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Fertil Steril. 2011 Nov;96(5):1134-7. doi: 10.1016/j.fertnstert.2011.08.016. Epub 2011 Sep 13.

Report of results obtained in 2,934 women using donor sperm: donor insemination versus in vitro fertilization according to indication.

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1
Instituto Universitario IVI, Universidad de Valencia, Valencia, Spain.

Abstract

OBJECTIVE:

To demonstrate that the use of donor sperm leads to varying outcome rates and that its use has evolved.

DESIGN:

Retrospective observational cohort study.

SETTING:

University-affiliated private IVF setting.

PATIENT(S):

Women (2,934) undergoing donor insemination (DI) or IVF with donor sperm (IVF-D).

INTERVENTION(S):

None.

MAIN OUTCOME MEASUREMENT(S):

We evaluated the distribution of the clinical indications for the use of donated sperm, studying the reproductive outcome.

RESULT(S):

A total of 1,663 DI (57%) and 1,271 IVF-D (43%) were performed. There were significant differences in the indications for the use of donated sperm (DI vs. IVF-D). Regarding pregnancy rates (PR), cases of nonobstructive azoospermia presented the highest rate (29.1%), whereas cases of intracytoplasmic sperm injection (ICSI) failures and single women showed rates of 27.6% and 22.6%, respectively. Meanwhile, patients with ICSI failures achieved the highest PRs in IVF cycles (48.7%), whereas nonobstructive azoospermia and single women showed rates of 42.0% and 38.2%, respectively. There have been significant increases in the use of donated sperm in single women.

CONCLUSION(S):

Single women, which also represented the oldest group, show a lower probability of achieving pregnancy, and thus represent a subfertile population. Associated factors could include advanced maternal age.

[Indexed for MEDLINE]

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