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Cystatin 9 and C modulates serum biomarkers associated with inflammation and provides prophylactic as well as long-term protection against multi-drug resistant Klebsiella pneumoniae.

Holloway AJ, Yu J, Arulanandam BP, Milligan GN, Eaves-Pyles TD.

Antimicrob Agents Chemother. 2019 Feb 19. pii: AAC.02519-18. doi: 10.1128/AAC.02519-18. [Epub ahead of print]


On-target and off-target effects of novel orthosteric and allosteric activators of GPR84.

Mancini SJ, Mahmud ZA, Jenkins L, Bolognini D, Newman R, Barnes M, Edye ME, McMahon SB, Tobin AB, Milligan G.

Sci Rep. 2019 Feb 12;9(1):1861. doi: 10.1038/s41598-019-38539-1.


Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.

Mackenzie AE, Quon T, Lin LC, Hauser AS, Jenkins L, Inoue A, Tobin AB, Gloriam DE, Hudson BD, Milligan G.

FASEB J. 2019 Jan 2:fj201801956R. doi: 10.1096/fj.201801956R. [Epub ahead of print]


Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors.

Müskens FM, Ward RJ, Herkt D, van de Langemheen H, Tobin AB, Liskamp RMJ, Milligan G.

Mol Pharmacol. 2019 Feb;95(2):196-209. doi: 10.1124/mol.118.114249. Epub 2018 Dec 4.


Increased Frequency of Virus Shedding by Herpes Simplex Virus 2-Infected Guinea Pigs in the Absence of CD4+ T Lymphocytes.

Bourne N, Perry CL, Banasik BN, Miller AL, White M, Pyles RB, Schäfer H, Milligan GN.

J Virol. 2019 Feb 5;93(4). pii: e01721-18. doi: 10.1128/JVI.01721-18. Print 2019 Feb 15.


GPCR homo-oligomerization.

Milligan G, Ward RJ, Marsango S.

Curr Opin Cell Biol. 2018 Nov 16;57:40-47. doi: 10.1016/ [Epub ahead of print] Review.


Defining a correlate of protection for chikungunya virus vaccines.

Milligan GN, Schnierle BS, McAuley AJ, Beasley DWC.

Vaccine. 2018 Nov 15. pii: S0264-410X(18)31399-9. doi: 10.1016/j.vaccine.2018.10.033. [Epub ahead of print]


Development of disease and immunity at the genital epithelium following intrarectal inoculation of male guinea pigs with herpes simplex virus type 2.

Bourne N, Banasik BN, Perry CL, Miller AL, White M, Pyles RB, Milligan GN.

Virology. 2019 Jan 2;526:180-188. doi: 10.1016/j.virol.2018.10.023. Epub 2018 Nov 6.


Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition.

Drew JE, Reichardt N, Williams LM, Mayer CD, Walker AW, Farquharson AJ, Kastora S, Farquharson F, Milligan G, Morrison DJ, Preston T, Flint HJ, Louis P.

Sci Rep. 2018 Oct 22;8(1):15566. doi: 10.1038/s41598-018-34081-8.


Effect of sleeve gastrectomy on hypertension.

Samson R, Milligan G, Lewine E, Sindi F, Garagliano J, Fernandez C, Moore R, DuCoin C, Oparil S, LE Jemtel TH.

J Am Soc Hypertens. 2018 Nov;12(11):e19-e25. doi: 10.1016/j.jash.2018.09.007. Epub 2018 Sep 19.


Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties.

Hansen AH, Sergeev E, Bolognini D, Sprenger RR, Ekberg JH, Ejsing CS, McKenzie CJ, Rexen Ulven E, Milligan G, Ulven T.

J Med Chem. 2018 Nov 8;61(21):9534-9550. doi: 10.1021/acs.jmedchem.8b00855. Epub 2018 Oct 12.


Physiologic assessment of moderate coronary lesions: a step towards complete revascularization in coronary artery bypass grafting.

Moscona JC, Stencel JD, Milligan G, Salmon C, Maini R, Katigbak P, Saleh Q, Nelson R, Srivastav S, Mogabgab O, Samson R, Le Jemtel T.

Ann Transl Med. 2018 Aug;6(15):300. doi: 10.21037/atm.2018.06.31.


Visceral Adipose Tissue Accumulation and Residual Cardiovascular Risk.

Le Jemtel TH, Samson R, Milligan G, Jaiswal A, Oparil S.

Curr Hypertens Rep. 2018 Jul 10;20(9):77. doi: 10.1007/s11906-018-0880-0. Review.


Skin Involvement in Psoriatic Arthritis Worsens Overall Disease Activity, Patient-Reported Outcomes, and Increases Healthcare Resource Utilization: An Observational, Cross-Sectional Study.

de Vlam K, Merola JF, Birt JA, Sandoval DM, Lobosco S, Moon R, Milligan G, Boehncke WH.

Rheumatol Ther. 2018 Dec;5(2):423-436. doi: 10.1007/s40744-018-0120-8. Epub 2018 Jul 6.


Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.

Binti Mohd Amir NAS, Mackenzie AE, Jenkins L, Boustani K, Hillier MC, Tsuchiya T, Milligan G, Pease JE.

J Immunol. 2018 Jul 15;201(2):714-724. doi: 10.4049/jimmunol.1700884. Epub 2018 Jun 6.


The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice.

Divorty N, Milligan G, Graham D, Nicklin SA.

Am J Hypertens. 2018 Aug 3;31(9):1049-1058. doi: 10.1093/ajh/hpy073.


Spectrum of activity testing for therapeutics against all four dengue virus serotypes in AG129 mouse models: Proof-of-concept studies with the adenosine nucleoside inhibitor NITD-008.

Milligan GN, White M, Zavala D, Pyles RB, Sarathy VV, Barrett ADT, Bourne N.

Antiviral Res. 2018 Jun;154:104-109. doi: 10.1016/j.antiviral.2018.04.012. Epub 2018 Apr 14.


Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development.

Reece LM, Beasley DW, Milligan GN, Sarathy VV, Barrett AD.

Curr Opin Virol. 2018 Apr;29:72-78. doi: 10.1016/j.coviro.2018.03.005. Epub 2018 Apr 9. Review.


Transcriptional Analysis of the Guinea Pig Mucosal Immune Response to Intravaginal Infection with Herpes Simplex Virus Type 2.

Veselenak RL, Milligan GN, Miller AL, Pyles RB, Bourne N.

Virology. 2018 May;518:349-357. doi: 10.1016/j.virol.2018.03.019. Epub 2018 Mar 28.


Baseline mapping of Lassa fever virology, epidemiology and vaccine research and development.

Hallam HJ, Hallam S, Rodriguez SE, Barrett ADT, Beasley DWC, Chua A, Ksiazek TG, Milligan GN, Sathiyamoorthy V, Reece LM.

NPJ Vaccines. 2018 Mar 20;3:11. doi: 10.1038/s41541-018-0049-5. eCollection 2018. Review.


Characterization of a murine model of non-lethal, symptomatic dengue virus infection.

Sarathy VV, White M, Li L, Kaiser JA, Campbell GA, Milligan GN, Bourne N, Barrett ADT.

Sci Rep. 2018 Mar 20;8(1):4900. doi: 10.1038/s41598-018-22618-w.


Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways.

Milligan G, Inoue A.

Trends Pharmacol Sci. 2018 May;39(5):481-493. doi: 10.1016/ Epub 2018 Mar 13. Review.


Coronary sinus thrombosis: Echocardiographic visualization in a patient with known risk factors.

Milligan G, Moscona JC.

J Clin Ultrasound. 2018 Oct;46(8):555-557. doi: 10.1002/jcu.22578. Epub 2018 Feb 12.


Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84.

Mahmud ZA, Jenkins L, Ulven T, Labéguère F, Gosmini R, De Vos S, Hudson BD, Tikhonova IG, Milligan G.

Sci Rep. 2017 Dec 20;7(1):17953. doi: 10.1038/s41598-017-18159-3.


Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States.

Viskaitis P, Irvine EE, Smith MA, Choudhury AI, Alvarez-Curto E, Glegola JA, Hardy DG, Pedroni SMA, Paiva Pessoa MR, Fernando ABP, Katsouri L, Sardini A, Ungless MA, Milligan G, Withers DJ.

Cell Rep. 2017 Dec 19;21(12):3559-3572. doi: 10.1016/j.celrep.2017.11.089.


A combined carrier-adjuvant system of peptide nanofibers and toll-like receptor agonists potentiates robust CD8+ T cell responses.

Rudra JS, Banasik BN, Milligan GN.

Vaccine. 2018 Jan 25;36(4):438-441. doi: 10.1016/j.vaccine.2017.12.017. Epub 2017 Dec 14.


Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production.

Reichardt N, Vollmer M, Holtrop G, Farquharson FM, Wefers D, Bunzel M, Duncan SH, Drew JE, Williams LM, Milligan G, Preston T, Morrison D, Flint HJ, Louis P.

ISME J. 2018 Feb;12(2):610-622. doi: 10.1038/ismej.2017.196. Epub 2017 Dec 1.


Change to ecosystem properties through changing the dominant species: Impact of Pteridium aquilinum-control and heathland restoration treatments on selected soil properties.

Milligan G, Booth KE, Cox ES, Pakeman RJ, Le Duc MG, Connor L, Blackbird S, Marrs RH.

J Environ Manage. 2018 Feb 1;207:1-9. doi: 10.1016/j.jenvman.2017.11.013. Epub 2017 Nov 14.


Muscarinic receptor oligomerization.

Marsango S, Ward RJ, Alvarez-Curto E, Milligan G.

Neuropharmacology. 2018 Jul 1;136(Pt C):401-410. doi: 10.1016/j.neuropharm.2017.11.023. Epub 2017 Nov 14. Review.


Evaluation of a Postdischarge Call System Using the Logic Model.

Frye TC, Poe TL, Wilson ML, Milligan G.

Comput Inform Nurs. 2018 Feb;36(2):106-112. doi: 10.1097/CIN.0000000000000397.


A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.

Sergeev E, Hansen AH, Bolognini D, Kawakami K, Kishi T, Aoki J, Ulven T, Inoue A, Hudson BD, Milligan G.

Sci Rep. 2017 Oct 23;7(1):13741. doi: 10.1038/s41598-017-14096-3.


Evaluation of immunological markers of ovine vaginal irritation: Implications for preclinical assessment of non-vaccine HIV preventive agents.

Milligan GN, Vargas G, Vincent KL, Zhu Y, Bourne N, Motamedi M.

J Reprod Immunol. 2017 Nov;124:38-43. doi: 10.1016/j.jri.2017.09.014. Epub 2017 Oct 13.


Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation.

Pediani JD, Ward RJ, Marsango S, Milligan G.

Trends Pharmacol Sci. 2018 Feb;39(2):175-186. doi: 10.1016/ Epub 2017 Oct 9. Review.


A Real-World Analysis of Migraine: A Cross-Sectional Study of Disease Burden and Treatment Patterns.

Ford JH, Jackson J, Milligan G, Cotton S, Ahl J, Aurora SK.

Headache. 2017 Nov;57(10):1532-1544. doi: 10.1111/head.13202. Epub 2017 Oct 6.


A lethal model of disseminated dengue virus type 1 infection in AG129 mice.

Milligan GN, Sarathy VV, White MM, Greenberg MB, Campbell GA, Pyles RB, Barrett ADT, Bourne N.

J Gen Virol. 2017 Oct;98(10):2507-2519. doi: 10.1099/jgv.0.000923. Epub 2017 Sep 27.


G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35.

Milligan G.

Br J Pharmacol. 2018 Jul;175(13):2543-2553. doi: 10.1111/bph.14042. Epub 2017 Nov 2. Review.


FFA4/GPR120: Pharmacology and Therapeutic Opportunities.

Milligan G, Alvarez-Curto E, Hudson BD, Prihandoko R, Tobin AB.

Trends Pharmacol Sci. 2017 Sep;38(9):809-821. doi: 10.1016/ Epub 2017 Jul 19. Review.


Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43).

Hansen AH, Sergeev E, Pandey SK, Hudson BD, Christiansen E, Milligan G, Ulven T.

J Med Chem. 2017 Jul 13;60(13):5638-5645. doi: 10.1021/acs.jmedchem.7b00338. Epub 2017 Jun 16.


A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.

Marsango S, Caltabiano G, Jiménez-Rosés M, Millan MJ, Pediani JD, Ward RJ, Milligan G.

Sci Rep. 2017 May 18;7(1):2134. doi: 10.1038/s41598-017-02249-3.


Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84.

Kaspersen MH, Jenkins L, Dunlop J, Milligan G, Ulven T.

Medchemcomm. 2017 May 12;8(6):1360-1365. doi: 10.1039/c7md00130d. eCollection 2017 Jun 1.


Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors.

Prokop S, Perry NA, Vishnivetskiy SA, Toth AD, Inoue A, Milligan G, Iverson TM, Hunyady L, Gurevich VV.

Cell Signal. 2017 Aug;36:98-107. doi: 10.1016/j.cellsig.2017.04.021. Epub 2017 Apr 28.


Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.

Ward RJ, Pediani JD, Harikumar KG, Miller LJ, Milligan G.

Biochem J. 2017 May 24;474(11):1879-1895. doi: 10.1042/BCJ20170184.


M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes.

Lopez-Gimenez JF, Alvarez-Curto E, Milligan G.

Cell Signal. 2017 Jul;35:208-222. doi: 10.1016/j.cellsig.2017.04.006. Epub 2017 Apr 11.


Probe-Dependent Negative Allosteric Modulators of the Long-Chain Free Fatty Acid Receptor FFA4.

Watterson KR, Hansen SVF, Hudson BD, Alvarez-Curto E, Raihan SZ, Azevedo CMG, Martin G, Dunlop J, Yarwood SJ, Ulven T, Milligan G.

Mol Pharmacol. 2017 Jun;91(6):630-641. doi: 10.1124/mol.116.107821. Epub 2017 Apr 6.


The physiological demand of pulling a rescue sled across the mud and the impact experience has on this task.

Milligan GS, House JR, Tipton MJ.

Work. 2017;56(2):239-245. doi: 10.3233/WOR-172487.


Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance.

Houthuijzen JM, Oosterom I, Hudson BD, Hirasawa A, Daenen LGM, McLean CM, Hansen SVF, van Jaarsveld MTM, Peeper DS, Jafari Sadatmand S, Roodhart JML, van de Lest CHA, Ulven T, Ishihara K, Milligan G, Voest EE.

FASEB J. 2017 May;31(5):2195-2209. doi: 10.1096/fj.201601248R. Epub 2017 Feb 9.


Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.

Alvarez-Curto E, Inoue A, Jenkins L, Raihan SZ, Prihandoko R, Tobin AB, Milligan G.

J Biol Chem. 2016 Dec 30;291(53):27147-27159. doi: 10.1074/jbc.M116.754887. Epub 2016 Nov 16.


Trends in medication use in patients with type 2 diabetes mellitus: a long-term view of real-world treatment between 2000 and 2015.

Higgins V, Piercy J, Roughley A, Milligan G, Leith A, Siddall J, Benford M.

Diabetes Metab Syndr Obes. 2016 Nov 1;9:371-380. eCollection 2016.


Ligands at the Free Fatty Acid Receptors 2/3 (GPR43/GPR41).

Milligan G, Bolognini D, Sergeev E.

Handb Exp Pharmacol. 2017;236:17-32. doi: 10.1007/164_2016_49. Review.


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