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Items: 1 to 50 of 91

1.

Identification by virtual screening and functional characterisation of novel positive and negative allosteric modulators of the α7 nicotinic acetylcholine receptor.

Smelt CLC, Sanders VR, Newcombe J, Burt RP, Sheppard TD, Topf M, Millar NS.

Neuropharmacology. 2018 Jul 12. pii: S0028-3908(18)30367-8. doi: 10.1016/j.neuropharm.2018.07.009. [Epub ahead of print]

PMID:
30009834
2.

Nicotinic acetylcholine receptors.

Wonnacott S, Bermudez I, Millar NS, Tzartos SJ.

Br J Pharmacol. 2018 Jun;175(11):1785-1788. doi: 10.1111/bph.14209.

PMID:
29878346
3.

Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model.

Newcombe J, Chatzidaki A, Sheppard TD, Topf M, Millar NS.

Mol Pharmacol. 2018 Feb;93(2):128-140. doi: 10.1124/mol.117.110551. Epub 2017 Dec 1.

4.

Mutations on M3 helix of Plutella xylostella glutamate-gated chloride channel confer unequal resistance to abamectin by two different mechanisms.

Wang X, Puinean AM, O Reilly AO, Williamson MS, Smelt CLC, Millar NS, Wu Y.

Insect Biochem Mol Biol. 2017 Jul;86:50-57. doi: 10.1016/j.ibmb.2017.05.006. Epub 2017 May 31.

PMID:
28576654
5.

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function.

Boffi JC, Marcovich I, Gill-Thind JK, Corradi J, Collins T, Lipovsek MM, Moglie M, Plazas PV, Craig PO, Millar NS, Bouzat C, Elgoyhen AB.

Mol Pharmacol. 2017 Mar;91(3):250-262. doi: 10.1124/mol.116.107482. Epub 2017 Jan 9. Erratum in: Mol Pharmacol. 2017 May;91(5):437.

6.

Synergistic and compensatory effects of two point mutations conferring target-site resistance to fipronil in the insect GABA receptor RDL.

Zhang Y, Meng X, Yang Y, Li H, Wang X, Yang B, Zhang J, Li C, Millar NS, Liu Z.

Sci Rep. 2016 Aug 25;6:32335. doi: 10.1038/srep32335.

7.

Stressed out symbiotes: hypotheses for the influence of abiotic stress on arbuscular mycorrhizal fungi.

Millar NS, Bennett AE.

Oecologia. 2016 Nov;182(3):625-41. doi: 10.1007/s00442-016-3673-7. Epub 2016 Jun 27.

8.

A three amino acid deletion in the transmembrane domain of the nicotinic acetylcholine receptor α6 subunit confers high-level resistance to spinosad in Plutella xylostella.

Wang J, Wang X, Lansdell SJ, Zhang J, Millar NS, Wu Y.

Insect Biochem Mol Biol. 2016 Apr;71:29-36. doi: 10.1016/j.ibmb.2016.02.001. Epub 2016 Feb 6.

9.

Inhibition of human α7 nicotinic acetylcholine receptors by cyclic monoterpene carveol.

Lozon Y, Sultan A, Lansdell SJ, Prytkova T, Sadek B, Yang KH, Howarth FC, Millar NS, Oz M.

Eur J Pharmacol. 2016 Apr 5;776:44-51. doi: 10.1016/j.ejphar.2016.02.004. Epub 2016 Feb 2.

10.

Allosteric modulation of nicotinic acetylcholine receptors.

Chatzidaki A, Millar NS.

Biochem Pharmacol. 2015 Oct 15;97(4):408-417. doi: 10.1016/j.bcp.2015.07.028. Epub 2015 Jul 29. Review.

PMID:
26231943
11.

The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors.

Chatzidaki A, D'Oyley JM, Gill-Thind JK, Sheppard TD, Millar NS.

Neuropharmacology. 2015 Oct;97:75-85. doi: 10.1016/j.neuropharm.2015.05.006. Epub 2015 May 19.

12.

Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons.

Chatzidaki A, Fouillet A, Li J, Dage J, Millar NS, Sher E, Ursu D.

PLoS One. 2015 Apr 23;10(4):e0125116. doi: 10.1371/journal.pone.0125116. eCollection 2015.

13.

Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects.

Gill-Thind JK, Dhankher P, D'Oyley JM, Sheppard TD, Millar NS.

J Biol Chem. 2015 Feb 6;290(6):3552-62. doi: 10.1074/jbc.M114.619221. Epub 2014 Dec 16.

14.

Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.

Lansdell SJ, Sathyaprakash C, Doward A, Millar NS.

Mol Pharmacol. 2015 Jan;87(1):87-95. doi: 10.1124/mol.114.094540. Epub 2014 Oct 22.

15.

Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor.

Lipovsek M, Fierro A, Pérez EG, Boffi JC, Millar NS, Fuchs PA, Katz E, Elgoyhen AB.

Mol Biol Evol. 2014 Dec;31(12):3250-65. doi: 10.1093/molbev/msu258. Epub 2014 Sep 5.

16.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

17.

Contrasting properties of α7-selective orthosteric and allosteric agonists examined on native nicotinic acetylcholine receptors.

Gill JK, Chatzidaki A, Ursu D, Sher E, Millar NS.

PLoS One. 2013;8(1):e55047. doi: 10.1371/journal.pone.0055047. Epub 2013 Jan 29.

18.

A nicotinic acetylcholine receptor transmembrane point mutation (G275E) associated with resistance to spinosad in Frankliniella occidentalis.

Puinean AM, Lansdell SJ, Collins T, Bielza P, Millar NS.

J Neurochem. 2013 Mar;124(5):590-601. doi: 10.1111/jnc.12029. Epub 2013 Jan 13.

19.

Activation of α7 nicotinic receptors by orthosteric and allosteric agonists: influence on single-channel kinetics and conductance.

Pałczyńska MM, Jindrichova M, Gibb AJ, Millar NS.

Mol Pharmacol. 2012 Nov;82(5):910-7. doi: 10.1124/mol.112.080259. Epub 2012 Aug 8.

20.

The Drosophila nicotinic acetylcholine receptor subunits Dα5 and Dα7 form functional homomeric and heteromeric ion channels.

Lansdell SJ, Collins T, Goodchild J, Millar NS.

BMC Neurosci. 2012 Jun 22;13:73. doi: 10.1186/1471-2202-13-73.

21.

A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats.

Rasoulpour RJ, Ellis-Hutchings RG, Terry C, Millar NS, Zablotny CL, Gibb A, Marshall V, Collins T, Carney EW, Billington R.

Toxicol Sci. 2012 Jun;127(2):522-34. doi: 10.1093/toxsci/kfs118. Epub 2012 Mar 29.

PMID:
22461452
22.

Changes in temperature have opposing effects on current amplitude in α7 and α4β2 nicotinic acetylcholine receptors.

Jindrichova M, Lansdell SJ, Millar NS.

PLoS One. 2012;7(2):e32073. doi: 10.1371/journal.pone.0032073. Epub 2012 Feb 16.

23.

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties.

Gill JK, Dhankher P, Sheppard TD, Sher E, Millar NS.

Mol Pharmacol. 2012 May;81(5):710-8. doi: 10.1124/mol.111.076026. Epub 2012 Feb 10.

24.

Competitive binding at a nicotinic receptor transmembrane site of two α7-selective positive allosteric modulators with differing effects on agonist-evoked desensitization.

Collins T, Young GT, Millar NS.

Neuropharmacology. 2011 Dec;61(8):1306-13. doi: 10.1016/j.neuropharm.2011.07.035. Epub 2011 Jul 30.

25.

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Gill JK, Savolainen M, Young GT, Zwart R, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5867-72. doi: 10.1073/pnas.1017975108. Epub 2011 Mar 21.

26.

Characterisation of insect nicotinic acetylcholine receptors by heterologous expression.

Millar NS, Lansdell SJ.

Adv Exp Med Biol. 2010;683:65-73. Review.

PMID:
20737789
27.

Amplification of a cytochrome P450 gene is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae.

Puinean AM, Foster SP, Oliphant L, Denholm I, Field LM, Millar NS, Williamson MS, Bass C.

PLoS Genet. 2010 Jun 24;6(6):e1000999. doi: 10.1371/journal.pgen.1000999.

28.

Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator.

Collins T, Millar NS.

Mol Pharmacol. 2010 Aug;78(2):198-204. doi: 10.1124/mol.110.064295. Epub 2010 May 12.

29.

Native subunit composition of two insect nicotinic receptor subtypes with differing affinities for the insecticide imidacloprid.

Li J, Shao Y, Ding Z, Bao H, Liu Z, Han Z, Millar NS.

Insect Biochem Mol Biol. 2010 Jan;40(1):17-22. doi: 10.1016/j.ibmb.2009.12.003. Epub 2009 Dec 30.

PMID:
20005950
30.

Functional co-expression of two insect nicotinic receptor subunits (Nlalpha3 and Nlalpha8) reveals the effects of a resistance-associated mutation (Nlalpha3) on neonicotinoid insecticides.

Yixi Z, Liu Z, Han Z, Song F, Yao X, Shao Y, Li J, Millar NS.

J Neurochem. 2009 Sep;110(6):1855-62. doi: 10.1111/j.1471-4159.2009.06280.x. Epub 2009 Jul 14.

31.

A review of experimental techniques used for the heterologous expression of nicotinic acetylcholine receptors.

Millar NS.

Biochem Pharmacol. 2009 Oct 1;78(7):766-76. doi: 10.1016/j.bcp.2009.06.015. Epub 2009 Jun 18. Review.

PMID:
19540210
32.

The increased trafficking of the calcium channel subunit alpha2delta-1 to presynaptic terminals in neuropathic pain is inhibited by the alpha2delta ligand pregabalin.

Bauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin I, Sri Ranjan Y, Fernandez-Alacid L, Millar NS, Dickenson AH, Lujan R, Dolphin AC.

J Neurosci. 2009 Apr 1;29(13):4076-88. doi: 10.1523/JNEUROSCI.0356-09.2009.

33.

Heteromeric co-assembly of two insect nicotinic acetylcholine receptor alpha subunits: influence on sensitivity to neonicotinoid insecticides.

Liu Z, Han Z, Zhang Y, Song F, Yao X, Liu S, Gu J, Millar NS.

J Neurochem. 2009 Jan;108(2):498-506. doi: 10.1111/j.1471-4159.2008.05790.x. Epub 2008 Nov 19.

34.

Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site.

Young GT, Zwart R, Walker AS, Sher E, Millar NS.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14686-91. doi: 10.1073/pnas.0804372105. Epub 2008 Sep 12.

35.

Diversity of vertebrate nicotinic acetylcholine receptors.

Millar NS, Gotti C.

Neuropharmacology. 2009 Jan;56(1):237-46. doi: 10.1016/j.neuropharm.2008.07.041. Epub 2008 Aug 5. Review.

PMID:
18723036
36.

Assembly and trafficking of nicotinic acetylcholine receptors (Review).

Millar NS, Harkness PC.

Mol Membr Biol. 2008 May;25(4):279-92. doi: 10.1080/09687680802035675. Review.

PMID:
18446614
37.

RIC-3: a nicotinic acetylcholine receptor chaperone.

Millar NS.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S177-83. doi: 10.1038/sj.bjp.0707661. Epub 2008 Feb 4. Review.

38.

Host-cell specific effects of the nicotinic acetylcholine receptor chaperone RIC-3 revealed by a comparison of human and Drosophila RIC-3 homologues.

Lansdell SJ, Collins T, Yabe A, Gee VJ, Gibb AJ, Millar NS.

J Neurochem. 2008 Jun;105(5):1573-81. doi: 10.1111/j.1471-4159.2008.05235.x. Epub 2008 Jan 18.

39.

Influence of the M3-M4 intracellular domain upon nicotinic acetylcholine receptor assembly, targeting and function.

Kracun S, Harkness PC, Gibb AJ, Millar NS.

Br J Pharmacol. 2008 Apr;153(7):1474-84. doi: 10.1038/sj.bjp.0707676. Epub 2008 Jan 21.

40.

Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.

Gee VJ, Kracun S, Cooper ST, Gibb AJ, Millar NS.

Br J Pharmacol. 2007 Oct;152(4):501-12. Epub 2007 Aug 27.

41.

Inhibition of the alpha9alpha10 nicotinic cholinergic receptor by neramexane, an open channel blocker of N-methyl-D-aspartate receptors.

Plazas PV, Savino J, Kracun S, Gomez-Casati ME, Katz E, Parsons CG, Millar NS, Elgoyhen AB.

Eur J Pharmacol. 2007 Jul 2;566(1-3):11-9. Epub 2007 Mar 24.

PMID:
17466293
42.

Nicotinic acetylcholine receptors: targets for commercially important insecticides.

Millar NS, Denholm I.

Invert Neurosci. 2007 Mar;7(1):53-66. Epub 2007 Jan 10. Review.

PMID:
17216290
43.
44.

A nicotinic acetylcholine receptor mutation (Y151S) causes reduced agonist potency to a range of neonicotinoid insecticides.

Liu Z, Williamson MS, Lansdell SJ, Han Z, Denholm I, Millar NS.

J Neurochem. 2006 Nov;99(4):1273-81. Epub 2006 Sep 18.

45.

Incorporation of the beta3 subunit has a dominant-negative effect on the function of recombinant central-type neuronal nicotinic receptors.

Broadbent S, Groot-Kormelink PJ, Krashia PA, Harkness PC, Millar NS, Beato M, Sivilotti LG.

Mol Pharmacol. 2006 Oct;70(4):1350-7. Epub 2006 Jul 5.

46.

Molecular characterisation of nicotinic acetylcholine receptor subunits from the cat flea, Ctenocephalides felis (Siphonaptera: Pulicidae).

Bass C, Lansdell SJ, Millar NS, Schroeder I, Turberg A, Field LM, Williamson MS.

Insect Biochem Mol Biol. 2006 Jan;36(1):86-96. Epub 2005 Dec 1.

PMID:
16360954
47.

Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors.

Tomizawa M, Millar NS, Casida JE.

Insect Biochem Mol Biol. 2005 Dec;35(12):1347-55. Epub 2005 Sep 15.

PMID:
16291090
48.

RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells.

Lansdell SJ, Gee VJ, Harkness PC, Doward AI, Baker ER, Gibb AJ, Millar NS.

Mol Pharmacol. 2005 Nov;68(5):1431-8. Epub 2005 Aug 24.

49.

Effects of quinine, quinidine, and chloroquine on alpha9alpha10 nicotinic cholinergic receptors.

Ballestero JA, Plazas PV, Kracun S, Gómez-Casati ME, Taranda J, Rothlin CV, Katz E, Millar NS, Elgoyhen AB.

Mol Pharmacol. 2005 Sep;68(3):822-9. Epub 2005 Jun 13.

50.

A nicotinic acetylcholine receptor mutation conferring target-site resistance to imidacloprid in Nilaparvata lugens (brown planthopper).

Liu Z, Williamson MS, Lansdell SJ, Denholm I, Han Z, Millar NS.

Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8420-5. Epub 2005 Jun 3.

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