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Items: 1 to 50 of 104

1.

Defying strain in the synthesis of an electroactive bilayer helicene.

Milton M, Schuster NJ, Paley DW, Hernández Sánchez R, Ng F, Steigerwald ML, Nuckolls C.

Chem Sci. 2018 Nov 20;10(4):1029-1034. doi: 10.1039/c8sc04216k. eCollection 2019 Jan 28.

2.

Models and Approaches Describing the Metabolism, Transport, and Toxicity of Drugs Administered by the Ocular Route.

Dumouchel JL, Chemuturi N, Milton MN, Camenisch G, Chastain J, Walles M, Sasseville V, Gunduz M, Iyer GR, Argikar UA.

Drug Metab Dispos. 2018 Nov;46(11):1670-1683. doi: 10.1124/dmd.118.082974. Epub 2018 Aug 15. Review.

PMID:
30111625
3.

Current strategies in the non-clinical safety assessment of biologics: New targets, new molecules, new challenges.

Brennan FR, Andrews L, Arulanandam AR, Blumel J, Fikes J, Grimaldi C, Lansita J, Loberg LI, MacLachlan T, Milton M, Parker S, Tibbitts J, Wolf J, Allamneni KP.

Regul Toxicol Pharmacol. 2018 Oct;98:98-107. doi: 10.1016/j.yrtph.2018.07.009. Epub 2018 Jul 17.

PMID:
30026135
4.

It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology.

Milton M, Smith PD.

Front Cell Neurosci. 2018 Feb 16;12:36. doi: 10.3389/fncel.2018.00036. eCollection 2018. Review.

5.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Milton ME, Minrovic BM, Harris DL, Kang B, Jung D, Lewis CP, Thompson RJ, Melander RJ, Zeng D, Melander C, Cavanagh J.

Front Mol Biosci. 2018 Feb 13;5:15. doi: 10.3389/fmolb.2018.00015. eCollection 2018.

6.

The Structure of the Biofilm-controlling Response Regulator BfmR from Acinetobacter baumannii Reveals Details of Its DNA-binding Mechanism.

Draughn GL, Milton ME, Feldmann EA, Bobay BG, Roth BM, Olson AL, Thompson RJ, Actis LA, Davies C, Cavanagh J.

J Mol Biol. 2018 Mar 16;430(6):806-821. doi: 10.1016/j.jmb.2018.02.002. Epub 2018 Feb 10.

7.

Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa.

MacLachlan TK, Milton MN, Turner O, Tukov F, Choi VW, Penraat J, Delmotte MH, Michaut L, Jaffee BD, Bigelow CE.

Mol Ther Methods Clin Dev. 2017 Dec 22;8:105-120. doi: 10.1016/j.omtm.2017.12.001. eCollection 2018 Mar 16.

8.

Molecular Materials for Nonaqueous Flow Batteries with a High Coulombic Efficiency and Stable Cycling.

Milton M, Cheng Q, Yang Y, Nuckolls C, Hernández Sánchez R, Sisto TJ.

Nano Lett. 2017 Dec 13;17(12):7859-7863. doi: 10.1021/acs.nanolett.7b04131. Epub 2017 Nov 10.

PMID:
29125302
9.

Two Case Studies on How Study Designs Can Be Made More Informative Using Modeling and Simulation Approaches.

Lowe PJ, Fink M, Milton MN.

Clin Pharmacol Ther. 2017 Dec;102(6):908-911. doi: 10.1002/cpt.867. Epub 2017 Sep 25.

PMID:
28944961
10.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds.

Milton ME, Allen CL, Feldmann EA, Bobay BG, Jung DK, Stephens MD, Melander RJ, Theisen KE, Zeng D, Thompson RJ, Melander C, Cavanagh J.

Mol Microbiol. 2017 Oct;106(2):223-235. doi: 10.1111/mmi.13759. Epub 2017 Aug 16.

11.

Additive effects of sensory-enhanced satiety and memory for recent eating on appetite.

Yeomans MR, Milton MR, Chambers L.

Appetite. 2017 Oct 1;117:335-341. doi: 10.1016/j.appet.2017.07.018. Epub 2017 Jul 17.

PMID:
28729200
12.

Corrigendum to "Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics" [Regul. Toxicol. Pharmacol. (2017) 221-230].

de Zafra CLZ, Sasseville VG, Matsumoto S, Freichel C, Milton M, MacLachlan TK, Farman C, Raymond I, Gupta S, Newton R, Atzpodien EA, Thackaberry EA.

Regul Toxicol Pharmacol. 2017 Aug;88:364. doi: 10.1016/j.yrtph.2017.04.006. Epub 2017 Apr 18. No abstract available.

PMID:
28431771
13.

Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics.

de Zafra CLZ, Sasseville VG, Matsumoto S, Freichel C, Milton M, MacLachlan TK, Farman C, Raymond I, Gupta S, Newton R, Atzpodien EA, Thackaberry EA.

Regul Toxicol Pharmacol. 2017 Jun;86:221-230. doi: 10.1016/j.yrtph.2017.03.013. Epub 2017 Mar 16. Erratum in: Regul Toxicol Pharmacol. 2017 Aug;88:364.

PMID:
28322894
14.

A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions.

Damelin M, Bankovich A, Bernstein J, Lucas J, Chen L, Williams S, Park A, Aguilar J, Ernstoff E, Charati M, Dushin R, Aujay M, Lee C, Ramoth H, Milton M, Hampl J, Lazetic S, Pulito V, Rosfjord E, Sun Y, King L, Barletta F, Betts A, Guffroy M, Falahatpisheh H, O'Donnell CJ, Stull R, Pysz M, Escarpe P, Liu D, Foord O, Gerber HP, Sapra P, Dylla SJ.

Sci Transl Med. 2017 Jan 11;9(372). pii: eaag2611. doi: 10.1126/scitranslmed.aag2611.

PMID:
28077676
15.

Crystal Structure of the Apicoplast DNA Polymerase from Plasmodium falciparum: The First Look at a Plastidic A-Family DNA Polymerase.

Milton ME, Choe JY, Honzatko RB, Nelson SW.

J Mol Biol. 2016 Oct 9;428(20):3920-3934. doi: 10.1016/j.jmb.2016.07.016. Epub 2016 Jul 31.

PMID:
27487482
16.

The Trichoptera barcode initiative: a strategy for generating a species-level Tree of Life.

Zhou X, Frandsen PB, Holzenthal RW, Beet CR, Bennett KR, Blahnik RJ, Bonada N, Cartwright D, Chuluunbat S, Cocks GV, Collins GE, deWaard J, Dean J, Flint OS Jr, Hausmann A, Hendrich L, Hess M, Hogg ID, Kondratieff BC, Malicky H, Milton MA, Morinière J, Morse JC, Mwangi FN, Pauls SU, Gonzalez MR, Rinne A, Robinson JL, Salokannel J, Shackleton M, Smith B, Stamatakis A, StClair R, Thomas JA, Zamora-Muñoz C, Ziesmann T, Kjer KM.

Philos Trans R Soc Lond B Biol Sci. 2016 Sep 5;371(1702). pii: 20160025. doi: 10.1098/rstb.2016.0025.

17.

Counting animal species with DNA barcodes: Canadian insects.

Hebert PD, Ratnasingham S, Zakharov EV, Telfer AC, Levesque-Beaudin V, Milton MA, Pedersen S, Jannetta P, deWaard JR.

Philos Trans R Soc Lond B Biol Sci. 2016 Sep 5;371(1702). pii: 20150333. doi: 10.1098/rstb.2015.0333.

18.

Replication and maintenance of the Plasmodium falciparum apicoplast genome.

Milton ME, Nelson SW.

Mol Biochem Parasitol. 2016 Aug;208(2):56-64. doi: 10.1016/j.molbiopara.2016.06.006. Epub 2016 Jun 20. Review.

PMID:
27338018
19.

Protecting Against Tax ID Theft and Avoiding Other Fraudulent Tax Schemes.

Milton M.

Mo Med. 2016 Jan-Feb;113(1):22-4. No abstract available.

20.

A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo.

Saunders LR, Bankovich AJ, Anderson WC, Aujay MA, Bheddah S, Black K, Desai R, Escarpe PA, Hampl J, Laysang A, Liu D, Lopez-Molina J, Milton M, Park A, Pysz MA, Shao H, Slingerland B, Torgov M, Williams SA, Foord O, Howard P, Jassem J, Badzio A, Czapiewski P, Harpole DH, Dowlati A, Massion PP, Travis WD, Pietanza MC, Poirier JT, Rudin CM, Stull RA, Dylla SJ.

Sci Transl Med. 2015 Aug 26;7(302):302ra136. doi: 10.1126/scitranslmed.aac9459.

21.

Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.

Brennan FR, Baumann A, Blaich G, de Haan L, Fagg R, Kiessling A, Kronenberg S, Locher M, Milton M, Tibbitts J, Ulrich P, Weir L.

Regul Toxicol Pharmacol. 2015 Oct;73(1):265-75. doi: 10.1016/j.yrtph.2015.07.019. Epub 2015 Jul 26.

PMID:
26219199
22.

Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans.

Pusalkar S, Plesescu M, Milton M, Balani SK, Chowdhury S, Prakash S.

Drug Metab Lett. 2016;10(1):22-37.

PMID:
26031460
23.

Effects of lipoprotein apheresis on PCSK9 levels.

Julius U, Milton M, Stoellner D, Rader D, Gordon B, Polk D, Waldmann E, Parhofer KG, Moriarty PM.

Atheroscler Suppl. 2015 May;18:180-6. doi: 10.1016/j.atherosclerosissup.2015.02.028.

PMID:
25936324
24.

Crystallization and preliminary X-ray analysis of the Plasmodium falciparum apicoplast DNA polymerase.

Milton ME, Choe JY, Honzatko RB, Nelson SW.

Acta Crystallogr F Struct Biol Commun. 2015 Mar;71(Pt 3):333-7. doi: 10.1107/S2053230X15002423. Epub 2015 Feb 19.

25.

Who takes risks in high-risk sport?: the role of alexithymia.

Barlow M, Woodman T, Chapman C, Milton M, Stone D, Dodds T, Allen B.

J Sport Exerc Psychol. 2015 Feb;37(1):83-96. doi: 10.1123/jsep.2014-0130.

PMID:
25730894
26.

Synthesis of 2-aryl/heteroaryloxazolines from nitriles under metal- and catalyst-free conditions and evaluation of their antioxidant activities.

Garg P, Chaudhary S, Milton MD.

J Org Chem. 2014 Sep 19;79(18):8668-77. doi: 10.1021/jo501430p. Epub 2014 Sep 9.

PMID:
25165864
27.

Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis.

Chadha N, Tiwari AK, Kumar V, Lal S, Milton MD, Mishra AK.

J Biomol Struct Dyn. 2015;33(5):978-90. doi: 10.1080/07391102.2014.921793. Epub 2014 May 29.

PMID:
24805972
28.

In silico thermodynamics stability change analysis involved in BH4 responsive mutations in phenylalanine hydroxylase: QM/MM and MD simulations analysis.

Chadha N, Tiwari AK, Kumar V, Milton MD, Mishra AK.

J Biomol Struct Dyn. 2015;33(3):573-83. doi: 10.1080/07391102.2014.897258. Epub 2014 Mar 17.

PMID:
24628256
29.

Preparation and validation of fully synthetic standard gas mixtures with atmospheric isotopic composition for global CO2 and CH4 monitoring.

Brewer PJ, Brown RJ, Miller MN, Miñarro MD, Murugan A, Milton MJ, Rhoderick GC.

Anal Chem. 2014 Feb 4;86(3):1887-93. doi: 10.1021/ac403982m. Epub 2014 Jan 24.

PMID:
24410374
30.

Gaseous reference standards of formaldehyde from trioxane.

Brewer PJ, di Meane EA, Vargha GM, Brown RJ, Milton MJ.

Talanta. 2013 Apr 15;108:83-7. doi: 10.1016/j.talanta.2013.02.075. Epub 2013 Mar 7.

PMID:
23601873
31.

Taxonomic history and invasion biology of two Phyllonorycter leaf miners (Lepidoptera: Gracillariidae) with links to taxonomic and molecular datasets.

De Prins J, De Prins W, De Coninck E, Kawahara AY, Milton MA, Hebert PD.

Zootaxa. 2013;3709:341-62.

PMID:
26240915
32.

Dichlorodiphenyl trichloroethane (DDT) and its observed effects on body functions in vertebrates.

Milton M, Ambrose K, Abraham C, Charles N, Kiriamiti K.

East Afr J Public Health. 2011 Dec;8(4):271-4.

PMID:
23120935
33.

Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial.

Horvath C, Andrews L, Baumann A, Black L, Blanset D, Cavagnaro J, Hastings KL, Hutto DL, MacLachlan TK, Milton M, Reynolds T, Roberts S, Rogge M, Sims J, Treacy G, Warner G, Green JD.

Nat Rev Immunol. 2012 Oct;12(10):740; author reply 740. doi: 10.1038/nri3192-c1. Epub 2012 Aug 31. No abstract available. Erratum in: Nat Rev Immunol. 2012 Oct;12(10):740.

PMID:
22941443
34.

The determination and interpretation of the therapeutic index in drug development.

Muller PY, Milton MN.

Nat Rev Drug Discov. 2012 Oct;11(10):751-61. doi: 10.1038/nrd3801. Epub 2012 Aug 31. Review.

PMID:
22935759
35.

Accurate measurements of water vapor transmission through high-performance barrier layers.

Brewer PJ, Goody BA, Kumar Y, Milton MJ.

Rev Sci Instrum. 2012 Jul;83(7):075118. doi: 10.1063/1.4738775.

PMID:
22852735
36.

Participation in mindfulness-based stress reduction is not associated with reductions in emotional eating or uncontrolled eating.

Kearney DJ, Milton ML, Malte CA, McDermott KA, Martinez M, Simpson TL.

Nutr Res. 2012 Jun;32(6):413-20. doi: 10.1016/j.nutres.2012.05.008. Epub 2012 Jun 22.

PMID:
22749177
37.

Synthesis of [DTPA-bis(D-ser)] chelate (DBDSC): an approach for the design of SPECT radiopharmaceuticals based on technetium.

Varshney R, Sethi SK, Hazari PP, Chuttani K, Soni S, Milton MD, Mishra AK.

Curr Radiopharm. 2012 Oct;5(4):348-55.

PMID:
22642421
38.

A dynamic gravimetric standard for trace water.

Brewer PJ, Goody BA, Woods PT, Milton MJ.

Rev Sci Instrum. 2011 Oct;82(10):105102. doi: 10.1063/1.3642660.

PMID:
22047324
39.

A new definition for the mole based on the Avogadro constant: a journey from physics to chemistry.

Milton MJ.

Philos Trans A Math Phys Eng Sci. 2011 Oct 28;369(1953):3993-4003. doi: 10.1098/rsta.2011.0176.

PMID:
21930561
40.

Molecular characterization of eight Indian Snakehead species (Pisces: Perciformes Channidae) using RAPD markers.

Bhat AA, Haniffa MA, Divya PR, Gopalakrishnan A, Milton MJ, Kumar R, Paray BA.

Mol Biol Rep. 2012 Apr;39(4):4267-73. doi: 10.1007/s11033-011-1213-4. Epub 2011 Aug 4.

PMID:
21814812
41.

Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile.

Byrn SR, Tishmack PA, Milton MJ, van de Velde H.

AAPS PharmSciTech. 2011 Jun;12(2):461-7. doi: 10.1208/s12249-010-9554-1. Epub 2011 Apr 1.

42.

Lithographical gap-size engineered nanoarrays for surface-enhanced Raman probing of biomarkers.

Stosch R, Yaghobian F, Weimann T, Brown RJ, Milton MJ, Güttler B.

Nanotechnology. 2011 Mar 11;22(10):105303. doi: 10.1088/0957-4484/22/10/105303. Epub 2011 Feb 2.

PMID:
21289393
43.

P-glycoprotein and breast cancer resistance protein affect disposition of tandutinib, a tyrosine kinase inhibitor.

Yang JJ, Milton MN, Yu S, Liao M, Liu N, Wu JT, Gan L, Balani SK, Lee FW, Prakash S, Xia CQ.

Drug Metab Lett. 2010 Dec;4(4):201-12.

PMID:
20670210
44.

Utility of intracardiac ultrasound imaging to guide pulmonary vein ablation using laser balloon catheter.

Leite L, Su W, Johnson SB, Milton M, Henz B, Sarabanda A, Santos SN, Packer DL.

Arq Bras Cardiol. 2009 Dec;93(6):616-21, 666-71. English, Portuguese.

45.

Microfabricated planar glass gas chromatography with photoionization detection.

Lewis AC, Hamilton JF, Rhodes CN, Halliday J, Bartle KD, Homewood P, Grenfell RJ, Goody B, Harling AM, Brewer P, Vargha G, Milton MJ.

J Chromatogr A. 2010 Jan 29;1217(5):768-74. doi: 10.1016/j.chroma.2009.12.009. Epub 2009 Dec 4.

PMID:
20022335
46.

The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies.

Muller PY, Milton M, Lloyd P, Sims J, Brennan FR.

Curr Opin Biotechnol. 2009 Dec;20(6):722-9. doi: 10.1016/j.copbio.2009.10.013. Epub 2009 Nov 5. Review.

PMID:
19896825
47.

The EMEA guideline on first-in-human clinical trials and its impact on pharmaceutical development.

Milton MN, Horvath CJ.

Toxicol Pathol. 2009 Apr;37(3):363-71. doi: 10.1177/0192623309332997. Epub 2009 Feb 26. No abstract available.

PMID:
19246571
48.

The TeGenero incident and the Duff Report conclusions: a series of unfortunate events or an avoidable event?

Horvath CJ, Milton MN.

Toxicol Pathol. 2009 Apr;37(3):372-83. doi: 10.1177/0192623309332986. Epub 2009 Feb 24. No abstract available.

PMID:
19244218
49.

A practical method to fabricate gold substrates for surface-enhanced Raman spectroscopy.

Tantra R, Brown RJ, Milton MJ, Gohil D.

Appl Spectrosc. 2008 Sep;62(9):992-1000.

PMID:
18801238
50.

PhRMA white paper on ADME pharmacogenomics.

Williams JA, Andersson T, Andersson TB, Blanchard R, Behm MO, Cohen N, Edeki T, Franc M, Hillgren KM, Johnson KJ, Katz DA, Milton MN, Murray BP, Polli JW, Ricci D, Shipley LA, Vangala S, Wrighton SA.

J Clin Pharmacol. 2008 Jul;48(7):849-89. doi: 10.1177/0091270008319329. Epub 2008 Jun 4. Review.

PMID:
18524998

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