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Items: 43

1.

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

Blevitt JM, Hack MD, Herman KL, Jackson PF, Krawczuk PJ, Lebsack AD, Liu AX, Mirzadegan T, Nelen MI, Patrick AN, Steinbacher S, Milla ME, Lumb KJ.

J Med Chem. 2017 Apr 27;60(8):3511-3517. doi: 10.1021/acs.jmedchem.6b01836. Epub 2017 Mar 16.

PMID:
28300404
2.

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo.

Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, Yaron A, Milla ME, Sagi I.

Sci Rep. 2016 Dec 16;6:35598. doi: 10.1038/srep35598.

3.

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors.

Blevitt JM, Hack MD, Herman K, Chang L, Keith JM, Mirzadegan T, Rao NL, Lebsack AD, Milla ME.

J Biol Chem. 2016 Jun 10;291(24):12724-31. doi: 10.1074/jbc.M116.725325. Epub 2016 Apr 16.

4.

Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform.

Song J, Liu X, Zhu J, Tootoonchi M, Keith JM, Meduna SP, Dvorak CA, Eccles W, Krawczuk PJ, Blevitt JM, Wu J, Rao NL, Lebsack AD, Milla ME.

J Biomol Screen. 2016 Feb;21(2):127-35. doi: 10.1177/1087057115607815. Epub 2015 Oct 6.

PMID:
26442913
5.

Phenotyping drug polypharmacology via eicosanoid profiling of blood.

Song J, Liu X, Rao TS, Chang L, Meehan MJ, Blevitt JM, Wu J, Dorrestein PC, Milla ME.

J Lipid Res. 2015 Aug;56(8):1492-500. doi: 10.1194/jlr.M058677. Epub 2015 May 28.

6.

Phenotypic Approaches to Identify Inhibitors of B Cell Activation.

Rex EB, Kim S, Wiener J, Rao NL, Milla ME, DiSepio D.

J Biomol Screen. 2015 Aug;20(7):876-86. doi: 10.1177/1087057115585724. Epub 2015 May 6.

7.

Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.

Copik AJ, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, Dietrich PJ, Fitch B, Raymond JR, Ford AP, Button D, Milla ME.

PLoS One. 2015 Jan 21;10(1):e0115701. doi: 10.1371/journal.pone.0115701. eCollection 2015.

8.

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation.

Soroosh P, Wu J, Xue X, Song J, Sutton SW, Sablad M, Yu J, Nelen MI, Liu X, Castro G, Luna R, Crawford S, Banie H, Dandridge RA, Deng X, Bittner A, Kuei C, Tootoonchi M, Rozenkrants N, Herman K, Gao J, Yang XV, Sachen K, Ngo K, Fung-Leung WP, Nguyen S, de Leon-Tabaldo A, Blevitt J, Zhang Y, Cummings MD, Rao T, Mani NS, Liu C, McKinnon M, Milla ME, Fourie AM, Sun S.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8. doi: 10.1073/pnas.1322807111. Epub 2014 Aug 4.

9.

Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator.

Sahdeo S, Wallace T, Hirakawa R, Knoflach F, Bertrand D, Maag H, Misner D, Tombaugh GC, Santarelli L, Brameld K, Milla ME, Button DC.

J Pharmacol Exp Ther. 2014 Aug;350(2):455-68. doi: 10.1124/jpet.113.210963. Epub 2014 Jun 10.

PMID:
24917542
10.

A highly efficient, high-throughput lipidomics platform for the quantitative detection of eicosanoids in human whole blood.

Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein PC, Milla ME.

Anal Biochem. 2013 Feb 15;433(2):181-8. doi: 10.1016/j.ab.2012.10.022. Epub 2012 Oct 26.

PMID:
23103340
11.

Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations.

Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC.

Anal Chem. 2012 Nov 6;84(21):9259-67. doi: 10.1021/ac302039u. Epub 2012 Oct 10.

12.

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist.

Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, Rubas W, Oglesby IB, Dillon MP, Milla ME, Burnstock G, Ford AP.

Br J Pharmacol. 2010 Jul;160(6):1387-98. doi: 10.1111/j.1476-5381.2010.00796.x.

13.

Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction.

Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME.

Mol Pharmacol. 2009 Mar;75(3):713-28. doi: 10.1124/mol.108.050765. Epub 2008 Dec 24.

PMID:
19109357
14.

Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.

Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM.

J Neurosci. 2008 Nov 12;28(46):12052-61. doi: 10.1523/JNEUROSCI.2913-08.2008.

15.

Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors.

Martin RS, Henningsen RA, Suen A, Apparsundaram S, Leung B, Jia Z, Kondru RK, Milla ME.

J Pharmacol Exp Ther. 2008 Dec;327(3):991-1000. doi: 10.1124/jpet.108.142307. Epub 2008 Sep 18.

PMID:
18801948
16.

Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism.

Apparsundaram S, Stockdale DJ, Henningsen RA, Milla ME, Martin RS.

J Pharmacol Exp Ther. 2008 Dec;327(3):982-90. doi: 10.1124/jpet.108.142315. Epub 2008 Sep 18.

PMID:
18801947
17.

Identification of key sequence determinants for the inhibitory function of the prodomain of TACE.

Gonzales PE, Galli JD, Milla ME.

Biochemistry. 2008 Sep 16;47(37):9911-9. doi: 10.1021/bi801049v. Epub 2008 Aug 16.

PMID:
18707126
18.
19.

Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core.

Solomon A, Akabayov B, Frenkel A, Milla ME, Sagi I.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4931-6. Epub 2007 Mar 13.

20.

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury.

Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF.

Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1621-6. Epub 2007 Jan 23.

21.

The TACE zymogen: re-examining the role of the cysteine switch.

Milla ME, Gonzales PE, Leonard JD.

Cell Biochem Biophys. 2006;44(3):342-8. Review.

PMID:
16679521
22.

Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-kappaB ligand.

Schneeweis LA, Willard D, Milla ME.

J Biol Chem. 2005 Dec 16;280(50):41155-64. Epub 2005 Oct 7.

23.
24.
25.

Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain.

Gonzales PE, Solomon A, Miller AB, Leesnitzer MA, Sagi I, Milla ME.

J Biol Chem. 2004 Jul 23;279(30):31638-45. Epub 2004 Apr 20.

26.

Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha).

Hinkle CL, Mohan MJ, Lin P, Yeung N, Rasmussen F, Milla ME, Moss ML.

Biochemistry. 2003 Feb 25;42(7):2127-36.

PMID:
12590602
27.

The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.

Mohan MJ, Seaton T, Mitchell J, Howe A, Blackburn K, Burkhart W, Moyer M, Patel I, Waitt GM, Becherer JD, Moss ML, Milla ME.

Biochemistry. 2002 Jul 30;41(30):9462-9. Erratum in: Biochemistry. 2003 Sep 23;42(37):11092.

PMID:
12135369
28.
29.
30.

Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

Milla ME, Leesnitzer MA, Moss ML, Clay WC, Carter HL, Miller AB, Su JL, Lambert MH, Willard DH, Sheeley DM, Kost TA, Burkhart W, Moyer M, Blackburn RK, Pahel GL, Mitchell JL, Hoffman CR, Becherer JD.

J Biol Chem. 1999 Oct 22;274(43):30563-70.

31.

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.

Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al.

Nature. 1997 Feb 20;385(6618):733-6. Erratum in: Nature 1997 Apr 17;386(6626):738.

PMID:
9034191
32.
33.

Sequence determinants of folding and stability for the P22 Arc repressor dimer.

Sauer RT, Milla ME, Waldburger CD, Brown BM, Schildbach JF.

FASEB J. 1996 Jan;10(1):42-8. Review.

PMID:
8566546
34.

P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding.

Milla ME, Brown BM, Waldburger CD, Sauer RT.

Biochemistry. 1995 Oct 24;34(42):13914-9.

PMID:
7577986
35.

Critical side-chain interactions at a subunit interface in the Arc repressor dimer.

Milla ME, Sauer RT.

Biochemistry. 1995 Mar 14;34(10):3344-51.

PMID:
7880830
36.

Crystal structure, folding, and operator binding of the hyperstable Arc repressor mutant PL8.

Schildbach JF, Milla ME, Jeffrey PD, Raumann BE, Sauer RT.

Biochemistry. 1995 Jan 31;34(4):1405-12.

PMID:
7827088
37.

Purification of the Golgi adenosine 3'-phosphate 5'-phosphosulfate transporter, a homodimer within the membrane.

Mandon EC, Milla ME, Kempner E, Hirschberg CB.

Proc Natl Acad Sci U S A. 1994 Oct 25;91(22):10707-11.

38.

Protein stability effects of a complete set of alanine substitutions in Arc repressor.

Milla ME, Brown BM, Sauer RT.

Nat Struct Biol. 1994 Aug;1(8):518-23. Erratum in: Nat Struct Biol 1994 Nov;1(11):830.

PMID:
7664079
39.

Scanning mutagenesis of the Arc repressor as a functional probe of operator recognition.

Brown BM, Milla ME, Smith TL, Sauer RT.

Nat Struct Biol. 1994 Mar;1(3):164-8.

PMID:
7656034
40.

P22 Arc repressor: folding kinetics of a single-domain, dimeric protein.

Milla ME, Sauer RT.

Biochemistry. 1994 Feb 8;33(5):1125-33.

PMID:
8110744
41.
43.

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