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Assessment of GFP Tag Position on Protein Localization and Growth Fitness in Yeast.

Weill U, Krieger G, Avihou Z, Milo R, Schuldiner M, Davidi D.

J Mol Biol. 2018 Dec 12. pii: S0022-2836(18)30648-X. doi: 10.1016/j.jmb.2018.12.004. [Epub ahead of print]


A Bird's-Eye View of Enzyme Evolution: Chemical, Physicochemical, and Physiological Considerations.

Davidi D, Longo LM, Jabłońska J, Milo R, Tawfik DS.

Chem Rev. 2018 Sep 26;118(18):8786-8797. doi: 10.1021/acs.chemrev.8b00039. Epub 2018 Aug 22.


A retrospective analysis of the development of seizure frequency in patients with seizures during a period of military conflict.

Appel S, Gelfand A, Kotlyar G, Milo R.

Seizure. 2018 Oct;61:119-121. doi: 10.1016/j.seizure.2018.08.003. Epub 2018 Aug 7.


Patient and caregiver involvement in the formulation of guideline questions: findings from the European Academy of Neurology guideline on palliative care of people with severe multiple sclerosis.

Köpke S, Giordano A, Veronese S, Christin Rahn A, Kleiter I, Basedow-Rajwich B, Fornari A, Battaglia MA, Drulovic J, Kooij L, Koops J, Mens J, Meza Murillo ER, Milanov I, Milo R, Patti F, Pekmezovic T, Sastre-Garriga J, Vosburgh J, Voltz R, Bay J, Oliver DJ, Solari A.

Eur J Neurol. 2019 Jan;26(1):41-50. doi: 10.1111/ene.13760. Epub 2018 Sep 9.


The biomass distribution on Earth.

Bar-On YM, Phillips R, Milo R.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):6506-6511. doi: 10.1073/pnas.1711842115. Epub 2018 May 21.


The opportunity cost of animal based diets exceeds all food losses.

Shepon A, Eshel G, Noor E, Milo R.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3804-3809. doi: 10.1073/pnas.1713820115. Epub 2018 Mar 26.


A model for 'sustainable' US beef production.

Eshel G, Shepon A, Shaket T, Cotler BD, Gilutz S, Giddings D, Raymo ME, Milo R.

Nat Ecol Evol. 2018 Jan;2(1):81-85. doi: 10.1038/s41559-017-0390-5. Epub 2017 Dec 4.


The genetic basis for the adaptation of E. coli to sugar synthesis from CO2.

Herz E, Antonovsky N, Bar-On Y, Davidi D, Gleizer S, Prywes N, Noda-Garcia L, Lyn Frisch K, Zohar Y, Wernick DG, Savidor A, Barenholz U, Milo R.

Nat Commun. 2017 Nov 22;8(1):1705. doi: 10.1038/s41467-017-01835-3.


Mycosis fungoides - A cutaneous lymphoproliferative disorder in a patient treated with fingolimod for multiple sclerosis.

Nitsan Z, Kucuk N, Appel S, Tichmanovich N, Osherov M, Milo R.

J Clin Neurosci. 2018 Feb;48:102-103. doi: 10.1016/j.jocn.2017.10.077. Epub 2017 Nov 3.


Daclizumab for the treatment of adults with relapsing forms of multiple sclerosis.

Osherov M, Milo R.

Expert Rev Clin Pharmacol. 2017 Oct;10(10):1037-1047. doi: 10.1080/17512433.2017.1366854. Epub 2017 Aug 22. Review.


Engineering carbon fixation in E. coli: from heterologous RuBisCO expression to the Calvin-Benson-Bassham cycle.

Antonovsky N, Gleizer S, Milo R.

Curr Opin Biotechnol. 2017 Oct;47:83-91. doi: 10.1016/j.copbio.2017.06.006. Epub 2017 Jul 15. Review.


Parinaud syndrome: Any clinicoradiological correlation?

Pollak L, Zehavi-Dorin T, Eyal A, Milo R, Huna-Baron R.

Acta Neurol Scand. 2017 Dec;136(6):721-726. doi: 10.1111/ane.12795. Epub 2017 Jun 26.


Energetic cost of building a virus.

Mahmoudabadi G, Milo R, Phillips R.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4324-E4333. doi: 10.1073/pnas.1701670114. Epub 2017 May 16.


Daclizumab and its use in multiple sclerosis treatment.

Milo R, Osherov M.

Drugs Today (Barc). 2017 Jan;53(1):7-18. doi: 10.1358/dot.2017.53.1.2570979. Review.


Lessons on enzyme kinetics from quantitative proteomics.

Davidi D, Milo R.

Curr Opin Biotechnol. 2017 Aug;46:81-89. doi: 10.1016/j.copbio.2017.02.007. Epub 2017 Mar 10. Review.


Design principles of autocatalytic cycles constrain enzyme kinetics and force low substrate saturation at flux branch points.

Barenholz U, Davidi D, Reznik E, Bar-On Y, Antonovsky N, Noor E, Milo R.

Elife. 2017 Feb 7;6. pii: e20667. doi: 10.7554/eLife.20667.


Spotlight on daclizumab: its potential in the treatment of multiple sclerosis.

Milo R, Stüve O.

Degener Neurol Neuromuscul Dis. 2016 Nov 17;6:95-109. doi: 10.2147/DNND.S85747. eCollection 2016. Review.


The Protein Cost of Metabolic Fluxes: Prediction from Enzymatic Rate Laws and Cost Minimization.

Noor E, Flamholz A, Bar-Even A, Davidi D, Milo R, Liebermeister W.

PLoS Comput Biol. 2016 Nov 3;12(11):e1005167. doi: 10.1371/journal.pcbi.1005167. eCollection 2016 Nov.


pH determines the energetic efficiency of the cyanobacterial CO2 concentrating mechanism.

Mangan NM, Flamholz A, Hood RD, Milo R, Savage DF.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5354-62. doi: 10.1073/pnas.1525145113. Epub 2016 Aug 22.


Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness.

Keren L, Hausser J, Lotan-Pompan M, Vainberg Slutskin I, Alisar H, Kaminski S, Weinberger A, Alon U, Milo R, Segal E.

Cell. 2016 Aug 25;166(5):1282-1294.e18. doi: 10.1016/j.cell.2016.07.024. Epub 2016 Aug 18.


Revised Estimates for the Number of Human and Bacteria Cells in the Body.

Sender R, Fuchs S, Milo R.

PLoS Biol. 2016 Aug 19;14(8):e1002533. doi: 10.1371/journal.pbio.1002533. eCollection 2016 Aug.


Environmentally Optimal, Nutritionally Aware Beef Replacement Plant-Based Diets.

Eshel G, Shepon A, Noor E, Milo R.

Environ Sci Technol. 2016 Aug 2;50(15):8164-8. doi: 10.1021/acs.est.6b01006. Epub 2016 Jul 14.


Sugar Synthesis from CO2 in Escherichia coli.

Antonovsky N, Gleizer S, Noor E, Zohar Y, Herz E, Barenholz U, Zelcbuch L, Amram S, Wides A, Tepper N, Davidi D, Bar-On Y, Bareia T, Wernick DG, Shani I, Malitsky S, Jona G, Bar-Even A, Milo R.

Cell. 2016 Jun 30;166(1):115-25. doi: 10.1016/j.cell.2016.05.064. Epub 2016 Jun 23.


Mutation in West Nile Virus Structural Protein prM during Human Infection.

Lustig Y, Lanciotti RS, Hindiyeh M, Keller N, Milo R, Mayan S, Mendelson E.

Emerg Infect Dis. 2016 Sep;22(9):1647-9. doi: 10.3201/eid2209.160132. Epub 2016 Sep 15.


Pyruvate Formate-Lyase Enables Efficient Growth of Escherichia coli on Acetate and Formate.

Zelcbuch L, Lindner SN, Zegman Y, Vainberg Slutskin I, Antonovsky N, Gleizer S, Milo R, Bar-Even A.

Biochemistry. 2016 May 3;55(17):2423-6. doi: 10.1021/acs.biochem.6b00184. Epub 2016 Apr 21.


A Minimalistic Resource Allocation Model to Explain Ubiquitous Increase in Protein Expression with Growth Rate.

Barenholz U, Keren L, Segal E, Milo R.

PLoS One. 2016 Apr 13;11(4):e0153344. doi: 10.1371/journal.pone.0153344. eCollection 2016.


Therapeutic strategies targeting B-cells in multiple sclerosis.

Milo R.

Autoimmun Rev. 2016 Jul;15(7):714-8. doi: 10.1016/j.autrev.2016.03.006. Epub 2016 Mar 9. Review.


SnapShot: Timescales in Cell Biology.

Shamir M, Bar-On Y, Phillips R, Milo R.

Cell. 2016 Mar 10;164(6):1302-1302.e1. doi: 10.1016/j.cell.2016.02.058. No abstract available.


Global characterization of in vivo enzyme catalytic rates and their correspondence to in vitro kcat measurements.

Davidi D, Noor E, Liebermeister W, Bar-Even A, Flamholz A, Tummler K, Barenholz U, Goldenfeld M, Shlomi T, Milo R.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3401-6. doi: 10.1073/pnas.1514240113. Epub 2016 Mar 7.


Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans.

Sender R, Fuchs S, Milo R.

Cell. 2016 Jan 28;164(3):337-40. doi: 10.1016/j.cell.2016.01.013.


Noise in gene expression is coupled to growth rate.

Keren L, van Dijk D, Weingarten-Gabbay S, Davidi D, Jona G, Weinberger A, Milo R, Segal E.

Genome Res. 2015 Dec;25(12):1893-902. doi: 10.1101/gr.191635.115. Epub 2015 Sep 9.


Evaluation of the national tuberculosis surveillance program in Haiti.

Salyer SJ, Fitter DL, Milo R, Blanton C, Ho JL, Geffrard H, Morose W, Marston BJ.

Int J Tuberc Lung Dis. 2015 Sep;19(9):1045-50. doi: 10.5588/ijtld.15.0051.


The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.

Bar-Even A, Milo R, Noor E, Tawfik DS.

Biochemistry. 2015 Aug 18;54(32):4969-77. doi: 10.1021/acs.biochem.5b00621. Epub 2015 Aug 6. Review.


Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.

Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen BE, Nielsen CH, Milo R, Zeilig G, Lassmann H, Altmann DM, Ben-Nun A.

J Biol Chem. 2015 Jun 12;290(24):15260-78. doi: 10.1074/jbc.M115.641209. Epub 2015 Apr 24.


An in vivo metabolic approach for deciphering the product specificity of glycerate kinase proves that both E. coli's glycerate kinases generate 2-phosphoglycerate.

Zelcbuch L, Razo-Mejia M, Herz E, Yahav S, Antonovsky N, Kroytoro H, Milo R, Bar-Even A.

PLoS One. 2015 Mar 30;10(3):e0122957. doi: 10.1371/journal.pone.0122957. eCollection 2015.


Reply to Tichenor: Proposed update to beef greenhouse gas footprint is numerically questionable and well within current uncertainty bounds.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E822-3. doi: 10.1073/pnas.1422670112. Epub 2015 Feb 4. No abstract available.


Effectiveness of multiple sclerosis treatment with current immunomodulatory drugs.

Milo R.

Expert Opin Pharmacother. 2015 Apr;16(5):659-73. doi: 10.1517/14656566.2015.1002769. Epub 2015 Jan 13. Review.


Reply to Metson et al.: The importance of phosphorus perturbations.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4908. doi: 10.1073/pnas.1418658111. Epub 2014 Nov 10. No abstract available.


The quantified cell.

Flamholz A, Phillips R, Milo R.

Mol Biol Cell. 2014 Nov 5;25(22):3497-500. doi: 10.1091/mbc.E14-09-1347.


Land, irrigation water, greenhouse gas, and reactive nitrogen burdens of meat, eggs, and dairy production in the United States.

Eshel G, Shepon A, Makov T, Milo R.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):11996-2001. doi: 10.1073/pnas.1402183111. Epub 2014 Jul 21.


Visual account of protein investment in cellular functions.

Liebermeister W, Noor E, Flamholz A, Davidi D, Bernhardt J, Milo R.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8488-93. doi: 10.1073/pnas.1314810111. Epub 2014 Jun 2.


Noise genetics: inferring protein function by correlating phenotype with protein levels and localization in individual human cells.

Farkash-Amar S, Zimmer A, Eden E, Cohen A, Geva-Zatorsky N, Cohen L, Milo R, Sigal A, Danon T, Alon U.

PLoS Genet. 2014 Mar 6;10(3):e1004176. doi: 10.1371/journal.pgen.1004176. eCollection 2014 Mar.


Pathway thermodynamics highlights kinetic obstacles in central metabolism.

Noor E, Bar-Even A, Flamholz A, Reznik E, Liebermeister W, Milo R.

PLoS Comput Biol. 2014 Feb 20;10(2):e1003483. doi: 10.1371/journal.pcbi.1003483. eCollection 2014 Feb.


Revised diagnostic criteria of multiple sclerosis.

Milo R, Miller A.

Autoimmun Rev. 2014 Apr-May;13(4-5):518-24. doi: 10.1016/j.autrev.2014.01.012. Epub 2014 Jan 12. Review.


The efficacy and safety of daclizumab and its potential role in the treatment of multiple sclerosis.

Milo R.

Ther Adv Neurol Disord. 2014 Jan;7(1):7-21. doi: 10.1177/1756285613504021. Review.


Promoters maintain their relative activity levels under different growth conditions.

Keren L, Zackay O, Lotan-Pompan M, Barenholz U, Dekel E, Sasson V, Aidelberg G, Bren A, Zeevi D, Weinberger A, Alon U, Milo R, Segal E.

Mol Syst Biol. 2013 Oct 29;9:701. doi: 10.1038/msb.2013.59.


What is the total number of protein molecules per cell volume? A call to rethink some published values.

Milo R.

Bioessays. 2013 Dec;35(12):1050-5. doi: 10.1002/bies.201300066. Epub 2013 Sep 20.


Steady-state metabolite concentrations reflect a balance between maximizing enzyme efficiency and minimizing total metabolite load.

Tepper N, Noor E, Amador-Noguez D, Haraldsdóttir HS, Milo R, Rabinowitz J, Liebermeister W, Shlomi T.

PLoS One. 2013 Sep 26;8(9):e75370. doi: 10.1371/journal.pone.0075370. eCollection 2013.


A note on the kinetics of enzyme action: a decomposition that highlights thermodynamic effects.

Noor E, Flamholz A, Liebermeister W, Bar-Even A, Milo R.

FEBS Lett. 2013 Sep 2;587(17):2772-7. doi: 10.1016/j.febslet.2013.07.028. Epub 2013 Jul 23. Review.


Consistent estimation of Gibbs energy using component contributions.

Noor E, Haraldsdóttir HS, Milo R, Fleming RM.

PLoS Comput Biol. 2013;9(7):e1003098. doi: 10.1371/journal.pcbi.1003098. Epub 2013 Jul 11.

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