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Items: 16


MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state.

Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, Miluzio A, Gaudioso G, Vaira V, Turdo A, Giaggianesi M, Chinnici A, Lipari E, Bicciato S, Bosari S, Todaro M, Zippo A.

Nat Commun. 2018 Mar 9;9(1):1024. doi: 10.1038/s41467-018-03264-2.


Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.

Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S.

Data Brief. 2017 Aug 30;14:653-658. doi: 10.1016/j.dib.2017.08.023. eCollection 2017 Oct.


High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.

Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S.

Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22.


SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.

Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S.

PLoS Genet. 2017 Jan 5;13(1):e1006552. doi: 10.1371/journal.pgen.1006552. eCollection 2017 Jan.


Translational control by mTOR-independent routes: how eIF6 organizes metabolism.

Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S.

Biochem Soc Trans. 2016 Dec 15;44(6):1667-1673.


Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.

Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S.

Oncotarget. 2015 Nov 10;6(35):37471-85. doi: 10.18632/oncotarget.5462.


Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.

Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.

J Thromb Haemost. 2015 Nov;13(11):2108-18. doi: 10.1111/jth.13150. Epub 2015 Oct 23.


eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.

Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.

Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261.


eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.

Brina D, Miluzio A, Ricciardi S, Biffo S.

Biochim Biophys Acta. 2015 Jul;1849(7):830-5. doi: 10.1016/j.bbagrm.2014.09.010. Epub 2014 Sep 22. Review.


Translational control by 80S formation and 60S availability: the central role of eIF6, a rate limiting factor in cell cycle progression and tumorigenesis.

Brina D, Grosso S, Miluzio A, Biffo S.

Cell Cycle. 2011 Oct 15;10(20):3441-6. doi: 10.4161/cc.10.20.17796. Epub 2011 Oct 15. Review.


Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.

Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S.

Cancer Cell. 2011 Jun 14;19(6):765-75. doi: 10.1016/j.ccr.2011.04.018.


Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation.

Miluzio A, Beugnet A, Volta V, Biffo S.

EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17. Review.


Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.

Gandin V, Miluzio A, Barbieri AM, Beugnet A, Kiyokawa H, Marchisio PC, Biffo S.

Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10.


Nuclear myosin VI enhances RNA polymerase II-dependent transcription.

Vreugde S, Ferrai C, Miluzio A, Hauben E, Marchisio PC, Crippa MP, Bussi M, Biffo S.

Mol Cell. 2006 Sep 1;23(5):749-55.


Massive apoptosis erodes nasal mucosa of cocaine abusers.

Trimarchi M, Miluzio A, Nicolai P, Morassi ML, Bussi M, Marchisio PC.

Am J Rhinol. 2006 Mar-Apr;20(2):160-4.


Differential cytokine pattern in the spleens and livers of BALB/c mice infected with Penicillium marneffei: protective role of gamma interferon.

Sisto F, Miluzio A, Leopardi O, Mirra M, Boelaert JR, Taramelli D.

Infect Immun. 2003 Jan;71(1):465-73.

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