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Items: 1 to 50 of 289

1.

A Semi-Automated Tuberculosis Testing Workflow Reduces Manual Hazardous Sample Handling and Hands-On Time: A Proof-of-Concept Study.

Miller KWP, Grossman N, Haviernik P, Wolff J, Fu CL, Bare B, Sindelar E.

SLAS Technol. 2019 Nov 1:2472630319884519. doi: 10.1177/2472630319884519. [Epub ahead of print]

PMID:
31674264
2.

Binding site location on GABAA receptors determines whether mixtures of intravenous general anaesthetics interact synergistically or additively in vivo.

Kent DE, Savechenkov PY, Bruzik KS, Miller KW.

Br J Pharmacol. 2019 Aug 27. doi: 10.1111/bph.14843. [Epub ahead of print]

PMID:
31454409
3.

Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the α1β3γ2 GABAAR Transmembrane Domain.

Jayakar SS, Zhou X, Chiara DC, Jarava-Barrera C, Savechenkov PY, Bruzik KS, Tortosa M, Miller KW, Cohen JB.

Mol Pharmacol. 2019 Jun;95(6):615-628. doi: 10.1124/mol.118.114975. Epub 2019 Apr 5.

PMID:
30952799
4.

Automation of the standard DNA differential extraction on the Hamilton AutoLys STAR system: A proof-of-concept study.

Timken MD, Klein SB, Kubala S, Scharnhorst G, Buoncristiani MR, Miller KWP.

Forensic Sci Int Genet. 2019 May;40:96-104. doi: 10.1016/j.fsigen.2019.02.011. Epub 2019 Feb 13.

PMID:
30785062
5.

Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Feb;566(7744):E8. doi: 10.1038/s41586-019-0929-5.

PMID:
30733619
6.

GABAA receptor signalling mechanisms revealed by structural pharmacology.

Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):454-459. doi: 10.1038/s41586-018-0832-5. Epub 2019 Jan 2. Erratum in: Nature. 2019 Feb 7;:.

7.

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer.

Laverty D, Desai R, Uchański T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR.

Nature. 2019 Jan;565(7740):516-520. doi: 10.1038/s41586-018-0833-4. Epub 2019 Jan 2.

8.

Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.

Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS.

Eur J Med Chem. 2019 Jan 15;162:810-824. doi: 10.1016/j.ejmech.2018.11.019. Epub 2018 Nov 19.

PMID:
30544077
9.

A Novel, Automated Dispersive Pipette Extraction Technology Greatly Simplifies Catecholamine Sample Preparation for Downstream LC-MS/MS Analysis.

Mastrianni KR, Kemnitzer WE, Miller KWP.

SLAS Technol. 2019 Feb;24(1):117-123. doi: 10.1177/2472630318792659. Epub 2018 Aug 15.

PMID:
30111228
10.

Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect.

McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE.

Anesthesiology. 2018 Nov;129(5):959-969. doi: 10.1097/ALN.0000000000002356.

11.

Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors.

Woll KA, Zhou X, Bhanu NV, Garcia BA, Covarrubias M, Miller KW, Eckenhoff RG.

FASEB J. 2018 Aug;32(8):4172-4189. doi: 10.1096/fj.201701347R. Epub 2018 Mar 5.

12.

High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits.

Zhou X, Desai R, Zhang Y, Stec WJ, Miller KW, Jounaidi Y.

PLoS One. 2018 Jan 19;13(1):e0191583. doi: 10.1371/journal.pone.0191583. eCollection 2018.

13.

CodY-Mediated c-di-GMP-Dependent Inhibition of Mammalian Cell Invasion in Listeria monocytogenes.

Elbakush AM, Miller KW, Gomelsky M.

J Bacteriol. 2018 Feb 7;200(5). pii: e00457-17. doi: 10.1128/JB.00457-17. Print 2018 Mar 1.

14.

Self-Driving Cars and Engineering Ethics: The Need for a System Level Analysis.

Borenstein J, Herkert JR, Miller KW.

Sci Eng Ethics. 2019 Apr;25(2):383-398. doi: 10.1007/s11948-017-0006-0. Epub 2017 Nov 13.

PMID:
29134429
15.

Tethering IL2 to Its Receptor IL2Rβ Enhances Antitumor Activity and Expansion of Natural Killer NK92 Cells.

Jounaidi Y, Cotten JF, Miller KW, Forman SA.

Cancer Res. 2017 Nov 1;77(21):5938-5951. doi: 10.1158/0008-5472.CAN-17-1007. Epub 2017 Sep 15.

16.

Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy.

Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE.

Anesthesiology. 2017 Nov;127(5):824-837. doi: 10.1097/ALN.0000000000001840.

17.

Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.

Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS.

Eur J Med Chem. 2017 Aug 18;136:334-347. doi: 10.1016/j.ejmech.2017.04.043. Epub 2017 Apr 21.

18.

General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).

Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2016 Dec 16;291(51):26529-26539. Epub 2016 Nov 7.

19.

Unlocking the Mechanisms of Anesthesia.

Roth SH, Miller KW, Orser BA, Urban BW.

Anesth Analg. 2016 Nov;123(5):1070-1071. No abstract available.

PMID:
27454067
22.

This "Ethical Trap" Is for Roboticists, Not Robots: On the Issue of Artificial Agent Ethical Decision-Making.

Miller KW, Wolf MJ, Grodzinsky F.

Sci Eng Ethics. 2017 Apr;23(2):389-401. doi: 10.1007/s11948-016-9785-y. Epub 2016 Apr 26.

PMID:
27116039
23.

Impact of Advertising on Tampon Wear-time Practices.

Woeller KE, Miller KW, Robertson-Smith AL, Bohman LC.

Clin Med Insights Womens Health. 2015 Nov 29;8:29-38. doi: 10.4137/CMWH.S25123. eCollection 2015.

24.

Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.

Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW.

J Physiol. 2015 Nov 15;593(22):4943-61. doi: 10.1113/JP270971.

25.

Hadza hunter-gatherer men do not have more masculine digit ratios (2D:4D).

Apicella CL, Tobolsky VA, Marlowe FW, Miller KW.

Am J Phys Anthropol. 2016 Feb;159(2):223-32. doi: 10.1002/ajpa.22864. Epub 2015 Sep 10.

PMID:
26354727
26.

Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.

Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2015 Sep 18;290(38):23432-46. doi: 10.1074/jbc.M115.672006. Epub 2015 Jul 30.

27.

TrueAllele(®) Genotype Identification on DNA Mixtures Containing up to Five Unknown Contributors.

Perlin MW, Hornyak JM, Sugimoto G, Miller KW.

J Forensic Sci. 2015 Jul;60(4):857-68. doi: 10.1111/1556-4029.12788. Epub 2015 Jul 17.

PMID:
26189920
28.

A Feminine Care Clinical Research Program Transforms Women's Lives.

Tzeghai GE, Ajayi FO, Miller KW, Imbescheid F, Sobel JD, Farage MA.

Glob J Health Sci. 2012 Dec 17;7(4):45-59. doi: 10.5539/gjhs.v7n4p45. Review.

29.

Listeria monocytogenes exopolysaccharide: origin, structure, biosynthetic machinery and c-di-GMP-dependent regulation.

Köseoğlu VK, Heiss C, Azadi P, Topchiy E, Güvener ZT, Lehmann TE, Miller KW, Gomelsky M.

Mol Microbiol. 2015 May;96(4):728-43. doi: 10.1111/mmi.12966. Epub 2015 Mar 11.

30.

Female genital cutting: confronting cultural challenges and health complications across the lifespan.

Farage MA, Miller KW, Tzeghai GE, Azuka CE, Sobel JD, Ledger WJ.

Womens Health (Lond). 2015 Jan;11(1):79-94. doi: 10.2217/whe.14.63. Review.

PMID:
25581057
31.

Dodecyl maltopyranoside enabled purification of active human GABA type A receptors for deep and direct proteomic sequencing.

Zhang X, Miller KW.

Mol Cell Proteomics. 2015 Mar;14(3):724-38. doi: 10.1074/mcp.M114.042556. Epub 2014 Dec 3.

32.

Anesthetics target interfacial transmembrane sites in nicotinic acetylcholine receptors.

Forman SA, Chiara DC, Miller KW.

Neuropharmacology. 2015 Sep;96(Pt B):169-77. doi: 10.1016/j.neuropharm.2014.10.002. Epub 2014 Oct 12. Review.

33.

Research at the Harvard Anesthesia Departments.

Forman SA, Miller KW, Talmor D, Hickey P, Strichartz G, Wiener-Kronish J.

Anesthesiology. 2014 Dec;121(6):1141-3. doi: 10.1097/ALN.0000000000000483. No abstract available.

34.

Cyclic di-GMP-dependent signaling pathways in the pathogenic Firmicute Listeria monocytogenes.

Chen LH, Köseoğlu VK, Güvener ZT, Myers-Morales T, Reed JM, D'Orazio SE, Miller KW, Gomelsky M.

PLoS Pathog. 2014 Aug 7;10(8):e1004301. doi: 10.1371/journal.ppat.1004301. eCollection 2014 Aug.

35.

Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.

Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB.

J Biol Chem. 2014 Oct 3;289(40):27456-68. doi: 10.1074/jbc.M114.581728. Epub 2014 Aug 1.

36.

Characteristics of the Aging Skin.

Farage MA, Miller KW, Elsner P, Maibach HI.

Adv Wound Care (New Rochelle). 2013 Feb;2(1):5-10. Review.

37.

Thermal sensitivity of DASH interferometers: the role of thermal effects during the calibration of an Echelle DASH interferometer.

Marr KD, Englert CR, Harlander JM, Miller KW.

Appl Opt. 2013 Nov 20;52(33):8082-8. doi: 10.1364/AO.52.008082.

PMID:
24513761
38.

Human α1β3γ2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state.

Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, Forman SA, Miller KW.

Protein Sci. 2014 Feb;23(2):157-66. doi: 10.1002/pro.2401. Epub 2013 Dec 16.

39.

Structural models of ligand-gated ion channels: sites of action for anesthetics and ethanol.

Olsen RW, Li GD, Wallner M, Trudell JR, Bertaccini EJ, Lindahl E, Miller KW, Alkana RL, Davies DL.

Alcohol Clin Exp Res. 2014 Mar;38(3):595-603. doi: 10.1111/acer.12283. Epub 2013 Oct 24. Review.

40.

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.

Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB.

J Biol Chem. 2013 Jul 5;288(27):19343-57. doi: 10.1074/jbc.M113.479725. Epub 2013 May 15.

41.

Carboetomidate: an analog of etomidate that interacts weakly with 11β-hydroxylase.

Shanmugasundararaj S, Zhou X, Neunzig J, Bernhardt R, Cotten JF, Ge R, Miller KW, Raines DE.

Anesth Analg. 2013 Jun;116(6):1249-56. doi: 10.1213/ANE.0b013e31828b3637. Epub 2013 Mar 14.

42.

The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis.

Desai R, Miller KW, Raines DE.

Anesth Analg. 2013 Mar;116(3):573-9. doi: 10.1213/ANE.0b013e31827d204d. Epub 2013 Feb 11.

43.

Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*.

Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW.

Biophys J. 2012 Dec 5;103(11):2331-40. doi: 10.1016/j.bpj.2012.10.034.

44.

Skin benefits with a novel emollient-treated menstrual pad.

Farage MA, Miller KW, Azuka CE, Wang B, Lankhof S, Henn D, Messerschmidt A, Goldhammer A, Wilhelm KP, Maibach HI.

Rev Recent Clin Trials. 2013 Mar;8(1):29-35.

PMID:
23259459
45.

Assessing menstrual tampon irritation using the "Behind-The-Knee" test.

Farage MA, Miller KW, Ledger WJ.

Arch Gynecol Obstet. 2013 Mar;287(3):435-9. doi: 10.1007/s00404-012-2641-7. Epub 2012 Nov 24.

PMID:
23179806
46.

Assessing quality of life in older adult patients with skin disorders.

Farage MA, Miller KW, Sherman SN, Tsevat J.

Glob J Health Sci. 2012 Feb 29;4(2):119-31. doi: 10.5539/gjhs.v4n2p119.

47.

Design principles to accommodate older adults.

Farage MA, Miller KW, Ajayi F, Hutchins D.

Glob J Health Sci. 2012 Feb 29;4(2):2-25. doi: 10.5539/gjhs.v4n2p2. Review.

48.

Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic.

Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS.

J Med Chem. 2012 Jul 26;55(14):6554-65. doi: 10.1021/jm300631e. Epub 2012 Jul 17.

49.

The location and nature of general anesthetic binding sites on the active conformation of firefly luciferase; a time resolved photolabeling study.

Shanmugasundararaj S, Lehle S, Yamodo HI, Husain SS, Tseng C, Nguyen K, Addona GH, Miller KW.

PLoS One. 2012;7(1):e29854. doi: 10.1371/journal.pone.0029854. Epub 2012 Jan 17.

50.

Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.

Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB.

Biochemistry. 2012 Jan 31;51(4):836-47. doi: 10.1021/bi201772m. Epub 2012 Jan 23.

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