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Items: 1 to 50 of 59

1.

One-Pot Total Synthesis of Cannabinol via Iodine-Mediated Deconstructive Annulation.

Caprioglio D, Mattoteia D, Minassi A, Pollastro F, Lopatriello A, Muňoz E, Taglialatela-Scafati O, Appendino G.

Org Lett. 2019 Aug 2;21(15):6122-6125. doi: 10.1021/acs.orglett.9b02258. Epub 2019 Jul 24.

PMID:
31339327
2.

Identification of a Strigoterpenoid with Dual Nrf2 and Nf-κB Modulatory Activity.

Rogati F, Millán E, Appendino G, Correa A, Caprioglio D, Minassi A, Muñoz E.

ACS Med Chem Lett. 2019 Jan 8;10(4):606-610. doi: 10.1021/acsmedchemlett.8b00604. eCollection 2019 Apr 11.

PMID:
30996804
3.

Chemoproteomic fishing identifies arzanol as a positive modulator of brain glycogen phosphorylase.

Del Gaudio F, Pollastro F, Mozzicafreddo M, Riccio R, Minassi A, Monti MC.

Chem Commun (Camb). 2018 Nov 13;54(91):12863-12866. doi: 10.1039/c8cc07692h.

PMID:
30375590
4.

Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.

Minassi A, Rogati F, Cruz C, Prados ME, Galera N, Jinénez C, Appendino G, Bellido ML, Calzado MA, Caprioglio D, Muñoz E.

J Nat Prod. 2018 Oct 26;81(10):2235-2243. doi: 10.1021/acs.jnatprod.8b00514. Epub 2018 Oct 10.

PMID:
30350996
5.

Iodine-mediated cyclization of cannabigerol (CBG) expands the cannabinoid biological and chemical space.

Lopatriello A, Caprioglio D, Minassi A, Schiano Moriello A, Formisano C, De Petrocellis L, Appendino G, Taglialatela-Scafati O.

Bioorg Med Chem. 2018 Aug 15;26(15):4532-4536. doi: 10.1016/j.bmc.2018.07.044. Epub 2018 Jul 27.

PMID:
30077611
6.

Cannabis Phenolics and their Bioactivities.

Pollastro F, Minassi A, Fresu LG.

Curr Med Chem. 2018;25(10):1160-1185. doi: 10.2174/0929867324666170810164636. Review.

PMID:
28799497
7.

Electrophilic Triterpenoid Enones: A Comparative Thiol-Trapping and Bioactivity Study.

Del Prete D, Taglialatela-Scafati O, Minassi A, Sirignano C, Cruz C, Bellido ML, Muñoz E, Appendino G.

J Nat Prod. 2017 Aug 25;80(8):2276-2283. doi: 10.1021/acs.jnatprod.7b00271. Epub 2017 Jul 28.

PMID:
28753294
8.

The reaction of cinnamaldehyde and cinnam(o)yl derivatives with thiols.

Autelitano A, Minassi A, Pagani A, Taglialatela-Scafati O, Appendino G.

Acta Pharm Sin B. 2017 Jul;7(4):523-526. doi: 10.1016/j.apsb.2017.06.005. Epub 2017 Jul 8.

9.

Carbonyl Activation in Electrophilic Polyene Cyclizations: A Toolbox for the Design of Isoprenoid Libraries.

Minassi A, Pollastro F, Chianese G, Caprioglio D, Taglialatela-Scafati O, Appendino G.

Angew Chem Int Ed Engl. 2017 Jun 26;56(27):7935-7938. doi: 10.1002/anie.201703455. Epub 2017 Jun 5.

PMID:
28488372
10.

Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2.

Riva B, De Dominici M, Gnemmi I, Mariani SA, Minassi A, Minieri V, Salomoni P, Canonico PL, Genazzani AA, Calabretta B, Condorelli F.

Oncotarget. 2016 Dec 6;7(49):81555-81570. doi: 10.18632/oncotarget.13146.

11.

Triazole-curcuminoids: A new class of derivatives for 'tuning' curcumin bioactivities?

Caprioglio D, Torretta S, Ferrari M, Travelli C, Grolla AA, Condorelli F, Genazzani AA, Minassi A.

Bioorg Med Chem. 2016 Jan 15;24(2):140-52. doi: 10.1016/j.bmc.2015.11.044. Epub 2015 Nov 30.

PMID:
26705144
12.

Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.

Del Prete D, Caprioglio D, Appendino G, Minassi A, Schiano-Moriello A, Di Marzo V, De Petrocellis L.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1009-11. doi: 10.1016/j.bmcl.2015.01.039. Epub 2015 Jan 28.

PMID:
25666822
13.

SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, Collado JA, Werz O.

J Med Chem. 2014 Jul 10;57(13):5638-48. doi: 10.1021/jm500308c. Epub 2014 Jun 24.

PMID:
24920381
14.

Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system.

Chicca A, Caprioglio D, Minassi A, Petrucci V, Appendino G, Taglialatela-Scafati O, Gertsch J.

ACS Chem Biol. 2014 Jul 18;9(7):1499-507. doi: 10.1021/cb500177c. Epub 2014 May 15.

PMID:
24831513
15.

Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs.

Appendino G, Minassi A, Taglialatela-Scafati O.

Nat Prod Rep. 2014 Jul;31(7):880-904. doi: 10.1039/c4np00010b. Epub 2014 May 14. Review.

PMID:
24823967
16.

Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids.

Caldarelli A, Penucchini E, Caprioglio D, Genazzani AA, Minassi A.

Bioorg Med Chem. 2013 Sep 1;21(17):5510-7. doi: 10.1016/j.bmc.2013.05.053. Epub 2013 Jun 13.

PMID:
23830698
17.

Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?

Minassi A, Sánchez-Duffhues G, Collado JA, Muñoz E, Appendino G.

J Nat Prod. 2013 Jun 28;76(6):1105-12. doi: 10.1021/np400148e. Epub 2013 Jun 6.

PMID:
23742639
18.

Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates.

Lefranc J, Minassi A, Clayden J.

Beilstein J Org Chem. 2013 Mar 28;9:628-32. doi: 10.3762/bjoc.9.70. Print 2013.

19.

Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum.

Taglialatela-Scafati O, Pollastro F, Chianese G, Minassi A, Gibbons S, Arunotayanun W, Mabebie B, Ballero M, Appendino G.

J Nat Prod. 2013 Mar 22;76(3):346-53. doi: 10.1021/np3007149. Epub 2012 Dec 24.

PMID:
23265253
20.

Amines bearing tertiary substituents by tandem enantioselective carbolithiation-rearrangement of vinylureas.

Tait M, Donnard M, Minassi A, Lefranc J, Bechi B, Carbone G, O'Brien P, Clayden J.

Org Lett. 2013 Jan 4;15(1):34-7. doi: 10.1021/ol3029324. Epub 2012 Dec 19. Erratum in: Org Lett. 2013 Feb 15;15(4):974-6.

PMID:
23252812
21.

Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.

Muzzi M, Felici R, Cavone L, Gerace E, Minassi A, Appendino G, Moroni F, Chiarugi A.

J Cereb Blood Flow Metab. 2012 Jun;32(6):978-82. doi: 10.1038/jcbfm.2012.36. Epub 2012 Mar 21.

22.

Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.

Bottos A, Martini M, Di Nicolantonio F, Comunanza V, Maione F, Minassi A, Appendino G, Bussolino F, Bardelli A.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E353-9. doi: 10.1073/pnas.1105026109. Epub 2011 Dec 27.

23.

Umbellulone modulates TRP channels.

Zhong J, Minassi A, Prenen J, Taglialatela-Scafati O, Appendino G, Nilius B.

Pflugers Arch. 2011 Dec;462(6):861-70. doi: 10.1007/s00424-011-1043-1. Epub 2011 Oct 29.

PMID:
22038323
24.

Geometry-selective synthesis of E or Z N-vinyl ureas (N-carbamoyl enamines).

Lefranc J, Tetlow DJ, Donnard M, Minassi A, Gálvez E, Clayden J.

Org Lett. 2011 Jan 21;13(2):296-9. doi: 10.1021/ol1027442. Epub 2010 Dec 17.

PMID:
21166427
25.

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

Avonto C, Taglialatela-Scafati O, Pollastro F, Minassi A, Di Marzo V, De Petrocellis L, Appendino G.

Angew Chem Int Ed Engl. 2011 Jan 10;50(2):467-71. doi: 10.1002/anie.201005959. No abstract available.

PMID:
21132828
26.

Tandem beta-alkylation-alpha-arylation of amines by carbolithiation and rearrangement of N-carbamoyl enamines (vinyl ureas).

Clayden J, Donnard M, Lefranc J, Minassi A, Tetlow DJ.

J Am Chem Soc. 2010 May 19;132(19):6624-5. doi: 10.1021/ja1007992.

PMID:
20411935
27.

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The side chain benzylic methylene.

Appendino G, Ech-Chahad A, Minassi A, De Petrocellis L, Di Marzo V.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):97-9. doi: 10.1016/j.bmcl.2009.11.035. Epub 2009 Nov 14.

PMID:
19951840
28.

Anti-inflammatory and vascularprotective properties of 8-prenylapigenin.

Paoletti T, Fallarini S, Gugliesi F, Minassi A, Appendino G, Lombardi G.

Eur J Pharmacol. 2009 Oct 12;620(1-3):120-30. doi: 10.1016/j.ejphar.2009.08.015. Epub 2009 Aug 15.

PMID:
19686724
29.

The biosynthesis of N-arachidonoyl dopamine (NADA), a putative endocannabinoid and endovanilloid, via conjugation of arachidonic acid with dopamine.

Hu SS, Bradshaw HB, Benton VM, Chen JS, Huang SM, Minassi A, Bisogno T, Masuda K, Tan B, Roskoski R Jr, Cravatt BF, Di Marzo V, Walker JM.

Prostaglandins Leukot Essent Fatty Acids. 2009 Oct;81(4):291-301. doi: 10.1016/j.plefa.2009.05.026. Epub 2009 Jun 30.

30.

Protective effect and relation structure-activity of nonivamide and iododerivatives in several models of lipid oxidation.

Rosa A, Appendino G, Melis MP, Deiana M, Atzeri A, Alessandra I, Minassi A, Dessì MA.

Chem Biol Interact. 2009 Jul 15;180(2):183-92. doi: 10.1016/j.cbi.2009.01.002. Epub 2009 Jan 21.

PMID:
19497416
31.

Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death.

Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, Brunelleschi S, Lombardi G.

Br J Pharmacol. 2009 Jul;157(6):1072-84. doi: 10.1111/j.1476-5381.2009.00213.x. Epub 2009 May 21.

32.

Flavonoid-induced autophagy in hormone sensitive breast cancer cells.

Brunelli E, Pinton G, Bellini P, Minassi A, Appendino G, Moro L.

Fitoterapia. 2009 Sep;80(6):327-32. doi: 10.1016/j.fitote.2009.04.002. Epub 2009 Apr 14.

PMID:
19371773
33.

Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes.

Appendino G, Ligresti A, Minassi A, Cascio MG, Allarà M, Taglialatela-Scafati O, Pertwee RG, De Petrocellis L, Di Marzo V.

J Med Chem. 2009 May 14;52(9):3001-9. doi: 10.1021/jm900130m.

PMID:
19361197
34.

Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study.

Klausen TK, Pagani A, Minassi A, Ech-Chahad A, Prenen J, Owsianik G, Hoffmann EK, Pedersen SF, Appendino G, Nilius B.

J Med Chem. 2009 May 14;52(9):2933-9. doi: 10.1021/jm9001007.

PMID:
19361196
35.

In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin.

Overk CR, Guo J, Chadwick LR, Lantvit DD, Minassi A, Appendino G, Chen SN, Lankin DC, Farnsworth NR, Pauli GF, van Breemen RB, Bolton JL.

Chem Biol Interact. 2008 Oct 22;176(1):30-9. doi: 10.1016/j.cbi.2008.06.005. Epub 2008 Jun 20.

36.

A regiodivergent synthesis of ring a C-prenylflavones.

Minassi A, Giana A, Ech-Chahad A, Appendino G.

Org Lett. 2008 Jun 5;10(11):2267-70. doi: 10.1021/ol800665w. Epub 2008 May 3.

PMID:
18454537
37.

Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation.

Márquez N, Calzado MA, Sánchez-Duffhues G, Pérez M, Minassi A, Pagani A, Appendino G, Diaz L, Muñoz-Fernández MA, Muñoz E.

Biochem Pharmacol. 2008 Mar 15;75(6):1370-80. doi: 10.1016/j.bcp.2007.12.004. Epub 2007 Dec 23.

PMID:
18241838
38.

The role of natural products in the ligand deorphanization of TRP channels.

Appendino G, Minassi A, Pagani A, Ech-Chahad A.

Curr Pharm Des. 2008;14(1):2-17. Review.

PMID:
18220814
39.

The 1,2,3-triazole ring as a peptido- and olefinomimetic element: discovery of click vanilloids and cannabinoids.

Appendino G, Bacchiega S, Minassi A, Cascio MG, De Petrocellis L, Di Marzo V.

Angew Chem Int Ed Engl. 2007;46(48):9312-5. No abstract available.

PMID:
17968870
40.

8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells.

Brunelli E, Minassi A, Appendino G, Moro L.

J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):140-8. Epub 2007 Jun 22.

PMID:
17681752
41.

Oxyhomologation of the amide bond potentiates neuroprotective effects of the endolipid N-palmitoylethanolamine.

Lombardi G, Miglio G, Varsaldi F, Minassi A, Appendino G.

J Pharmacol Exp Ther. 2007 Feb;320(2):599-606. Epub 2006 Oct 26.

PMID:
17068202
42.

Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): the homovanillyl moiety.

Appendino G, Ech-Chahad A, Minassi A, Bacchiega S, De Petrocellis L, Di Marzo V.

Bioorg Med Chem Lett. 2007 Jan 1;17(1):132-5. Epub 2006 Sep 29.

PMID:
17046253
43.

Protective activation of the endocannabinoid system during ischemia in dopamine neurons.

Melis M, Pillolla G, Bisogno T, Minassi A, Petrosino S, Perra S, Muntoni AL, Lutz B, Gessa GL, Marsicano G, Di Marzo V, Pistis M.

Neurobiol Dis. 2006 Oct;24(1):15-27. Epub 2006 Jun 8.

PMID:
16762556
44.

Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity.

Appendino G, Minassi A, Berton L, Moriello AS, Cascio MG, De Petrocellis L, Di Marzo V.

J Med Chem. 2006 Apr 6;49(7):2333-8.

PMID:
16570929
45.

Development of the first potent and specific inhibitors of endocannabinoid biosynthesis.

Bisogno T, Cascio MG, Saha B, Mahadevan A, Urbani P, Minassi A, Appendino G, Saturnino C, Martin B, Razdan R, Di Marzo V.

Biochim Biophys Acta. 2006 Feb;1761(2):205-12. Epub 2006 Jan 23.

PMID:
16466961
46.

First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands.

Appendino G, Cascio MG, Bacchiega S, Moriello AS, Minassi A, Thomas A, Ross R, Pertwee R, De Petrocellis L, Di Marzo V.

FEBS Lett. 2006 Jan 23;580(2):568-74. Epub 2005 Dec 29.

47.

Iodinated N-acylvanillamines: potential "multiple-target" anti-inflammatory agents acting via the inhibition of t-cell activation and antagonism at vanilloid TRPV1 channels.

Márquez N, De Petrocellis L, Caballero FJ, Macho A, Schiano-Moriello A, Minassi A, Appendino G, Muñoz E, Di Marzo V.

Mol Pharmacol. 2006 Apr;69(4):1373-82. Epub 2006 Jan 4.

PMID:
16394182
48.

The taming of capsaicin. Reversal of the vanilloid activity of N-acylvanillamines by aromatic iodination.

Appendino G, Daddario N, Minassi A, Moriello AS, De Petrocellis L, Di Marzo V.

J Med Chem. 2005 Jul 14;48(14):4663-9.

PMID:
16000002
49.

Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.

Appendino G, De Petrocellis L, Trevisani M, Minassi A, Daddario N, Moriello AS, Gazzieri D, Ligresti A, Campi B, Fontana G, Pinna C, Geppetti P, Di Marzo V.

J Pharmacol Exp Ther. 2005 Feb;312(2):561-70. Epub 2004 Sep 8.

PMID:
15356216
50.

A structure-activity relationship study on N-arachidonoyl-amino acids as possible endogenous inhibitors of fatty acid amide hydrolase.

Grazia Cascio M, Minassi A, Ligresti A, Appendino G, Burstein S, Di Marzo V.

Biochem Biophys Res Commun. 2004 Jan 30;314(1):192-6.

PMID:
14715265

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