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Antimicrobial activity of amphiphilic neamine derivatives: Understanding the mechanism of action on Gram-positive bacteria.

Swain J, El Khoury M, Flament A, Dezanet C, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

Biochim Biophys Acta Biomembr. 2019 Oct 1;1861(10):182998. doi: 10.1016/j.bbamem.2019.05.020. Epub 2019 May 31.


The activity of the saponin ginsenoside Rh2 is enhanced by the interaction with membrane sphingomyelin but depressed by cholesterol.

Verstraeten SL, Deleu M, Janikowska-Sagan M, Claereboudt EJS, Lins L, Tyteca D, Mingeot-Leclercq MP.

Sci Rep. 2019 May 13;9(1):7285. doi: 10.1038/s41598-019-43674-w.


Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components.

Le TB, Beaufay C, Nghiem DT, Pham TA, Mingeot-Leclercq MP, Quetin-Leclercq J.

Molecules. 2019 Mar 23;24(6). pii: E1158. doi: 10.3390/molecules24061158.


The origin of neural stem cells impacts their interactions with targeted-lipid nanocapsules: Potential role of plasma membrane lipid composition and fluidity.

Carradori D, Dos Santos AG, Masquelier J, Paquot A, Saulnier P, Eyer J, Préat V, Muccioli GG, Mingeot-Leclercq MP, des Rieux A.

J Control Release. 2018 Dec 28;292:248-255. doi: 10.1016/j.jconrel.2018.11.005. Epub 2018 Nov 5.


Broad-spectrum antibacterial amphiphilic aminoglycosides: A new focus on the structure of the lipophilic groups extends the series of active dialkyl neamines.

Zimmermann L, Kempf J, Briée F, Swain J, Mingeot-Leclercq MP, Décout JL.

Eur J Med Chem. 2018 Sep 5;157:1512-1525. doi: 10.1016/j.ejmech.2018.08.022. Epub 2018 Aug 11.


Effect of cardiolipin on the antimicrobial activity of a new amphiphilic aminoglycoside derivative on Pseudomonas aeruginosa.

Swain J, El Khoury M, Kempf J, Briée F, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

PLoS One. 2018 Aug 20;13(8):e0201752. doi: 10.1371/journal.pone.0201752. eCollection 2018.


Tuning of Differential Lipid Order Between Submicrometric Domains and Surrounding Membrane Upon Erythrocyte Reshaping.

Leonard C, Pollet H, Vermylen C, Gov N, Tyteca D, Mingeot-Leclercq MP.

Cell Physiol Biochem. 2018;48(6):2563-2582. doi: 10.1159/000492700. Epub 2018 Aug 17.


Membrane cholesterol delays cellular apoptosis induced by ginsenoside Rh2, a steroid saponin.

Verstraeten SL, Albert M, Paquot A, Muccioli GG, Tyteca D, Mingeot-Leclercq MP.

Toxicol Appl Pharmacol. 2018 Aug 1;352:59-67. doi: 10.1016/j.taap.2018.05.014. Epub 2018 May 18.


The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition.

Dos Santos AG, Marquês JT, Carreira AC, Castro IR, Viana AS, Mingeot-Leclercq MP, de Almeida RFM, Silva LC.

Phys Chem Chem Phys. 2017 Nov 15;19(44):30078-30088. doi: 10.1039/c7cp05353c.


Targeting Bacterial Cardiolipin Enriched Microdomains: An Antimicrobial Strategy Used by Amphiphilic Aminoglycoside Antibiotics.

El Khoury M, Swain J, Sautrey G, Zimmermann L, Van Der Smissen P, Décout JL, Mingeot-Leclercq MP.

Sci Rep. 2017 Sep 6;7(1):10697. doi: 10.1038/s41598-017-10543-3.


Contribution of plasma membrane lipid domains to red blood cell (re)shaping.

Leonard C, Conrard L, Guthmann M, Pollet H, Carquin M, Vermylen C, Gailly P, Van Der Smissen P, Mingeot-Leclercq MP, Tyteca D.

Sci Rep. 2017 Jun 27;7(1):4264. doi: 10.1038/s41598-017-04388-z.


In Vitro Anti-Leishmanial Activity of Essential Oils Extracted from Vietnamese Plants.

Le TB, Beaufay C, Nghiem DT, Mingeot-Leclercq MP, Quetin-Leclercq J.

Molecules. 2017 Jun 27;22(7). pii: E1071. doi: 10.3390/molecules22071071.


Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-β-cyclodextrin complex.

Dos Santos AG, Bayiha JC, Dufour G, Cataldo D, Evrard B, Silva LC, Deleu M, Mingeot-Leclercq MP.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1930-1940. doi: 10.1016/j.bbamem.2017.06.010. Epub 2017 Jun 20.


Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms.

Anantharajah A, Buyck JM, Sundin C, Tulkens PM, Mingeot-Leclercq MP, Van Bambeke F.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e02566-16. doi: 10.1128/AAC.02566-16. Print 2017 Jun.


The antifungal caspofungin increases fluoroquinolone activity against Staphylococcus aureus biofilms by inhibiting N-acetylglucosamine transferase.

Siala W, Kucharíková S, Braem A, Vleugels J, Tulkens PM, Mingeot-Leclercq MP, Van Dijck P, Van Bambeke F.

Nat Commun. 2016 Nov 3;7:13286. doi: 10.1038/ncomms13286.


New Broad-Spectrum Antibacterial Amphiphilic Aminoglycosides Active against Resistant Bacteria: From Neamine Derivatives to Smaller Neosamine Analogues.

Zimmermann L, Das I, Désiré J, Sautrey G, Barros R S V, El Khoury M, Mingeot-Leclercq MP, Décout JL.

J Med Chem. 2016 Oct 27;59(20):9350-9369. Epub 2016 Oct 17.


α-Hederin Induces Apoptosis, Membrane Permeabilization and Morphologic Changes in Two Cancer Cell Lines Through a Cholesterol-Dependent Mechanism.

Lorent JH, Léonard C, Abouzi M, Akabi F, Quetin-Leclercq J, Mingeot-Leclercq MP.

Planta Med. 2016 Dec;82(18):1532-1539. Epub 2016 Aug 30.


Subcellular mechanisms involved in apoptosis induced by aminoglycoside antibiotics: Insights on p53, proteasome and endoplasmic reticulum.

Denamur S, Boland L, Beyaert M, Verstraeten SL, Fillet M, Tulkens PM, Bontemps F, Mingeot-Leclercq MP.

Toxicol Appl Pharmacol. 2016 Oct 15;309:24-36. doi: 10.1016/j.taap.2016.08.020. Epub 2016 Aug 26.


Inhibition of the Injectisome and Flagellar Type III Secretion Systems by INP1855 Impairs Pseudomonas aeruginosa Pathogenicity and Inflammasome Activation.

Anantharajah A, Faure E, Buyck JM, Sundin C, Lindmark T, Mecsas J, Yahr TL, Tulkens PM, Mingeot-Leclercq MP, Guery B, Van Bambeke F.

J Infect Dis. 2016 Oct 1;214(7):1105-16. doi: 10.1093/infdis/jiw295. Epub 2016 Jul 13.


Targeting the Type Three Secretion System in Pseudomonas aeruginosa.

Anantharajah A, Mingeot-Leclercq MP, Van Bambeke F.

Trends Pharmacol Sci. 2016 Sep;37(9):734-749. doi: 10.1016/ Epub 2016 Jun 22. Review.


Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY.

Sautrey G, El Khoury M, Dos Santos AG, Zimmermann L, Deleu M, Lins L, Décout JL, Mingeot-Leclercq MP.

J Biol Chem. 2016 Jun 24;291(26):13864-74. doi: 10.1074/jbc.M115.665364. Epub 2016 May 4.


Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes.

Anantharajah A, Buyck JM, Faure E, Glupczynski Y, Rodriguez-Villalobos H, De Vos D, Pirnay JP, Bilocq F, Guery B, Tulkens PM, Mingeot-Leclercq MP, Van Bambeke F.

Pathog Dis. 2015 Oct;73(7). pii: ftv049. doi: 10.1093/femspd/ftv049. Epub 2015 Jul 22.


The amphiphilic nature of saponins and their effects on artificial and biological membranes and potential consequences for red blood and cancer cells.

Lorent JH, Quetin-Leclercq J, Mingeot-Leclercq MP.

Org Biomol Chem. 2014 Nov 28;12(44):8803-22. doi: 10.1039/c4ob01652a. Review.


Comparison of the antibiotic activities of Daptomycin, Vancomycin, and the investigational Fluoroquinolone Delafloxacin against biofilms from Staphylococcus aureus clinical isolates.

Siala W, Mingeot-Leclercq MP, Tulkens PM, Hallin M, Denis O, Van Bambeke F.

Antimicrob Agents Chemother. 2014 Nov;58(11):6385-97. doi: 10.1128/AAC.03482-14. Epub 2014 Aug 11.


New amphiphilic neamine derivatives active against resistant Pseudomonas aeruginosa and their interactions with lipopolysaccharides.

Sautrey G, Zimmermann L, Deleu M, Delbar A, Souza Machado L, Jeannot K, Van Bambeke F, Buyck JM, Decout JL, Mingeot-Leclercq MP.

Antimicrob Agents Chemother. 2014 Aug;58(8):4420-30. doi: 10.1128/AAC.02536-13. Epub 2014 May 27.


Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer.

Lorent J, Lins L, Domenech Ò, Quetin-Leclercq J, Brasseur R, Mingeot-Leclercq MP.

Langmuir. 2014 Apr 29;30(16):4556-69. doi: 10.1021/la4049902. Epub 2014 Apr 14.


Study of macrophage functions in murine J774 cells and human activated THP-1 cells exposed to oritavancin, a lipoglycopeptide with high cellular accumulation.

Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.

Antimicrob Agents Chemother. 2014;58(4):2059-66. doi: 10.1128/AAC.02475-13. Epub 2014 Jan 21.


Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.

Marquez B, Pourcelle V, Vallet CM, Mingeot-Leclercq MP, Tulkens PM, Marchand-Bruynaert J, Van Bambeke F.

Pharm Res. 2014 May;31(5):1290-301. doi: 10.1007/s11095-013-1250-x. Epub 2013 Dec 5.


Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues.

Zimmermann L, Bussière A, Ouberai M, Baussanne I, Jolivalt C, Mingeot-Leclercq MP, Décout JL.

J Med Chem. 2013 Oct 10;56(19):7691-705. doi: 10.1021/jm401148j. Epub 2013 Oct 1.


Surfactins modulate the lateral organization of fluorescent membrane polar lipids: a new tool to study drug:membrane interaction and assessment of the role of cholesterol and drug acyl chain length.

D'Auria L, Deleu M, Dufour S, Mingeot-Leclercq MP, Tyteca D.

Biochim Biophys Acta. 2013 Sep;1828(9):2064-73. doi: 10.1016/j.bbamem.2013.05.006. Epub 2013 May 17.


Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.

Lorent J, Le Duff CS, Quetin-Leclercq J, Mingeot-Leclercq MP.

J Biol Chem. 2013 May 17;288(20):14000-17. doi: 10.1074/jbc.M112.407635. Epub 2013 Mar 25.


Analysis of the membrane proteome of ciprofloxacin-resistant macrophages by stable isotope labeling with amino acids in cell culture (SILAC).

Caceres NE, Aerts M, Marquez B, Mingeot-Leclercq MP, Tulkens PM, Devreese B, Van Bambeke F.

PLoS One. 2013;8(3):e58285. doi: 10.1371/journal.pone.0058285. Epub 2013 Mar 7.


Effects of surfactin on membrane models displaying lipid phase separation.

Deleu M, Lorent J, Lins L, Brasseur R, Braun N, El Kirat K, Nylander T, Dufrêne YF, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2013 Feb;1828(2):801-15. doi: 10.1016/j.bbamem.2012.11.007. Epub 2012 Nov 14.


Interaction of gentamicin polycation with model and cell membranes.

Kovács E, Savopol T, Iordache MM, Săplăcan L, Sobaru I, Istrate C, Mingeot-Leclercq MP, Moisescu MG.

Bioelectrochemistry. 2012 Oct;87:230-5. doi: 10.1016/j.bioelechem.2012.03.001. Epub 2012 Mar 23.


Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells.

Mingeot-Leclercq MP, Tulkens PM, Denamur S, Vaara T, Vaara M.

Peptides. 2012 Jun;35(2):248-52. doi: 10.1016/j.peptides.2012.03.033. Epub 2012 Apr 6.


Modulation of the expression of ABC transporters in murine (J774) macrophages exposed to large concentrations of the fluoroquinolone antibiotic moxifloxacin.

Vallet CM, Marquez B, Nhiri N, Anantharajah A, Mingeot-Leclercq MP, Tulkens PM, Lallemand JY, Jacquet E, Van Bambeke F.

Toxicology. 2011 Dec 18;290(2-3):178-86. doi: 10.1016/j.tox.2011.09.003. Epub 2011 Sep 17.


Role of oxidative stress in lysosomal membrane permeabilization and apoptosis induced by gentamicin, an aminoglycoside antibiotic.

Denamur S, Tyteca D, Marchand-Brynaert J, Van Bambeke F, Tulkens PM, Courtoy PJ, Mingeot-Leclercq MP.

Free Radic Biol Med. 2011 Nov 1;51(9):1656-65. doi: 10.1016/j.freeradbiomed.2011.07.015. Epub 2011 Jul 23.


Cellular accumulation of fluoroquinolones is not predictive of their intracellular activity: studies with gemifloxacin, moxifloxacin and ciprofloxacin in a pharmacokinetic/pharmacodynamic model of uninfected and infected macrophages.

Vallet CM, Marquez B, Ngabirano E, Lemaire S, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.

Int J Antimicrob Agents. 2011 Sep;38(3):249-56. doi: 10.1016/j.ijantimicag.2011.05.011. Epub 2011 Jul 20.


The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?

Ouberai M, El Garch F, Bussiere A, Riou M, Alsteens D, Lins L, Baussanne I, Dufrêne YF, Brasseur R, Decout JL, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2011 Jun;1808(6):1716-27. doi: 10.1016/j.bbamem.2011.01.014. Epub 2011 Feb 1.


Acylated and unacylated ghrelin binding to membranes and to ghrelin receptor: towards a better understanding of the underlying mechanisms.

Staes E, Absil PA, Lins L, Brasseur R, Deleu M, Lecouturier N, Fievez V, Rieux Ad, Mingeot-Leclercq MP, Raussens V, Préat V.

Biochim Biophys Acta. 2010 Nov;1798(11):2102-13. doi: 10.1016/j.bbamem.2010.07.002. Epub 2010 Jul 13.


Interactions of oritavancin, a new semi-synthetic lipoglycopeptide, with lipids extracted from Staphylococcus aureus.

Domenech O, Dufrêne YF, Van Bambeke F, Tukens PM, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2010 Oct;1798(10):1876-85. doi: 10.1016/j.bbamem.2010.06.011. Epub 2010 Jun 23.


Synthesis and antimicrobial evaluation of amphiphilic neamine derivatives.

Baussanne I, Bussière A, Halder S, Ganem-Elbaz C, Ouberai M, Riou M, Paris JM, Ennifar E, Mingeot-Leclercq MP, Décout JL.

J Med Chem. 2010 Jan 14;53(1):119-27. doi: 10.1021/jm900615h.


Interactions of oritavancin, a new lipoglycopeptide derived from vancomycin, with phospholipid bilayers: Effect on membrane permeability and nanoscale lipid membrane organization.

Domenech O, Francius G, Tulkens PM, Van Bambeke F, Dufrêne Y, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2009 Sep;1788(9):1832-40. doi: 10.1016/j.bbamem.2009.05.003. Epub 2009 May 18.


Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.

Marquez B, Caceres NE, Mingeot-Leclercq MP, Tulkens PM, Van Bambeke F.

Antimicrob Agents Chemother. 2009 Jun;53(6):2410-6. doi: 10.1128/AAC.01428-08. Epub 2009 Mar 23.


Direct observation of Staphylococcus aureus cell wall digestion by lysostaphin.

Francius G, Domenech O, Mingeot-Leclercq MP, Dufrêne YF.

J Bacteriol. 2008 Dec;190(24):7904-9. doi: 10.1128/JB.01116-08. Epub 2008 Oct 3.


Atomic force microscopy of supported lipid bilayers.

Mingeot-Leclercq MP, Deleu M, Brasseur R, Dufrêne YF.

Nat Protoc. 2008;3(10):1654-9. doi: 10.1038/nprot.2008.149.


Interactions of ciprofloxacin with DPPC and DPPG: fluorescence anisotropy, ATR-FTIR and 31P NMR spectroscopies and conformational analysis.

Bensikaddour H, Snoussi K, Lins L, Van Bambeke F, Tulkens PM, Brasseur R, Goormaghtigh E, Mingeot-Leclercq MP.

Biochim Biophys Acta. 2008 Nov;1778(11):2535-43. doi: 10.1016/j.bbamem.2008.08.015. Epub 2008 Sep 6.


Cooperation between prokaryotic (Lde) and eukaryotic (MRP) efflux transporters in J774 macrophages infected with Listeria monocytogenes: studies with ciprofloxacin and moxifloxacin.

Lismond A, Tulkens PM, Mingeot-Leclercq MP, Courvalin P, Van Bambeke F.

Antimicrob Agents Chemother. 2008 Sep;52(9):3040-6. doi: 10.1128/AAC.00105-08. Epub 2008 Jun 23.


Nanoscale membrane activity of surfactins: influence of geometry, charge and hydrophobicity.

Francius G, Dufour S, Deleu M, Paquot M, Mingeot-Leclercq MP, Dufrêne YF.

Biochim Biophys Acta. 2008 Oct;1778(10):2058-68. doi: 10.1016/j.bbamem.2008.03.023. Epub 2008 Apr 11.


Apoptosis induced by aminoglycosides in LLC-PK1 Cells: comparative study of neomycin, gentamicin, amikacin, and isepamicin using electroporation.

Denamur S, Van Bambeke F, Mingeot-Leclercq MP, Tulkens PM.

Antimicrob Agents Chemother. 2008 Jun;52(6):2236-8. doi: 10.1128/AAC.01680-07. Epub 2008 Apr 7.

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