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Urinary PGE-M levels and risk of ovarian cancer.

Barnard ME, Beeghly-Fadiel A, Milne GL, Akam EY, Chan AT, Eliaseen AH, Rosner BA, Shu XO, Terry KL, Xiang YB, Zheng W, Tworoger SS.

Cancer Epidemiol Biomarkers Prev. 2019 Aug 6. pii: cebp.0597.2019. doi: 10.1158/1055-9965.EPI-19-0597. [Epub ahead of print]


Associations between socioeconomic status, psychosocial stress, and urinary levels of 8-iso-prostaglandin-F during pregnancy in Puerto Rico.

Eick SM, Meeker JD, Brown P, Swartzendruber A, Rios-McConnell R, Shen Y, Milne GL, Vélez Vega C, Rosario Z, Alshawabkeh A, Cordero JF, Ferguson KK.

Free Radic Biol Med. 2019 Jul 29;143:95-100. doi: 10.1016/j.freeradbiomed.2019.07.032. [Epub ahead of print]


Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents.

Detterich JA, Liu H, Suriany S, Kato RM, Chalacheva P, Tedla B, Shah PM, Khoo MC, Wood JC, Coates TD, Milne GL, Oh JY, Patel RP, Forman HJ.

Free Radic Biol Med. 2019 Sep;141:408-415. doi: 10.1016/j.freeradbiomed.2019.07.004. Epub 2019 Jul 3.


Correction: Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the ω -3 polyunsaturated fatty acid docosahexaenoic acid.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD.

J Biol Chem. 2019 Apr 19;294(16):6657. doi: 10.1074/jbc.AAC119.008639. No abstract available.


Dietary Arginine Regulates Severity of Experimental Colitis and Affects the Colonic Microbiome.

Singh K, Gobert AP, Coburn LA, Barry DP, Allaman M, Asim M, Luis PB, Schneider C, Milne GL, Boone HH, Shilts MH, Washington MK, Das SR, Piazuelo MB, Wilson KT.

Front Cell Infect Microbiol. 2019 Mar 26;9:66. doi: 10.3389/fcimb.2019.00066. eCollection 2019.


Phthalates and Phthalate Alternatives Have Diverse Associations with Oxidative Stress and Inflammation in Pregnant Women.

van T Erve TJ, Rosen EM, Barrett ES, Nguyen RHN, Sathyanarayana S, Milne GL, Calafat AM, Swan SH, Ferguson KK.

Environ Sci Technol. 2019 Mar 19;53(6):3258-3267. doi: 10.1021/acs.est.8b05729. Epub 2019 Mar 11.


Effects of fish oil supplementation on eicosanoid production in patients at higher risk for colorectal cancer.

White MN, Shrubsole MJ, Cai Q, Su T, Hardee J, Coppola JA, Cai SS, Martin SM, Motley S, Swift LL, Milne GL, Zheng W, Dai Q, Murff HJ.

Eur J Cancer Prev. 2019 May;28(3):188-195. doi: 10.1097/CEJ.0000000000000455.


Tea consumption and oxidative stress: a cross-sectional analysis of 889 premenopausal women from the Sister Study.

Zhang D, Ferguson K, Troester M, Bensen JT, Cai J, Milne GL, Sandler DP, Nichols HB.

Br J Nutr. 2018 Dec 20:1-23. doi: 10.1017/S0007114518003732. [Epub ahead of print] No abstract available.


Urinary oxidative stress biomarkers and accelerated time to spontaneous delivery.

Rosen EM, van 't Erve TJ, Boss J, Sathyanarayana S, Barrett ES, Nguyen RHN, Bush NR, Milne GL, McElrath TF, Swan SH, Ferguson KK.

Free Radic Biol Med. 2019 Jan;130:419-425. doi: 10.1016/j.freeradbiomed.2018.11.011. Epub 2018 Nov 14.


N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice.

Karuppagounder SS, Alin L, Chen Y, Brand D, Bourassa MW, Dietrich K, Wilkinson CM, Nadeau CA, Kumar A, Perry S, Pinto JT, Darley-Usmar V, Sanchez S, Milne GL, Pratico D, Holman TR, Carmichael ST, Coppola G, Colbourne F, Ratan RR.

Ann Neurol. 2018 Dec;84(6):854-872. doi: 10.1002/ana.25356. Epub 2018 Nov 29.


Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data.

Shelton EL, Waleh N, Plosa EJ, Benjamin JT, Milne GL, Hooper CW, Ehinger NJ, Poole S, Brown N, Seidner S, McCurnin D, Reese J, Clyman RI.

Pediatr Res. 2018 Sep;84(3):458-465. doi: 10.1038/s41390-018-0006-z. Epub 2018 Jul 6.


Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment".

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 May 11;122(10):e84-e85. doi: 10.1161/CIRCRESAHA.118.312976. No abstract available.


Dietary Glycemic Index and Glycemic Load Are Positively Associated with Oxidative Stress among Premenopausal Women.

Anderson C, Milne GL, Park YM, Sandler DP, Nichols HB.

J Nutr. 2018 Jan 1;148(1):125-130. doi: 10.1093/jn/nxx022.


Postmenopausal breast cancer and oestrogen associations with the IgA-coated and IgA-noncoated faecal microbiota.

Goedert JJ, Hua X, Bielecka A, Okayasu I, Milne GL, Jones GS, Fujiwara M, Sinha R, Wan Y, Xu X, Ravel J, Shi J, Palm NW, Feigelson HS.

Br J Cancer. 2018 Feb 20;118(4):471-479. doi: 10.1038/bjc.2017.435. Epub 2018 Jan 23.


Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.

Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.


Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects.

Elijovich F, Milne GL, Brown NJ, Laniado-Schwartzman M, Laffer CL.

Hypertension. 2018 Feb;71(2):346-355. doi: 10.1161/HYPERTENSIONAHA.117.10392. Epub 2017 Dec 26.


Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women.

Alemán JO, Iyengar NM, Walker JM, Milne GL, Da Rosa JC, Liang Y, Giri DD, Zhou XK, Pollak MN, Hudis CA, Breslow JL, Holt PR, Dannenberg AJ.

J Endocr Soc. 2017 Apr 25;1(6):625-637. doi: 10.1210/js.2017-00020. eCollection 2017 Jun 1.


F2-Isoprostanes Reflect Oxidative Stress Correlated With Lean Mass and Bone Density but Not Insulin Resistance.

Ma E, Ingram KH, Milne GL, Garvey WT.

J Endocr Soc. 2017 Apr 7;1(5):436-448. doi: 10.1210/js.2017-00006. eCollection 2017 May 1. Erratum in: J Endocr Soc. 2018 Feb 07;2(3):240.


Cardiovascular disease risk factors and oxidative stress among premenopausal women.

Anderson C, Milne GL, Park YM, Sandler DP, Nichols HB.

Free Radic Biol Med. 2018 Feb 1;115:246-251. doi: 10.1016/j.freeradbiomed.2017.12.006. Epub 2017 Dec 9.


Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB.

Sci Signal. 2017 Nov 28;10(507). pii: eaan2787. doi: 10.1126/scisignal.aan2787.


Deuterium-reinforced polyunsaturated fatty acids improve cognition in a mouse model of sporadic Alzheimer's disease.

Elharram A, Czegledy NM, Golod M, Milne GL, Pollock E, Bennett BM, Shchepinov MS.

FEBS J. 2017 Dec;284(23):4083-4095. doi: 10.1111/febs.14291. Epub 2017 Oct 27.


Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia.

Berbée JFP, Mol IM, Milne GL, Pollock E, Hoeke G, Lütjohann D, Monaco C, Rensen PCN, van der Ploeg LHT, Shchepinov MS.

Atherosclerosis. 2017 Sep;264:100-107. doi: 10.1016/j.atherosclerosis.2017.06.916. Epub 2017 Jun 21.


Association of gain-of-function EPHX2 polymorphism Lys55Arg with acute kidney injury following cardiac surgery.

Shuey MM, Billings FT 4th, Wei S, Milne GL, Nian H, Yu C, Brown NJ.

PLoS One. 2017 May 26;12(5):e0175292. doi: 10.1371/journal.pone.0175292. eCollection 2017.


Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice.

Crawford DR, Ilic Z, Guest I, Milne GL, Hayes JD, Sell S.

Carcinogenesis. 2017 Jul 1;38(7):717-727. doi: 10.1093/carcin/bgx048.


Oxidative Stress and Breast Cancer Risk in Premenopausal Women.

Nichols HB, Anderson C, White AJ, Milne GL, Sandler DP.

Epidemiology. 2017 Sep;28(5):667-674. doi: 10.1097/EDE.0000000000000685.


Classifying oxidative stress by F2-Isoprostane levels in human disease: The re-imagining of a biomarker.

Milne GL.

Redox Biol. 2017 Aug;12:897-898. doi: 10.1016/j.redox.2017.04.028. Epub 2017 Apr 26. No abstract available.


2,4 DNP improves motor function, preserves medium spiny neuronal identity, and reduces oxidative stress in a mouse model of Huntington's disease.

Wu B, Jiang M, Peng Q, Li G, Hou Z, Milne GL, Mori S, Alonso R, Geisler JG, Duan W.

Exp Neurol. 2017 Jul;293:83-90. doi: 10.1016/j.expneurol.2017.03.020. Epub 2017 Mar 28.


Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer.

Li C, Singh B, Graves-Deal R, Ma H, Starchenko A, Fry WH, Lu Y, Wang Y, Bogatcheva G, Khan MP, Milne GL, Zhao S, Ayers GD, Li N, Hu H, Washington MK, Yeatman TJ, McDonald OG, Liu Q, Coffey RJ.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2852-E2861. doi: 10.1073/pnas.1618297114. Epub 2017 Mar 20.


ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial.

Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP 3rd, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT.

Trials. 2017 Feb 1;18(1):50. doi: 10.1186/s13063-016-1744-z.


Urine Eicosanoids in the Metabolic Abnormalities, Telmisartan, and HIV Infection (MATH) Trial.

Le CN, Hulgan T, Tseng CH, Milne GL, Lake JE.

PLoS One. 2017 Jan 24;12(1):e0170515. doi: 10.1371/journal.pone.0170515. eCollection 2017.


Intraoperative cerebral oxygenation, oxidative injury, and delirium following cardiac surgery.

Lopez MG, Pandharipande P, Morse J, Shotwell MS, Milne GL, Pretorius M, Shaw AD, Roberts LJ 2nd, Billings FT 4th.

Free Radic Biol Med. 2017 Feb;103:192-198. doi: 10.1016/j.freeradbiomed.2016.12.039. Epub 2016 Dec 27.


Docosahexaenoic Acid Supplementation is Not Anti-Inflammatory in Adipose Tissue of Healthy Obese Postmenopausal Women.

Holt PR, Alemán JO, Walker JM, Jiang CS, Liang Y, de Rosa JC, Giri DD, Iyengar NM, Milne GL, Hudis CA, Breslow JL.

Int J Nutr. 2017;1(4):31-49. doi: 10.14302/issn.2379-7835.ijn-17-1636. Epub 2017 Jul 21.


Lipid profiling of polarized human monocyte-derived macrophages.

Montenegro-Burke JR, Sutton JA, Rogers LM, Milne GL, McLean JA, Aronoff DM.

Prostaglandins Other Lipid Mediat. 2016 Dec;127:1-8. doi: 10.1016/j.prostaglandins.2016.11.002. Epub 2016 Nov 15.


Oxidative stress in relation to diet and physical activity among premenopausal women.

Anderson C, Milne GL, Sandler DP, Nichols HB.

Br J Nutr. 2016 Oct;116(8):1416-1424. Epub 2016 Oct 11.


Smoking and red blood cell phospholipid membrane fatty acids.

Murff HJ, Tindle HA, Shrubsole MJ, Cai Q, Smalley W, Milne GL, Swift LL, Ness RM, Zheng W.

Prostaglandins Leukot Essent Fatty Acids. 2016 Sep;112:24-31. doi: 10.1016/j.plefa.2016.08.004. Epub 2016 Aug 16.


Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice.

Woodling NS, Colas D, Wang Q, Minhas P, Panchal M, Liang X, Mhatre SD, Brown H, Ko N, Zagol-Ikapitte I, van der Hart M, Khroyan TV, Chuluun B, Priyam PG, Milne GL, Rassoulpour A, Boutaud O, Manning-Boğ AB, Heller HC, Andreasson KI.

Brain. 2016 Jul;139(Pt 7):2063-81. doi: 10.1093/brain/aww117. Epub 2016 May 13.


Increasing F2-isoprostanes in the first month after birth predicts poor respiratory and neurodevelopmental outcomes in very preterm infants.

Matthews MA, Aschner JL, Stark AR, Moore PE, Slaughter JC, Steele S, Beller A, Milne GL, Settles O, Chorna O, Maitre NL.

J Perinatol. 2016 Sep;36(9):779-83. doi: 10.1038/jp.2016.74. Epub 2016 May 12.


Elevated Levels of Urinary PGE-M Are Found in Tobacco Users and Indicate a Poor Prognosis for Oral Squamous Cell Carcinoma Patients.

Kekatpure VD, Bs N, Wang H, Zhou XK, Kandasamy C, Sunny SP, Suresh A, Milne GL, Kuriakose MA, Dannenberg AJ.

Cancer Prev Res (Phila). 2016 Jun;9(6):428-36. doi: 10.1158/1940-6207.CAPR-15-0412. Epub 2016 Apr 4.


Factors Associated with Multiple Biomarkers of Systemic Inflammation.

Navarro SL, Kantor ED, Song X, Milne GL, Lampe JW, Kratz M, White E.

Cancer Epidemiol Biomarkers Prev. 2016 Mar;25(3):521-31. doi: 10.1158/1055-9965.EPI-15-0956. Epub 2016 Jan 11.


Phase Ib Randomized, Double-Blinded, Placebo-Controlled, Dose Escalation Study of Polyphenon E in Patients with Barrett's Esophagus.

Joe AK, Schnoll-Sussman F, Bresalier RS, Abrams JA, Hibshoosh H, Cheung K, Friedman RA, Yang CS, Milne GL, Liu DD, Lee JJ, Abdul K, Bigg M, Foreman J, Su T, Wang X, Ahmed A, Neugut AI, Akpa E, Lippman SM, Perloff M, Brown PH, Lightdale CJ.

Cancer Prev Res (Phila). 2015 Dec;8(12):1131-7. doi: 10.1158/1940-6207.CAPR-14-0274-T. Epub 2015 Oct 15.


Urinary metabolites of prostanoids and risk of recurrent colorectal adenomas in the Aspirin/Folate Polyp Prevention Study (AFPPS).

Fedirko V, Bradshaw PT, Figueiredo JC, Sandler RS, Barry EL, Ahnen DJ, Milne GL, Bresalier RS, Baron JA.

Cancer Prev Res (Phila). 2015 Nov;8(11):1061-8. doi: 10.1158/1940-6207.CAPR-15-0212. Epub 2015 Aug 24.


Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD.

FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065. Epub 2015 Jul 16.


IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging.

Toth P, Tarantini S, Ashpole NM, Tucsek Z, Milne GL, Valcarcel-Ares NM, Menyhart A, Farkas E, Sonntag WE, Csiszar A, Ungvari Z.

Aging Cell. 2015 Dec;14(6):1034-44. doi: 10.1111/acel.12372. Epub 2015 Jul 14.


Timing of solid food introduction is associated with urinary F2-isoprostane concentrations in childhood.

Frederiksen BN, Seifert J, Kroehl M, Lamb MM, Milne GL, Rewers M, Norris JM.

Pediatr Res. 2015 Oct;78(4):451-6. doi: 10.1038/pr.2015.116. Epub 2015 Jun 17.


TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.

Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD.

Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340.


Randomized phase 2 trial of erlotinib in combination with high-dose celecoxib or placebo in patients with advanced non-small cell lung cancer.

Reckamp KL, Koczywas M, Cristea MC, Dowell JE, Wang HJ, Gardner BK, Milne GL, Figlin RA, Fishbein MC, Elashoff RM, Dubinett SM.

Cancer. 2015 Sep 15;121(18):3298-306. doi: 10.1002/cncr.29480. Epub 2015 May 29.


Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.

Wu JH, Marchioli R, Silletta MG, Masson S, Sellke FW, Libby P, Milne GL, Brown NJ, Lombardi F, Damiano RJ Jr, Marsala J, Rinaldi M, Domenech A, Simon C, Tavazzi L, Mozaffarian D.

J Am Heart Assoc. 2015 May 20;4(5). pii: e001886. doi: 10.1161/JAHA.115.001886.


Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans.

Navarro SL, White E, Kantor ED, Zhang Y, Rho J, Song X, Milne GL, Lampe PD, Lampe JW.

PLoS One. 2015 Feb 26;10(2):e0117534. doi: 10.1371/journal.pone.0117534. eCollection 2015.


Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress.

Andreyev AY, Tsui HS, Milne GL, Shmanai VV, Bekish AV, Fomich MA, Pham MN, Nong Y, Murphy AN, Clarke CF, Shchepinov MS.

Free Radic Biol Med. 2015 May;82:63-72. doi: 10.1016/j.freeradbiomed.2014.12.023. Epub 2015 Jan 8.


The isoprostanes--25 years later.

Milne GL, Dai Q, Roberts LJ 2nd.

Biochim Biophys Acta. 2015 Apr;1851(4):433-45. doi: 10.1016/j.bbalip.2014.10.007. Epub 2014 Oct 30. Review.

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