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Items: 1 to 50 of 69

1.

Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation.

Regué L, Minichiello L, Avruch J, Dai N.

J Biol Chem. 2019 Aug 2;294(31):11944-11951. doi: 10.1074/jbc.RA119.008778. Epub 2019 Jun 17.

2.

Pancreatic islet chromatin accessibility and conformation reveals distal enhancer networks of type 2 diabetes risk.

Greenwald WW, Chiou J, Yan J, Qiu Y, Dai N, Wang A, Nariai N, Aylward A, Han JY, Kadakia N, Regue L, Okino ML, Drees F, Kramer D, Vinckier N, Minichiello L, Gorkin D, Avruch J, Frazer KA, Sander M, Ren B, Gaulton KJ.

Nat Commun. 2019 May 7;10(1):2078. doi: 10.1038/s41467-019-09975-4.

3.

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism.

Regué L, Ji F, Flicker D, Kramer D, Pierce W, Davidoff T, Widrick JJ, Houstis N, Minichiello L, Dai N, Avruch J.

Mol Cell Biol. 2019 Mar 19;39(7). pii: e00528-18. doi: 10.1128/MCB.00528-18. Print 2019 Apr 1.

4.

IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1.

Dai N, Ji F, Wright J, Minichiello L, Sadreyev R, Avruch J.

Elife. 2017 Jul 28;6. pii: e27155. doi: 10.7554/eLife.27155.

5.

NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice.

Tomlinson RE, Li Z, Li Z, Minichiello L, Riddle RC, Venkatesan A, Clemens TL.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):E3632-E3641. doi: 10.1073/pnas.1701054114. Epub 2017 Apr 17.

6.

Neurotrophin Signaling Is Required for Glucose-Induced Insulin Secretion.

Houtz J, Borden P, Ceasrine A, Minichiello L, Kuruvilla R.

Dev Cell. 2016 Nov 7;39(3):329-345. doi: 10.1016/j.devcel.2016.10.003.

7.

Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling.

Arregi I, Climent M, Iliev D, Strasser J, Gouignard N, Johansson JK, Singh T, Mazur M, Semb H, Artner I, Minichiello L, Pera EM.

Endocrinology. 2016 Dec;157(12):4615-4631. Epub 2016 Oct 14.

PMID:
27740873
8.

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone.

Tomlinson RE, Li Z, Zhang Q, Goh BC, Li Z, Thorek DLJ, Rajbhandari L, Brushart TM, Minichiello L, Zhou F, Venkatesan A, Clemens TL.

Cell Rep. 2016 Sep 6;16(10):2723-2735. doi: 10.1016/j.celrep.2016.08.002. Epub 2016 Aug 25.

9.

IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.

Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J.

Cell Metab. 2015 Apr 7;21(4):609-21. doi: 10.1016/j.cmet.2015.03.006.

10.

Synaptic mechanisms of adenosine A2A receptor-mediated hyperexcitability in the hippocampus.

Rombo DM, Newton K, Nissen W, Badurek S, Horn JM, Minichiello L, Jefferys JG, Sebastiao AM, Lamsa KP.

Hippocampus. 2015 May;25(5):566-80. doi: 10.1002/hipo.22392. Epub 2014 Nov 29.

PMID:
25402014
11.

Innate immunity. A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus.

Hepburn L, Prajsnar TK, Klapholz C, Moreno P, Loynes CA, Ogryzko NV, Brown K, Schiebler M, Hegyi K, Antrobus R, Hammond KL, Connolly J, Ochoa B, Bryant C, Otto M, Surewaard B, Seneviratne SL, Grogono DM, Cachat J, Ny T, Kaser A, Török ME, Peacock SJ, Holden M, Blundell T, Wang L, Ligoxygakis P, Minichiello L, Woods CG, Foster SJ, Renshaw SA, Floto RA.

Science. 2014 Oct 31;346(6209):641-646. doi: 10.1126/science.1258705.

12.

Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system.

Koudelka J, Horn JM, Vatanashevanopakorn C, Minichiello L.

Neural Dev. 2014 Sep 26;9:21. doi: 10.1186/1749-8104-9-21.

13.

GABAergic and glutamatergic efferents of the mouse ventral tegmental area.

Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR.

J Comp Neurol. 2014 Oct 1;522(14):3308-34. doi: 10.1002/cne.23603.

14.

Ablation of TrkB signalling in CCK neurons results in hypercortisolism and obesity.

Geibel M, Badurek S, Horn JM, Vatanashevanopakorn C, Koudelka J, Wunderlich CM, Brönneke HS, Wunderlich FT, Minichiello L.

Nat Commun. 2014 Mar 12;5:3427. doi: 10.1038/ncomms4427.

PMID:
24619096
15.

Synaptic membrane rafts: traffic lights for local neurotrophin signaling?

Zonta B, Minichiello L.

Front Synaptic Neurosci. 2013 Oct 18;5:9. doi: 10.3389/fnsyn.2013.00009. Review.

16.

BDNF-TrkB signaling in striatopallidal neurons controls inhibition of locomotor behavior.

Besusso D, Geibel M, Kramer D, Schneider T, Pendolino V, Picconi B, Calabresi P, Bannerman DM, Minichiello L.

Nat Commun. 2013;4:2031. doi: 10.1038/ncomms3031.

17.

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5.

Ohtsuka N, Badurek S, Busslinger M, Benes FM, Minichiello L, Rudolph U.

Genesis. 2013 Apr;51(4):234-45. doi: 10.1002/dvg.22370. Epub 2013 Feb 25.

18.

Loss of NGF-TrkA signaling from the CNS is not sufficient to induce cognitive impairments in young adult or intermediate-aged mice.

Müller M, Triaca V, Besusso D, Costanzi M, Horn JM, Koudelka J, Geibel M, Cestari V, Minichiello L.

J Neurosci. 2012 Oct 24;32(43):14885-98. doi: 10.1523/JNEUROSCI.2849-12.2012.

19.

BDNF-TrkB signalling in fear learning: from genetics to neural networks.

Musumeci G, Minichiello L.

Rev Neurosci. 2011;22(3):303-15. doi: 10.1515/RNS.2011.031. Review.

PMID:
21639804
20.

TrkB (tropomyosin-related kinase B) controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex.

Chen AI, Nguyen CN, Copenhagen DR, Badurek S, Minichiello L, Ranscht B, Reichardt LF.

J Neurosci. 2011 Feb 23;31(8):2769-80. doi: 10.1523/JNEUROSCI.4991-10.2011.

21.

PLCγ-activated signalling is essential for TrkB mediated sensory neuron structural plasticity.

Sciarretta C, Fritzsch B, Beisel K, Rocha-Sanchez SM, Buniello A, Horn JM, Minichiello L.

BMC Dev Biol. 2010 Oct 8;10:103. doi: 10.1186/1471-213X-10-103.

22.

Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.

He XP, Pan E, Sciarretta C, Minichiello L, McNamara JO.

J Neurosci. 2010 May 5;30(18):6188-96. doi: 10.1523/JNEUROSCI.5821-09.2010.

23.

Cell culture of primary cerebellar granule cells.

Krämer D, Minichiello L.

Methods Mol Biol. 2010;633:233-9. doi: 10.1007/978-1-59745-019-5_17.

PMID:
20204632
24.

The preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry.

Sciarretta C, Minichiello L.

Methods Mol Biol. 2010;633:221-31. doi: 10.1007/978-1-59745-019-5_16.

PMID:
20204631
25.

TrkB signalling pathways in LTP and learning.

Minichiello L.

Nat Rev Neurosci. 2009 Dec;10(12):850-60. doi: 10.1038/nrn2738. Review.

PMID:
19927149
26.

TrkB modulates fear learning and amygdalar synaptic plasticity by specific docking sites.

Musumeci G, Sciarretta C, Rodríguez-Moreno A, Al Banchaabouchi M, Negrete-Díaz V, Costanzi M, Berno V, Egorov AV, von Bohlen Und Halbach O, Cestari V, Delgado-García JM, Minichiello L.

J Neurosci. 2009 Aug 12;29(32):10131-43. doi: 10.1523/JNEUROSCI.1707-09.2009.

27.

Increased dopamine after mating impairs olfaction and prevents odor interference with pregnancy.

Serguera C, Triaca V, Kelly-Barrett J, Banchaabouchi MA, Minichiello L.

Nat Neurosci. 2008 Aug;11(8):949-56. doi: 10.1038/nn.2154. Epub 2008 Jul 20.

PMID:
18641644
28.

TrkB but not trkC receptors are necessary for postnatal maintenance of hippocampal spines.

von Bohlen und Halbach O, Minichiello L, Unsicker K.

Neurobiol Aging. 2008 Aug;29(8):1247-55. Epub 2007 Apr 17.

PMID:
17442456
29.

Mutation at the TrkB PLC{gamma}-docking site affects hippocampal LTP and associative learning in conscious mice.

Gruart A, Sciarretta C, Valenzuela-Harrington M, Delgado-García JM, Minichiello L.

Learn Mem. 2007 Jan-Feb;14(1):54-62.

30.
31.

BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons.

Pastrana E, Moreno-Flores MT, Avila J, Wandosell F, Minichiello L, Diaz-Nido J.

Neurochem Int. 2007 Feb;50(3):491-8. Epub 2006 Dec 8.

PMID:
17157963
32.
33.

Neurotrophin receptor heterozygosity causes deficits in catecholaminergic innervation of amygdala and hippocampus in aged mice.

von Bohlen Und Halbach O, Minichiello L.

J Neural Transm (Vienna). 2006 Dec;113(12):1829-36. Epub 2006 Jun 1.

PMID:
16736233
34.

Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signaling.

Gärtner A, Polnau DG, Staiger V, Sciarretta C, Minichiello L, Thoenen H, Bonhoeffer T, Korte M.

J Neurosci. 2006 Mar 29;26(13):3496-504.

35.

Regional- and age-dependent reduction in trkB receptor expression in the hippocampus is associated with altered spine morphologies.

von Bohlen und Halbach O, Krause S, Medina D, Sciarretta C, Minichiello L, Unsicker K.

Biol Psychiatry. 2006 May 1;59(9):793-800. Epub 2005 Dec 1.

PMID:
16325153
36.

Apoptosis of oligodendrocytes via Fas and TNF-R1 is a key event in the induction of experimental autoimmune encephalomyelitis.

Hövelmeyer N, Hao Z, Kranidioti K, Kassiotis G, Buch T, Frommer F, von Hoch L, Kramer D, Minichiello L, Kollias G, Lassmann H, Waisman A.

J Immunol. 2005 Nov 1;175(9):5875-84.

37.

Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo.

Stenqvist A, Agerman K, Marmigère F, Minichiello L, Ernfors P.

EMBO Rep. 2005 Oct;6(10):973-8.

38.

Haploinsufficiency for trkB and trkC receptors induces cell loss and accumulation of alpha-synuclein in the substantia nigra.

von Bohlen und Halbach O, Minichiello L, Unsicker K.

FASEB J. 2005 Oct;19(12):1740-2. Epub 2005 Jul 21.

PMID:
16037097
39.

TrkB regulates neocortex formation through the Shc/PLCgamma-mediated control of neuronal migration.

Medina DL, Sciarretta C, Calella AM, Von Bohlen Und Halbach O, Unsicker K, Minichiello L.

EMBO J. 2004 Oct 1;23(19):3803-14. Epub 2004 Sep 16.

40.

Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.

Rivera C, Voipio J, Thomas-Crusells J, Li H, Emri Z, Sipilä S, Payne JA, Minichiello L, Saarma M, Kaila K.

J Neurosci. 2004 May 12;24(19):4683-91.

41.

Haploinsufficiency in trkB and/or trkC neurotrophin receptors causes structural alterations in the aged hippocampus and amygdala.

von Bohlen und Halbach O, Minichiello L, Unsicker K.

Eur J Neurosci. 2003 Oct;18(8):2319-25.

PMID:
14622193
42.

Lack of Bdnf and TrkB signalling in the postnatal cochlea leads to a spatial reshaping of innervation along the tonotopic axis and hearing loss.

Schimmang T, Tan J, Müller M, Zimmermann U, Rohbock K, Kôpschall I, Limberger A, Minichiello L, Knipper M.

Development. 2003 Oct;130(19):4741-50.

43.

Neurotrophin-4 mediated TrkB activation reinforces morphine-induced analgesia.

Lucas G, Hendolin P, Harkany T, Agerman K, Paratcha G, Holmgren C, Zilberter Y, Sairanen M, Minichiello L, Castren E, Ernfors P.

Nat Neurosci. 2003 Mar;6(3):221-2. No abstract available.

PMID:
12601381
44.

Mechanism of TrkB-mediated hippocampal long-term potentiation.

Minichiello L, Calella AM, Medina DL, Bonhoeffer T, Klein R, Korte M.

Neuron. 2002 Sep 26;36(1):121-37.

45.
46.

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

Zhang SQ, Tsiaras WG, Araki T, Wen G, Minichiello L, Klein R, Neel BG.

Mol Cell Biol. 2002 Jun;22(12):4062-72.

47.
48.

Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons.

Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R, Minichiello L.

Genes Dev. 2002 Mar 1;16(5):633-45.

49.

Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities.

Fan G, Egles C, Sun Y, Minichiello L, Renger JJ, Klein R, Liu G, Jaenisch R.

Nat Neurosci. 2000 Apr;3(4):350-7.

PMID:
10725924
50.

Shc-binding site in the TrkB receptor is not required for hippocampal long-term potentiation.

Korte M, Minichiello L, Klein R, Bonhoeffer T.

Neuropharmacology. 2000 Mar 3;39(5):717-24.

PMID:
10699438

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