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Items: 1 to 50 of 144

1.

Efficacy of a Therapeutic Diet on Dogs With Signs of Cognitive Dysfunction Syndrome (CDS): A Prospective Double Blinded Placebo Controlled Clinical Study.

Pan Y, Landsberg G, Mougeot I, Kelly S, Xu H, Bhatnagar S, Gardner CL, Milgram NW.

Front Nutr. 2018 Dec 12;5:127. doi: 10.3389/fnut.2018.00127. eCollection 2018.

2.

Cognitive enhancement in old dogs from dietary supplementation with a nutrient blend containing arginine, antioxidants, B vitamins and fish oil.

Pan Y, Kennedy AD, Jönsson TJ, Milgram NW.

Br J Nutr. 2018 Feb;119(3):349-358. doi: 10.1017/S0007114517003464. Epub 2018 Jan 10.

PMID:
29316985
3.

Effects of dietary supplementation with a mixed blueberry and grape extract on working memory in aged beagle dogs.

Fragua V, Lepoudère A, Leray V, Baron C, Araujo JA, Nguyen P, Milgram NW.

J Nutr Sci. 2017 Jul 12;6:e35. doi: 10.1017/jns.2017.33. eCollection 2017.

4.

The oil-rich alga Schizochytrium sp. as a dietary source of docosahexaenoic acid improves shape discrimination learning associated with visual processing in a canine model of senescence.

Hadley KB, Bauer J, Milgram NW.

Prostaglandins Leukot Essent Fatty Acids. 2017 Mar;118:10-18. doi: 10.1016/j.plefa.2017.01.011. Epub 2017 Feb 2.

5.

Pattern separation and goal-directed behavior in the aged canine.

Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW.

Learn Mem. 2017 Feb 15;24(3):123-131. doi: 10.1101/lm.043422.116. Print 2017 Mar.

6.

Diurnal changes in core body temperature, day/night locomotor activity patterns, and actigraphy-generated behavioral sleep in aged canines with varying levels of cognitive dysfunction.

Zanghi BM, Gardner C, Araujo J, Milgram NW.

Neurobiol Sleep Circadian Rhythms. 2016 Jul 13;1(1):8-18. doi: 10.1016/j.nbscr.2016.07.001. eCollection 2016 Oct.

7.

Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.

Snigdha S, de Rivera C, Milgram NW, Cotman CW.

Neurobiol Aging. 2016 Jan;37:171-178. doi: 10.1016/j.neurobiolaging.2015.09.015. Epub 2015 Sep 30.

PMID:
26481404
8.

Dog-appeasing pheromone collars reduce sound-induced fear and anxiety in beagle dogs: a placebo-controlled study.

Landsberg GM, Beck A, Lopez A, Deniaud M, Araujo JA, Milgram NW.

Vet Rec. 2015 Sep 12;177(10):260. doi: 10.1136/vr.103172. Epub 2015 Aug 26.

9.

Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers.

Lazarowski L, Foster ML, Gruen ME, Sherman BL, Fish RE, Milgram NW, Dorman DC.

Anim Cogn. 2015 Nov;18(6):1255-65. doi: 10.1007/s10071-015-0894-9. Epub 2015 Jul 10.

PMID:
26160342
10.

Cognitive domains in the dog: independence of working memory from object learning, selective attention, and motor learning.

Zanghi BM, Araujo J, Milgram NW.

Anim Cogn. 2015 May;18(3):789-800. doi: 10.1007/s10071-015-0847-3. Epub 2015 Feb 13.

PMID:
25677729
11.

Exercise enhances memory consolidation in the aging brain.

Snigdha S, de Rivera C, Milgram NW, Cotman CW.

Front Aging Neurosci. 2014 Feb 3;6:3. doi: 10.3389/fnagi.2014.00003. eCollection 2014.

12.

Acquisition of a visual discrimination and reversal learning task by Labrador retrievers.

Lazarowski L, Foster ML, Gruen ME, Sherman BL, Case BC, Fish RE, Milgram NW, Dorman DC.

Anim Cogn. 2014 May;17(3):787-92. doi: 10.1007/s10071-013-0712-1. Epub 2013 Nov 26.

13.

Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs.

Zanghi BM, Cupp CJ, Pan Y, Tissot-Favre DG, Milgram NW, Nagy TR, Dobson H.

Am J Vet Res. 2013 May;74(5):733-43. doi: 10.2460/ajvr.74.5.733.

PMID:
23627386
14.

Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in cats.

Zanghi BM, Cupp CJ, Pan Y, Tissot-Favre DG, Milgram NW, Nagy TR, Dobson H.

Am J Vet Res. 2013 May;74(5):721-32. doi: 10.2460/ajvr.74.5.721.

PMID:
23627385
15.

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap.

Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW.

Neurobiol Aging. 2013 Jul;34(7):1891-901. doi: 10.1016/j.neurobiolaging.2013.01.018. Epub 2013 Feb 20. Review.

16.

Cognitive enhancement in middle-aged and old cats with dietary supplementation with a nutrient blend containing fish oil, B vitamins, antioxidants and arginine.

Pan Y, Araujo JA, Burrows J, de Rivera C, Gore A, Bhatnagar S, Milgram NW.

Br J Nutr. 2013 Jul 14;110(1):40-9. doi: 10.1017/S0007114512004771. Epub 2012 Dec 5.

PMID:
23211671
17.
18.

Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.

Araujo JA, Greig NH, Ingram DK, Sandin J, de Rivera C, Milgram NW.

J Alzheimers Dis. 2011;26(1):143-55. doi: 10.3233/JAD-2011-110005.

19.

Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile.

Collison KS, Zaidi MZ, Saleh SM, Inglis A, Mondreal R, Makhoul NJ, Bakheet R, Burrows J, Milgram NW, Al-Mohanna FA.

Br J Nutr. 2011 Jul;106(2):218-26. doi: 10.1017/S000711451000588X.

PMID:
21429276
20.

Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs.

Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW.

Age (Dordr). 2012 Feb;34(1):67-73. doi: 10.1007/s11357-011-9219-3. Epub 2011 Feb 19.

21.

Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density.

Araujo JA, Nobrega JN, Raymond R, Milgram NW.

Pharmacol Biochem Behav. 2011 Apr;98(2):203-9. doi: 10.1016/j.pbb.2011.01.005. Epub 2011 Jan 14.

PMID:
21238475
22.

Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines.

Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW.

J Neurosci. 2010 Jul 21;30(29):9831-9. doi: 10.1523/JNEUROSCI.6194-09.2010.

23.

Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications.

Creed MC, Milgram NW.

Age (Dordr). 2010 Sep;32(3):365-84. doi: 10.1007/s11357-010-9142-z. Epub 2010 Apr 20. Review.

24.

Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs.

Pan Y, Larson B, Araujo JA, Lau W, de Rivera C, Santana R, Gore A, Milgram NW.

Br J Nutr. 2010 Jun;103(12):1746-54. doi: 10.1017/S0007114510000097. Epub 2010 Feb 9.

PMID:
20141643
25.

Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy?

Trepanier CH, Milgram NW.

J Alzheimers Dis. 2010;21(4):1089-99. Review.

PMID:
21504126
26.

Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory.

Collison KS, Makhoul NJ, Inglis A, Al-Johi M, Zaidi MZ, Maqbool Z, Saleh SM, Bakheet R, Mondreal R, Al-Rabiah R, Shoukri M, Milgram NW, Al-Mohanna FA.

Physiol Behav. 2010 Mar 3;99(3):334-42. doi: 10.1016/j.physbeh.2009.11.010. Epub 2009 Nov 27.

PMID:
19945473
27.

Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.

Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW.

Exp Gerontol. 2009 Dec;44(12):752-9. doi: 10.1016/j.exger.2009.08.012. Epub 2009 Sep 6.

28.

A comparative neuropsychological test battery differentiates cognitive signatures of Fragile X and Down syndrome.

Kogan CS, Boutet I, Cornish K, Graham GE, Berry-Kravis E, Drouin A, Milgram NW.

J Intellect Disabil Res. 2009 Feb;53(2):125-42. doi: 10.1111/j.1365-2788.2008.01135.x. Epub 2008 Nov 27.

PMID:
19054268
29.

MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses.

Poma R, Chambers H, da Costa RC, Konyer NB, Nykamp S, Dobson H, Milgram NW.

Vet Comp Orthop Traumatol. 2008;21(3):238-42.

PMID:
18536850
31.

Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease.

Chow TW, Pollock BG, Milgram NW.

Neuropsychiatr Dis Treat. 2007;3(5):627-36.

32.

Cognitive decline and human (Homo sapiens) aging: an investigation using a comparative neuropsychological approach.

Boutet I, Milgram NW, Freedman M.

J Comp Psychol. 2007 Aug;121(3):270-81.

PMID:
17696653
33.

Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN.

FASEB J. 2007 Nov;21(13):3756-62. Epub 2007 Jul 10.

PMID:
17622567
34.

Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function.

Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW.

Neurobiol Learn Mem. 2007 Sep;88(2):249-59. Epub 2007 Jun 22.

35.

Enhanced spatial ability in aged dogs following dietary and behavioural enrichment.

Nippak PM, Mendelson J, Muggenburg B, Milgram NW.

Neurobiol Learn Mem. 2007 May;87(4):610-23. Epub 2007 Feb 15.

PMID:
17303448
36.

Region specific neuron loss in the aged canine hippocampus is reduced by enrichment.

Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW.

Neurobiol Aging. 2008 Jan;29(1):39-50. Epub 2006 Nov 7.

37.

Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease.

Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA.

Neurobiol Aging. 2008 Jan;29(1):51-70. Epub 2006 Oct 20.

38.

Neuroprotective effects of cognitive enrichment.

Milgram NW, Siwak-Tapp CT, Araujo J, Head E.

Ageing Res Rev. 2006 Aug;5(3):354-69. Epub 2006 Sep 1. Review.

PMID:
16949888
39.

Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia.

Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW.

Neurobiol Learn Mem. 2006 Sep;86(2):197-204. Epub 2006 Apr 17.

PMID:
16616528
40.

Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta.

Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW.

Vaccine. 2006 Apr 5;24(15):2824-34. Epub 2006 Jan 19.

PMID:
16460841
41.

Extensive spatial training does not negate age differences in response latency.

Nippak PM, Ikeda-Douglas C, Milgram NW.

Brain Res. 2006 Jan 27;1070(1):171-88. Epub 2006 Feb 7.

PMID:
16460702
42.

Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging.

Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY.

Neuroimage. 2006 Jan 1;29(1):234-44. Epub 2005 Nov 7.

PMID:
16275022
43.

Nutritional management of brain aging in dogs.

Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E.

J Am Vet Med Assoc. 2005 Sep 1;227(5):722-8. Review. No abstract available.

PMID:
16178393
44.

The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs.

Studzinski CM, Araujo JA, Milgram NW.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):489-98. Review.

PMID:
15795058
45.

Effect of feeding patterns on performance of a visuospatial memory task in the beagle dog: a novel cognitive-based protocol for assessing satiety.

Chan JW, Araujo JA, Zicker SC, Pun TW, Milgram NW.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):481-8.

PMID:
15795057
46.

Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs.

Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):461-9.

PMID:
15795055
47.

Learning and memory as a function of age in Down syndrome: a study using animal-based tasks.

Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):443-53.

PMID:
15795053
48.

Age-associated cognitive deficits in humans and dogs: a comparative neuropsychological approach.

Boutet I, Ryan M, Kulaga V, McShane C, Christie LA, Freedman M, Milgram NW.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):433-41.

PMID:
15795052
49.

Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging.

Araujo JA, Studzinski CM, Milgram NW.

Prog Neuropsychopharmacol Biol Psychiatry. 2005 Mar;29(3):411-22. Review.

PMID:
15795050
50.

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