behary P, Tharakan G, Minnion J, Al-Najim W, Albrechtsen NJW, Holst JJ, Bloom SR.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2364-2372. doi: 10.1210/jc.2017-00469.


Degradation Paradigm of the Gut Hormone, Pancreatic Polypeptide, by Hepatic and Renal Peptidases.

Cuenco J, Minnion J, Tan T, Scott R, Germain N, Ling Y, Chen R, Ghatei M, Bloom S.

Endocrinology. 2017 Jun 1;158(6):1755-1765. doi: 10.1210/en.2016-1827.


Measuring the Pharmacokinetic Properties of Drugs with a Novel Surgical Rat Model.

Christakis I, Scott R, Minnion J, Cuenco J, Tan T, Palazzo F, Bloom S.

J Invest Surg. 2017 Jun;30(3):162-169. doi: 10.1080/08941939.2016.1231856. Epub 2016 Sep 30.


Investigating the Glucagon Receptor and Glucagon-Like Peptide 1 Receptor Activity of Oxyntomodulin-Like Analogues in Male Wistar Rats.

Price SL, Minnion JS, Bloom SR.

Curr Ther Res Clin Exp. 2015 Nov 2;77:111-5. doi: 10.1016/j.curtheres.2015.10.003. eCollection 2015 Dec.


Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats.

Akalestou E, Christakis I, Solomou AM, Minnion JS, Rutter GA, Bloom SR.

Pancreas. 2016 Aug;45(7):967-73. doi: 10.1097/MPA.0000000000000585.


Increased food intake with oxyntomodulin analogues.

Price SL, Minnion JS, Bloom SR.

Peptides. 2015 Nov;73:95-100. doi: 10.1016/j.peptides.2015.09.006. Epub 2015 Sep 30.


Pharmacokinetics and pharmacodynamics of subcutaneously administered PYY3-36 and its analogues in vivo.

Cegla J, Cuenco J, Minnion J, Ghourab S, Hostomska K, Tan T, Bloom S.

Lancet. 2015 Feb 26;385 Suppl 1:S28. doi: 10.1016/S0140-6736(15)60343-9.


Identification of plasma protease derived metabolites of glucagon and their formation under typical laboratory sample handling conditions.

Howard JW, Kay RG, Tan T, Minnion J, Creaser CS.

Rapid Commun Mass Spectrom. 2015 Jan 30;29(2):171-81. doi: 10.1002/rcm.7090.


Development of a high-throughput UHPLC-MS/MS (SRM) method for the quantitation of endogenous glucagon from human plasma.

Howard JW, Kay RG, Tan T, Minnion J, Ghatei M, Bloom S, Creaser CS.

Bioanalysis. 2014;6(24):3295-309. doi: 10.4155/bio.14.226.


Combination of peptide YY3-36 with GLP-1(7-36) amide causes an increase in first-phase insulin secretion after IV glucose.

Tan TM, Salem V, Troke RC, Alsafi A, Field BC, De Silva A, Misra S, Baynes KC, Donaldson M, Minnion J, Ghatei MA, Godsland IF, Bloom SR.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2317-24. doi: 10.1210/jc.2014-2143. Epub 2014 Aug 21.


Learning curve of vessel cannulation in rats using cumulative sum analysis.

Christakis I, Georgiou P, Minnion J, Constantinides V, Cuenco J, Scott R, Tan T, Palazzo F, Murphy K, Bloom S.

J Surg Res. 2015 Jan;193(1):69-76. doi: 10.1016/j.jss.2014.06.048. Epub 2014 Jul 1.


Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness.

Germain N, Galusca B, Caron-Dorval D, Martin JF, Pujos-Guillot E, Boirie Y, Khalfallah Y, Ling Y, Minnion JS, Bloom SR, Epelbaum J, Estour B.

Nutr Diabetes. 2014 Jul 14;4:e126. doi: 10.1038/nutd.2014.17.


Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake.

Cegla J, Troke RC, Jones B, Tharakan G, Kenkre J, McCullough KA, Lim CT, Parvizi N, Hussein M, Chambers ES, Minnion J, Cuenco J, Ghatei MA, Meeran K, Tan TM, Bloom SR.

Diabetes. 2014 Nov;63(11):3711-20. doi: 10.2337/db14-0242. Epub 2014 Jun 17.


Relaxin-3 stimulates the neuro-endocrine stress axis via corticotrophin-releasing hormone.

McGowan BM, Minnion JS, Murphy KG, Roy D, Stanley SA, Dhillo WS, Gardiner JV, Ghatei MA, Bloom SR.

J Endocrinol. 2014 May 12;221(2):337-46. doi: 10.1530/JOE-13-0603. Print 2014 May.


Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala.

Parker JA, McCullough KA, Field BC, Minnion JS, Martin NM, Ghatei MA, Bloom SR.

Int J Obes (Lond). 2013 Oct;37(10):1391-8. doi: 10.1038/ijo.2012.227. Epub 2013 Jan 22.


Analogs of pancreatic polypeptide and peptide YY with a locked PP-fold structure are biologically active.

Germain N, Minnion JS, Tan T, Shillito J, Gibbard C, Ghatei M, Bloom S.

Peptides. 2013 Jan;39:6-10. doi: 10.1016/j.peptides.2012.10.010. Epub 2012 Nov 2.


A role for metalloendopeptidases in the breakdown of the gut hormone, PYY 3-36.

Addison ML, Minnion JS, Shillito JC, Suzuki K, Tan TM, Field BC, Germain-Zito N, Becker-Pauly C, Ghatei MA, Bloom SR, Murphy KG.

Endocrinology. 2011 Dec;152(12):4630-40. doi: 10.1210/en.2011-1195. Epub 2011 Sep 27.


Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420.

Tan TM, Field BC, Minnion JS, Cuenco-Shillito J, Chambers ES, Zac-Varghese S, Brindley CJ, Mt-Isa S, Fiorentino F, Ashby D, Ward I, Ghatei MA, Bloom SR.

Br J Clin Pharmacol. 2012 Feb;73(2):232-9. doi: 10.1111/j.1365-2125.2011.04082.x.


Peptide YY 3-36 and pancreatic polypeptide differentially regulate hypothalamic neuronal activity in mice in vivo as measured by manganese-enhanced magnetic resonance imaging.

Hankir MK, Parkinson JR, Minnion JS, Addison ML, Bloom SR, Bell JD.

J Neuroendocrinol. 2011 Apr;23(4):371-80. doi: 10.1111/j.1365-2826.2011.02111.x.


Central and peripheral administration of human relaxin-2 to adult male rats inhibits food intake.

McGowan BM, Minnion JS, Murphy KG, White NE, Roy D, Stanley SA, Dhillo WS, Gardiner JV, Ghatei MA, Bloom SR.

Diabetes Obes Metab. 2010 Dec;12(12):1090-6. doi: 10.1111/j.1463-1326.2010.01302.x.


Subcutaneous oxyntomodulin analogue administration reduces body weight in lean and obese rodents.

Liu YL, Ford HE, Druce MR, Minnion JS, Field BC, Shillito JC, Baxter J, Murphy KG, Ghatei MA, Bloom SR.

Int J Obes (Lond). 2010 Dec;34(12):1715-25. doi: 10.1038/ijo.2010.110. Epub 2010 Jun 8.


The role of gut hormones and the hypothalamus in appetite regulation.

Suzuki K, Simpson KA, Minnion JS, Shillito JC, Bloom SR.

Endocr J. 2010;57(5):359-72. Epub 2010 Apr 14. Review.


Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs.

Druce MR, Minnion JS, Field BC, Patel SR, Shillito JC, Tilby M, Beale KE, Murphy KG, Ghatei MA, Bloom SR.

Endocrinology. 2009 Apr;150(4):1712-22. doi: 10.1210/en.2008-0828. Epub 2008 Dec 12.


Effects of acute and chronic relaxin-3 on food intake and energy expenditure in rats.

McGowan BM, Stanley SA, Smith KL, Minnion JS, Donovan J, Thompson EL, Patterson M, Connolly MM, Abbott CR, Small CJ, Gardiner JV, Ghatei MA, Bloom SR.

Regul Pept. 2006 Sep 11;136(1-3):72-7. Epub 2006 Jun 9.

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