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Interv Med Appl Sci. 2018 Sep;10(3):127-132. doi: 10.1556/1646.10.2018.22.

The association between blood vitamins D and E with age-related macular degeneration: A pilot study.

Author information

1
Department of Geriatric Medicine, Ziaeian Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Obstetric and Gynecology, Ziaeian Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
3
Ziaean Hospital, Tehran University of Medical Sciences, Tehran, Iran.
4
Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
5
Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
6
Faculty of Medicine, Department of Community Medicine, Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
7
Department and Faculty of Medical Sciences and Technology, Islamic Azad University, Tehran, Iran.
8
Department of Ophthalmology, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background:

This study was aimed to evaluate the association of serum vitamins D and E level with age-related macular degeneration (AMD).

Methods:

This pilot study was performed in two groups of 15 patients in treatment group and 15 patients in control group. Measurements of blood factors [such as C-reactive protein (CRP) and high-density lipoprotein (HDL)] were performed after 12 h of fasting. To measure vitamins D and E, the serum was isolated from 5 cc blood samples.

Results:

HDL was higher in the control group as compared with the AMD group. However, no significant difference was found between the two groups (p = 0.08). On the other hand, serum vitamin E in the AMD group was remarkably higher as compared to the control group (p < 0.002). However, no significant difference was found in serum vitamin D levels between the two groups (p = 0.662). Our findings also revealed that there was no statistically significant relationship between BMI and AMD. Moreover, no significant correlation was determined between serum CRP and AMD (p = 0.96).

Conclusions:

Our data indicated that none provides evidence for associations between AMD and serum vitamin D levels. The association between vitamin D and AMD requires further investigations in a large population studies, to elucidate whether vitamin D deficiency can be an important risk factor for AMD.

KEYWORDS:

age-related macular degeneration; blood factors; healthy lifestyles; serum; vitamins D and E

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