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Items: 1 to 50 of 159

1.

Ready Experimental Translocation of Mycobacterium canettii Yields Pulmonary Tuberculosis.

Bouzid F, Brégeon F, Lepidi H, Donoghue HD, Minnikin DE, Drancourt M.

Infect Immun. 2017 Nov 17;85(12). pii: e00507-17. doi: 10.1128/IAI.00507-17. Print 2017 Dec.

2.

The role of hydrophobicity in tuberculosis evolution and pathogenicity.

Jankute M, Nataraj V, Lee OY, Wu HHT, Ridell M, Garton NJ, Barer MR, Minnikin DE, Bhatt A, Besra GS.

Sci Rep. 2017 May 2;7(1):1315. doi: 10.1038/s41598-017-01501-0.

3.

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.

Singh A, Varela C, Bhatt K, Veerapen N, Lee OY, Wu HH, Besra GS, Minnikin DE, Fujiwara N, Teramoto K, Bhatt A.

PLoS One. 2016 Oct 14;11(10):e0164253. doi: 10.1371/journal.pone.0164253. eCollection 2016.

4.

Osteological, biomolecular and geochemical examination of an early anglo-saxon case of lepromatous leprosy.

Inskip SA, Taylor GM, Zakrzewski SR, Mays SA, Pike AW, Llewellyn G, Williams CM, Lee OY, Wu HH, Minnikin DE, Besra GS, Stewart GR.

PLoS One. 2015 May 13;10(5):e0124282. doi: 10.1371/journal.pone.0124282. eCollection 2015.

5.

MKAN27435 is required for the biosynthesis of higher subclasses of lipooligosaccharides in Mycobacterium kansasii.

Nataraj V, Pang PC, Haslam SM, Veerapen N, Minnikin DE, Dell A, Besra GS, Bhatt A.

PLoS One. 2015 Apr 20;10(3):e0122804. doi: 10.1371/journal.pone.0122804. eCollection 2015.

6.

Human tuberculosis predates domestication in ancient Syria.

Baker O, Lee OY, Wu HH, Besra GS, Minnikin DE, Llewellyn G, Williams CM, Maixner F, O'Sullivan N, Zink A, Chamel B, Khawam R, Coqueugniot E, Helmer D, Le Mort F, Perrin P, Gourichon L, Dutailly B, Pálfi G, Coqueugniot H, Dutour O.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S4-S12. doi: 10.1016/j.tube.2015.02.001. Epub 2015 Feb 26.

PMID:
25819157
7.

Lipid biomarkers provide evolutionary signposts for the oldest known cases of tuberculosis.

Lee OY, Wu HH, Besra GS, Rothschild BM, Spigelman M, Hershkovitz I, Bar-Gal GK, Donoghue HD, Minnikin DE.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S127-32. doi: 10.1016/j.tube.2015.02.013. Epub 2015 Feb 25.

PMID:
25797611
8.

Ancient DNA analysis - An established technique in charting the evolution of tuberculosis and leprosy.

Donoghue HD, Spigelman M, O'Grady J, Szikossy I, Pap I, Lee OY, Wu HH, Besra GS, Minnikin DE.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S140-4. doi: 10.1016/j.tube.2015.02.020. Epub 2015 Feb 13.

PMID:
25773651
9.

Morphological and biomolecular evidence for tuberculosis in 8th century AD skeletons from Bélmegyer-Csömöki domb, Hungary.

Molnár E, Donoghue HD, Lee OY, Wu HH, Besra GS, Minnikin DE, Bull ID, Llewellyn G, Williams CM, Spekker O, Pálfi G.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S35-41. doi: 10.1016/j.tube.2015.02.032. Epub 2015 Feb 13.

PMID:
25771204
10.

7000 year-old tuberculosis cases from Hungary - Osteological and biomolecular evidence.

Masson M, Bereczki Z, Molnár E, Donoghue HD, Minnikin DE, Lee OY, Wu HH, Besra GS, Bull ID, Pálfi G.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S13-7. doi: 10.1016/j.tube.2015.02.007. Epub 2015 Feb 12.

PMID:
25736538
11.

Ancient mycobacterial lipids: Key reference biomarkers in charting the evolution of tuberculosis.

Minnikin DE, Lee OY, Wu HH, Besra GS, Bhatt A, Nataraj V, Rothschild BM, Spigelman M, Donoghue HD.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S133-9. doi: 10.1016/j.tube.2015.02.009. Epub 2015 Feb 12.

PMID:
25736170
12.

Development of sample clean up methods for the analysis of Mycobacterium tuberculosis methyl mycocerosate biomarkers in sputum extracts by gas chromatography-mass spectrometry.

Nicoara SC, Turner NW, Minnikin DE, Lee OY, O'Sullivan DM, McNerney R, Mutetwa R, Corbett LE, Morgan GH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1;986-987:135-42. doi: 10.1016/j.jchromb.2015.02.010. Epub 2015 Feb 16.

13.

Tuberculosis origin: The Neolithic scenario.

Hershkovitz I, Donoghue HD, Minnikin DE, May H, Lee OY, Feldman M, Galili E, Spigelman M, Rothschild BM, Bar-Gal GK.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S122-6. doi: 10.1016/j.tube.2015.02.021. Epub 2015 Feb 13.

PMID:
25726364
14.

A migration-driven model for the historical spread of leprosy in medieval Eastern and Central Europe.

Donoghue HD, Michael Taylor G, Marcsik A, Molnár E, Pálfi G, Pap I, Teschler-Nicola M, Pinhasi R, Erdal YS, Velemínsky P, Likovsky J, Belcastro MG, Mariotti V, Riga A, Rubini M, Zaio P, Besra GS, Lee OY, Wu HH, Minnikin DE, Bull ID, O'Grady J, Spigelman M.

Infect Genet Evol. 2015 Apr;31:250-6. doi: 10.1016/j.meegid.2015.02.001. Epub 2015 Feb 11.

PMID:
25680828
15.

Differential spontaneous folding of mycolic acids from Mycobacterium tuberculosis.

Groenewald W, Baird MS, Verschoor JA, Minnikin DE, Croft AK.

Chem Phys Lipids. 2014 May;180:15-22. doi: 10.1016/j.chemphyslip.2013.12.004. Epub 2013 Dec 18.

16.

Osteological and biomolecular evidence of a 7000-year-old case of hypertrophic pulmonary osteopathy secondary to tuberculosis from neolithic hungary.

Masson M, Molnár E, Donoghue HD, Besra GS, Minnikin DE, Wu HH, Lee OY, Bull ID, Pálfi G.

PLoS One. 2013 Oct 30;8(10):e78252. doi: 10.1371/journal.pone.0078252. eCollection 2013.

17.

Development and optimization of a gas chromatography/mass spectrometry method for the analysis of thermochemolytic degradation products of phthiocerol dimycocerosate waxes found in Mycobacterium tuberculosis.

Nicoara SC, Minnikin DE, Lee OC, O'Sullivan DM, McNerney R, Pillinger CT, Wright IP, Morgan GH.

Rapid Commun Mass Spectrom. 2013 Nov 15;27(21):2374-82. doi: 10.1002/rcm.6694.

18.

Conformational folding of mycobacterial methoxy- and ketomycolic acids facilitated by α-methyl trans-cyclopropane groups rather than cis-cyclopropane units.

Villeneuve M, Kawai M, Horiuchi K, Watanabe M, Aoyagi Y, Hitotsuyanagi Y, Takeya K, Gouda H, Hirono S, Minnikin DE.

Microbiology. 2013 Nov;159(Pt 11):2405-15. doi: 10.1099/mic.0.068866-0. Epub 2013 Sep 6.

PMID:
24014663
19.

Metagenomic analysis of tuberculosis in a mummy.

Chan JZ, Sergeant MJ, Lee OY, Minnikin DE, Besra GS, Pap I, Spigelman M, Donoghue HD, Pallen MJ.

N Engl J Med. 2013 Jul 18;369(3):289-90. doi: 10.1056/NEJMc1302295. No abstract available.

PMID:
23863071
20.

Genome-wide comparison of medieval and modern Mycobacterium leprae.

Schuenemann VJ, Singh P, Mendum TA, Krause-Kyora B, Jäger G, Bos KI, Herbig A, Economou C, Benjak A, Busso P, Nebel A, Boldsen JL, Kjellström A, Wu H, Stewart GR, Taylor GM, Bauer P, Lee OY, Wu HH, Minnikin DE, Besra GS, Tucker K, Roffey S, Sow SO, Cole ST, Nieselt K, Krause J.

Science. 2013 Jul 12;341(6142):179-83. doi: 10.1126/science.1238286. Epub 2013 Jun 13.

21.

Detection and strain typing of ancient Mycobacterium leprae from a medieval leprosy hospital.

Taylor GM, Tucker K, Butler R, Pike AW, Lewis J, Roffey S, Marter P, Lee OY, Wu HH, Minnikin DE, Besra GS, Singh P, Cole ST, Stewart GR.

PLoS One. 2013 Apr 30;8(4):e62406. doi: 10.1371/journal.pone.0062406. Print 2013.

22.

Mycobacterium tuberculosis complex lipid virulence factors preserved in the 17,000-year-old skeleton of an extinct bison, Bison antiquus.

Lee OY, Wu HH, Donoghue HD, Spigelman M, Greenblatt CL, Bull ID, Rothschild BM, Martin LD, Minnikin DE, Besra GS.

PLoS One. 2012;7(7):e41923. doi: 10.1371/journal.pone.0041923. Epub 2012 Jul 30.

23.

Detection of Mycobacterium tuberculosis in sputum by gas chromatography-mass spectrometry of methyl mycocerosates released by thermochemolysis.

O'Sullivan DM, Nicoara SC, Mutetwa R, Mungofa S, Lee OY, Minnikin DE, Bardwell MW, Corbett EL, McNerney R, Morgan GH.

PLoS One. 2012;7(3):e32836. doi: 10.1371/journal.pone.0032836. Epub 2012 Mar 5.

24.

A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection.

Montamat-Sicotte DJ, Millington KA, Willcox CR, Hingley-Wilson S, Hackforth S, Innes J, Kon OM, Lammas DA, Minnikin DE, Besra GS, Willcox BE, Lalvani A.

J Clin Invest. 2011 Jun;121(6):2493-503. doi: 10.1172/JCI46216. Epub 2011 May 16.

25.

Differential conformational behaviors of alpha-mycolic acids in Langmuir monolayers and computer simulations.

Villeneuve M, Kawai M, Watanabe M, Aoyagi Y, Hitotsuyanagi Y, Takeya K, Gouda H, Hirono S, Minnikin DE, Nakahara H.

Chem Phys Lipids. 2010 Jun;163(6):569-79. doi: 10.1016/j.chemphyslip.2010.04.010. Epub 2010 May 11.

PMID:
20465994
26.

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis.

Donoghue HD, Lee OY, Minnikin DE, Besra GS, Taylor JH, Spigelman M.

Proc Biol Sci. 2010 Jan 7;277(1678):51-6. doi: 10.1098/rspb.2009.1484. Epub 2009 Sep 30.

27.

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

Andersen CA, Rosenkrands I, Olsen AW, Nordly P, Christensen D, Lang R, Kirschning C, Gomes JM, Bhowruth V, Minnikin DE, Besra GS, Follmann F, Andersen P, Agger EM.

J Immunol. 2009 Aug 15;183(4):2294-302. doi: 10.4049/jimmunol.0804091. Epub 2009 Jul 20.

28.

Mycocerosic acid biomarkers for the diagnosis of tuberculosis in the Coimbra Skeletal Collection.

Redman JE, Shaw MJ, Mallet AI, Santos AL, Roberts CA, Gernaey AM, Minnikin DE.

Tuberculosis (Edinb). 2009 Jul;89(4):267-77. doi: 10.1016/j.tube.2009.04.001. Epub 2009 Jun 2.

PMID:
19493698
29.

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.

Bhowruth V, Minnikin DE, Agger EM, Andersen P, Bramwell VW, Perrie Y, Besra GS.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2029-32. doi: 10.1016/j.bmcl.2009.02.027. Epub 2009 Feb 11.

PMID:
19251417
30.

A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.

Andersen CS, Agger EM, Rosenkrands I, Gomes JM, Bhowruth V, Gibson KJ, Petersen RV, Minnikin DE, Besra GS, Andersen P.

J Immunol. 2009 Jan 1;182(1):424-32.

31.

Detection and molecular characterization of 9,000-year-old Mycobacterium tuberculosis from a Neolithic settlement in the Eastern Mediterranean.

Hershkovitz I, Donoghue HD, Minnikin DE, Besra GS, Lee OY, Gernaey AM, Galili E, Eshed V, Greenblatt CL, Lemma E, Bar-Gal GK, Spigelman M.

PLoS One. 2008;3(10):e3426. doi: 10.1371/journal.pone.0003426. Epub 2008 Oct 15.

32.

Loss of a mycobacterial gene encoding a reductase leads to an altered cell wall containing beta-oxo-mycolic acid analogs and accumulation of ketones.

Bhatt A, Brown AK, Singh A, Minnikin DE, Besra GS.

Chem Biol. 2008 Sep 22;15(9):930-9. doi: 10.1016/j.chembiol.2008.07.007.

33.

Conformational behavior of oxygenated mycobacterial mycolic acids from Mycobacterium bovis BCG.

Villeneuve M, Kawai M, Watanabe M, Aoyagi Y, Hitotsuyanagi Y, Takeya K, Gouda H, Hirono S, Minnikin DE, Nakahara H.

Biochim Biophys Acta. 2007 Jul;1768(7):1717-26. Epub 2007 Apr 19. Erratum in: Biochim Biophys Acta. 2007 Sep;1768(9):2343.

34.

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.

Bhowruth V, Brown AK, Reynolds RC, Coxon GD, Mackay SP, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4743-7. Epub 2006 Jul 27.

PMID:
16875817
35.

LosA, a key glycosyltransferase involved in the biosynthesis of a novel family of glycosylated acyltrehalose lipooligosaccharides from Mycobacterium marinum.

Burguière A, Hitchen PG, Dover LG, Kremer L, Ridell M, Alexander DC, Liu J, Morris HR, Minnikin DE, Dell A, Besra GS.

J Biol Chem. 2005 Dec 23;280(51):42124-33. Epub 2005 Oct 28.

36.

Temperature dependence of the Langmuir monolayer packing of mycolic acids from Mycobacterium tuberculosis.

Villeneuve M, Kawai M, Kanashima H, Watanabe M, Minnikin DE, Nakahara H.

Biochim Biophys Acta. 2005 Sep 15;1715(2):71-80.

37.

Identification and structural characterization of an unusual mycobacterial monomeromycolyl-diacylglycerol.

Kremer L, de Chastellier C, Dobson G, Gibson KJ, Bifani P, Balor S, Gorvel JP, Locht C, Minnikin DE, Besra GS.

Mol Microbiol. 2005 Aug;57(4):1113-26.

38.

Inactivation of polyketide synthase and related genes results in the loss of complex lipids in Mycobacterium tuberculosis H37Rv.

Waddell SJ, Chung GA, Gibson KJ, Everett MJ, Minnikin DE, Besra GS, Butcher PD.

Lett Appl Microbiol. 2005;40(3):201-6.

39.

Novel prenyl-linked benzophenone substrate analogues of mycobacterial mannosyltransferases.

Guy MR, Illarionov PA, Gurcha SS, Dover LG, Gibson KJ, Smith PW, Minnikin DE, Besra GS.

Biochem J. 2004 Sep 15;382(Pt 3):905-12.

40.

Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids.

Coxon GD, Al Dulayymi JR, Morehouse C, Brennan PJ, Besra GS, Baird MS, Minnikin DE.

Chem Phys Lipids. 2004 Jan;127(1):35-46.

PMID:
14706739
41.

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):373-6.

PMID:
14698162
42.

Facile synthesis of (Z)-tetracos-5-enoic acid and racemic cis-4-(2-octadecylcyclopropane-1-yl)-butanoic acid.

Coxon GD, Douglas JD, Minnikin DE.

Chem Phys Lipids. 2003 Nov;126(1):49-53.

PMID:
14580710
43.

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2003 Nov 3;13(21):3685-8.

PMID:
14552758
44.

A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum.

Waller RF, Ralph SA, Reed MB, Su V, Douglas JD, Minnikin DE, Cowman AF, Besra GS, McFadden GI.

Antimicrob Agents Chemother. 2003 Jan;47(1):297-301.

45.

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity.

Douglas JD, Senior SJ, Morehouse C, Phetsukiri B, Campbell IB, Besra GS, Minnikin DE.

Microbiology. 2002 Oct;148(Pt 10):3101-9.

PMID:
12368443
46.

Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum.

Garton NJ, Christensen H, Minnikin DE, Adegbola RA, Barer MR.

Microbiology. 2002 Oct;148(Pt 10):2951-8.

PMID:
12368428
47.

Location of functional groups in mycobacterial meromycolate chains; the recognition of new structural principles in mycolic acids.

Watanabe M, Aoyagi Y, Mitome H, Fujita T, Naoki H, Ridell M, Minnikin DE.

Microbiology. 2002 Jun;148(Pt 6):1881-902.

PMID:
12055308
48.

The methyl-branched fortifications of Mycobacterium tuberculosis.

Minnikin DE, Kremer L, Dover LG, Besra GS.

Chem Biol. 2002 May;9(5):545-53. Review.

49.

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS.

Biochem J. 2002 Jun 1;364(Pt 2):423-30.

50.

Mycolic acids and ancient DNA confirm an osteological diagnosis of tuberculosis.

Gernaey AM, Minnikin DE, Copley MS, Dixon RA, Middleton JC, Roberts CA.

Tuberculosis (Edinb). 2001;81(4):259-65.

PMID:
11584593

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