Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 162

1.

Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine derivatives as potent Mnk2 inhibitors: design, synthesis, SAR analysis, and evaluation of in vitro anti-leukaemic activity.

Abdelaziz AM, Diab S, Islam S, Basnet SKC, Noll B, Li P, Mekonnen LB, Lu J, Albrecht H, Milne RW, Gerber C, Yu M, Wang S.

Med Chem. 2018 Dec 18. doi: 10.2174/1573406415666181219111511. [Epub ahead of print]

PMID:
30569866
2.

Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats.

Licari G, Milne RW, Somogyi AA, Sallustio BC.

Pharmacol Res Perspect. 2018 Jun;6(3):e00406. doi: 10.1002/prp2.406. Epub 2018 May 22.

3.

Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction.

Blackburn NJR, Vulesevic B, McNeill B, Cimenci CE, Ahmadi A, Gonzalez-Gomez M, Ostojic A, Zhong Z, Brownlee M, Beisswenger PJ, Milne RW, Suuronen EJ.

Basic Res Cardiol. 2017 Sep 1;112(5):57. doi: 10.1007/s00395-017-0646-x.

PMID:
28864889
4.

Dual Inhibition of Mnk2 and FLT3 for potential treatment of acute myeloid leukaemia.

Diab S, Abdelaziz AM, Li P, Teo T, Basnet SKC, Noll B, Rahaman MH, Lu J, Hou J, Yu M, Le BT, Albrecht H, Milne RW, Wang S.

Eur J Med Chem. 2017 Oct 20;139:762-772. doi: 10.1016/j.ejmech.2017.08.006. Epub 2017 Aug 3.

PMID:
28863357
5.

The association between total phthalate concentration and non-communicable diseases and chronic inflammation in South Australian urban dwelling men.

Bai PY, Wittert G, Taylor AW, Martin SA, Milne RW, Jenkins AJ, Januszewski AS, Shi Z.

Environ Res. 2017 Oct;158:366-372. doi: 10.1016/j.envres.2017.06.021. Epub 2017 Jul 4.

PMID:
28686951
6.

Effect of Garlic, Gingko, and St. John's Wort Extracts on the Pharmacokinetics of Fexofenadine: A Mechanistic Study.

Turkanovic J, Ward MB, Gerber JP, Milne RW.

Drug Metab Dispos. 2017 May;45(5):569-575. doi: 10.1124/dmd.116.073528. Epub 2017 Feb 10.

PMID:
28188296
7.

Targeting CDK9: a promising therapeutic opportunity in prostate cancer.

Rahaman MH, Kumarasiri M, Mekonnen LB, Yu M, Diab S, Albrecht H, Milne RW, Wang S.

Endocr Relat Cancer. 2016 Dec;23(12):T211-T226. Epub 2016 Aug 31. Review.

PMID:
27582311
8.

Methylglyoxal-Induced Endothelial Cell Loss and Inflammation Contribute to the Development of Diabetic Cardiomyopathy.

Vulesevic B, McNeill B, Giacco F, Maeda K, Blackburn NJ, Brownlee M, Milne RW, Suuronen EJ.

Diabetes. 2016 Jun;65(6):1699-713. doi: 10.2337/db15-0568. Epub 2016 Mar 8.

9.

Unveiling new chemical scaffolds as Mnk inhibitors.

Diab S, Li P, Basnet SK, Lu J, Yu M, Albrecht H, Milne RW, Wang S.

Future Med Chem. 2016;8(3):271-85. doi: 10.4155/fmc.15.190. Epub 2016 Feb 24.

PMID:
26910782
10.

The association of socio-demographic status, lifestyle factors and dietary patterns with total urinary phthalates in Australian men.

Bai PY, Wittert GA, Taylor AW, Martin SA, Milne RW, Shi Z.

PLoS One. 2015 Apr 15;10(4):e0122140. doi: 10.1371/journal.pone.0122140. eCollection 2015.

11.

Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague-Dawley and Dark Agouti rats.

Licari G, Somogyi AA, Milne RW, Sallustio BC.

Xenobiotica. 2015 Jan;45(1):3-9. doi: 10.3109/00498254.2014.942721. Epub 2014 Jul 22.

PMID:
25050791
12.

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.

Geoffrion M, Du X, Irshad Z, Vanderhyden BC, Courville K, Sui G, D'Agati VD, Ott-Braschi S, Rabbani N, Thornalley PJ, Brownlee M, Milne RW.

Physiol Rep. 2014 Jun 11;2(6). pii: e12043. doi: 10.14814/phy2.12043. Print 2014 Jun 1.

13.

Reducing methylglyoxal as a therapeutic target for diabetic heart disease.

Vulesevic B, Milne RW, Suuronen EJ.

Biochem Soc Trans. 2014 Apr;42(2):523-7. doi: 10.1042/BST20130254. Review.

PMID:
24646272
14.

Glyoxalase-1 overexpression in bone marrow cells reverses defective neovascularization in STZ-induced diabetic mice.

Vulesevic B, McNeill B, Geoffrion M, Kuraitis D, McBane JE, Lochhead M, Vanderhyden BC, Korbutt GS, Milne RW, Suuronen EJ.

Cardiovasc Res. 2014 Feb 1;101(2):306-16. doi: 10.1093/cvr/cvt259. Epub 2013 Nov 20.

PMID:
24259499
15.

Role of renin-angiotensin system in activation of macrophages by modified lipoproteins.

Rafatian N, Milne RW, Leenen FH, Whitman SC.

Am J Physiol Heart Circ Physiol. 2013 Nov 1;305(9):H1309-20. doi: 10.1152/ajpheart.00826.2012. Epub 2013 Aug 30.

16.

Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice.

Rafatian N, Karunakaran D, Rayner KJ, Leenen FH, Milne RW, Whitman SC.

Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1141-8. doi: 10.1152/ajpheart.00618.2012. Epub 2013 Aug 9.

17.

Cohort profile: The men androgen inflammation lifestyle environment and stress (MAILES) study.

Grant JF, Martin SA, Taylor AW, Wilson DH, Araujo A, Adams RJ, Jenkins A, Milne RW, Hugo GJ, Atlantis E, Wittert GA.

Int J Epidemiol. 2014 Aug;43(4):1040-53. doi: 10.1093/ije/dyt064. Epub 2013 Jun 19.

18.

Insulin-degrading enzyme deficiency in bone marrow cells increases atherosclerosis in LDL receptor-deficient mice.

Caravaggio JW, Hasu M, MacLaren R, Thabet M, Raizman JE, Veinot JP, Marcel YL, Milne RW, Whitman SC.

Cardiovasc Pathol. 2013 Nov-Dec;22(6):458-64. doi: 10.1016/j.carpath.2013.03.006. Epub 2013 May 17.

PMID:
23684818
19.

Immunochemical analysis of the electronegative LDL subfraction shows that abnormal N-terminal apolipoprotein B conformation is involved in increased binding to proteoglycans.

Bancells C, Benítez S, Ordóñez-Llanos J, Öörni K, Kovanen PT, Milne RW, Sánchez-Quesada JL.

J Biol Chem. 2011 Jan 14;286(2):1125-33. doi: 10.1074/jbc.M110.175315. Epub 2010 Nov 15.

20.

Stability of Myrmecia pilosula (Jack Jumper) Ant venom for use in immunotherapy.

Wiese MD, Davies NW, Chataway TK, Milne RW, Brown SG, Heddle RJ.

J Pharm Biomed Anal. 2011 Jan 25;54(2):303-10. doi: 10.1016/j.jpba.2010.08.024. Epub 2010 Sep 24.

PMID:
20869831
21.

In memoriam: Stewart Charles Whitman (1964-2010).

Marcel Y, McBride H, Milne RW, Huff M, Daugherty A.

J Lipid Res. 2010 Nov;51(11):3089-90. doi: 10.1194/jlr.E009894. Epub 2010 Aug 10. No abstract available.

22.

Intravascular transfer contributes to postprandial increase in numbers of very-low-density hepatitis C virus particles.

Felmlee DJ, Sheridan DA, Bridge SH, Nielsen SU, Milne RW, Packard CJ, Caslake MJ, McLauchlan J, Toms GL, Neely RD, Bassendine MF.

Gastroenterology. 2010 Nov;139(5):1774-83, 1783.e1-6. doi: 10.1053/j.gastro.2010.07.047. Epub 2010 Aug 2.

PMID:
20682323
23.

Inhibition of morphine metabolism by ketamine.

Qi X, Evans AM, Wang J, Miners JO, Upton RN, Milne RW.

Drug Metab Dispos. 2010 May;38(5):728-31. doi: 10.1124/dmd.109.030957. Epub 2010 Feb 2.

PMID:
20124399
24.

Elucidation of the pharmacokinetic/pharmacodynamic determinant of colistin activity against Pseudomonas aeruginosa in murine thigh and lung infection models.

Dudhani RV, Turnidge JD, Coulthard K, Milne RW, Rayner CR, Li J, Nation RL.

Antimicrob Agents Chemother. 2010 Mar;54(3):1117-24. doi: 10.1128/AAC.01114-09. Epub 2009 Dec 22.

25.

Effect of St John's wort on the disposition of fexofenadine in the isolated perfused rat liver.

Turkanovic J, Ngo SN, Milne RW.

J Pharm Pharmacol. 2009 Aug;61(8):1037-42. doi: 10.1211/jpp/61.08.0007.

PMID:
19703347
26.

Renal disposition of colistin in the isolated perfused rat kidney.

Ma Z, Wang J, Nation RL, Li J, Turnidge JD, Coulthard K, Milne RW.

Antimicrob Agents Chemother. 2009 Jul;53(7):2857-64. doi: 10.1128/AAC.00030-09. Epub 2009 Apr 20.

27.

Cloning of apoB intrabodies: specific knockdown of apoB in HepG2 cells.

Liao W, Strube RW, Milne RW, Chen SY, Chan L.

Biochem Biophys Res Commun. 2008 Aug 22;373(2):235-40. doi: 10.1016/j.bbrc.2008.06.020. Epub 2008 Jun 17.

28.

Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model.

Bergen PJ, Li J, Nation RL, Turnidge JD, Coulthard K, Milne RW.

J Antimicrob Chemother. 2008 Mar;61(3):636-42. doi: 10.1093/jac/dkm511. Epub 2008 Jan 28.

PMID:
18227094
29.

Determination of colistin in human plasma, urine and other biological samples using LC-MS/MS.

Ma Z, Wang J, Gerber JP, Milne RW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 1;862(1-2):205-12. doi: 10.1016/j.jchromb.2007.12.009. Epub 2008 Jan 9.

PMID:
18187372
30.

Subacute toxicity of colistin methanesulfonate in rats: comparison of various intravenous dosage regimens.

Wallace SJ, Li J, Nation RL, Rayner CR, Taylor D, Middleton D, Milne RW, Coulthard K, Turnidge JD.

Antimicrob Agents Chemother. 2008 Mar;52(3):1159-61. doi: 10.1128/AAC.01101-07. Epub 2008 Jan 7.

31.

Myrmecia pilosula (Jack Jumper) ant venom: validation of a procedure to standardise an allergy vaccine.

Wiese MD, Milne RW, Davies NW, Chataway TK, Brown SG, Heddle RJ.

J Pharm Biomed Anal. 2008 Jan 7;46(1):58-65. Epub 2007 Sep 7.

PMID:
17933477
32.

Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline.

Davies BJ, Herbert MK, Coller JK, Somogyi AA, Milne RW, Sallustio BC.

Br J Clin Pharmacol. 2008 Mar;65(3):347-54. Epub 2007 Sep 13.

33.

Isosteviol reduces plasma glucose levels in the intravenous glucose tolerance test in Zucker diabetic fatty rats.

Ma J, Ma Z, Wang J, Milne RW, Xu D, Davey AK, Evans AM.

Diabetes Obes Metab. 2007 Jul;9(4):597-9.

PMID:
17587403
34.

Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.

Inglis SC, Herbert MK, Davies BJ, Coller JK, James HM, Horowitz JD, Morris RG, Milne RW, Somogyi AA, Sallustio BC.

Pharmacogenet Genomics. 2007 May;17(5):305-12.

PMID:
17429312
35.

Myrmecia pilosula (Jack Jumper) ant venom: identification of allergens and revised nomenclature.

Wiese MD, Brown SG, Chataway TK, Davies NW, Milne RW, Aulfrey SJ, Heddle RJ.

Allergy. 2007 Apr;62(4):437-43.

PMID:
17362256
36.

Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects.

Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL.

Arterioscler Thromb Vasc Biol. 2007 May;27(5):1139-45. Epub 2007 Feb 15.

PMID:
17303779
37.

Dietary fatty acids make a rapid and substantial contribution to VLDL-triacylglycerol in the fed state.

Heath RB, Karpe F, Milne RW, Burdge GC, Wootton SA, Frayn KN.

Am J Physiol Endocrinol Metab. 2007 Mar;292(3):E732-9. Epub 2006 Nov 7.

38.

Loading-washout studies of the stereoselective sinusoidal uptake of (R)- and (s)-2-phenylpropionyl acyl glucuronide.

Shackleford DM, Evans AM, Milne RW, Nation RL.

Curr Drug Metab. 2006 Oct;7(7):817-26.

PMID:
17073581
39.

Oral L-carnitine: metabolite formation and hemodialysis.

Bain MA, Faull R, Milne RW, Evans AM.

Curr Drug Metab. 2006 Oct;7(7):811-6.

PMID:
17073580
40.

CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes.

Davies BJ, Coller JK, Somogyi AA, Milne RW, Sallustio BC.

Drug Metab Dispos. 2007 Jan;35(1):128-38. Epub 2006 Oct 18.

PMID:
17050648
41.

Disposition and metabolite kinetics of oral L-carnitine in humans.

Bain MA, Milne RW, Evans AM.

J Clin Pharmacol. 2006 Oct;46(10):1163-70.

PMID:
16988205
42.

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections.

Li J, Nation RL, Turnidge JD, Milne RW, Coulthard K, Rayner CR, Paterson DL.

Lancet Infect Dis. 2006 Sep;6(9):589-601. Review.

PMID:
16931410
43.

Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography.

Davies BJ, Herbert MK, Coller JK, Somogyi AA, Milne RW, Sallustio BC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Nov 7;843(2):302-9. Epub 2006 Jul 11.

PMID:
16837252
44.

The expression of apolipoprotein B epitopes is normal in LDL of diabetic and end-stage renal disease patients.

Braschi S, Geoffrion M, Nguyen A, Gaudreau Y, Milne RW.

Diabetologia. 2006 Jun;49(6):1394-401. Epub 2006 Apr 4.

PMID:
16586068
45.

Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography.

Davies BJ, Herbert MK, Culbert JA, Pyke SM, Coller JK, Somogyi AA, Milne RW, Sallustio BC.

J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Feb 17;832(1):114-20. Epub 2006 Jan 24.

PMID:
16434242
46.

Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis.

Bain MA, Faull R, Fornasini G, Milne RW, Evans AM.

Nephrol Dial Transplant. 2006 May;21(5):1300-4. Epub 2006 Jan 9.

PMID:
16401621
47.

Proteomic analysis of Myrmecia pilosula (jack jumper) ant venom.

Wiese MD, Chataway TK, Davies NW, Milne RW, Brown SG, Gai WP, Heddle RJ.

Toxicon. 2006 Feb;47(2):208-17. Epub 2005 Dec 27.

PMID:
16376960
48.

Evaluation of colistin as an agent against multi-resistant Gram-negative bacteria.

Li J, Nation RL, Milne RW, Turnidge JD, Coulthard K.

Int J Antimicrob Agents. 2005 Jan;25(1):11-25. Review.

PMID:
15620821
49.

Quantifying trimethylamine and trimethylamine-N-oxide in human plasma: interference from endogenous quaternary ammonium compounds.

Bain MA, Faull R, Fornasini G, Milne RW, Schumann R, Evans AM.

Anal Biochem. 2004 Nov 15;334(2):403-5. No abstract available.

PMID:
15494149
50.

Stereoselective hepatic disposition of model diastereomeric acyl glucuronides.

Shackleford DM, Nation RL, Milne RW, Hayball PJ, Evans AM.

J Pharmacokinet Pharmacodyn. 2004 Feb;31(1):1-27.

PMID:
15346849

Supplemental Content

Loading ...
Support Center