Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 94

1.

An integrated in silico analysis of drug-binding to human serum albumin.

Estrada E, Uriarte E, Molina E, Simón-Manso Y, Milne GW.

J Chem Inf Model. 2006 Nov-Dec;46(6):2709-24.

PMID:
17125211
2.

The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands.

Marquez VE, Nacro K, Benzaria S, Lee J, Sharma R, Teng K, Milne GW, Bienfait B, Wang S, Lewin NE, Blumberg PM.

Pharmacol Ther. 1999 May-Jun;82(2-3):251-61. Review.

PMID:
10454202
3.

Monocarboxylic-based phosphotyrosyl mimetics in the design of GRB2 SH2 domain inhibitors.

Burke TR Jr, Luo J, Yao ZJ, Gao Y, Zhao H, Milne GW, Guo R, Voigt JH, King CR, Yang D.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):347-52.

PMID:
10091682
4.

Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.

Yao ZJ, King CR, Cao T, Kelley J, Milne GW, Voigt JH, Burke TR Jr.

J Med Chem. 1999 Jan 14;42(1):25-35.

PMID:
9888830
5.

Identification of HIV-1 integrase inhibitors based on a four-point pharmacophore.

Hong H, Neamati N, Winslow HE, Christensen JL, Orr A, Pommier Y, Milne GW.

Antivir Chem Chemother. 1998 Nov;9(6):461-72.

PMID:
9865384
6.

Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.

Neamati N, Hong H, Owen JM, Sunder S, Winslow HE, Christensen JL, Zhao H, Burke TR Jr, Milne GW, Pommier Y.

J Med Chem. 1998 Aug 13;41(17):3202-9.

PMID:
9703465
7.

Identification of a nucleotide binding site in HIV-1 integrase.

Drake RR, Neamati N, Hong H, Pilon AA, Sunthankar P, Hume SD, Milne GW, Pommier Y.

Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4170-5.

8.

Recognition and interaction of small rings with the ricin A-chain binding site.

Yan X, Day P, Hollis T, Monzingo AF, Schelp E, Robertus JD, Milne GW, Wang S.

Proteins. 1998 Apr 1;31(1):33-41.

PMID:
9552157
9.

Pharmacophores in drug design and discovery.

Milne GW, Nicklaus MC, Wang S.

SAR QSAR Environ Res. 1998;9(1-2):23-38. Review.

PMID:
9517013
10.
11.

Mathematics as a basis for chemistry.

Milne GW.

J Chem Inf Comput Sci. 1997 Jul-Aug;37(4):639-44.

PMID:
9254910
12.

Structure-based identification of a ricin inhibitor.

Yan X, Hollis T, Svinth M, Day P, Monzingo AF, Milne GW, Robertus JD.

J Mol Biol. 1997 Mar 14;266(5):1043-9.

PMID:
9086280
13.

Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.

Neamati N, Hong H, Mazumder A, Wang S, Sunder S, Nicklaus MC, Milne GW, Proksa B, Pommier Y.

J Med Chem. 1997 Mar 14;40(6):942-51.

PMID:
9083483
14.

Hydrazide-containing inhibitors of HIV-1 integrase.

Zhao H, Neamati N, Sunder S, Hong H, Wang S, Milne GW, Pommier Y, Burke TR Jr.

J Med Chem. 1997 Mar 14;40(6):937-41.

PMID:
9083482
15.

Discovery of HIV-1 integrase inhibitors by pharmacophore searching.

Hong H, Neamati N, Wang S, Nicklaus MC, Mazumder A, Zhao H, Burke TR Jr, Pommier Y, Milne GW.

J Med Chem. 1997 Mar 14;40(6):930-6.

PMID:
9083481
16.

HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.

Nicklaus MC, Neamati N, Hong H, Mazumder A, Sunder S, Chen J, Milne GW, Pommier Y.

J Med Chem. 1997 Mar 14;40(6):920-9.

PMID:
9083480
17.

Coumarin-based inhibitors of HIV integrase.

Zhao H, Neamati N, Hong H, Mazumder A, Wang S, Sunder S, Milne GW, Pommier Y, Burke TR Jr.

J Med Chem. 1997 Jan 17;40(2):242-9.

PMID:
9003523
18.

Molecular modeling in the discovery of drug leads.

Milne GW, Wang S, Nicklaus MC.

J Chem Inf Comput Sci. 1996 Jul-Aug;36(4):726-30.

PMID:
8768766
19.

Molecular modeling and site-directed mutagenesis studies of a phorbol ester-binding site in protein kinase C.

Wang S, Kazanietz MG, Blumberg PM, Marquez VE, Milne GW.

J Med Chem. 1996 Jun 21;39(13):2541-53.

PMID:
8691452
20.

Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.

Mazumder A, Wang S, Neamati N, Nicklaus M, Sunder S, Chen J, Milne GW, Rice WG, Burke TR Jr, Pommier Y.

J Med Chem. 1996 Jun 21;39(13):2472-81.

PMID:
8691444
21.

Discovery of novel, non-peptide HIV-1 protease inhibitors by pharmacophore searching.

Wang S, Milne GW, Yan X, Posey IJ, Nicklaus MC, Graham L, Rice WG.

J Med Chem. 1996 May 10;39(10):2047-54.

PMID:
8642563
22.

Conformationally constrained analogues of diacylglycerol. 12. Ultrapotent protein kinase C ligands based on a chiral 4,4-disubstituted heptono-1,4-lactone template.

Lee J, Sharma R, Wang S, Milne GW, Lewin NE, Szallasi Z, Blumberg PM, George C, Marquez VE.

J Med Chem. 1996 Jan 5;39(1):36-45.

PMID:
8568825
23.
24.
25.

Residues in the second cysteine-rich region of protein kinase C delta relevant to phorbol ester binding as revealed by site-directed mutagenesis.

Kazanietz MG, Wang S, Milne GW, Lewin NE, Liu HL, Blumberg PM.

J Biol Chem. 1995 Sep 15;270(37):21852-9.

26.

Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids.

Acs G, Lee J, Marquez VE, Wang S, Milne GW, Du L, Lewin NE, Blumberg PM.

J Neurochem. 1995 Jul;65(1):301-18.

PMID:
7790875
27.

Conformational changes of small molecules binding to proteins.

Nicklaus MC, Wang S, Driscoll JS, Milne GW.

Bioorg Med Chem. 1995 Apr;3(4):411-28.

PMID:
8581425
28.

The discovery of novel, structurally diverse protein kinase C agonists through computer 3D-database pharmacophore search. Molecular modeling studies.

Wang S, Zaharevitz DW, Sharma R, Marquez VE, Lewin NE, Du L, Blumberg PM, Milne GW.

J Med Chem. 1994 Dec 23;37(26):4479-89.

PMID:
7799398
29.

Graph theory and group contributions in the estimation of boiling points.

Wang S, Milne GW, Klopman G.

J Chem Inf Comput Sci. 1994 Nov-Dec;34(6):1242-50.

PMID:
7989396
30.

National Cancer Institute Drug Information System 3D database.

Milne GW, Nicklaus MC, Driscoll JS, Wang S, Zaharevitz D.

J Chem Inf Comput Sci. 1994 Sep-Oct;34(5):1219-24.

PMID:
7962217
31.

Protein kinase C. Modeling of the binding site and prediction of binding constants.

Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM.

J Med Chem. 1994 Apr 29;37(9):1326-38. Erratum in: J Med Chem 1994 Dec 9;37(25):4422.

PMID:
8176711
32.

Applications of computers to toxicological research.

Wang S, Milne GW.

Chem Res Toxicol. 1993 Nov-Dec;6(6):748-53. Review.

PMID:
8117912
33.

Chem-X and CAMBRIDGE. Comparison of computer generated chemical structures with X-ray crystallographic data.

Nicklaus MC, Milne GW, Zaharevitz D.

J Chem Inf Comput Sci. 1993 Jul-Aug;33(4):639-46.

PMID:
8366147
34.

Use of computer graphics in drug design.

Milne GW, Nicklaus MC.

NIDA Res Monogr. 1993;134:129-45. Review. No abstract available.

PMID:
8289875
35.

QSAR of conformationally flexible molecules: comparative molecular field analysis of protein-tyrosine kinase inhibitors.

Nicklaus MC, Milne GW, Burke TR Jr.

J Comput Aided Mol Des. 1992 Oct;6(5):487-504.

PMID:
1474396
36.

DrawPerfect and CorelDraw.

Milne GW.

J Chem Inf Comput Sci. 1992 Sep-Oct;32(5):570-1. No abstract available.

PMID:
1400665
37.

Very broad Markush claims; a solution or a problem? Proceedings of a round-table discussion held on August 29, 1990.

Milne GW.

J Chem Inf Comput Sci. 1991 Feb;31(1):9-30. No abstract available.

PMID:
2026664
38.

A ring-enlarged oxetanocin A analogue as an inhibitor of HIV infectivity.

Tseng CK, Marquez VE, Milne GW, Wysocki RJ Jr, Mitsuya H, Shirasaki T, Driscoll JS.

J Med Chem. 1991 Jan;34(1):343-9.

PMID:
1992135
39.

The NCI Drug Information System. 5. DIS Biology Module.

Zehnacker MT, Brennan RH, Milne GW, Miller JA.

J Chem Inf Comput Sci. 1986 Nov;26(4):186-93. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3818819
40.

The NCI Drug Information System. 4. Inventory and Shipping Modules.

Milne GW, Miller JA, Hoover JR.

J Chem Inf Comput Sci. 1986 Nov;26(4):179-85. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3818818
41.

The NCI Drug Information System. 3. The DIS Chemistry Module.

Milne GW, Feldman A, Miller JA, Daly GP.

J Chem Inf Comput Sci. 1986 Nov;26(4):168-79. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3818817
42.

The NCI Drug Information System. 2. DIS Pre-Registry.

Milne GW, Feldman A, Miller JA, Daly GP, Hammel MJ.

J Chem Inf Comput Sci. 1986 Nov;26(4):159-68. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3818816
43.

The NCI Drug Information System. 1. System overview.

Milne GW, Miller JA.

J Chem Inf Comput Sci. 1986 Nov;26(4):154-9. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3818815
44.

The NCI Drug Information System. 6. System maintenance.

Zehnacker MT, Brennan RH, Milne GW, Miller JA, Hammel MJ.

J Chem Inf Comput Sci. 1986 Nov;26(4):193-7. Erratum in: J Chem Inf Comput Sci 1987 Feb;27(1):49.

PMID:
3580042
45.

Toxicities derived from anti-tumor screening data.

Quinn FR, Milne GW.

Fundam Appl Toxicol. 1986 Feb;6(2):270-7.

PMID:
3699317
46.

Development of a chemical information system.

Milne GW.

J Assoc Off Anal Chem. 1982 Sep;65(5):1249-58.

PMID:
7130096
47.

Environmental uses of the NIH-EPA chemical information system.

Milne GW, Fisk CL, Heller SR, Potenzone R Jr.

Science. 1982 Jan 22;215(4531):371-5.

PMID:
7058322
48.

The influence of tumor-bearing on protein metabolism in the rat.

Norton JA, Shamberger R, Stein TP, Milne GW, Brennan MF.

J Surg Res. 1981 May;30(5):456-62. No abstract available.

PMID:
7242064
49.

NIH/EPA Chemical Information System.

Milne GW, Heller SR.

J Chem Inf Comput Sci. 1980 Nov;20(4):204-11. No abstract available.

PMID:
7440661
50.

A computer-based toxicology search system.

McGill JR, Heller SR, Milne GW.

J Environ Pathol Toxicol. 1978 Nov-Dec;2(2):539-51.

PMID:
739231

Supplemental Content

Loading ...
Support Center