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ORMDL3 and allergic asthma: From physiology to pathology.

James B, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2019 Sep;144(3):634-640. doi: 10.1016/j.jaci.2019.07.023. Epub 2019 Jul 31.


Role of Sphingosine Kinase 1 and Sphingosine-1-Phosphate Axis in Hepatocellular Carcinoma.

Maceyka M, Rohrbach T, Milstien S, Spiegel S.

Handb Exp Pharmacol. 2019 Jul 19. doi: 10.1007/164_2019_217. [Epub ahead of print]


New insights into functions of the sphingosine-1-phosphate transporter SPNS2.

Spiegel S, Maczis MA, Maceyka M, Milstien S.

J Lipid Res. 2019 Mar;60(3):484-489. doi: 10.1194/jlr.S091959. Epub 2019 Jan 17.


Sphingosine kinase 1 activation by estrogen receptor α36 contributes to tamoxifen resistance in breast cancer.

Maczis MA, Maceyka M, Waters MR, Newton J, Singh M, Rigsby MF, Turner TH, Alzubi MA, Harrell JC, Milstien S, Spiegel S.

J Lipid Res. 2018 Dec;59(12):2297-2307. doi: 10.1194/jlr.M085191. Epub 2018 Oct 12.


Niemann-Pick type C disease: The atypical sphingolipidosis.

Newton J, Milstien S, Spiegel S.

Adv Biol Regul. 2018 Dec;70:82-88. doi: 10.1016/j.jbior.2018.08.001. Epub 2018 Aug 28. Review.


ABCC1-Exported Sphingosine-1-phosphate, Produced by Sphingosine Kinase 1, Shortens Survival of Mice and Patients with Breast Cancer.

Yamada A, Nagahashi M, Aoyagi T, Huang WC, Lima S, Hait NC, Maiti A, Kida K, Terracina KP, Miyazaki H, Ishikawa T, Endo I, Waters MR, Qi Q, Yan L, Milstien S, Spiegel S, Takabe K.

Mol Cancer Res. 2018 Jun;16(6):1059-1070. doi: 10.1158/1541-7786.MCR-17-0353. Epub 2018 Mar 9.


TP53 is required for BECN1- and ATG5-dependent cell death induced by sphingosine kinase 1 inhibition.

Lima S, Takabe K, Newton J, Saurabh K, Young MM, Leopoldino AM, Hait NC, Roberts JL, Wang HG, Dent P, Milstien S, Booth L, Spiegel S.

Autophagy. 2018;14(6):942-957. doi: 10.1080/15548627.2018.1429875. Epub 2018 Mar 11.


Targeting the SphK1/S1P/S1PR1 Axis That Links Obesity, Chronic Inflammation, and Breast Cancer Metastasis.

Nagahashi M, Yamada A, Katsuta E, Aoyagi T, Huang WC, Terracina KP, Hait NC, Allegood JC, Tsuchida J, Yuza K, Nakajima M, Abe M, Sakimura K, Milstien S, Wakai T, Spiegel S, Takabe K.

Cancer Res. 2018 Apr 1;78(7):1713-1725. doi: 10.1158/0008-5472.CAN-17-1423. Epub 2018 Jan 19.


FTY720/fingolimod increases NPC1 and NPC2 expression and reduces cholesterol and sphingolipid accumulation in Niemann-Pick type C mutant fibroblasts.

Newton J, Hait NC, Maceyka M, Colaco A, Maczis M, Wassif CA, Cougnoux A, Porter FD, Milstien S, Platt N, Platt FM, Spiegel S.

FASEB J. 2017 Apr;31(4):1719-1730. doi: 10.1096/fj.201601041R. Epub 2017 Jan 12.


Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking.

Lima S, Milstien S, Spiegel S.

J Biol Chem. 2017 Feb 24;292(8):3074-3088. doi: 10.1074/jbc.M116.762377. Epub 2017 Jan 3.


ORMDL proteins regulate ceramide levels during sterile inflammation.

Cai L, Oyeniran C, Biswas DD, Allegood J, Milstien S, Kordula T, Maceyka M, Spiegel S.

J Lipid Res. 2016 Aug;57(8):1412-22. doi: 10.1194/jlr.M065920. Epub 2016 Jun 16.


Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods.

Nagahashi M, Yamada A, Miyazaki H, Allegood JC, Tsuchida J, Aoyagi T, Huang WC, Terracina KP, Adams BJ, Rashid OM, Milstien S, Wakai T, Spiegel S, Takabe K.

J Mammary Gland Biol Neoplasia. 2016 Jun;21(1-2):9-17. doi: 10.1007/s10911-016-9354-7. Epub 2016 May 19.


Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans.

Huang WC, Liang J, Nagahashi M, Avni D, Yamada A, Maceyka M, Wolen AR, Kordula T, Milstien S, Takabe K, Oravecz T, Spiegel S.

FASEB J. 2016 Aug;30(8):2945-58. doi: 10.1096/fj.201600394R. Epub 2016 Apr 29.


Sphingosine-1-phosphate and estrogen signaling in breast cancer.

Maczis M, Milstien S, Spiegel S.

Adv Biol Regul. 2016 Jan;60:160-165. doi: 10.1016/j.jbior.2015.09.006. Epub 2015 Oct 19. Review.


Spinster 2, a sphingosine-1-phosphate transporter, plays a critical role in inflammatory and autoimmune diseases.

Donoviel MS, Hait NC, Ramachandran S, Maceyka M, Takabe K, Milstien S, Oravecz T, Spiegel S.

FASEB J. 2015 Dec;29(12):5018-28. doi: 10.1096/fj.15-274936. Epub 2015 Aug 31.


Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.

Yester JW, Bryan L, Waters MR, Mierzenski B, Biswas DD, Gupta AS, Bhardwaj R, Surace MJ, Eltit JM, Milstien S, Spiegel S, Kordula T.

FASEB J. 2015 Dec;29(12):4853-65. doi: 10.1096/fj.15-275180. Epub 2015 Aug 5.


The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer.

Hait NC, Avni D, Yamada A, Nagahashi M, Aoyagi T, Aoki H, Dumur CI, Zelenko Z, Gallagher EJ, Leroith D, Milstien S, Takabe K, Spiegel S.

Oncogenesis. 2015 Jun 8;4:e156. doi: 10.1038/oncsis.2015.16.


Aberrant ORM (yeast)-like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice.

Oyeniran C, Sturgill JL, Hait NC, Huang WC, Avni D, Maceyka M, Newton J, Allegood JC, Montpetit A, Conrad DH, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2015 Oct;136(4):1035-46.e6. doi: 10.1016/j.jaci.2015.02.031. Epub 2015 Apr 2.


The sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 axis regulates early airway T-cell infiltration in murine mast cell-dependent acute allergic responses.

Oskeritzian CA, Hait NC, Wedman P, Chumanevich A, Kolawole EM, Price MM, Falanga YT, Harikumar KB, Ryan JJ, Milstien S, Sabbadini R, Spiegel S.

J Allergy Clin Immunol. 2015 Apr;135(4):1008-18.e1. doi: 10.1016/j.jaci.2014.10.044. Epub 2014 Dec 13.


An improved syngeneic orthotopic murine model of human breast cancer progression.

Rashid OM, Nagahashi M, Ramachandran S, Dumur C, Schaum J, Yamada A, Terracina KP, Milstien S, Spiegel S, Takabe K.

Breast Cancer Res Treat. 2014 Oct;147(3):501-12. doi: 10.1007/s10549-014-3118-0. Epub 2014 Sep 9.


Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching.

Kim EY, Sturgill JL, Hait NC, Avni D, Valencia EC, Maceyka M, Lima S, Allegood J, Huang WC, Zhang S, Milstien S, Conrad D, Spiegel S.

FASEB J. 2014 Oct;28(10):4347-58. doi: 10.1096/fj.14-251611. Epub 2014 Jul 1.


Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.

Hait NC, Wise LE, Allegood JC, O'Brien M, Avni D, Reeves TM, Knapp PE, Lu J, Luo C, Miles MF, Milstien S, Lichtman AH, Spiegel S.

Nat Neurosci. 2014 Jul;17(7):971-80. doi: 10.1038/nn.3728. Epub 2014 May 25.


A real-time high-throughput fluorescence assay for sphingosine kinases.

Lima S, Milstien S, Spiegel S.

J Lipid Res. 2014 Jul;55(7):1525-30. doi: 10.1194/jlr.D048132. Epub 2014 May 2.


K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5.

Harikumar KB, Yester JW, Surace MJ, Oyeniran C, Price MM, Huang WC, Hait NC, Allegood JC, Yamada A, Kong X, Lazear HM, Bhardwaj R, Takabe K, Diamond MS, Luo C, Milstien S, Spiegel S, Kordula T.

Nat Immunol. 2014 Mar;15(3):231-8. doi: 10.1038/ni.2810. Epub 2014 Jan 26.


Sphingosine-1-phosphate in chronic intestinal inflammation and cancer.

Nagahashi M, Hait NC, Maceyka M, Avni D, Takabe K, Milstien S, Spiegel S.

Adv Biol Regul. 2014 Jan;54:112-20. doi: 10.1016/j.jbior.2013.10.001. Epub 2013 Oct 16. Review.


The potential of histone deacetylase inhibitors in Niemann - Pick type C disease.

Maceyka M, Milstien S, Spiegel S.

FEBS J. 2013 Dec;280(24):6367-72. doi: 10.1111/febs.12505. Epub 2013 Sep 23. Review.


Is tail vein injection a relevant breast cancer lung metastasis model?

Rashid OM, Nagahashi M, Ramachandran S, Dumur CI, Schaum JC, Yamada A, Aoyagi T, Milstien S, Spiegel S, Takabe K.

J Thorac Dis. 2013 Aug;5(4):385-92. doi: 10.3978/j.issn.2072-1439.2013.06.17.


Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.

Kunkel GT, Maceyka M, Milstien S, Spiegel S.

Nat Rev Drug Discov. 2013 Sep;12(9):688-702. doi: 10.1038/nrd4099. Epub 2013 Aug 19. Review.


Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer.

Liang J, Nagahashi M, Kim EY, Harikumar KB, Yamada A, Huang WC, Hait NC, Allegood JC, Price MM, Avni D, Takabe K, Kordula T, Milstien S, Spiegel S.

Cancer Cell. 2013 Jan 14;23(1):107-20. doi: 10.1016/j.ccr.2012.11.013. Epub 2012 Dec 27.


Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network.

Nagahashi M, Kim EY, Yamada A, Ramachandran S, Allegood JC, Hait NC, Maceyka M, Milstien S, Takabe K, Spiegel S.

FASEB J. 2013 Mar;27(3):1001-11. doi: 10.1096/fj.12-219618. Epub 2012 Nov 24.


A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.

Price MM, Oskeritzian CA, Falanga YT, Harikumar KB, Allegood JC, Alvarez SE, Conrad D, Ryan JJ, Milstien S, Spiegel S.

J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. doi: 10.1016/j.jaci.2012.07.014. Epub 2012 Aug 30.


Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis.

Nagahashi M, Ramachandran S, Kim EY, Allegood JC, Rashid OM, Yamada A, Zhao R, Milstien S, Zhou H, Spiegel S, Takabe K.

Cancer Res. 2012 Feb 1;72(3):726-35. doi: 10.1158/0008-5472.CAN-11-2167.


Autophagy induced by deficiency of sphingosine-1-phosphate phosphohydrolase 1 is switched to apoptosis by calpain-mediated autophagy-related gene 5 (Atg5) cleavage.

Lépine S, Allegood JC, Edmonds Y, Milstien S, Spiegel S.

J Biol Chem. 2011 Dec 30;286(52):44380-90. doi: 10.1074/jbc.M111.257519. Epub 2011 Nov 3.


Sphingosine-1-phosphate signaling and its role in disease.

Maceyka M, Harikumar KB, Milstien S, Spiegel S.

Trends Cell Biol. 2012 Jan;22(1):50-60. doi: 10.1016/j.tcb.2011.09.003. Epub 2011 Oct 14. Review.


Development of small-molecule inhibitors of sphingosine-1-phosphate signaling.

Edmonds Y, Milstien S, Spiegel S.

Pharmacol Ther. 2011 Dec;132(3):352-60. doi: 10.1016/j.pharmthera.2011.08.004. Epub 2011 Aug 27. Review.


Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.

Spiegel S, Milstien S, Grant S.

Oncogene. 2012 Feb 2;31(5):537-51. doi: 10.1038/onc.2011.267. Epub 2011 Jul 4. Review.


Targeting sphingosine-1-phosphate in hematologic malignancies.

Stevenson CE, Takabe K, Nagahashi M, Milstien S, Spiegel S.

Anticancer Agents Med Chem. 2011 Nov;11(9):794-8. Review.


The outs and the ins of sphingosine-1-phosphate in immunity.

Spiegel S, Milstien S.

Nat Rev Immunol. 2011 Jun;11(6):403-15. doi: 10.1038/nri2974. Epub 2011 May 6. Review.


Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration.

Strub GM, Paillard M, Liang J, Gomez L, Allegood JC, Hait NC, Maceyka M, Price MM, Chen Q, Simpson DC, Kordula T, Milstien S, Lesnefsky EJ, Spiegel S.

FASEB J. 2011 Feb;25(2):600-12. doi: 10.1096/fj.10-167502. Epub 2010 Oct 19.


Extracellular and intracellular actions of sphingosine-1-phosphate.

Strub GM, Maceyka M, Hait NC, Milstien S, Spiegel S.

Adv Exp Med Biol. 2010;688:141-55. Review.


Lysophosphatidic acid stimulates gastric cancer cell proliferation via ERK1-dependent upregulation of sphingosine kinase 1 transcription.

Ramachandran S, Shida D, Nagahashi M, Fang X, Milstien S, Takabe K, Spiegel S.

FEBS Lett. 2010 Sep 24;584(18):4077-82. doi: 10.1016/j.febslet.2010.08.035. Epub 2010 Sep 7.


Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy.

Lépine S, Allegood JC, Park M, Dent P, Milstien S, Spiegel S.

Cell Death Differ. 2011 Feb;18(2):350-61. doi: 10.1038/cdd.2010.104. Epub 2010 Aug 27.


Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.

Alvarez SE, Harikumar KB, Hait NC, Allegood J, Strub GM, Kim EY, Maceyka M, Jiang H, Luo C, Kordula T, Milstien S, Spiegel S.

Nature. 2010 Jun 24;465(7301):1084-8. doi: 10.1038/nature09128.


Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema.

Oskeritzian CA, Price MM, Hait NC, Kapitonov D, Falanga YT, Morales JK, Ryan JJ, Milstien S, Spiegel S.

J Exp Med. 2010 Mar 15;207(3):465-74. doi: 10.1084/jem.20091513. Epub 2010 Mar 1.


Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2.

Takabe K, Kim RH, Allegood JC, Mitra P, Ramachandran S, Nagahashi M, Harikumar KB, Hait NC, Milstien S, Spiegel S.

J Biol Chem. 2010 Apr 2;285(14):10477-86. doi: 10.1074/jbc.M109.064162. Epub 2010 Jan 28.


Sphingosine-1-phosphate synthesis and functions in mast cells.

Price MM, Oskeritzian CA, Milstien S, Spiegel S.

Future Lipidol. 2008 Dec 1;3(6):665-674.


Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

Hait NC, Allegood J, Maceyka M, Strub GM, Harikumar KB, Singh SK, Luo C, Marmorstein R, Kordula T, Milstien S, Spiegel S.

Science. 2009 Sep 4;325(5945):1254-7. doi: 10.1126/science.1176709. Erratum in: Science. 2009 Oct 16;326(5951):366.


Targeting sphingosine kinase 1 inhibits Akt signaling, induces apoptosis, and suppresses growth of human glioblastoma cells and xenografts.

Kapitonov D, Allegood JC, Mitchell C, Hait NC, Almenara JA, Adams JK, Zipkin RE, Dent P, Kordula T, Milstien S, Spiegel S.

Cancer Res. 2009 Sep 1;69(17):6915-23. doi: 10.1158/0008-5472.CAN-09-0664.


Sphingosine-1-phosphate induces development of functionally mature chymase-expressing human mast cells from hematopoietic progenitors.

Price MM, Kapitonov D, Allegood J, Milstien S, Oskeritzian CA, Spiegel S.

FASEB J. 2009 Oct;23(10):3506-15. doi: 10.1096/fj.08-128900. Epub 2009 Jun 17.


Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS.

Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE.

J Neurochem. 2009 Aug;110(4):1191-202. doi: 10.1111/j.1471-4159.2009.06202.x. Epub 2009 May 31.

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