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Items: 1 to 50 of 64

1.

Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases.

Lazar JT, Shuvalova L, Rosas-Lemus M, Kiryukhina O, Satchell KJF, Minasov G.

Acta Crystallogr F Struct Biol Commun. 2019 Jul 1;75(Pt 7):507-514. doi: 10.1107/S2053230X19008653. Epub 2019 Jul 2.

PMID:
31282871
2.

A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.

Roy SM, Minasov G, Arancio O, Chico LW, Van Eldik LJ, Anderson WF, Pelletier JC, Watterson DM.

J Med Chem. 2019 Jun 13;62(11):5298-5311. doi: 10.1021/acs.jmedchem.9b00058. Epub 2019 Apr 23.

3.

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii.

Lykins JD, Filippova EV, Halavaty AS, Minasov G, Zhou Y, Dubrovska I, Flores KJ, Shuvalova LA, Ruan J, El Bissati K, Dovgin S, Roberts CW, Woods S, Moulton JD, Moulton H, McPhillie MJ, Muench SP, Fishwick CWG, Sabini E, Shanmugam D, Roos DS, McLeod R, Anderson WF, Ngô HM.

Front Cell Infect Microbiol. 2018 Oct 5;8:352. doi: 10.3389/fcimb.2018.00352. eCollection 2018.

4.

The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling.

Biancucci M, Minasov G, Banerjee A, Herrera A, Woida PJ, Kieffer MB, Bindu L, Abreu-Blanco M, Anderson WF, Gaponenko V, Stephen AG, Holderfield M, Satchell KJF.

Sci Signal. 2018 Oct 2;11(550). pii: eaat8335. doi: 10.1126/scisignal.aat8335.

5.

Structural and immunological characterization of E. coli derived recombinant CRM197 protein used as carrier in conjugate vaccines.

Mishra RPN, Yadav RSP, Jones C, Nocadello S, Minasov G, Shuvalova LA, Anderson WF, Goel A.

Biosci Rep. 2018 Sep 25;38(5). pii: BSR20180238. doi: 10.1042/BSR20180238. Print 2018 Oct 31.

6.

Structure of the Bacillus anthracis dTDP-l-rhamnose biosynthetic pathway enzyme: dTDP-α-d-glucose 4,6-dehydratase, RfbB.

Gokey T, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

J Struct Biol. 2018 May;202(2):175-181. doi: 10.1016/j.jsb.2018.01.006. Epub 2018 Jan 10.

7.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose 3,5-epimerase (RfbC).

Shornikov A, Tran H, Macias J, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Dec 1;73(Pt 12):664-671. doi: 10.1107/S2053230X17015849. Epub 2017 Nov 10.

8.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme dTDP-4-dehydrorhamnose reductase (RfbD).

Law A, Stergioulis A, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Dec 1;73(Pt 12):644-650. doi: 10.1107/S2053230X17015746. Epub 2017 Nov 6.

9.

Structure of the Bacillus anthracis dTDP-L-rhamnose-biosynthetic enzyme glucose-1-phosphate thymidylyltransferase (RfbA).

Baumgartner J, Lee J, Halavaty AS, Minasov G, Anderson WF, Kuhn ML.

Acta Crystallogr F Struct Biol Commun. 2017 Nov 1;73(Pt 11):621-628. doi: 10.1107/S2053230X17015357. Epub 2017 Oct 30.

10.

Novel Aldo-Keto Reductases for the Biocatalytic Conversion of 3-Hydroxybutanal to 1,3-Butanediol: Structural and Biochemical Studies.

Kim T, Flick R, Brunzelle J, Singer A, Evdokimova E, Brown G, Joo JC, Minasov GA, Anderson WF, Mahadevan R, Savchenko A, Yakunin AF.

Appl Environ Microbiol. 2017 Mar 17;83(7). pii: e03172-16. doi: 10.1128/AEM.03172-16. Print 2017 Apr 1.

11.

Identification of novel small molecule inhibitors against NS2B/NS3 serine protease from Zika virus.

Lee H, Ren J, Nocadello S, Rice AJ, Ojeda I, Light S, Minasov G, Vargas J, Nagarathnam D, Anderson WF, Johnson ME.

Antiviral Res. 2017 Mar;139:49-58. doi: 10.1016/j.antiviral.2016.12.016. Epub 2016 Dec 26.

12.

Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis.

Kuhn ML, Alexander E, Minasov G, Page HJ, Warwrzak Z, Shuvalova L, Flores KJ, Wilson DJ, Shi C, Aldrich CC, Anderson WF.

ACS Infect Dis. 2016 Aug 12;2(8):579-591. Epub 2016 Jul 1.

13.

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation.

Nocadello S, Minasov G, Shuvalova LS, Dubrovska I, Sabini E, Anderson WF.

J Biol Chem. 2016 Jul 15;291(29):14915-26. doi: 10.1074/jbc.M116.729749. Epub 2016 May 18.

14.

Crystal structures of the components of the Staphylococcus aureus leukotoxin ED.

Nocadello S, Minasov G, Shuvalova L, Dubrovska I, Sabini E, Bagnoli F, Grandi G, Anderson WF.

Acta Crystallogr D Struct Biol. 2016 Jan;72(Pt 1):113-20. doi: 10.1107/S2059798315023207. Epub 2016 Jan 1.

15.

An Unusual Cation-Binding Site and Distinct Domain-Domain Interactions Distinguish Class II Enolpyruvylshikimate-3-phosphate Synthases.

Light SH, Krishna SN, Minasov G, Anderson WF.

Biochemistry. 2016 Mar 1;55(8):1239-45. doi: 10.1021/acs.biochem.5b00553. Epub 2016 Feb 12.

PMID:
26813771
16.

Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.

Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A.

J Biol Chem. 2015 Jul 31;290(31):19008. doi: 10.1074/jbc.A110.192831. No abstract available.

17.

Structural and functional analysis of betaine aldehyde dehydrogenase from Staphylococcus aureus.

Halavaty AS, Rich RL, Chen C, Joo JC, Minasov G, Dubrovska I, Winsor JR, Myszka DG, Duban M, Shuvalova L, Yakunin AF, Anderson WF.

Acta Crystallogr D Biol Crystallogr. 2015 May;71(Pt 5):1159-75. doi: 10.1107/S1399004715004228. Epub 2015 Apr 25.

18.

The structure of bradyzoite-specific enolase from Toxoplasma gondii reveals insights into its dual cytoplasmic and nuclear functions.

Ruan J, Mouveaux T, Light SH, Minasov G, Anderson WF, Tomavo S, Ngô HM.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):417-26. doi: 10.1107/S1399004714026479. Epub 2015 Feb 26.

19.

Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.

Roy SM, Grum-Tokars VL, Schavocky JP, Saeed F, Staniszewski A, Teich AF, Arancio O, Bachstetter AD, Webster SJ, Van Eldik LJ, Minasov G, Anderson WF, Pelletier JC, Watterson DM.

ACS Chem Neurosci. 2015 Apr 15;6(4):666-80. doi: 10.1021/acschemneuro.5b00002. Epub 2015 Feb 23.

20.

Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition.

Hoyland CN, Aldridge C, Cleverley RM, Duchêne MC, Minasov G, Onopriyenko O, Sidiq K, Stogios PJ, Anderson WF, Daniel RA, Savchenko A, Vollmer W, Lewis RJ.

Structure. 2014 Jul 8;22(7):949-60. doi: 10.1016/j.str.2014.04.015. Epub 2014 Jun 5.

21.

Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation.

Kuhn ML, Zemaitaitis B, Hu LI, Sahu A, Sorensen D, Minasov G, Lima BP, Scholle M, Mrksich M, Anderson WF, Gibson BW, Schilling B, Wolfe AJ.

PLoS One. 2014 Apr 22;9(4):e94816. doi: 10.1371/journal.pone.0094816. eCollection 2014.

22.

Structure determination, refinement, and validation.

Minasov G, Anderson WF.

Methods Mol Biol. 2014;1140:239-49. doi: 10.1007/978-1-4939-0354-2_18.

PMID:
24590722
23.

Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila.

Filippova EV, Luan CH, Dunne SF, Kiryukhina O, Minasov G, Shuvalova L, Anderson WF.

J Struct Funct Genomics. 2014 Mar;15(1):33-40. doi: 10.1007/s10969-014-9176-z. Epub 2014 Feb 22.

24.

Adherence to Bürgi-Dunitz stereochemical principles requires significant structural rearrangements in Schiff-base formation: insights from transaldolase complexes.

Light SH, Minasov G, Duban ME, Anderson WF.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):544-52. doi: 10.1107/S1399004713030666. Epub 2014 Jan 31.

25.

Structure and protective efficacy of the Staphylococcus aureus autocleaving protease EpiP.

Kuhn ML, Prachi P, Minasov G, Shuvalova L, Ruan J, Dubrovska I, Winsor J, Giraldi M, Biagini M, Liberatori S, Savino S, Bagnoli F, Anderson WF, Grandi G.

FASEB J. 2014 Apr;28(4):1780-93. doi: 10.1096/fj.13-241737. Epub 2014 Jan 13.

26.

Mechanisms of allosteric activation and inhibition of the deoxyribonucleoside triphosphate triphosphohydrolase from Enterococcus faecalis.

Vorontsov II, Wu Y, DeLucia M, Minasov G, Mehrens J, Shuvalova L, Anderson WF, Ahn J.

J Biol Chem. 2014 Jan 31;289(5):2815-24. doi: 10.1074/jbc.M113.524207. Epub 2013 Dec 12.

27.

Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae.

Seo HS, Minasov G, Seepersaud R, Doran KS, Dubrovska I, Shuvalova L, Anderson WF, Iverson TM, Sullam PM.

J Biol Chem. 2013 Dec 13;288(50):35982-96. doi: 10.1074/jbc.M113.513358. Epub 2013 Oct 28.

28.

Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.

Watterson DM, Grum-Tokars VL, Roy SM, Schavocky JP, Bradaric BD, Bachstetter AD, Xing B, Dimayuga E, Saeed F, Zhang H, Staniszewski A, Pelletier JC, Minasov G, Anderson WF, Arancio O, Van Eldik LJ.

PLoS One. 2013 Jun 26;8(6):e66226. doi: 10.1371/journal.pone.0066226. Print 2013.

29.

Large scale structural rearrangement of a serine hydrolase from Francisella tularensis facilitates catalysis.

Filippova EV, Weston LA, Kuhn ML, Geissler B, Gehring AM, Armoush N, Adkins CT, Minasov G, Dubrovska I, Shuvalova L, Winsor JR, Lavis LD, Satchell KJ, Becker DP, Anderson WF, Johnson RJ.

J Biol Chem. 2013 Apr 12;288(15):10522-35. doi: 10.1074/jbc.M112.446625. Epub 2013 Feb 19.

30.

Structure of the type III secretion effector protein ExoU in complex with its chaperone SpcU.

Halavaty AS, Borek D, Tyson GH, Veesenmeyer JL, Shuvalova L, Minasov G, Otwinowski Z, Hauser AR, Anderson WF.

PLoS One. 2012;7(11):e49388. doi: 10.1371/journal.pone.0049388. Epub 2012 Nov 14.

31.

Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria.

Halavaty AS, Kim Y, Minasov G, Shuvalova L, Dubrovska I, Winsor J, Zhou M, Onopriyenko O, Skarina T, Papazisi L, Kwon K, Peterson SN, Joachimiak A, Savchenko A, Anderson WF.

Acta Crystallogr D Biol Crystallogr. 2012 Oct;68(Pt 10):1359-70. Epub 2012 Sep 13.

32.

Structural analysis of a 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase with an N-terminal chorismate mutase-like regulatory domain.

Light SH, Halavaty AS, Minasov G, Shuvalova L, Anderson WF.

Protein Sci. 2012 Jun;21(6):887-95. doi: 10.1002/pro.2075. Epub 2012 Apr 23.

33.

Characterization of the deoxynucleotide triphosphate triphosphohydrolase (dNTPase) activity of the EF1143 protein from Enterococcus faecalis and crystal structure of the activator-substrate complex.

Vorontsov II, Minasov G, Kiryukhina O, Brunzelle JS, Shuvalova L, Anderson WF.

J Biol Chem. 2011 Sep 23;286(38):33158-66. doi: 10.1074/jbc.M111.250456. Epub 2011 Jul 13.

34.

Crystal structure of the novel PaiA N-acetyltransferase from Thermoplasma acidophilum involved in the negative control of sporulation and degradative enzyme production.

Filippova EV, Shuvalova L, Minasov G, Kiryukhina O, Zhang Y, Clancy S, Radhakrishnan I, Joachimiak A, Anderson WF.

Proteins. 2011 Aug;79(8):2566-77. doi: 10.1002/prot.23062. Epub 2011 Jun 1.

35.

A conserved surface loop in type I dehydroquinate dehydratases positions an active site arginine and functions in substrate binding.

Light SH, Minasov G, Shuvalova L, Peterson SN, Caffrey M, Anderson WF, Lavie A.

Biochemistry. 2011 Mar 29;50(12):2357-63. doi: 10.1021/bi102020s. Epub 2011 Feb 21.

36.

Insights into the mechanism of type I dehydroquinate dehydratases from structures of reaction intermediates.

Light SH, Minasov G, Shuvalova L, Duban ME, Caffrey M, Anderson WF, Lavie A.

J Biol Chem. 2011 Feb 4;286(5):3531-9. doi: 10.1074/jbc.M110.192831. Epub 2010 Nov 18. Erratum in: J Biol Chem. 2015 Jul 31;290(31):19008.

37.

Structural and molecular mechanism for autoprocessing of MARTX toxin of Vibrio cholerae at multiple sites.

Prochazkova K, Shuvalova LA, Minasov G, Voburka Z, Anderson WF, Satchell KJ.

J Biol Chem. 2009 Sep 25;284(39):26557-68. doi: 10.1074/jbc.M109.025510. Epub 2009 Jul 20.

38.

Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains.

Minasov G, Padavattan S, Shuvalova L, Brunzelle JS, Miller DJ, Baslé A, Massa C, Collart FR, Schirmer T, Anderson WF.

J Biol Chem. 2009 May 8;284(19):13174-84. doi: 10.1074/jbc.M808221200. Epub 2009 Feb 24.

39.

Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity.

Vorontsov II, Minasov G, Brunzelle JS, Shuvalova L, Kiryukhina O, Collart FR, Anderson WF.

Protein Sci. 2007 Nov;16(11):2483-90.

40.

The 2.2 A resolution crystal structure of Bacillus cereus Nif3-family protein YqfO reveals a conserved dimetal-binding motif and a regulatory domain.

Godsey MH, Minasov G, Shuvalova L, Brunzelle JS, Vorontsov II, Collart FR, Anderson WF.

Protein Sci. 2007 Jul;16(7):1285-93.

41.

Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system.

Egli M, Pallan PS, Pattanayek R, Wilds CJ, Lubini P, Minasov G, Dobler M, Leumann CJ, Eschenmoser A.

J Am Chem Soc. 2006 Aug 23;128(33):10847-56.

PMID:
16910680
42.

The deacylation mechanism of AmpC beta-lactamase at ultrahigh resolution.

Chen Y, Minasov G, Roth TA, Prati F, Shoichet BK.

J Am Chem Soc. 2006 Mar 8;128(9):2970-6.

43.

Probing the influence of stereoelectronic effects on the biophysical properties of oligonucleotides: comprehensive analysis of the RNA affinity, nuclease resistance, and crystal structure of ten 2'-O-ribonucleic acid modifications.

Egli M, Minasov G, Tereshko V, Pallan PS, Teplova M, Inamati GB, Lesnik EA, Owens SR, Ross BS, Prakash TP, Manoharan M.

Biochemistry. 2005 Jun 28;44(25):9045-57. Erratum in: Biochemistry. 2013 Mar 12;52(10):1838.

PMID:
15966728
44.

Independent movement, dimerization and stability of tandem repeats of chicken brain alpha-spectrin.

Kusunoki H, Minasov G, Macdonald RI, Mondragón A.

J Mol Biol. 2004 Nov 19;344(2):495-511.

PMID:
15522301
45.

Thermodynamic cycle analysis and inhibitor design against beta-lactamase.

Roth TA, Minasov G, Morandi S, Prati F, Shoichet BK.

Biochemistry. 2003 Dec 16;42(49):14483-91.

PMID:
14661960
46.

Structural aspects for evolution of beta-lactamases from penicillin-binding proteins.

Meroueh SO, Minasov G, Lee W, Shoichet BK, Mobashery S.

J Am Chem Soc. 2003 Aug 13;125(32):9612-8.

PMID:
12904027
47.

Recognition and resistance in TEM beta-lactamase.

Wang X, Minasov G, Blázquez J, Caselli E, Prati F, Shoichet BK.

Biochemistry. 2003 Jul 22;42(28):8434-44.

PMID:
12859188
48.

2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects.

Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M.

Org Lett. 2003 Jun 12;5(12):2017-20.

PMID:
12790517
49.

Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh.

Ramirez UD, Minasov G, Focia PJ, Stroud RM, Walter P, Kuhn P, Freymann DM.

J Mol Biol. 2002 Jul 19;320(4):783-99.

50.

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs.

Wang X, Minasov G, Shoichet BK.

J Mol Biol. 2002 Jun 28;320(1):85-95.

PMID:
12079336

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