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Earliest amyloid and tau deposition modulate the influence of limbic networks during closed-loop hippocampal downregulation.

Skouras S, Torner J, Andersson P, Koush Y, Falcon C, Minguillon C, Fauria K, Alpiste F, Blenow K, Zetterberg H, Gispert JD, Molinuevo JL; ALFA Study .

Brain. 2020 Feb 24. pii: awaa011. doi: 10.1093/brain/awaa011. [Epub ahead of print]


Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults.

Grau-Rivera O, Operto G, Falcón C, Sánchez-Benavides G, Cacciaglia R, Brugulat-Serrat A, Gramunt N, Salvadó G, Suárez-Calvet M, Minguillon C, Iranzo Á, Gispert JD, Molinuevo JL; ALFA Study.

Alzheimers Res Ther. 2020 Jan 7;12(1):4. doi: 10.1186/s13195-019-0547-3.


White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants.

Brugulat-Serrat A, Salvadó G, Operto G, Cacciaglia R, Sudre CH, Grau-Rivera O, Suárez-Calvet M, Falcon C, Sánchez-Benavides G, Gramunt N, Minguillon C, Fauria K, Barkhof F, Molinuevo JL, Gispert JD; ALFA Study.

Hum Brain Mapp. 2019 Nov 28. doi: 10.1002/hbm.24877. [Epub ahead of print]


Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers.

Salvadó G, Molinuevo JL, Brugulat-Serrat A, Falcon C, Grau-Rivera O, Suárez-Calvet M, Pavia J, Niñerola-Baizán A, Perissinotti A, Lomeña F, Minguillon C, Fauria K, Zetterberg H, Blennow K, Gispert JD; Alzheimer’s Disease Neuroimaging Initiative, for the ALFA Study.

Alzheimers Res Ther. 2019 Mar 21;11(1):27. doi: 10.1186/s13195-019-0478-z.


Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort.

Sánchez-Benavides G, Grau-Rivera O, Suárez-Calvet M, Minguillon C, Cacciaglia R, Gramunt N, Falcon C; ALFA Study, Gispert JD, Molinuevo JL.

Alzheimers Res Ther. 2018 Dec 20;10(1):123. doi: 10.1186/s13195-018-0449-9.


Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline.

Sánchez-Benavides G, Grau-Rivera O, Cacciaglia R, Suárez-Calvet M, Falcon C, Minguillon C, Gramunt N, Sala-Vila A, Gispert JD, Molinuevo JL.

J Alzheimers Dis. 2018;65(1):181-191. doi: 10.3233/JAD-180378.


Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.

Cacciaglia R, Molinuevo JL, Falcón C, Brugulat-Serrat A, Sánchez-Benavides G, Gramunt N, Esteller M, Morán S, Minguillón C, Fauria K, Gispert JD; ALFA study.

Alzheimers Dement. 2018 Jul;14(7):902-912. doi: 10.1016/j.jalz.2018.01.016. Epub 2018 Mar 28.


The Rationale Behind the New Alzheimer's Disease Conceptualization: Lessons Learned During the Last Decades.

Molinuevo JL, Minguillon C, Rami L, Gispert JD.

J Alzheimers Dis. 2018;62(3):1067-1077. doi: 10.3233/JAD-170698. Review.


Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration.

Sánchez-Iranzo H, Galardi-Castilla M, Minguillón C, Sanz-Morejón A, González-Rosa JM, Felker A, Ernst A, Guzmán-Martínez G, Mosimann C, Mercader N.

Nat Commun. 2018 Jan 30;9(1):428. doi: 10.1038/s41467-017-02650-6.


Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry.

Lewczuk P, Riederer P, O'Bryant SE, Verbeek MM, Dubois B, Visser PJ, Jellinger KA, Engelborghs S, Ramirez A, Parnetti L, Jack CR Jr, Teunissen CE, Hampel H, Lleó A, Jessen F, Glodzik L, de Leon MJ, Fagan AM, Molinuevo JL, Jansen WJ, Winblad B, Shaw LM, Andreasson U, Otto M, Mollenhauer B, Wiltfang J, Turner MR, Zerr I, Handels R, Thompson AG, Johansson G, Ermann N, Trojanowski JQ, Karaca I, Wagner H, Oeckl P, van Waalwijk van Doorn L, Bjerke M, Kapogiannis D, Kuiperij HB, Farotti L, Li Y, Gordon BA, Epelbaum S, Vos SJB, Klijn CJM, Van Nostrand WE, Minguillon C, Schmitz M, Gallo C, Lopez Mato A, Thibaut F, Lista S, Alcolea D, Zetterberg H, Blennow K, Kornhuber J; Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut.

World J Biol Psychiatry. 2018 Jun;19(4):244-328. doi: 10.1080/15622975.2017.1375556. Epub 2017 Oct 27. Review.


Alzheimer's disease prevention: from risk factors to early intervention.

Crous-Bou M, Minguillón C, Gramunt N, Molinuevo JL.

Alzheimers Res Ther. 2017 Sep 12;9(1):71. doi: 10.1186/s13195-017-0297-z. Review.


A right-handed signalling pathway drives heart looping in vertebrates.

Ocaña OH, Coskun H, Minguillón C, Murawala P, Tanaka EM, Galcerán J, Muñoz-Chápuli R, Nieto MA.

Nature. 2017 Sep 6;549(7670):86-90. doi: 10.1038/nature23454.


Higher prevalence of cerebral white matter hyperintensities in homozygous APOE-ɛ4 allele carriers aged 45-75: Results from the ALFA study.

Rojas S, Brugulat-Serrat A, Bargalló N, Minguillón C, Tucholka A, Falcon C, Carvalho A, Morán S, Esteller M, Gramunt N, Fauria K, Camí J, Molinuevo JL, Gispert JD.

J Cereb Blood Flow Metab. 2018 Feb;38(2):250-261. doi: 10.1177/0271678X17707397. Epub 2017 May 11.


Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project.

Brugulat-Serrat A, Rojas S, Bargalló N, Conesa G, Minguillón C, Fauria K, Gramunt N, Molinuevo JL, Gispert JD.

BMJ Open. 2017 Mar 24;7(3):e013215. doi: 10.1136/bmjopen-2016-013215.


Metabolic profile modifications in milk after enrofloxacin administration studied by liquid chromatography coupled with high resolution mass spectrometry.

Junza A, Saurina J, Barrón D, Minguillón C.

J Chromatogr A. 2016 Aug 19;1460:92-9. doi: 10.1016/j.chroma.2016.07.016. Epub 2016 Jul 7.


The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease.

Molinuevo JL, Gramunt N, Gispert JD, Fauria K, Esteller M, Minguillon C, Sánchez-Benavides G, Huesa G, Morán S, Dal-Ré R, Camí J.

Alzheimers Dement (N Y). 2016 Mar 3;2(2):82-92. doi: 10.1016/j.trci.2016.02.003. eCollection 2016 Jun.


Effects of supercritical fluid chromatography conditions on enantioselectivity and performance of polyproline-derived chiral stationary phases.

Novell A, Méndez A, Minguillón C.

J Chromatogr A. 2015 Jul 17;1403:138-43. doi: 10.1016/j.chroma.2015.05.026. Epub 2015 May 21.


Monolithic silica columns with covalently attached octaproline chiral selector. Dependence of performance on derivatization degree and comparison with a bead-based analogue.

Novell A, Minguillón C.

J Chromatogr A. 2015 Mar 6;1384:124-32. doi: 10.1016/j.chroma.2015.01.060. Epub 2015 Jan 28.


High resolution mass spectrometry in the identification of transformation products and metabolites from β-lactam antibiotics in thermally treated milk.

Junza A, Montané A, Barbosa J, Minguillón C, Barrón D.

J Chromatogr A. 2014 Nov 14;1368:89-99. doi: 10.1016/j.chroma.2014.09.056. Epub 2014 Oct 2.


Monolithic silica columns functionalized with substituted polyproline-derived chiral selectors as chiral stationary phases for high-performance liquid chromatography.

Sancho R, Novell A, Svec F, Minguillón C.

J Sep Sci. 2014 Oct;37(20):2805-13. doi: 10.1002/jssc.201400640. Epub 2014 Sep 10.


Octaproline, a conformationally flexible chiral selector in liquid chromatographic enantioseparation.

Novell A, Minguillón C.

J Chromatogr A. 2014 Oct 10;1363:109-18. doi: 10.1016/j.chroma.2014.05.020. Epub 2014 May 14.


Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development.

Pi-Roig A, Martin-Blanco E, Minguillon C.

Open Biol. 2014 Apr 23;4:140014. doi: 10.1098/rsob.140014.


A combination of activation and repression by a colinear Hox code controls forelimb-restricted expression of Tbx5 and reveals Hox protein specificity.

Nishimoto S, Minguillon C, Wood S, Logan MP.

PLoS Genet. 2014 Mar 20;10(3):e1004245. doi: 10.1371/journal.pgen.1004245. eCollection 2014 Mar.


Hox genes regulate the onset of Tbx5 expression in the forelimb.

Minguillon C, Nishimoto S, Wood S, Vendrell E, Gibson-Brown JJ, Logan MP.

Development. 2012 Sep;139(17):3180-8. doi: 10.1242/dev.084814.


Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

Galdeano C, Viayna E, Sola I, Formosa X, Camps P, Badia A, Clos MV, Relat J, Ratia M, Bartolini M, Mancini F, Andrisano V, Salmona M, Minguillón C, González-Muñoz GC, Rodríguez-Franco MI, Bidon-Chanal A, Luque FJ, Muñoz-Torrero D.

J Med Chem. 2012 Jan 26;55(2):661-9. doi: 10.1021/jm200840c. Epub 2012 Jan 10.


The Prx1 limb enhancers: targeted gene expression in developing zebrafish pectoral fins.

Hernández-Vega A, Minguillón C.

Dev Dyn. 2011 Aug;240(8):1977-88. doi: 10.1002/dvdy.22678. Epub 2011 Jun 14.


Preparative enantioseparation of (+/-)-N-(3,4-cis-3-decyl-1,2,3,4-tetrahydrophenanthren-4-yl)-3,5-dinitrobenzamide by centrifugal partition chromatography.

Rubio N, Minguillón C.

J Chromatogr A. 2010 Feb 19;1217(8):1183-90. doi: 10.1016/j.chroma.2009.12.023. Epub 2009 Dec 18.


Tbx4/5 gene duplication and the origin of vertebrate paired appendages.

Minguillon C, Gibson-Brown JJ, Logan MP.

Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21726-30. doi: 10.1073/pnas.0910153106. Epub 2009 Dec 7.


Identification and characterisation of the developmental expression pattern of tbx5b, a novel tbx5 gene in zebrafish.

Albalat R, Baquero M, Minguillón C.

Gene Expr Patterns. 2010 Jan;10(1):24-30. doi: 10.1016/j.gep.2009.11.003. Epub 2009 Nov 17.


Multiple dual-mode countercurrent chromatography applied to chiral separations using a (S)-naproxen derivative as chiral selector.

Rubio N, Ignatova S, Minguillón C, Sutherland IA.

J Chromatogr A. 2009 Nov 27;1216(48):8505-11. doi: 10.1016/j.chroma.2009.10.006. Epub 2009 Oct 8.


Retention of fluorinated chiral selectors in biphasic fluorinated solvent systems and its application to the separation of enantiomers by countercurrent chromatography.

Pérez AM, Minguillón C.

J Chromatogr A. 2010 Feb 12;1217(7):1094-100. doi: 10.1016/j.chroma.2009.09.071. Epub 2009 Oct 2.


The chromatographic separation of enantiomers through nanoscale design.

Sancho R, Minguillón C.

Chem Soc Rev. 2009 Mar;38(3):797-805. doi: 10.1039/b718359n. Epub 2009 Jan 13. Review.


From the American to the European amphioxus: towards experimental Evo-Devo at the origin of chordates.

Garcia-Fernàndez J, Jiménez-Delgado S, Pascual-Anaya J, Maeso I, Irimia M, Minguillón C, Benito-Gutiérrez E, Gardenyes J, Bertrand S, D'Aniello S.

Int J Dev Biol. 2009;53(8-10):1359-66. doi: 10.1387/ijdb.072436jg.


Selective monosulfoxidation of tetrathiafulvalenes into chiral TTF-sulfoxides.

Chas M, Riobé F, Sancho R, Minguíllon C, Avarvari N.

Chirality. 2009 Oct;21(9):818-25. doi: 10.1002/chir.20692.


Conservation of linkage and evolution of developmental function within the Tbx2/3/4/5 subfamily of T-box genes: implications for the origin of vertebrate limbs.

Horton AC, Mahadevan NR, Minguillon C, Osoegawa K, Rokhsar DS, Ruvinsky I, de Jong PJ, Logan MP, Gibson-Brown JJ.

Dev Genes Evol. 2008 Dec;218(11-12):613-28. doi: 10.1007/s00427-008-0249-5. Epub 2008 Sep 25.


Polyproline derivatives as chiral selectors in high performance liquid chromatography: chromatographic and conformational studies.

Sancho R, Minguillón C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Nov 1;875(1):93-101. doi: 10.1016/j.jchromb.2008.05.041.


Application of cellulose and amylose arylcarbamates as chiral selectors in counter-current chromatography.

Pérez E, Santos MJ, Minguillón C.

J Chromatogr A. 2006 Feb 24;1107(1-2):165-74. Epub 2006 Jan 18.


Enantiomer separation by counter-current chromatography. Optimisation and drawbacks in the use of L-proline derivatives as chiral selectors.

Delgado B, Pérez E, Santano MC, Minguillón C.

J Chromatogr A. 2005 Oct 21;1092(1):36-42. Epub 2005 Apr 2.


Metabolism of fluoranthene by Mycobacterium sp. strain AP1.

López Z, Vila J, Minguillón C, Grifoll M.

Appl Microbiol Biotechnol. 2006 May;70(6):747-56. Epub 2005 Aug 25.


No more than 14: the end of the amphioxus Hox cluster.

Minguillón C, Gardenyes J, Serra E, Castro LF, Hill-Force A, Holland PW, Amemiya CT, Garcia-Fernàndez J.

Int J Biol Sci. 2005;1(1):19-23. Epub 2005 Jan 5.


The comparative genomics of T-box genes.

Minguillon C, Logan M.

Brief Funct Genomic Proteomic. 2003 Oct;2(3):224-33. Review.


Developmental biology reaches new lineages.

Minguillon C, Logan M.

Genome Biol. 2004;5(7):333. Epub 2004 Jun 24. No abstract available.


Evolution of the Hox/ParaHox gene clusters.

Ferrier DE, Minguillón C.

Int J Dev Biol. 2003;47(7-8):605-11. Review.


The amphioxus Hairy family: differential fate after duplication.

Minguillón C, Jiménez-Delgado S, Panopoulou G, Garcia-Fernàndez J.

Development. 2003 Dec;130(24):5903-14. Epub 2003 Oct 15.


Genesis and evolution of the Evx and Mox genes and the extended Hox and ParaHox gene clusters.

Minguillón C, Garcia-Fernàndez J.

Genome Biol. 2003;4(2):R12. Epub 2003 Jan 23.


Enantiomer separation by countercurrent chromatography using cinchona alkaloid derivatives as chiral selectors.

Franco P, Blanc J, Oberleitner WR, Maier NM, Lindner W, Minguillón C.

Anal Chem. 2002 Aug 15;74(16):4175-83.


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