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Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis.

Bremer Hinckel BC, Marlais T, Airs S, Bhattacharyya T, Imamura H, Dujardin JC, El-Safi S, Singh OP, Sundar S, Falconar AK, Andersson B, Litvinov S, Miles MA, Mertens P.

PLoS Negl Trop Dis. 2019 May 6;13(5):e0007353. doi: 10.1371/journal.pntd.0007353. eCollection 2019 May.


CrmA orthologs from diverse poxviruses potently inhibit caspases-1 and -8, yet cleavage site mutagenesis frequently produces caspase-1-specific variants.

Bloomer DT, Kitevska-Ilioski T, Pantaki-Eimany D, Ji Y, Miles MA, Heras B, Hawkins CJ.

Biochem J. 2019 May 7;476(9):1335-1357. doi: 10.1042/BCJ20190202.


Venezuela's humanitarian crisis, resurgence of vector-borne diseases, and implications for spillover in the region.

Grillet ME, Hernández-Villena JV, Llewellyn MS, Paniz-Mondolfi AE, Tami A, Vincenti-Gonzalez MF, Marquez M, Mogollon-Mendoza AC, Hernandez-Pereira CE, Plaza-Morr JD, Blohm G, Grijalva MJ, Costales JA, Ferguson HM, Schwabl P, Hernandez-Castro LE, Lamberton PHL, Streicker DG, Haydon DT, Miles MA, Acosta-Serrano A, Acquattela H, Basañez MG, Benaim G, Colmenares LA, Conn JE, Espinoza R, Freilij H, Graterol-Gil MC, Hotez PJ, Kato H, Lednicky JA, Martinez CE, Mas-Coma S, Morris JG Jr, Navarro JC, Ramirez JL, Rodriguez M, Urbina JA, Villegas L, Segovia MJ, Carrasco HJ, Crainey JL, Luz SLB, Moreno JD, Noya Gonzalez OO, Ramírez JD, Alarcón-de Noya B.

Lancet Infect Dis. 2019 May;19(5):e149-e161. doi: 10.1016/S1473-3099(18)30757-6. Epub 2019 Feb 21. Review. Erratum in: Lancet Infect Dis. 2019 Feb 27;:.


Resurgence of Vaccine-Preventable Diseases in Venezuela as a Regional Public Health Threat in the Americas.

Paniz-Mondolfi AE, Tami A, Grillet ME, Márquez M, Hernández-Villena J, Escalona-Rodríguez MA, Blohm GM, Mejías I, Urbina-Medina H, Rísquez A, Castro J, Carvajal A, Walter C, López MG, Schwabl P, Hernández-Castro L, Miles MA, Hotez PJ, Lednicky J, Morris JG Jr, Crainey J, Luz S, Ramírez JD, Sordillo E, Llewellyn M, Canache M, Araque M, Oletta J.

Emerg Infect Dis. 2019 Apr;25(4):625-632. doi: 10.3201/eid2504.181305. Epub 2019 Apr 17.


Synthetic peptides as a novel approach for detecting antibodies against sand fly saliva.

Sima M, Ferencova B, Bhattacharyya T, Miles MA, Litvinov SV, Hailu A, Baneth G, Volf P.

PLoS Negl Trop Dis. 2019 Jan 24;13(1):e0007078. doi: 10.1371/journal.pntd.0007078. eCollection 2019 Jan.


Visceral Leishmaniasis IgG1 Rapid Monitoring of Cure vs. Relapse, and Potential for Diagnosis of Post Kala-Azar Dermal Leishmaniasis.

Marlais T, Bhattacharyya T, Singh OP, Mertens P, Gilleman Q, Thunissen C, Hinckel BCB, Pearson C, Gardner BL, Airs S, de la Roche M, Hayes K, Hafezi H, Falconar AK, Eisa O, Saad A, Khanal B, Bhattarai NR, Rijal S, Boelaert M, El-Safi S, Sundar S, Miles MA.

Front Cell Infect Microbiol. 2018 Dec 13;8:427. doi: 10.3389/fcimb.2018.00427. eCollection 2018.


Detection of IgG1 against rK39 improves monitoring of treatment outcome in visceral leishmaniasis.

Mollett G, Bremer Hinckel BC, Bhattacharyya T, Marlais T, Singh OP, Mertens P, Falconar AK, El-Safi S, Sundar S, Miles MA.

Clin Infect Dis. 2018 Dec 12. doi: 10.1093/cid/ciy1062. [Epub ahead of print]


Molecular typing reveals the co-existence of two transmission cycles of American cutaneous leishmaniasis in the Andean Region of Venezuela with Lutzomyia migonei as the vector.

Torrellas A, Ferrer E, Cruz I, Lima H, Delgado O, Rangel JC, Bravo JA, Chicharro C, Llanes-Acevedo IP, Miles MA, Feliciangeli MD.

Mem Inst Oswaldo Cruz. 2018 Dec 6;113(12):e180323. doi: 10.1590/0074-02760180323.


Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways.

Miles MA, Hawkins CJ.

Sci Rep. 2018 Sep 26;8(1):14421. doi: 10.1038/s41598-018-32517-9.


Dissecting the phyloepidemiology of Trypanosoma cruzi I (TcI) in Brazil by the use of high resolution genetic markers.

Roman F, das Chagas Xavier S, Messenger LA, Pavan MG, Miles MA, Jansen AM, Yeo M.

PLoS Negl Trop Dis. 2018 May 21;12(5):e0006466. doi: 10.1371/journal.pntd.0006466. eCollection 2018 May.


Severity of Chagasic Cardiomyopathy Is Associated With Response to a Novel Rapid Diagnostic Test for Trypanosoma cruzi TcII/V/VI.

Bhattacharyya T, Messenger LA, Bern C, Mertens P, Gilleman Q, Zeippen N, Bremer Hinckel BC, Murphy N, Gilman RH, Miles MA; Chagas Working Group in Bolivia and Peru .

Clin Infect Dis. 2018 Aug 1;67(4):519-524. doi: 10.1093/cid/ciy121.


Executioner caspases and CAD are essential for mutagenesis induced by TRAIL or vincristine.

Miles MA, Hawkins CJ.

Cell Death Dis. 2017 Oct 5;8(10):e3062. doi: 10.1038/cddis.2017.454.


Old and Novel Functions of Caspase-2.

Miles MA, Kitevska-Ilioski T, Hawkins CJ.

Int Rev Cell Mol Biol. 2017;332:155-212. doi: 10.1016/bs.ircmb.2016.12.002. Epub 2017 Jan 27. Review.


Diagnostic antigens for visceral leishmaniasis: clarification of nomenclatures.

Bhattacharyya T, Marlais T, Miles MA.

Parasit Vectors. 2017 Apr 13;10(1):178. doi: 10.1186/s13071-017-2120-x. Review.


Hosts and vectors of Trypanosoma cruzi discrete typing units in the Chagas disease endemic region of the Paraguayan Chaco.

Acosta N, López E, Lewis MD, Llewellyn MS, Gómez A, Román F, Miles MA, Yeo M.

Parasitology. 2017 Jun;144(7):884-898. doi: 10.1017/S0031182016002663. Epub 2017 Feb 9.


Importation of Hybrid Human-Associated Trypanosoma cruzi Strains of Southern South American Origin, Colombia.

Messenger LA, Ramirez JD, Llewellyn MS, Guhl F, Miles MA.

Emerg Infect Dis. 2016 Aug;22(8):1452-5. doi: 10.3201/eid2208.150786.


IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.

Shekhar TM, Miles MA, Gupte A, Taylor S, Tascone B, Walkley CR, Hawkins CJ.

Oncotarget. 2016 Jun 7;7(23):33866-86. doi: 10.18632/oncotarget.8980.


TRAIL causes deletions at the HPRT and TK1 loci of clonogenically competent cells.

Miles MA, Shekhar TM, Hall NE, Hawkins CJ.

Mutat Res. 2016 May;787:15-31. doi: 10.1016/j.mrfmmm.2016.02.006. Epub 2016 Feb 18.


Evidence and importance of genetic exchange among field populations of Trypanosoma cruzi.

Messenger LA, Miles MA.

Acta Trop. 2015 Nov;151:150-5. doi: 10.1016/j.actatropica.2015.05.007. Epub 2015 Jul 16.


Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease.

Messenger LA, Miles MA, Bern C.

Expert Rev Anti Infect Ther. 2015 Aug;13(8):995-1029. doi: 10.1586/14787210.2015.1056158. Review.


Prospects for T. cruzi lineage-specific serological surveillance of wild mammals.

Bhattacharyya T, Mills EA, Jansen AM, Miles MA.

Acta Trop. 2015 Nov;151:182-6. doi: 10.1016/j.actatropica.2015.06.017. Epub 2015 Jun 24.


Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.

Shekhar TM, Green MM, Rayner DM, Miles MA, Cutts SM, Hawkins CJ.

Mutat Res. 2015 Jul;777:23-32. doi: 10.1016/j.mrfmmm.2015.04.005. Epub 2015 Apr 15.


Deep sequencing of the Trypanosoma cruzi GP63 surface proteases reveals diversity and diversifying selection among chronic and congenital Chagas disease patients.

Llewellyn MS, Messenger LA, Luquetti AO, Garcia L, Torrico F, Tavares SB, Cheaib B, Derome N, Delepine M, Baulard C, Deleuze JF, Sauer S, Miles MA.

PLoS Negl Trop Dis. 2015 Apr 7;9(4):e0003458. doi: 10.1371/journal.pntd.0003458. eCollection 2015 Apr.


Ecological host fitting of Trypanosoma cruzi TcI in Bolivia: mosaic population structure, hybridization and a role for humans in Andean parasite dispersal.

Messenger LA, Garcia L, Vanhove M, Huaranca C, Bustamante M, Torrico M, Torrico F, Miles MA, Llewellyn MS.

Mol Ecol. 2015 May;24(10):2406-22. doi: 10.1111/mec.13186. Epub 2015 Apr 22.


Leishmania donovani populations in Eastern Sudan: temporal structuring and a link between human and canine transmission.

Baleela R, Llewellyn MS, Fitzpatrick S, Kuhls K, Schönian G, Miles MA, Mauricio IL.

Parasit Vectors. 2014 Nov 20;7:496. doi: 10.1186/s13071-014-0496-4.


Molecular genotyping of Trypanosoma cruzi for lineage assignment and population genetics.

Messenger LA, Yeo M, Lewis MD, Llewellyn MS, Miles MA.

Methods Mol Biol. 2015;1201:297-337. doi: 10.1007/978-1-4939-1438-8_19.


IgG1 as a potential biomarker of post-chemotherapeutic relapse in visceral leishmaniasis, and adaptation to a rapid diagnostic test.

Bhattacharyya T, Ayandeh A, Falconar AK, Sundar S, El-Safi S, Gripenberg MA, Bowes DE, Thunissen C, Singh OP, Kumar R, Ahmed O, Eisa O, Saad A, Silva Pereira S, Boelaert M, Mertens P, Miles MA.

PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3273. doi: 10.1371/journal.pntd.0003273. eCollection 2014 Oct.


Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity.

Zingales B, Miles MA, Moraes CB, Luquetti A, Guhl F, Schijman AG, Ribeiro I; Drugs for Neglected Disease Initiative; Chagas Clinical Research Platform Meeting.

Mem Inst Oswaldo Cruz. 2014 Sep;109(6):828-33. Epub 2014 Aug 22.


Optimized multilocus sequence typing (MLST) scheme for Trypanosoma cruzi.

Diosque P, Tomasini N, Lauthier JJ, Messenger LA, Monje Rumi MM, Ragone PG, Alberti-D'Amato AM, Pérez Brandán C, Barnabé C, Tibayrenc M, Lewis MD, Llewellyn MS, Miles MA, Yeo M.

PLoS Negl Trop Dis. 2014 Aug 28;8(8):e3117. doi: 10.1371/journal.pntd.0003117. eCollection 2014 Aug.


Multilocus sequence and microsatellite identification of intra-specific hybrids and ancestor-like donors among natural Ethiopian isolates of Leishmania donovani.

Gelanew T, Hailu A, Schőnian G, Lewis MD, Miles MA, Yeo M.

Int J Parasitol. 2014 Sep;44(10):751-7. doi: 10.1016/j.ijpara.2014.05.008. Epub 2014 Jul 1.


Wild Trypanosoma cruzi I genetic diversity in Brazil suggests admixture and disturbance in parasite populations from the Atlantic Forest region.

Lima VS, Jansen AM, Messenger LA, Miles MA, Llewellyn MS.

Parasit Vectors. 2014 Jun 5;7:263. doi: 10.1186/1756-3305-7-263.


Development of peptide-based lineage-specific serology for chronic Chagas disease: geographical and clinical distribution of epitope recognition.

Bhattacharyya T, Falconar AK, Luquetti AO, Costales JA, Grijalva MJ, Lewis MD, Messenger LA, Tran TT, Ramirez JD, Guhl F, Carrasco HJ, Diosque P, Garcia L, Litvinov SV, Miles MA.

PLoS Negl Trop Dis. 2014 May 22;8(5):e2892. doi: 10.1371/journal.pntd.0002892. eCollection 2014 May.


Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue-specific parasite dynamics and heart disease in the absence of locally persistent infection.

Lewis MD, Fortes Francisco A, Taylor MC, Burrell-Saward H, McLatchie AP, Miles MA, Kelly JM.

Cell Microbiol. 2014 Sep;16(9):1285-300. doi: 10.1111/cmi.12297. Epub 2014 May 1.


Percolation Diffusion into Self-Assembled Mesoporous Silica Microfibres.

Canning J, Huyang G, Ma M, Beavis A, Bishop D, Cook K, McDonagh A, Shi D, Peng GD, Crossley MJ.

Nanomaterials (Basel). 2014 Mar 10;4(1):157-174. doi: 10.3390/nano4010157.


Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis.

Bhattacharyya T, Bowes DE, El-Safi S, Sundar S, Falconar AK, Singh OP, Kumar R, Ahmed O, Boelaert M, Miles MA.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2675. doi: 10.1371/journal.pntd.0002675. eCollection 2014 Feb.


Molecular epidemiologic source tracking of orally transmitted Chagas disease, Venezuela.

Segovia M, Carrasco HJ, Martínez CE, Messenger LA, Nessi A, Londoño JC, Espinosa R, Martínez C, Alfredo M, Bonfante-Cabarcas R, Lewis MD, de Noya BA, Miles MA, Llewellyn MS.

Emerg Infect Dis. 2013 Jul;19(7):1098-101. doi: 10.3201/eid1907.121576.


Mucocutaneous leishmaniasis: knowledge, attitudes, and practices among paraguayan communities, patients, and health professionals.

Ruoti M, Oddone R, Lampert N, Orué E, Miles MA, Alexander N, Rehman AM, Njord R, Shu S, Brice S, Sinclair B, Krentel A.

J Trop Med. 2013;2013:538629. doi: 10.1155/2013/538629. Epub 2013 Apr 15.


Rapid diagnostic tests for neurological infections in central Africa.

Yansouni CP, Bottieau E, Lutumba P, Winkler AS, Lynen L, Büscher P, Jacobs J, Gillet P, Lejon V, Alirol E, Polman K, Utzinger J, Miles MA, Peeling RW, Muyembe JJ, Chappuis F, Boelaert M.

Lancet Infect Dis. 2013 Jun;13(6):546-58. doi: 10.1016/S1473-3099(13)70004-5. Epub 2013 Apr 24. Review.


Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms.

Bhattacharyya T, Boelaert M, Miles MA.

PLoS Negl Trop Dis. 2013;7(2):e2057. doi: 10.1371/journal.pntd.0002057. Epub 2013 Feb 28.


Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests.

Becker SL, Vogt J, Knopp S, Panning M, Warhurst DC, Polman K, Marti H, von Müller L, Yansouni CP, Jacobs J, Bottieau E, Sacko M, Rijal S, Meyanti F, Miles MA, Boelaert M, Lutumba P, van Lieshout L, N'Goran EK, Chappuis F, Utzinger J.

BMC Infect Dis. 2013 Jan 24;13:37. doi: 10.1186/1471-2334-13-37. Review.


New insights on taxonomy, phylogeny and population genetics of Leishmania (Viannia) parasites based on multilocus sequence analysis.

Boité MC, Mauricio IL, Miles MA, Cupolillo E.

PLoS Negl Trop Dis. 2012;6(11):e1888. doi: 10.1371/journal.pntd.0001888. Epub 2012 Nov 1.


North American import? Charting the origins of an enigmatic Trypanosoma cruzi domestic genotype.

Zumaya-Estrada FA, Messenger LA, Lopez-Ordonez T, Lewis MD, Flores-Lopez CA, Martínez-Ibarra AJ, Pennington PM, Cordon-Rosales C, Carrasco HV, Segovia M, Miles MA, Llewellyn MS.

Parasit Vectors. 2012 Oct 10;5:226. doi: 10.1186/1756-3305-5-226.


Comparative genomic analysis of human infective Trypanosoma cruzi lineages with the bat-restricted subspecies T. cruzi marinkellei.

Franzén O, Talavera-López C, Ochaya S, Butler CE, Messenger LA, Lewis MD, Llewellyn MS, Marinkelle CJ, Tyler KM, Miles MA, Andersson B.

BMC Genomics. 2012 Oct 5;13:531. doi: 10.1186/1471-2164-13-531.


Contemporary cryptic sexuality in Trypanosoma cruzi.

Ramírez JD, Guhl F, Messenger LA, Lewis MD, Montilla M, Cucunuba Z, Miles MA, Llewellyn MS.

Mol Ecol. 2012 Sep;21(17):4216-26. doi: 10.1111/j.1365-294X.2012.05699.x. Epub 2012 Jul 9. Erratum in: Mol Ecol. 2013 Mar;22(5):1482.


Geographical distribution of Trypanosoma cruzi genotypes in Venezuela.

Carrasco HJ, Segovia M, Llewellyn MS, Morocoima A, Urdaneta-Morales S, Martínez C, Martínez CE, Garcia C, Rodríguez M, Espinosa R, de Noya BA, Díaz-Bello Z, Herrera L, Fitzpatrick S, Yeo M, Miles MA, Feliciangeli MD.

PLoS Negl Trop Dis. 2012;6(6):e1707. doi: 10.1371/journal.pntd.0001707. Epub 2012 Jun 26.


Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing.

Messenger LA, Llewellyn MS, Bhattacharyya T, Franzén O, Lewis MD, Ramírez JD, Carrasco HJ, Andersson B, Miles MA.

PLoS Negl Trop Dis. 2012;6(4):e1584. doi: 10.1371/journal.pntd.0001584. Epub 2012 Apr 10.


The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications.

Zingales B, Miles MA, Campbell DA, Tibayrenc M, Macedo AM, Teixeira MM, Schijman AG, Llewellyn MS, Lages-Silva E, Machado CR, Andrade SG, Sturm NR.

Infect Genet Evol. 2012 Mar;12(2):240-53. doi: 10.1016/j.meegid.2011.12.009. Epub 2011 Dec 27. Review.


Candidate targets for Multilocus Sequence Typing of Trypanosoma cruzi: validation using parasite stocks from the Chaco Region and a set of reference strains.

Lauthier JJ, Tomasini N, Barnabé C, Rumi MM, D'Amato AM, Ragone PG, Yeo M, Lewis MD, Llewellyn MS, Basombrío MA, Miles MA, Tibayrenc M, Diosque P.

Infect Genet Evol. 2012 Mar;12(2):350-8. doi: 10.1016/j.meegid.2011.12.008. Epub 2011 Dec 22.


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