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Items: 1 to 50 of 259

1.

Anti-inflammatory Trained Immunity Mediated by Helminth Products Attenuates the Induction of T Cell-Mediated Autoimmune Disease.

Quinn SM, Cunningham K, Raverdeau M, Walsh RJ, Curham L, Malara A, Mills KHG.

Front Immunol. 2019 May 21;10:1109. doi: 10.3389/fimmu.2019.01109. eCollection 2019.

2.

A Pertussis Outer Membrane Vesicle-Based Vaccine Induces Lung-Resident Memory CD4 T Cells and Protection Against Bordetella pertussis, Including Pertactin Deficient Strains.

Zurita ME, Wilk MM, Carriquiriborde F, Bartel E, Moreno G, Misiak A, Mills KHG, Hozbor D.

Front Cell Infect Microbiol. 2019 Apr 26;9:125. doi: 10.3389/fcimb.2019.00125. eCollection 2019.

3.

Helminths products directly modulate T cells that mediate experimental autoimmune encephalomyelitis.

Quinn SM, Raverdeau M, McGinley AM, Mills KHG.

Eur J Immunol. 2019 Apr 23. doi: 10.1002/eji.201948147. [Epub ahead of print]

PMID:
31016721
4.

Retinoic acid-induced autoantigen-specific type 1 regulatory T cells suppress autoimmunity.

Raverdeau M, Christofi M, Malara A, Wilk MM, Misiak A, Kuffova L, Yu T, McGinley AM, Quinn SM, Massilamany C, Reddy J, Forrester JV, Mills KH.

EMBO Rep. 2019 May;20(5). pii: e47121. doi: 10.15252/embr.201847121. Epub 2019 Mar 20.

PMID:
30894405
5.

Immunization with whole cell but not acellular pertussis vaccines primes CD4 TRM cells that sustain protective immunity against nasal colonization with Bordetella pertussis.

Wilk MM, Borkner L, Misiak A, Curham L, Allen AC, Mills KHG.

Emerg Microbes Infect. 2019;8(1):169-185. doi: 10.1080/22221751.2018.1564630.

6.

The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation.

Burbank AJ, Vadlamudi A, Mills KH, Alt EM, Wells H, Zhou H, Alexis N, Hernandez ML, Peden DB.

J Allergy Clin Immunol. 2019 Jun;143(6):2299-2302.e3. doi: 10.1016/j.jaci.2019.02.006. Epub 2019 Feb 18. No abstract available.

PMID:
30790595
7.

Caspase-11 regulates the tumour suppressor function of STAT1 in a murine model of colitis-associated carcinogenesis.

Flood B, Manils J, Nulty C, Flis E, Kenealy S, Barber G, Fay J, Mills KHG, Kay EW, Creagh EM.

Oncogene. 2019 Apr;38(14):2658-2674. doi: 10.1038/s41388-018-0613-5. Epub 2018 Dec 11.

8.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses.

Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L.

Nat Immunol. 2018 Dec;19(12):1330-1340. doi: 10.1038/s41590-018-0251-7. Epub 2018 Nov 12.

PMID:
30420624
9.

CD4 TRM Cells Following Infection and Immunization: Implications for More Effective Vaccine Design.

Wilk MM, Mills KHG.

Front Immunol. 2018 Aug 10;9:1860. doi: 10.3389/fimmu.2018.01860. eCollection 2018. Review.

10.

Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting TRM cells.

Allen AC, Wilk MM, Misiak A, Borkner L, Murphy D, Mills KHG.

Mucosal Immunol. 2018 Nov;11(6):1763-1776. doi: 10.1038/s41385-018-0080-x. Epub 2018 Aug 20.

PMID:
30127384
11.

IL-17-dependent SIgA-mediated protection against nasal Bordetella pertussis infection by live attenuated BPZE1 vaccine.

Solans L, Debrie AS, Borkner L, Aguiló N, Thiriard A, Coutte L, Uranga S, Trottein F, Martín C, Mills KHG, Locht C.

Mucosal Immunol. 2018 Nov;11(6):1753-1762. doi: 10.1038/s41385-018-0073-9. Epub 2018 Aug 16.

PMID:
30115992
12.

Azithromycin Clears Bordetella pertussis Infection in Mice but Also Modulates Innate and Adaptive Immune Responses and T Cell Memory.

Borkner L, Misiak A, Wilk MM, Mills KHG.

Front Immunol. 2018 Jul 30;9:1764. doi: 10.3389/fimmu.2018.01764. eCollection 2018.

13.

Th17 cells, γδ T cells and their interplay in EAE and multiple sclerosis.

McGinley AM, Edwards SC, Raverdeau M, Mills KHG.

J Autoimmun. 2018 Jan 21. pii: S0896-8411(18)30007-6. doi: 10.1016/j.jaut.2018.01.001. [Epub ahead of print] Review.

PMID:
29395738
14.

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization.

Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P.

Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.

15.

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

Sutton CE, Finlay CM, Raverdeau M, Early JO, DeCourcey J, Zaslona Z, O'Neill LAJ, Mills KHG, Curtis AM.

Nat Commun. 2017 Dec 12;8(1):1923. doi: 10.1038/s41467-017-02111-0.

16.

Pyruvate Kinase M2 Is Required for the Expression of the Immune Checkpoint PD-L1 in Immune Cells and Tumors.

Palsson-McDermott EM, Dyck L, Zasłona Z, Menon D, McGettrick AF, Mills KHG, O'Neill LA.

Front Immunol. 2017 Oct 13;8:1300. doi: 10.3389/fimmu.2017.01300. eCollection 2017.

17.

Addition of a TLR7 agonist to an acellular pertussis vaccine enhances Th1 and Th17 responses and protective immunity in a mouse model.

Misiak A, Leuzzi R, Allen AC, Galletti B, Baudner BC, D'Oro U, O'Hagan DT, Pizza M, Seubert A, Mills KHG.

Vaccine. 2017 Sep 18;35(39):5256-5263. doi: 10.1016/j.vaccine.2017.08.009. Epub 2017 Aug 18.

18.

Secreted products of Fasciola hepatica inhibit the induction of T cell responses that mediate allergy.

Finlay CM, Stefanska AM, Coleman MM, Jahns H, Cassidy JP, McLoughlin RM, Mills KHG.

Parasite Immunol. 2017 Oct;39(10). doi: 10.1111/pim.12460. Epub 2017 Sep 6.

19.

A guiding map for inflammation.

Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA.

Nat Immunol. 2017 Jul 19;18(8):826-831. doi: 10.1038/ni.3790.

20.

FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation.

McManus RM, Finucane OM, Wilk MM, Mills KHG, Lynch MA.

J Neuroimmune Pharmacol. 2017 Dec;12(4):670-681. doi: 10.1007/s11481-017-9753-6. Epub 2017 Jun 15.

PMID:
28620801
21.

Lung CD4 Tissue-Resident Memory T Cells Mediate Adaptive Immunity Induced by Previous Infection of Mice with Bordetella pertussis.

Wilk MM, Misiak A, McManus RM, Allen AC, Lynch MA, Mills KHG.

J Immunol. 2017 Jul 1;199(1):233-243. doi: 10.4049/jimmunol.1602051. Epub 2017 May 22.

22.

Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis.

Nascimento IP, Rodriguez D, Santos CC, Amaral EP, Rofatto HK, Junqueira-Kipnis AP, Gonçalves EDC, D'Império-Lima MR, Hirata MH, Silva CL, Winter N, Gicquel B, Mills KHG, Pizza M, Rappuoli R, Leite LCC.

Sci Rep. 2017 May 18;7(1):2109. doi: 10.1038/s41598-017-02003-9.

23.

Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases.

Gu XX, Plotkin SA, Edwards KM, Sette A, Mills KHG, Levy O, Sant AJ, Mo A, Alexander W, Lu KT, Taylor CE.

Clin Vaccine Immunol. 2017 Jul 5;24(7). pii: e00034-17. doi: 10.1128/CVI.00034-17. Print 2017 Jul.

24.

Temporal structure/function variation in cultured differentiated human nasal epithelium associated with acute single exposure to tobacco smoke or E-cigarette vapor.

Carson JL, Zhou L, Brighton L, Mills KH, Zhou H, Jaspers I, Hazucha M.

Inhal Toxicol. 2017 Feb;29(3):137-144. doi: 10.1080/08958378.2017.1318985.

25.

Immune checkpoints and their inhibition in cancer and infectious diseases.

Dyck L, Mills KHG.

Eur J Immunol. 2017 May;47(5):765-779. doi: 10.1002/eji.201646875. Epub 2017 Apr 24. Review.

26.

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis.

Varghese S, Cotter M, Chevot F, Fergus C, Cunningham C, Mills KH, Connon SJ, Southern JM, Kelly VP.

Nucleic Acids Res. 2017 Feb 28;45(4):2029-2039. doi: 10.1093/nar/gkw847.

27.

IL-17-Producing Innate and Pathogen-Specific Tissue Resident Memory γδ T Cells Expand in the Lungs of Bordetella pertussis-Infected Mice.

Misiak A, Wilk MM, Raverdeau M, Mills KH.

J Immunol. 2017 Jan 1;198(1):363-374. Epub 2016 Nov 18.

28.

Pertussis: Biology, epidemiology and prevention.

Saadatian-Elahi M, Plotkin S, Mills KHG, Halperin SA, McIntyre PB, Picot V, Louis J, Johnson DR.

Vaccine. 2016 Nov 21;34(48):5819-5826. doi: 10.1016/j.vaccine.2016.10.029. Epub 2016 Oct 22.

PMID:
27780629
29.

What rheumatologists need to know about innate lymphocytes.

Exley MA, Tsokos GC, Mills KH, Elewaut D, Mulhearn B.

Nat Rev Rheumatol. 2016 Nov;12(11):658-668. doi: 10.1038/nrrheum.2016.140. Epub 2016 Sep 2. Review.

PMID:
27586381
30.

Anti-PD-1 inhibits Foxp3+ Treg cell conversion and unleashes intratumoural effector T cells thereby enhancing the efficacy of a cancer vaccine in a mouse model.

Dyck L, Wilk MM, Raverdeau M, Misiak A, Boon L, Mills KH.

Cancer Immunol Immunother. 2016 Dec;65(12):1491-1498. Epub 2016 Sep 28.

PMID:
27680570
31.

A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation.

Duran CG, Burbank AJ, Mills KH, Duckworth HR, Aleman MM, Kesic MJ, Peden DB, Pan Y, Zhou H, Hernandez ML.

Respir Res. 2016 Jul 22;17(1):89. doi: 10.1186/s12931-016-0406-8.

32.

Loss of autophagy enhances MIF/macrophage migration inhibitory factor release by macrophages.

Lee JP, Foote A, Fan H, Peral de Castro C, Lang T, Jones SA, Gavrilescu N, Mills KH, Leech M, Morand EF, Harris J.

Autophagy. 2016 Jun 2;12(6):907-16. doi: 10.1080/15548627.2016.1164358. Epub 2016 May 10.

33.

Trained immunity: A program of innate immune memory in health and disease.

Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ.

Science. 2016 Apr 22;352(6284):aaf1098. doi: 10.1126/science.aaf1098. Epub 2016 Apr 21. Review.

34.

Retinoic acid suppresses IL-17 production and pathogenic activity of γδ T cells in CNS autoimmunity.

Raverdeau M, Breen CJ, Misiak A, Mills KH.

Immunol Cell Biol. 2016 Sep;94(8):763-73. doi: 10.1038/icb.2016.39. Epub 2016 May 10.

PMID:
27089940
35.

Interleukin-22 regulates antimicrobial peptide expression and keratinocyte differentiation to control Staphylococcus aureus colonization of the nasal mucosa.

Mulcahy ME, Leech JM, Renauld JC, Mills KH, McLoughlin RM.

Mucosal Immunol. 2016 Nov;9(6):1429-1441. doi: 10.1038/mi.2016.24. Epub 2016 Mar 23.

PMID:
27007677
36.

The cells that mediate innate immune memory and their functional significance in inflammatory and infectious diseases.

Gardiner CM, Mills KH.

Semin Immunol. 2016 Aug;28(4):343-50. doi: 10.1016/j.smim.2016.03.001. Epub 2016 Mar 12. Review.

PMID:
26979658
37.

Helminth Products Protect against Autoimmunity via Innate Type 2 Cytokines IL-5 and IL-33, Which Promote Eosinophilia.

Finlay CM, Stefanska AM, Walsh KP, Kelly PJ, Boon L, Lavelle EC, Walsh PT, Mills KH.

J Immunol. 2016 Jan 15;196(2):703-14. doi: 10.4049/jimmunol.1501820. Epub 2015 Dec 16.

38.

γδ T Cells and NK Cells - Distinct Pathogenic Roles as Innate-Like Immune Cells in CNS Autoimmunity.

Edwards SC, McGinley AM, McGuinness NC, Mills KH.

Front Immunol. 2015 Sep 8;6:455. doi: 10.3389/fimmu.2015.00455. eCollection 2015. Review. No abstract available.

39.

Roads to the development of improved pertussis vaccines paved by immunology.

Brummelman J, Wilk MM, Han WG, van Els CA, Mills KH.

Pathog Dis. 2015 Nov;73(8):ftv067. doi: 10.1093/femspd/ftv067. Epub 2015 Sep 6. Review.

40.

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction.

Edwards SC, Higgins SC, Mills KHG.

Brain Behav Immun. 2015 Nov;50:41-46. doi: 10.1016/j.bbi.2015.06.009. Epub 2015 Jun 19.

PMID:
26100487
41.

Innate immune memory: a paradigm shift in understanding host defense.

Netea MG, Latz E, Mills KH, O'Neill LA.

Nat Immunol. 2015 Jul;16(7):675-9. doi: 10.1038/ni.3178. No abstract available.

PMID:
26086132
42.

Polyfunctional, Pathogenic CD161+ Th17 Lineage Cells Are Resistant to Regulatory T Cell-Mediated Suppression in the Context of Autoimmunity.

Basdeo SA, Moran B, Cluxton D, Canavan M, McCormick J, Connolly M, Orr C, Mills KH, Veale DJ, Fearon U, Fletcher JM.

J Immunol. 2015 Jul 15;195(2):528-40. doi: 10.4049/jimmunol.1402990. Epub 2015 Jun 10.

43.

The IL-1 axis is associated with airway inflammation after O3 exposure in allergic asthmatic patients.

Aleman MM, Kesic MJ, Mills KH, Peden DB, Hernandez ML.

J Allergy Clin Immunol. 2015 Oct;136(4):1099-101.e2. doi: 10.1016/j.jaci.2015.03.035. Epub 2015 May 8. No abstract available.

44.

T Cells-Protective or Pathogenic in Alzheimer's Disease?

McManus RM, Mills KH, Lynch MA.

J Neuroimmune Pharmacol. 2015 Dec;10(4):547-60. doi: 10.1007/s11481-015-9612-2. Epub 2015 May 10. Review.

PMID:
25957956
45.

Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer: Diagnostic and therapeutic potential.

Flood B, Oficjalska K, Laukens D, Fay J, O'Grady A, Caiazza F, Heetun Z, Mills KH, Sheahan K, Ryan EJ, Doherty GA, Kay E, Creagh EM.

Clin Exp Immunol. 2015 Jul;181(1):39-50. doi: 10.1111/cei.12617. Epub 2015 May 6.

46.

Correction: Staphylococcus aureus Infection of mice expands a population of memory γδ T cells that are protective against subsequent infection.

Murphy AG, O'Keeffe KM, Lalor SJ, Maher BM, Mills KH, McLoughlin RM.

J Immunol. 2015 May 1;194(9):4588. doi: 10.4049/jimmunol.1500594. No abstract available.

47.

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.

Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.

48.

Protective role for caspase-11 during acute experimental murine colitis.

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM.

J Immunol. 2015 Feb 1;194(3):1252-60. doi: 10.4049/jimmunol.1400501. Epub 2014 Dec 29.

49.

A critical role for the TLR signaling adapter Mal in alveolar macrophage-mediated protection against Bordetella pertussis.

Bernard NJ, Finlay CM, Tannahill GM, Cassidy JP, O'Neill LA, Mills KH.

Mucosal Immunol. 2015 Sep;8(5):982-92. doi: 10.1038/mi.2014.125. Epub 2014 Dec 17.

PMID:
25515629
50.

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.

Dunne A, Mielke LA, Allen AC, Sutton CE, Higgs R, Cunningham CC, Higgins SC, Mills KH.

Mucosal Immunol. 2015 May;8(3):607-17. doi: 10.1038/mi.2014.93. Epub 2014 Oct 15.

PMID:
25315966

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