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Items: 1 to 50 of 290

1.

DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration.

Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A.

Mol Neurobiol. 2019 Nov 7. doi: 10.1007/s12035-019-01796-2. [Epub ahead of print]

PMID:
31696428
2.

Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.

Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A.

JCI Insight. 2019 Sep 5;4(17). pii: 129920. doi: 10.1172/jci.insight.129920.

3.

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.

Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT.

Science. 2019 Aug 23;365(6455):799-803. doi: 10.1126/science.aax1771.

PMID:
31439793
4.

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J.

J Exp Med. 2019 Feb 4;216(2):294-303. doi: 10.1084/jem.20181040. Epub 2019 Jan 14.

5.

HSP90 is a chaperone for DLK and is required for axon injury signaling.

Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9899-E9908. doi: 10.1073/pnas.1805351115. Epub 2018 Oct 1.

6.

Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.

Avey D, Sankararaman S, Yim AKY, Barve R, Milbrandt J, Mitra RD.

Cell Rep. 2018 Sep 25;24(13):3619-3629.e4. doi: 10.1016/j.celrep.2018.08.080.

7.

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.

Summers DW, Milbrandt J, DiAntonio A.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):E8746-E8754. doi: 10.1073/pnas.1806933115. Epub 2018 Aug 27.

8.

Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN.

Kim S, Maynard JC, Strickland A, Burlingame AL, Milbrandt J.

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):8019-8024. doi: 10.1073/pnas.1805538115. Epub 2018 Jul 16.

9.

Dysregulation of NAD+ Metabolism Induces a Schwann Cell Dedifferentiation Program.

Sasaki Y, Hackett AR, Kim S, Strickland A, Milbrandt J.

J Neurosci. 2018 Jul 18;38(29):6546-6562. doi: 10.1523/JNEUROSCI.3304-17.2018. Epub 2018 Jun 19.

10.

TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.

Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A.

eNeuro. 2018 May 30;5(3). pii: ENEURO.0095-18.2018. doi: 10.1523/ENEURO.0095-18.2018. eCollection 2018 May-Jun.

11.

TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J.

Curr Biol. 2018 Feb 5;28(3):421-430.e4. doi: 10.1016/j.cub.2017.12.024. Epub 2018 Jan 25.

12.

Abnormal Microglia and Enhanced Inflammation-Related Gene Transcription in Mice with Conditional Deletion of Ctcf in Camk2a-Cre-Expressing Neurons.

McGill BE, Barve RA, Maloney SE, Strickland A, Rensing N, Wang PL, Wong M, Head R, Wozniak DF, Milbrandt J.

J Neurosci. 2018 Jan 3;38(1):200-219. doi: 10.1523/JNEUROSCI.0936-17.2017. Epub 2017 Nov 13.

13.

NMNAT3 is protective against the effects of neonatal cerebral hypoxia-ischemia.

Galindo R, Banks Greenberg M, Araki T, Sasaki Y, Mehta N, Milbrandt J, Holtzman DM.

Ann Clin Transl Neurol. 2017 Aug 30;4(10):722-738. doi: 10.1002/acn3.450. eCollection 2017 Oct.

14.

mTORC1 promotes proliferation of immature Schwann cells and myelin growth of differentiated Schwann cells.

Beirowski B, Wong KM, Babetto E, Milbrandt J.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4261-E4270. doi: 10.1073/pnas.1620761114. Epub 2017 May 8.

15.

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration.

Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J.

Neuron. 2017 Mar 22;93(6):1334-1343.e5. doi: 10.1016/j.neuron.2017.02.022.

16.

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2.

Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A.

Elife. 2017 Jan 17;6. pii: e22540. doi: 10.7554/eLife.22540.

17.

An NAD+-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma.

Gujar AD, Le S, Mao DD, Dadey DY, Turski A, Sasaki Y, Aum D, Luo J, Dahiya S, Yuan L, Rich KM, Milbrandt J, Hallahan DE, Yano H, Tran DD, Kim AH.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):E8247-E8256. doi: 10.1073/pnas.1610921114. Epub 2016 Dec 7.

18.

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.

Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A.

Brain. 2016 Dec;139(Pt 12):3092-3108. Epub 2016 Oct 25.

19.

Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

Kurowska Z, Kordower JH, Stoessl AJ, Burke RE, Brundin P, Yue Z, Brady ST, Milbrandt J, Trapp BD, Sherer TB, Medicetty S.

J Parkinsons Dis. 2016 Oct 19;6(4):703-707. Review.

PMID:
27497486
20.

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion.

Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J.

Elife. 2016 Oct 13;5. pii: e19749. doi: 10.7554/eLife.19749.

21.

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.

Summers DW, Gibson DA, DiAntonio A, Milbrandt J.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6271-E6280. Epub 2016 Sep 26.

22.

Schwann Cell O-GlcNAc Glycosylation Is Required for Myelin Maintenance and Axon Integrity.

Kim S, Maynard JC, Sasaki Y, Strickland A, Sherman DL, Brophy PJ, Burlingame AL, Milbrandt J.

J Neurosci. 2016 Sep 14;36(37):9633-46. doi: 10.1523/JNEUROSCI.1235-16.2016.

23.

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy.

Musiek ES, Xiong DD, Patel T, Sasaki Y, Wang Y, Bauer AQ, Singh R, Finn SL, Culver JP, Milbrandt J, Holtzman DM.

Ann Clin Transl Neurol. 2016 May 6;3(6):434-42. doi: 10.1002/acn3.308. eCollection 2016 Jun.

24.

Extracellular pH Modulates Neuroendocrine Prostate Cancer Cell Metabolism and Susceptibility to the Mitochondrial Inhibitor Niclosamide.

Ippolito JE, Brandenburg MW, Ge X, Crowley JR, Kirmess KM, Som A, D'Avignon DA, Arbeit JM, Achilefu S, Yarasheski KE, Milbrandt J.

PLoS One. 2016 Jul 20;11(7):e0159675. doi: 10.1371/journal.pone.0159675. eCollection 2016.

25.

TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance.

Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A.

J Neurosci. 2016 Apr 27;36(17):4681-9. doi: 10.1523/JNEUROSCI.2893-15.2016.

26.

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism.

Gerdts J, Summers DW, Milbrandt J, DiAntonio A.

Neuron. 2016 Feb 3;89(3):449-60. doi: 10.1016/j.neuron.2015.12.023. Review.

27.

Feeding the brain and nurturing the mind: Linking nutrition and the gut microbiota to brain development.

Goyal MS, Venkatesh S, Milbrandt J, Gordon JI, Raichle ME.

Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14105-12. doi: 10.1073/pnas.1511465112. Review.

28.

Comparison of rates of emergency department procedures and critical diagnoses in metropolitan and rural hospitals.

Waymack JR, Markwell S, Milbrandt JC, Clark TR.

Rural Remote Health. 2015 Oct-Dec;15(4):3298. Epub 2015 Oct 13.

29.

Characterization of Leber Congenital Amaurosis-associated NMNAT1 Mutants.

Sasaki Y, Margolin Z, Borgo B, Havranek JJ, Milbrandt J.

J Biol Chem. 2015 Jul 10;290(28):17228-38. doi: 10.1074/jbc.M115.637850. Epub 2015 May 27.

30.

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

Fairfield H, Srivastava A, Ananda G, Liu R, Kircher M, Lakshminarayana A, Harris BS, Karst SY, Dionne LA, Kane CC, Curtain M, Berry ML, Ward-Bailey PF, Greenstein I, Byers C, Czechanski A, Sharp J, Palmer K, Gudis P, Martin W, Tadenev A, Bogdanik L, Pratt CH, Chang B, Schroeder DG, Cox GA, Cliften P, Milbrandt J, Murray S, Burgess R, Bergstrom DE, Donahue LR, Hamamy H, Masri A, Santoni FA, Makrythanasis P, Antonarakis SE, Shendure J, Reinholdt LG.

Genome Res. 2015 Jul;25(7):948-57. doi: 10.1101/gr.186882.114. Epub 2015 Apr 27.

31.

SARM1 activation triggers axon degeneration locally via NAD⁺ destruction.

Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J.

Science. 2015 Apr 24;348(6233):453-7. doi: 10.1126/science.1258366. Epub 2015 Apr 23.

32.

An in vitro assay to study induction of the regenerative state in sensory neurons.

Frey E, Valakh V, Karney-Grobe S, Shi Y, Milbrandt J, DiAntonio A.

Exp Neurol. 2015 Jan;263:350-63. doi: 10.1016/j.expneurol.2014.10.012. Epub 2014 Nov 4.

33.

Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance.

Beirowski B, Babetto E, Golden JP, Chen YJ, Yang K, Gross RW, Patti GJ, Milbrandt J.

Nat Neurosci. 2014 Oct;17(10):1351-61. doi: 10.1038/nn.3809. Epub 2014 Sep 7.

34.

Typed versus voice recognition for data entry in electronic health records: emergency physician time use and interruptions.

Dela Cruz JE, Shabosky JC, Albrecht M, Clark TR, Milbrandt JC, Markwell SJ, Kegg JA.

West J Emerg Med. 2014 Jul;15(4):541-7. doi: 10.5811/westjem.2014.3.19658.

35.

Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons.

Summers DW, DiAntonio A, Milbrandt J.

J Neurosci. 2014 Jul 9;34(28):9338-50. doi: 10.1523/JNEUROSCI.0877-14.2014.

36.

Comparison of procedural sedation for the reduction of dislocated total hip arthroplasty.

Dela Cruz JE, Sullivan DN, Varboncouer E, Milbrandt JC, Duong M, Burdette S, O'Keefe D, Scaife SL, Saleh KJ.

West J Emerg Med. 2014 Feb;15(1):76-80. doi: 10.5811/westjem.2013.7.15616.

37.

Impact of an anesthesiology rotation on subsequent endotracheal intubation success.

Clark TR, Brizendine EJ, Milbrandt JC, Rodgers KG.

J Grad Med Educ. 2013 Mar;5(1):70-3. doi: 10.4300/JGME-D-11-00268.1.

38.

Clinical genomicist workstation.

Sharma MK, Phillips J, Agarwal S, Wiggins WS, Shrivastava S, Koul SB, Bhattacharjee M, Houchins CD, Kalakota RR, George B, Meyer RR, Spencer DH, Lockwood CM, Nguyen TT, Duncavage EJ, Al-Kateb H, Cottrell CE, Godala S, Lokineni R, Sawant SM, Chatti V, Surampudi S, Sunkishala RR, Darbha R, Macharla S, Milbrandt JD, Virgin HW, Mitra RD, Head RD, Kulkarni S, Bredemeyer A, Pfeifer JD, Seibert K, Nagarajan R.

AMIA Jt Summits Transl Sci Proc. 2013 Mar 18;2013:156-7. eCollection 2013.

PMID:
24303327
39.

Validation of a next-generation sequencing assay for clinical molecular oncology.

Cottrell CE, Al-Kateb H, Bredemeyer AJ, Duncavage EJ, Spencer DH, Abel HJ, Lockwood CM, Hagemann IS, O'Guin SM, Burcea LC, Sawyer CS, Oschwald DM, Stratman JL, Sher DA, Johnson MR, Brown JT, Cliften PF, George B, McIntosh LD, Shrivastava S, Nguyen TT, Payton JE, Watson MA, Crosby SD, Head RD, Mitra RD, Nagarajan R, Kulkarni S, Seibert K, Virgin HW 4th, Milbrandt J, Pfeifer JD.

J Mol Diagn. 2014 Jan;16(1):89-105. doi: 10.1016/j.jmoldx.2013.10.002. Epub 2013 Nov 6.

40.

Sarm1-mediated axon degeneration requires both SAM and TIR interactions.

Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J.

J Neurosci. 2013 Aug 14;33(33):13569-80. doi: 10.1523/JNEUROSCI.1197-13.2013.

41.

The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.

Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A.

Cell Rep. 2013 May 30;3(5):1422-9. doi: 10.1016/j.celrep.2013.04.013. Epub 2013 May 9.

42.

Role of oxygen consumption in hypoxia protection by translation factor depletion.

Scott B, Sun CL, Mao X, Yu C, Vohra BP, Milbrandt J, Crowder CM.

J Exp Biol. 2013 Jun 15;216(Pt 12):2283-92. doi: 10.1242/jeb.082263. Epub 2013 Mar 26.

43.

Aberrant Schwann cell lipid metabolism linked to mitochondrial deficits leads to axon degeneration and neuropathy.

Viader A, Sasaki Y, Kim S, Strickland A, Workman CS, Yang K, Gross RW, Milbrandt J.

Neuron. 2013 Mar 6;77(5):886-98. doi: 10.1016/j.neuron.2013.01.012.

44.

An integrated approach to characterize transcription factor and microRNA regulatory networks involved in Schwann cell response to peripheral nerve injury.

Chang LW, Viader A, Varghese N, Payton JE, Milbrandt J, Nagarajan R.

BMC Genomics. 2013 Feb 6;14:84. doi: 10.1186/1471-2164-14-84.

45.

Protection of mouse retinal ganglion cell axons and soma from glaucomatous and ischemic injury by cytoplasmic overexpression of Nmnat1.

Zhu Y, Zhang L, Sasaki Y, Milbrandt J, Gidday JM.

Invest Ophthalmol Vis Sci. 2013 Jan 2;54(1):25-36. doi: 10.1167/iovs.12-10861.

46.

SCG10 is a JNK target in the axonal degeneration pathway.

Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3696-705. doi: 10.1073/pnas.1216204109. Epub 2012 Nov 27.

47.

Gastric volvulus complication in an infant with undiagnosed congenital diaphragmatic hernia presenting with acute respiratory distress.

Ito TE, Hasnie R, Crosby DL, Milbrandt JC, Ettema S, Duong M.

Pediatr Emerg Care. 2012 Oct;28(10):1078-80. doi: 10.1097/PEC.0b013e31826cedaf.

PMID:
23034498
48.

Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.

Patel A, Harker N, Moreira-Santos L, Ferreira M, Alden K, Timmis J, Foster K, Garefalaki A, Pachnis P, Andrews P, Enomoto H, Milbrandt J, Pachnis V, Coles MC, Kioussis D, Veiga-Fernandes H.

Sci Signal. 2012 Jul 31;5(235):ra55. doi: 10.1126/scisignal.2002734.

49.

Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration.

Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A.

Neuron. 2012 Jun 21;74(6):1015-22. doi: 10.1016/j.neuron.2012.04.028.

50.

The AMPK β2 subunit is required for energy homeostasis during metabolic stress.

Dasgupta B, Ju JS, Sasaki Y, Liu X, Jung SR, Higashida K, Lindquist D, Milbrandt J.

Mol Cell Biol. 2012 Jul;32(14):2837-48. doi: 10.1128/MCB.05853-11. Epub 2012 May 14.

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