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Valproic acid interactions with the NavMs voltage-gated sodium channel.

Zanatta G, Sula A, Miles AJ, Ng LCT, Torella R, Pryde DC, DeCaen PG, Wallace BA.

Proc Natl Acad Sci U S A. 2019 Dec 10. pii: 201909696. doi: 10.1073/pnas.1909696116. [Epub ahead of print]


CDtoolX, a downloadable software package for processing and analyses of circular dichroism spectroscopic data.

Miles AJ, Wallace BA.

Protein Sci. 2018 Sep;27(9):1717-1722. doi: 10.1002/pro.3474.


The intrinsically disordered Tarp protein from chlamydia binds actin with a partially preformed helix.

Tolchard J, Walpole SJ, Miles AJ, Maytum R, Eaglen LA, Hackstadt T, Wallace BA, Blumenschein TMA.

Sci Rep. 2018 Jan 31;8(1):1960. doi: 10.1038/s41598-018-20290-8.


Mutagenesis of the NaChBac sodium channel discloses a functional role for a conserved S6 asparagine.

O'Reilly AO, Lattrell A, Miles AJ, Klinger AB, Nau C, Wallace BA, Lampert A.

Eur Biophys J. 2017 Oct;46(7):665-674. doi: 10.1007/s00249-017-1246-2. Epub 2017 Aug 20.


Differential dehydration effects on globular proteins and intrinsically disordered proteins during film formation.

Yoneda JS, Miles AJ, Araujo AP, Wallace BA.

Protein Sci. 2017 Apr;26(4):718-726. doi: 10.1002/pro.3118. Epub 2017 Feb 7.


Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.

Chin S, Yang D, Miles AJ, Eckford PD, Molinski S, Wallace BA, Bear CE.

J Biol Chem. 2017 Feb 3;292(5):1988-1999. doi: 10.1074/jbc.M116.762633. Epub 2016 Dec 21.


Isolated pores dissected from human two-pore channel 2 are functional.

Penny CJ, Rahman T, Sula A, Miles AJ, Wallace BA, Patel S.

Sci Rep. 2016 Dec 12;6:38426. doi: 10.1038/srep38426.


PCDDB: new developments at the Protein Circular Dichroism Data Bank.

Whitmore L, Miles AJ, Mavridis L, Janes RW, Wallace BA.

Nucleic Acids Res. 2017 Jan 4;45(D1):D303-D307. doi: 10.1093/nar/gkw796. Epub 2016 Sep 8.


Circular dichroism spectroscopy of membrane proteins.

Miles AJ, Wallace BA.

Chem Soc Rev. 2016 Sep 21;45(18):4859-72. doi: 10.1039/c5cs00084j. Epub 2016 Jun 27. Review.


Structure of the C-terminal domain of the prokaryotic sodium channel orthologue NsvBa.

Miller WC, Miles AJ, Wallace BA.

Eur Biophys J. 2016 Dec;45(8):807-814. Epub 2016 Apr 22.


Separation of cannabinoids on three different mixed-mode columns containing carbon/nanodiamond/amine-polymer superficially porous particles.

Hung CH, Zukowski J, Jensen DS, Miles AJ, Sulak C, Dadson AE, Linford MR.

J Sep Sci. 2015 Sep;38(17):2968-74. doi: 10.1002/jssc.201500156. Epub 2015 Jul 20.


X-ray, spectroscopic and normal-mode dynamics of calexcitin: structure-function studies of a neuronal calcium-signalling protein.

Erskine PT, Fokas A, Muriithi C, Rehman H, Yates LA, Bowyer A, Findlow IS, Hagan R, Werner JM, Miles AJ, Wallace BA, Wells SA, Wood SP, Cooper JB.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):615-31. doi: 10.1107/S1399004714026704. Epub 2015 Feb 26.


Distinct circular dichroism spectroscopic signatures of polyproline II and unordered secondary structures: applications in secondary structure analyses.

Lopes JL, Miles AJ, Whitmore L, Wallace BA.

Protein Sci. 2014 Dec;23(12):1765-72. doi: 10.1002/pro.2558. Epub 2014 Oct 30.


Lipid interactions of LAH4, a peptide with antimicrobial and nucleic acid transfection activities.

Perrone B, Miles AJ, Salnikov ES, Wallace BA, Bechinger B.

Eur Biophys J. 2014 Nov;43(10-11):499-507. doi: 10.1007/s00249-014-0980-y. Epub 2014 Sep 3.


Complexities of abdominoperineal surgery: synchronous resection of an ano-rectal adenocarcinoma and pelvic schwannoma.

Higgin RP, Glaysher MA, Zeidan BA, Miles AJ.

J Surg Case Rep. 2014 Jan 10;2014(1). pii: rjt120. doi: 10.1093/jscr/rjt120.


Large-scale genetic perturbations reveal regulatory networks and an abundance of gene-specific repressors.

Kemmeren P, Sameith K, van de Pasch LA, Benschop JJ, Lenstra TL, Margaritis T, O'Duibhir E, Apweiler E, van Wageningen S, Ko CW, van Heesch S, Kashani MM, Ampatziadis-Michailidis G, Brok MO, Brabers NA, Miles AJ, Bouwmeester D, van Hooff SR, van Bakel H, Sluiters E, Bakker LV, Snel B, Lijnzaad P, van Leenen D, Groot Koerkamp MJ, Holstege FC.

Cell. 2014 Apr 24;157(3):740-52. doi: 10.1016/j.cell.2014.02.054.


Improved efficiency of reversed-phase carbon/nanodiamond/polymer core-shell particles for HPLC using carbonized poly(divinylbenzene) microspheres as the core materials.

Hung CH, Wiest LA, Singh B, Diwan A, Valentim MJ, Christensen JM, Davis RC, Miles AJ, Jensen DS, Vail MA, Dadson AE, Linford MR.

J Sep Sci. 2013 Dec;36(24):3821-9. doi: 10.1002/jssc.201300988.


Rectal sling technique to assist rectal washout during laparoscopic anterior resection for colorectal cancer.

Glaysher MA, Moore T, Miles AJ.

Ann R Coll Surg Engl. 2013 Oct;95(7):531. doi: 10.1308/003588413X13781990150491e. No abstract available.


Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

van de Pasch LA, Miles AJ, Nijenhuis W, Brabers NA, van Leenen D, Lijnzaad P, Brown MK, Ouellet J, Barral Y, Kops GJ, Holstege FC.

PLoS One. 2013 Jun 13;8(6):e65628. doi: 10.1371/journal.pone.0065628. Print 2013.


Stabilisation of Na,K-ATPase structure by the cardiotonic steroid ouabain.

Miles AJ, Fedosova NU, Hoffmann SV, Wallace BA, Esmann M.

Biochem Biophys Res Commun. 2013 May 31;435(2):300-5. doi: 10.1016/j.bbrc.2013.04.021. Epub 2013 Apr 22.


Differential lipid dependence of the function of bacterial sodium channels.

D'Avanzo N, McCusker EC, Powl AM, Miles AJ, Nichols CG, Wallace BA.

PLoS One. 2013 Apr 8;8(4):e61216. doi: 10.1371/journal.pone.0061216. Print 2013.


Membrane defects enhance the interaction of antimicrobial peptides, aurein 1.2 versus caerin 1.1.

Fernandez DI, Sani MA, Miles AJ, Wallace BA, Separovic F.

Biochim Biophys Acta. 2013 Aug;1828(8):1863-72. doi: 10.1016/j.bbamem.2013.03.010. Epub 2013 Mar 15.


Circular dichroism spectral data and metadata in the Protein Circular Dichroism Data Bank (PCDDB): a tutorial guide to accession and deposition.

Janes RW, Miles AJ, Woollett B, Whitmore L, Klose D, Wallace BA.

Chirality. 2012 Sep;24(9):751-63. doi: 10.1002/chir.22050. Epub 2012 Jun 4.


Transmembrane and extramembrane contributions to membrane protein thermal stability: studies with the NaChBac sodium channel.

Powl AM, Miles AJ, Wallace BA.

Biochim Biophys Acta. 2012 Mar;1818(3):889-95. doi: 10.1016/j.bbamem.2011.12.019. Epub 2011 Dec 29.


Correlation of structural and functional thermal stability of the integral membrane protein Na,K-ATPase.

Miles AJ, Wallace BA, Esmann M.

Biochim Biophys Acta. 2011 Oct;1808(10):2573-80. doi: 10.1016/j.bbamem.2011.06.009. Epub 2011 Jun 25.


The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites.

Platzer G, Schedlbauer A, Chemelli A, Ozdowy P, Coudevylle N, Auer R, Kontaxis G, Hartl M, Miles AJ, Wallace BA, Glatter O, Bister K, Konrat R.

Biochemistry. 2011 Jul 12;50(27):6113-24. doi: 10.1021/bi200291e. Epub 2011 Jun 16.


The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein.

Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P Jr, Dwek RA, Wallace BA, Biggin PC, Zitzmann N.

Mol Membr Biol. 2011 Aug;28(5):254-64. doi: 10.3109/09687688.2011.581253. Epub 2011 May 23.


A reference dataset for the analyses of membrane protein secondary structures and transmembrane residues using circular dichroism spectroscopy.

Abdul-Gader A, Miles AJ, Wallace BA.

Bioinformatics. 2011 Jun 15;27(12):1630-6. doi: 10.1093/bioinformatics/btr234. Epub 2011 Apr 19.


Structural insights into the dynamics and function of the C-terminus of the E. coli RNA chaperone Hfq.

Beich-Frandsen M, Vecerek B, Konarev PV, Sjöblom B, Kloiber K, Hämmerle H, Rajkowitsch L, Miles AJ, Kontaxis G, Wallace BA, Svergun DI, Konrat R, Bläsi U, Djinovic-Carugo K.

Nucleic Acids Res. 2011 Jun;39(11):4900-15. doi: 10.1093/nar/gkq1346. Epub 2011 Feb 17.


Functional overlap and regulatory links shape genetic interactions between signaling pathways.

van Wageningen S, Kemmeren P, Lijnzaad P, Margaritis T, Benschop JJ, de Castro IJ, van Leenen D, Groot Koerkamp MJ, Ko CW, Miles AJ, Brabers N, Brok MO, Lenstra TL, Fiedler D, Fokkens L, Aldecoa R, Apweiler E, Taliadouros V, Sameith K, van de Pasch LA, van Hooff SR, Bakker LV, Krogan NJ, Snel B, Holstege FC.

Cell. 2010 Dec 10;143(6):991-1004. doi: 10.1016/j.cell.2010.11.021.


Structural basis of molecular recognition of the Leishmania small hydrophilic endoplasmic reticulum-associated protein (SHERP) at membrane surfaces.

Moore B, Miles AJ, Guerra-Giraldez C, Simpson P, Iwata M, Wallace BA, Matthews SJ, Smith DF, Brown KA.

J Biol Chem. 2011 Mar 18;286(11):9246-56. doi: 10.1074/jbc.M110.130427. Epub 2010 Nov 24.


PCDDB: the Protein Circular Dichroism Data Bank, a repository for circular dichroism spectral and metadata.

Whitmore L, Woollett B, Miles AJ, Klose DP, Janes RW, Wallace BA.

Nucleic Acids Res. 2011 Jan;39(Database issue):D480-6. doi: 10.1093/nar/gkq1026. Epub 2010 Nov 11.


The impact of stenting obstructing colorectal tumours in a district general hospital.

Phillips NJ, Arnold SJ, Elford J, Miles AJ.

Int J Surg. 2011;9(2):165-8. doi: 10.1016/j.ijsu.2010.10.013. Epub 2010 Nov 5.


The protein circular dichroism data bank, a Web-based site for access to circular dichroism spectroscopic data.

Whitmore L, Woollett B, Miles AJ, Janes RW, Wallace BA.

Structure. 2010 Oct 13;18(10):1267-9. doi: 10.1016/j.str.2010.08.008.


Consistent picture of the reversible thermal unfolding of hen egg-white lysozyme from experiment and molecular dynamics.

Meersman F, Atilgan C, Miles AJ, Bader R, Shang W, Matagne A, Wallace BA, Koch MH.

Biophys J. 2010 Oct 6;99(7):2255-63. doi: 10.1016/j.bpj.2010.07.060.


Changes in beta-lactoglobulin conformation at the oil/water interface of emulsions studied by synchrotron radiation circular dichroism spectroscopy.

Zhai J, Miles AJ, Pattenden LK, Lee TH, Augustin MA, Wallace BA, Aguilar MI, Wooster TJ.

Biomacromolecules. 2010 Aug 9;11(8):2136-42. doi: 10.1021/bm100510j.


Synchrotron radiation circular dichroism spectroscopy-defined structure of the C-terminal domain of NaChBac and its role in channel assembly.

Powl AM, O'Reilly AO, Miles AJ, Wallace BA.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14064-9. doi: 10.1073/pnas.1001793107. Epub 2010 Jul 27.


Anastomotic leak rate and outcome for laparoscopic intra-corporeal stapled anastomosis.

Goriainov V, Miles AJ.

J Minim Access Surg. 2010 Jan;6(1):6-10. doi: 10.4103/0972-9941.62527.


Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma.

Kintzer AF, Sterling HJ, Tang II, Abdul-Gader A, Miles AJ, Wallace BA, Williams ER, Krantz BA.

J Mol Biol. 2010 Jun 25;399(5):741-58. doi: 10.1016/j.jmb.2010.04.041. Epub 2010 Apr 28.


Subcutaneous lateral internal sphincterotomy (SLIS)--a safe technique for treatment of chronic anal fissure.

Khan JS, Tan N, Nikkhah D, Miles AJ.

Int J Colorectal Dis. 2009 Oct;24(10):1207-11. doi: 10.1007/s00384-009-0765-4. Epub 2009 Jul 21.


Effect of lipid on the conformation of the N-terminal region of equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study.

Drechsler A, Miles AJ, Norton RS, Wallace BA, Separovic F.

Eur Biophys J. 2009 Dec;39(1):121-7. doi: 10.1007/s00249-009-0445-x. Epub 2009 Apr 3.


Light flux density threshold at which protein denaturation is induced by synchrotron radiation circular dichroism beamlines.

Miles AJ, Janes RW, Brown A, Clarke DT, Sutherland JC, Tao Y, Wallace BA, Hoffmann SV.

J Synchrotron Radiat. 2008 Jul;15(Pt 4):420-2. doi: 10.1107/S0909049508009606. Epub 2008 May 8.


The effects of lipids on the structure of the eukaryotic cytolysin equinatoxin II: a synchrotron radiation circular dichroism spectroscopic study.

Miles AJ, Drechsler A, Kristan K, Anderluh G, Norton RS, Wallace BA, Separovic F.

Biochim Biophys Acta. 2008 Oct;1778(10):2091-6. doi: 10.1016/j.bbamem.2008.04.001. Epub 2008 Apr 8.


[Not Available].

Goriainov V, Miles AJ.

J Minim Access Surg. 2008 Apr;4(2):39-43.


Charge-transfer transitions in the vacuum-ultraviolet of protein circular dichroism spectra.

Bulheller BM, Miles AJ, Wallace BA, Hirst JD.

J Phys Chem B. 2008 Feb 14;112(6):1866-74. doi: 10.1021/jp077462k. Epub 2008 Jan 17.


Evaluating protein:protein complex formation using synchrotron radiation circular dichroism spectroscopy.

Cowieson NP, Miles AJ, Robin G, Forwood JK, Kobe B, Martin JL, Wallace BA.

Proteins. 2008 Mar;70(4):1142-6.


Day case haemorrhoidectomy.

Miles AJ, Dunkley AJ.

Colorectal Dis. 2007 Jul;9(6):532-5.


A reference database for circular dichroism spectroscopy covering fold and secondary structure space.

Lees JG, Miles AJ, Wien F, Wallace BA.

Bioinformatics. 2006 Aug 15;22(16):1955-62. Epub 2006 Jun 20.


Synchrotron radiation circular dichroism spectroscopy of proteins and applications in structural and functional genomics.

Miles AJ, Wallace BA.

Chem Soc Rev. 2006 Jan;35(1):39-51. Epub 2005 Nov 14. Review.


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