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Items: 48

1.

Cooperativity basis for small-molecule stabilization of protein-protein interactions.

de Vink PJ, Andrei SA, Higuchi Y, Ottmann C, Milroy LG, Brunsveld L.

Chem Sci. 2019 Jan 25;10(10):2869-2874. doi: 10.1039/c8sc05242e. eCollection 2019 Mar 14.

2.

Tetrazine- trans-Cyclooctene Chemistry Applied to Fabricate Self-Assembled Fluorescent and Radioactive Nanoparticles for in Vivo Dual Mode Imaging.

van Onzen AHAM, Rossin R, Schenning APHJ, Nicolay K, Milroy LG, Robillard MS, Brunsveld L.

Bioconjug Chem. 2019 Mar 20;30(3):547-551. doi: 10.1021/acs.bioconjchem.9b00038. Epub 2019 Feb 12.

3.

Mutually Exclusive Cellular Uptake of Combinatorial Supramolecular Copolymers.

van Dun S, Schill J, Milroy LG, Brunsveld L.

Chemistry. 2018 Nov 2;24(61):16445-16451. doi: 10.1002/chem.201804045. Epub 2018 Oct 11.

4.

Optimizing charge state distribution is a prerequisite for accurate protein biomarker quantification with LC-MS/MS, as illustrated by hepcidin measurement.

Schmitz EMH, Leijten NM, van Dongen JLJ, Broeren MAC, Milroy LG, Brunsveld L, Scharnhorst V, van de Kerkhof D.

Clin Chem Lab Med. 2018 Aug 28;56(9):1490-1497. doi: 10.1515/cclm-2018-0013.

PMID:
29777607
5.

Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes.

Andrei SA, Meijer FA, Neves JF, Brunsveld L, Landrieu I, Ottmann C, Milroy LG.

ACS Chem Neurosci. 2018 Nov 21;9(11):2639-2654. doi: 10.1021/acschemneuro.8b00118. Epub 2018 May 17.

6.

Synthesis and Self-Assembly of Bay-Substituted Perylene Diimide Gemini-Type Surfactants as Off-On Fluorescent Probes for Lipid Bilayers.

Schill J, van Dun S, Pouderoijen MJ, Janssen HM, Milroy LG, Schenning APHJ, Brunsveld L.

Chemistry. 2018 May 28;24(30):7734-7741. doi: 10.1002/chem.201801022. Epub 2018 May 3.

7.

A multi-gram-scale stereoselective synthesis of Z-endoxifen.

Milroy LG, Koning B, Scheppingen DSV, Jager NGL, Beijnen JH, Koek J, Brunsveld L.

Bioorg Med Chem Lett. 2018 May 1;28(8):1352-1356. doi: 10.1016/j.bmcl.2018.03.008. Epub 2018 Mar 13.

8.

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J.

J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23.

9.

Dual-Input Regulation and Positional Control in Hybrid Oligonucleotide/Discotic Supramolecular Wires.

Alemán García MÁ, Magdalena Estirado E, Milroy LG, Brunsveld L.

Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4976-4980. doi: 10.1002/anie.201800148. Epub 2018 Mar 23.

10.

Semisynthetic Bioluminescent Sensor Proteins for Direct Detection of Antibodies and Small Molecules in Solution.

Arts R, Ludwig SKJ, van Gerven BCB, Estirado EM, Milroy LG, Merkx M.

ACS Sens. 2017 Nov 22;2(11):1730-1736. doi: 10.1021/acssensors.7b00695. Epub 2017 Nov 2.

11.

Target of rapamycin FATC domain as a general membrane anchor: The FKBP-12 like domain of FKBP38 as a case study.

De Cicco M, Milroy LG, Dames SA.

Protein Sci. 2018 Feb;27(2):546-560. doi: 10.1002/pro.3321. Epub 2017 Oct 30.

12.

Fragmentation of organic ions bearing fixed multiple charges observed in MALDI MS.

Lou X, Li B, de Waal BFM, Schill J, Baker MB, Bovee RAA, van Dongen JLJ, Milroy LG, Meijer EW.

J Mass Spectrom. 2018 Jan;53(1):39-47. doi: 10.1002/jms.4035.

PMID:
28963745
13.

Supramolecular Chemistry Targeting Proteins.

van Dun S, Ottmann C, Milroy LG, Brunsveld L.

J Am Chem Soc. 2017 Oct 11;139(40):13960-13968. doi: 10.1021/jacs.7b01979. Epub 2017 Sep 28.

14.

Stabilization of protein-protein interactions in drug discovery.

Andrei SA, Sijbesma E, Hann M, Davis J, O'Mahony G, Perry MWD, Karawajczyk A, Eickhoff J, Brunsveld L, Doveston RG, Milroy LG, Ottmann C.

Expert Opin Drug Discov. 2017 Sep;12(9):925-940. doi: 10.1080/17460441.2017.1346608. Epub 2017 Jul 11. Review.

PMID:
28695752
15.

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.

Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L.

ACS Chem Neurosci. 2017 Sep 20;8(9):2065-2077. doi: 10.1021/acschemneuro.7b00216. Epub 2017 Jul 24.

16.

A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit[8]uril and Dimeric Adapter Protein 14-3-3.

de Vink PJ, Briels JM, Schrader T, Milroy LG, Brunsveld L, Ottmann C.

Angew Chem Int Ed Engl. 2017 Jul 24;56(31):8998-9002. doi: 10.1002/anie.201701807. Epub 2017 Jun 29.

17.

Relationship between Side-Chain Polarity and the Self-Assembly Characteristics of Perylene Diimide Derivatives in Aqueous Solution.

Schill J, Milroy LG, Lugger JAM, Schenning APHJ, Brunsveld L.

ChemistryOpen. 2017 Jan 20;6(2):266-272. doi: 10.1002/open.201600133. eCollection 2017 Apr.

18.

Designed Spiroketal Protein Modulation.

Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG.

Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13.

19.

Structural interface between LRRK2 and 14-3-3 protein.

Stevers LM, de Vries RM, Doveston RG, Milroy LG, Brunsveld L, Ottmann C.

Biochem J. 2017 Mar 23;474(7):1273-1287. doi: 10.1042/BCJ20161078.

PMID:
28202711
20.

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells.

van Onzen AHAM, Albertazzi L, Schenning APHJ, Milroy LG, Brunsveld L.

Chem Commun (Camb). 2017 Feb 4;53(10):1626-1629. doi: 10.1039/c6cc08793k. Epub 2017 Jan 18.

PMID:
28097276
21.
22.

Supramolecular Control over Split-Luciferase Complementation.

Bosmans RP, Briels JM, Milroy LG, de Greef TF, Merkx M, Brunsveld L.

Angew Chem Int Ed Engl. 2016 Jul 25;55(31):8899-903. doi: 10.1002/anie.201602807. Epub 2016 Jun 29.

23.

Batch and Flow Synthesis of Disulfides by Visible-Light-Induced TiO2 Photocatalysis.

Bottecchia C, Erdmann N, Tijssen PM, Milroy LG, Brunsveld L, Hessel V, Noël T.

ChemSusChem. 2016 Jul 21;9(14):1781-5. doi: 10.1002/cssc.201600602. Epub 2016 Jun 22.

PMID:
27329945
24.

Mandibular Canal Location: Cone-beam Computed Tomography Examination.

Koivisto T, Chiona D, Milroy LL, McClanahan SB, Ahmad M, Bowles WR.

J Endod. 2016 Jul;42(7):1018-21. doi: 10.1016/j.joen.2016.03.004. Epub 2016 May 11.

PMID:
27178249
25.

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Stevers LM, Lam CV, Leysen SF, Meijer FA, van Scheppingen DS, de Vries RM, Carlile GW, Milroy LG, Thomas DY, Brunsveld L, Ottmann C.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61. doi: 10.1073/pnas.1516631113. Epub 2016 Feb 17.

26.

Communication: Probing the absolute configuration of chiral molecules at aqueous interfaces.

Lotze S, Versluis J, Olijve LL, van Schijndel L, Milroy LG, Voets IK, Bakker HJ.

J Chem Phys. 2015 Nov 28;143(20):201101. doi: 10.1063/1.4936403.

PMID:
26627942
27.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR.

PLoS One. 2015 Dec 1;10(12):e0143634. doi: 10.1371/journal.pone.0143634. eCollection 2015.

28.

Stabilizer-Guided Inhibition of Protein-Protein Interactions.

Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15720-4. doi: 10.1002/anie.201507976. Epub 2015 Nov 5.

PMID:
26537010
29.

Estrogen Receptor Folding Modulates cSrc Kinase SH2 Interaction via a Helical Binding Mode.

Nieto L, Tharun IM, Balk M, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L.

ACS Chem Biol. 2015 Nov 20;10(11):2624-32. doi: 10.1021/acschembio.5b00568. Epub 2015 Sep 18.

PMID:
26352092
30.

A sample preparation method for recovering suppressed analyte ions in MALDI TOF MS.

Lou X, de Waal BF, Milroy LG, van Dongen JL.

J Mass Spectrom. 2015 May;50(5):766-70. doi: 10.1002/jms.3587.

PMID:
26259660
31.

Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A.

Arndt HD, Rizzo S, Nöcker C, Wakchaure VN, Milroy LG, Bieker V, Calderon A, Tran TT, Brand S, Dehmelt L, Waldmann H.

Chemistry. 2015 Mar 27;21(14):5311-6. doi: 10.1002/chem.201500368. Epub 2015 Feb 18.

PMID:
25694199
32.

The renaissance of Ras.

Milroy LG, Ottmann C.

ACS Chem Biol. 2014 Nov 21;9(11):2447-58. doi: 10.1021/cb500555h. Epub 2014 Sep 23. Review.

PMID:
25148694
33.

A natural-product switch for a dynamic protein interface.

Scheepstra M, Nieto L, Hirsch AK, Fuchs S, Leysen S, Lam CV, in het Panhuis L, van Boeckel CA, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L.

Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6443-8. doi: 10.1002/anie.201403773. Epub 2014 May 12.

PMID:
24821627
34.

Modulators of protein-protein interactions.

Milroy LG, Grossmann TN, Hennig S, Brunsveld L, Ottmann C.

Chem Rev. 2014 May 14;114(9):4695-748. doi: 10.1021/cr400698c. Epub 2014 Apr 15. Review. No abstract available.

PMID:
24735440
35.

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

Taha MS, Nouri K, Milroy LG, Moll JM, Herrmann C, Brunsveld L, Piekorz RP, Ahmadian MR.

PLoS One. 2014 Mar 21;9(3):e91465. doi: 10.1371/journal.pone.0091465. eCollection 2014.

36.

Pharmaceutical implications of helix length control in helix-mediated protein-protein interactions.

Milroy LG, Brunsveld L.

Future Med Chem. 2013 Dec;5(18):2175-83. doi: 10.4155/fmc.13.179. Review.

PMID:
24261893
37.

Supramolecular control of cell adhesion via ferrocene-cucurbit[7]uril host-guest binding on gold surfaces.

Neirynck P, Brinkmann J, An Q, van der Schaft DW, Milroy LG, Jonkheijm P, Brunsveld L.

Chem Commun (Camb). 2013 May 7;49(35):3679-81. doi: 10.1039/c3cc37592g.

PMID:
23536190
38.

Proline primed helix length as a modulator of the nuclear receptor-coactivator interaction.

Fuchs S, Nguyen HD, Phan TT, Burton MF, Nieto L, de Vries-van Leeuwen IJ, Schmidt A, Goodarzifard M, Agten SM, Rose R, Ottmann C, Milroy LG, Brunsveld L.

J Am Chem Soc. 2013 Mar 20;135(11):4364-71. doi: 10.1021/ja311748r. Epub 2013 Mar 7.

PMID:
23437920
39.

Immobilization of Ferrocene-Modified SNAP-Fusion Proteins.

Wasserberg D, Uhlenheuer DA, Neirynck P, Cabanas-Danés J, Schenkel JH, Ravoo BJ, An Q, Huskens J, Milroy LG, Brunsveld L, Jonkheijm P.

Int J Mol Sci. 2013 Feb 18;14(2):4066-80. doi: 10.3390/ijms14024066.

40.

Stabilization and inhibition of protein-protein interactions: the 14-3-3 case study.

Milroy LG, Brunsveld L, Ottmann C.

ACS Chem Biol. 2013 Jan 18;8(1):27-35. doi: 10.1021/cb300599t. Epub 2012 Dec 14. Review.

PMID:
23210482
41.

Selective chemical imaging of static actin in live cells.

Milroy LG, Rizzo S, Calderon A, Ellinger B, Erdmann S, Mondry J, Verveer P, Bastiaens P, Waldmann H, Dehmelt L, Arndt HD.

J Am Chem Soc. 2012 May 23;134(20):8480-6. doi: 10.1021/ja211708z. Epub 2012 May 14.

PMID:
22475347
42.

Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins.

Qi X, Loiseau F, Chan WL, Yan Y, Wei Z, Milroy LG, Myers RM, Ley SV, Read RJ, Carrell RW, Zhou A.

J Biol Chem. 2011 May 6;286(18):16163-73. doi: 10.1074/jbc.M110.171082. Epub 2011 Feb 16.

43.

Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin.

Tannert R, Milroy LG, Ellinger B, Hu TS, Arndt HD, Waldmann H.

J Am Chem Soc. 2010 Mar 10;132(9):3063-77. doi: 10.1021/ja9095126.

PMID:
20148556
44.

Natural-product-like spiroketals and fused bicyclic acetals as potential therapeutic agents for B-cell chronic lymphocytic leukaemia.

Milroy LG, Zinzalla G, Loiseau F, Qian Z, Prencipe G, Pepper C, Fegan C, Ley SV.

ChemMedChem. 2008 Dec;3(12):1922-35. doi: 10.1002/cmdc.200800265.

PMID:
19025736
45.

Chemical variation of natural-product-like scaffolds: design, synthesis, and biological activity of fused bicyclic acetal derivatives.

Milroy LG, Zinzalla G, Prencipe G, Michel P, Ley SV, Gunaratnam M, Beltran M, Neidle S.

Angew Chem Int Ed Engl. 2007;46(14):2493-6. No abstract available.

PMID:
17318936
46.

Chemical variation of natural product-like scaffolds: design and synthesis of spiroketal derivatives.

Zinzalla G, Milroy LG, Ley SV.

Org Biomol Chem. 2006 May 21;4(10):1977-2002. Epub 2006 Apr 21.

PMID:
16688343
47.

Repair strategies in aphasic discourse; towards a collaborative model.

Milroy L, Perkins L.

Clin Linguist Phon. 1992;6(1-2):27-40. doi: 10.3109/02699209208985517.

PMID:
20672882
48.

Phonological analysis and speech disorders: a comment.

Milroy L.

Br J Disord Commun. 1985 Aug;20(2):171-9. No abstract available.

PMID:
4052317

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