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Items: 1 to 50 of 55

1.

P21 activated kinase signaling in cancer.

Rane CK, Minden A.

Semin Cancer Biol. 2018 Jan 9. pii: S1044-579X(17)30249-3. doi: 10.1016/j.semcancer.2018.01.006. [Epub ahead of print] Review.

PMID:
29330094
2.

Rho GTPase effectors and NAD metabolism in cancer immune suppression.

Chaker M, Minden A, Chen S, Weiss RH, Chini EN, Mahipal A, Azmi AS.

Expert Opin Ther Targets. 2018 Jan;22(1):9-17. doi: 10.1080/14728222.2018.1413091. Epub 2017 Dec 10. Review.

PMID:
29207896
3.

Decrypting the PAK4 transcriptome profile in mammary tumor forming cells using Next Generation Sequencing.

Rane CK, Patel M, Cai L, Senapedis W, Baloglu E, Minden A.

Genomics. 2017 Oct 18. pii: S0888-7543(17)30128-3. doi: 10.1016/j.ygeno.2017.10.004. [Epub ahead of print]

4.

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development.

Zhao M, Rabieifar P, Costa TDF, Zhuang T, Minden A, Löhr M, Heuchel R, Strömblad S.

Sci Rep. 2017 Aug 1;7(1):7031. doi: 10.1038/s41598-017-07322-5.

5.

A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.

Rane C, Senapedis W, Baloglu E, Landesman Y, Crochiere M, Das-Gupta S, Minden A.

Sci Rep. 2017 Feb 15;7:42555. doi: 10.1038/srep42555.

6.

P21 activated kinases: structure, regulation, and functions.

Rane CK, Minden A.

Small GTPases. 2014;5. pii: e28003. doi: 10.4161/sgtp.28003. Epub 2014 Mar 21. Review.

7.

The Pak4 protein kinase is required for oncogenic transformation of MDA-MB-231 breast cancer cells.

Wong LE, Chen N, Karantza V, Minden A.

Oncogenesis. 2013 Jun 3;2:e50. doi: 10.1038/oncsis.2013.13.

8.

Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight.

Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC.

Nutr Neurosci. 2014 Apr;17(3):109-15. doi: 10.1179/1476830513Y.0000000072. Epub 2013 Nov 26.

9.

Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.

Gnad F, Young A, Zhou W, Lyle K, Ong CC, Stokes MP, Silva JC, Belvin M, Friedman LS, Koeppen H, Minden A, Hoeflich KP.

Mol Cell Proteomics. 2013 Aug;12(8):2070-80. doi: 10.1074/mcp.M112.027052. Epub 2013 Apr 22.

10.

Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice.

Furnari MA, Jobes ML, Nekrasova T, Minden A, Wagner GC.

PLoS One. 2013 Apr 8;8(4):e61321. doi: 10.1371/journal.pone.0061321. Print 2013.

11.

The pak4 protein kinase in breast cancer.

Minden A.

ISRN Oncol. 2012;2012:694201. doi: 10.5402/2012/694201. Epub 2012 Dec 27.

12.

PAK4-6 in cancer and neuronal development.

Minden A.

Cell Logist. 2012 Apr 1;2(2):95-104.

13.

The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors.

Coste O, Möser CV, Sisignano M, Kynast KL, Minden A, Geisslinger G, Niederberger E.

Behav Brain Res. 2012 Sep 1;234(1):121-8. doi: 10.1016/j.bbr.2012.06.017. Epub 2012 Jun 23.

PMID:
22732262
14.

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.

Strochlic TI, Concilio S, Viaud J, Eberwine RA, Wong LE, Minden A, Turk BE, Plomann M, Peterson JR.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4116-21. doi: 10.1073/pnas.1116560109. Epub 2012 Feb 27.

15.

Differential Expression of Key Signaling Proteins in MCF10 Cell Lines, a Human Breast Cancer Progression Model.

So JY, Lee HJ, Kramata P, Minden A, Suh N.

Mol Cell Pharmacol. 2012 Jan 1;4(1):31-40.

16.

Role for p21-activated kinase PAK4 in development of the mammalian heart.

Nekrasova T, Minden A.

Transgenic Res. 2012 Aug;21(4):797-811. doi: 10.1007/s11248-011-9578-7. Epub 2011 Dec 16.

PMID:
22173944
17.

A key role for Pak4 in proliferation and differentiation of neural progenitor cells.

Tian Y, Lei L, Minden A.

Dev Biol. 2011 May 15;353(2):206-16. doi: 10.1016/j.ydbio.2011.02.026. Epub 2011 Mar 4.

18.

PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression.

Nekrasova T, Minden A.

J Cell Biochem. 2011 Jul;112(7):1795-806. doi: 10.1002/jcb.23092.

PMID:
21381077
19.

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis.

Liu Y, Chen N, Cui X, Zheng X, Deng L, Price S, Karantza V, Minden A.

Oncogene. 2010 Nov 4;29(44):5883-94. doi: 10.1038/onc.2010.329. Epub 2010 Aug 9.

20.

p120-catenin is a binding partner and substrate for Group B Pak kinases.

Wong LE, Reynolds AB, Dissanayaka NT, Minden A.

J Cell Biochem. 2010 Aug 1;110(5):1244-54. doi: 10.1002/jcb.22639.

PMID:
20564219
21.

Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation.

Tian Y, Lei L, Cammarano M, Nekrasova T, Minden A.

Mech Dev. 2009 Aug-Sep;126(8-9):710-20. doi: 10.1016/j.mod.2009.05.002. Epub 2009 May 21.

22.

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.

Nekrasova T, Jobes ML, Ting JH, Wagner GC, Minden A.

Dev Biol. 2008 Oct 1;322(1):95-108. doi: 10.1016/j.ydbio.2008.07.006. Epub 2008 Jul 16.

23.

The pak4 protein kinase plays a key role in cell survival and tumorigenesis in athymic mice.

Liu Y, Xiao H, Tian Y, Nekrasova T, Hao X, Lee HJ, Suh N, Yang CS, Minden A.

Mol Cancer Res. 2008 Jul;6(7):1215-24. doi: 10.1158/1541-7786.MCR-08-0087.

24.

PAK4 and alphaPIX determine podosome size and number in macrophages through localized actin regulation.

Gringel A, Walz D, Rosenberger G, Minden A, Kutsche K, Kopp P, Linder S.

J Cell Physiol. 2006 Nov;209(2):568-79.

PMID:
16897755
25.
26.
27.

Transforming activity of the Rho family GTPase, Wrch-1, a Wnt-regulated Cdc42 homolog, is dependent on a novel carboxyl-terminal palmitoylation motif.

Berzat AC, Buss JE, Chenette EJ, Weinbaum CA, Shutes A, Der CJ, Minden A, Cox AD.

J Biol Chem. 2005 Sep 23;280(38):33055-65. Epub 2005 Jul 26.

28.

Roles of microtubules, cell polarity and adhesion in electric-field-mediated motility of 3T3 fibroblasts.

Finkelstein E, Chang W, Chao PH, Gruber D, Minden A, Hung CT, Bulinski JC.

J Cell Sci. 2004 Mar 15;117(Pt 8):1533-45.

29.
30.

Targeted disruption of the gene for the PAK5 kinase in mice.

Li X, Minden A.

Mol Cell Biol. 2003 Oct;23(20):7134-42. Erratum in: Mol Cell Biol. 2004 Jun;24(12):5637.

31.

PAK4 kinase is essential for embryonic viability and for proper neuronal development.

Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson R, Beg AA, Minden A.

Mol Cell Biol. 2003 Oct;23(20):7122-33.

32.

Rho regulates p21(CIP1), cyclin D1, and checkpoint control in mammary epithelial cells.

Liberto M, Cobrinik D, Minden A.

Oncogene. 2002 Feb 28;21(10):1590-9.

33.

Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.

Bouzahzah B, Albanese C, Ahmed F, Pixley F, Lisanti MP, Segall JD, Condeelis J, Joyce D, Minden A, Der CJ, Chan A, Symons M, Pestell RG.

Mol Med. 2001 Dec;7(12):816-30.

34.

PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.

Dan C, Nath N, Liberto M, Minden A.

Mol Cell Biol. 2002 Jan;22(2):567-77.

35.

Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin.

Dan C, Kelly A, Bernard O, Minden A.

J Biol Chem. 2001 Aug 24;276(34):32115-21. Epub 2001 Jun 18.

36.

Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways.

Cammarano MS, Minden A.

J Biol Chem. 2001 Jul 13;276(28):25876-82. Epub 2001 May 3.

37.

Activated PAK4 regulates cell adhesion and anchorage-independent growth.

Qu J, Cammarano MS, Shi Q, Ha KC, de Lanerolle P, Minden A.

Mol Cell Biol. 2001 May;21(10):3523-33.

38.

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis.

Gnesutta N, Qu J, Minden A.

J Biol Chem. 2001 Apr 27;276(17):14414-9. Epub 2001 Jan 24.

39.
40.

Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases.

Wang S, Nath N, Minden A, Chellappan S.

EMBO J. 1999 Mar 15;18(6):1559-70.

41.

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia.

Abo A, Qu J, Cammarano MS, Dan C, Fritsch A, Baud V, Belisle B, Minden A.

EMBO J. 1998 Nov 16;17(22):6527-40.

42.

Epidermal growth factor induction of the c-jun promoter by a Rac pathway.

Clarke N, Arenzana N, Hai T, Minden A, Prywes R.

Mol Cell Biol. 1998 Feb;18(2):1065-73.

43.

Regulation and function of the JNK subgroup of MAP kinases.

Minden A, Karin M.

Biochim Biophys Acta. 1997 Oct 24;1333(2):F85-104. Review. No abstract available.

PMID:
9395283
44.
45.

Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac.

Collins LR, Minden A, Karin M, Brown JH.

J Biol Chem. 1996 Jul 19;271(29):17349-53.

46.

Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death.

Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI, Johnson GL.

J Biol Chem. 1996 Feb 9;271(6):3229-37.

47.
48.

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2.

Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M.

Science. 1995 Apr 14;268(5208):286-90.

PMID:
7716521
49.

Multiple Ras functions can contribute to mammalian cell transformation.

White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH.

Cell. 1995 Feb 24;80(4):533-41.

50.

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.

Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M.

Science. 1994 Dec 9;266(5191):1719-23.

PMID:
7992057

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