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A novel secreted-cAMP pathway inhibits pulmonary hypertension via a feed-forward mechanism.

Jones C, Bisserier M, Bueno-Beti C, Bonnet G, Neves-Zaph S, Lee SY, Milara J, Dorfmüller P, Humbert M, Leopold JA, Hadri L, Hajjar RJ, Sassi Y.

Cardiovasc Res. 2019 Sep 14. pii: cvz244. doi: 10.1093/cvr/cvz244. [Epub ahead of print]


Mucins as a New Frontier in Pulmonary Fibrosis.

Ballester B, Milara J, Cortijo J.

J Clin Med. 2019 Sep 11;8(9). pii: E1447. doi: 10.3390/jcm8091447. Review.


Osimertinib in first-line treatment of advanced EGFR-mutated non-small-cell lung cancer: a cost-effectiveness analysis.

Aguilar-Serra J, Gimeno-Ballester V, Pastor-Clerigues A, Milara J, Marti-Bonmati E, Trigo-Vicente C, Alós-Almiñana M, Cortijo J.

J Comp Eff Res. 2019 Aug;8(11):853-863. doi: 10.2217/cer-2019-0029. Epub 2019 Sep 3.


Safe neoadjuvant trastuzumab-based treatment in HER2 + inflammatory early breast cancer in a glucose 6-phosphate dehydrogenase-deficient postmenopausal woman: A case report and review of the literature.

Cunquero-Tomás AJ, Ávila-Andrade CD, Milara J, Javier K, Iranzo V, Camps C.

J Oncol Pharm Pract. 2019 Jul 1:1078155219858173. doi: 10.1177/1078155219858173. [Epub ahead of print]


Idiopathic Pulmonary Fibrosis and Lung Cancer: Mechanisms and Molecular Targets.

Ballester B, Milara J, Cortijo J.

Int J Mol Sci. 2019 Jan 30;20(3). pii: E593. doi: 10.3390/ijms20030593. Review.


In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.

Milara J, Contreras S, de Diego A, Calbet M, Aparici M, Morcillo E, Miralpeix M, Cortijo J.

PLoS One. 2019 Jan 4;14(1):e0210188. doi: 10.1371/journal.pone.0210188. eCollection 2019.


MUC1 deficiency mediates corticosteroid resistance in chronic obstructive pulmonary disease.

Milara J, Díaz-Platas L, Contreras S, Ribera P, Roger I, Ballester B, Montero P, Cogolludo Á, Morcillo E, Cortijo J.

Respir Res. 2018 Nov 20;19(1):226. doi: 10.1186/s12931-018-0927-4.


Mucin 1 deficiency mediates corticosteroid insensitivity in asthma.

Milara J, Morell A, de Diego A, Artigues E, Morcillo E, Cortijo J.

Allergy. 2019 Jan;74(1):111-121. doi: 10.1111/all.13546. Epub 2018 Oct 2.


JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study.

Milara J, Ballester B, Morell A, Ortiz JL, Escrivá J, Fernández E, Perez-Vizcaino F, Cogolludo A, Pastor E, Artigues E, Morcillo E, Cortijo J.

Thorax. 2018 Jun;73(6):519-529. doi: 10.1136/thoraxjnl-2017-210728. Epub 2018 Feb 10.


The JAK2 pathway is activated in idiopathic pulmonary fibrosis.

Milara J, Hernandez G, Ballester B, Morell A, Roger I, Montero P, Escrivá J, Lloris JM, Molina-Molina M, Morcillo E, Cortijo J.

Respir Res. 2018 Feb 6;19(1):24. doi: 10.1186/s12931-018-0728-9.


Riociguat versus sildenafil on hypoxic pulmonary vasoconstriction and ventilation/perfusion matching.

Chamorro V, Morales-Cano D, Milara J, Barreira B, Moreno L, Callejo M, Mondejar-Parreño G, Esquivel-Ruiz S, Cortijo J, Cogolludo Á, Barberá JA, Perez-Vizcaino F.

PLoS One. 2018 Jan 24;13(1):e0191239. doi: 10.1371/journal.pone.0191239. eCollection 2018.


Selective Inhibition of Phosphodiesterases 4A, B, C and D Isoforms in Chronic Respiratory Diseases: Current and Future Evidences.

Contreras S, Milara J, Morcillo E, Cortijo J.

Curr Pharm Des. 2017;23(14):2073-2083. doi: 10.2174/1381612823666170214105651. Review.


Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients.

Milara J, Cervera A, de Diego A, Sanz C, Juan G, Gavaldà A, Miralpeix M, Morcillo E, Cortijo J.

Respir Res. 2016 Nov 8;17(1):145.


Evaluation of Mucociliary Clearance by Three Dimension Micro-CT-SPECT in Guinea Pig: Role of Bitter Taste Agonists.

Ortiz JL, Ortiz A, Milara J, Armengot M, Sanz C, Compañ D, Morcillo E, Cortijo J.

PLoS One. 2016 Oct 10;11(10):e0164399. doi: 10.1371/journal.pone.0164399. eCollection 2016.


MUC4 impairs the anti-inflammatory effects of corticosteroids in patients with chronic rhinosinusitis with nasal polyps.

Milara J, Morell A, Ballester B, Armengot M, Morcillo E, Cortijo J.

J Allergy Clin Immunol. 2017 Mar;139(3):855-862.e13. doi: 10.1016/j.jaci.2016.06.064. Epub 2016 Sep 14.


Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: an ex vivo/in vitro study.

Milara J, Escrivá J, Ortiz JL, Juan G, Artigues E, Morcillo E, Cortijo J.

Eur Respir J. 2016 Jun;47(6):1737-49. doi: 10.1183/13993003.01259-2015. Epub 2016 Mar 23.


mRNA PGC-1α levels in blood samples reliably correlates with its myocardial expression: study in patients undergoing cardiac surgery.

Fabregat-Andres O, Paredes F, Monsalve M, Milara J, Ridocci-Soriano F, Gonzalez-Hervas S, Mena A, Facila L, Hornero F, Morell S, Martinez-Leon J, Cortijo J.

Anatol J Cardiol. 2016 Aug;16(8):622-629. doi: 10.5152/AnatolJCardiol.2015.6466. Epub 2015 Nov 26.


Phosphatidylcholine liposomes as carriers to improve topical ascorbic acid treatment of skin disorders.

Serrano G, Almudéver P, Serrano JM, Milara J, Torrens A, Expósito I, Cortijo J.

Clin Cosmet Investig Dermatol. 2015 Dec 17;8:591-9. doi: 10.2147/CCID.S90781. eCollection 2015.


Evaluation of the Ocular Tolerance of Three Tacrolimus Topical Pharmaceutical Preparations by Bovine Corneal Opacity and Permeability Test.

Pastor-Clerigues A, Serrano A, Milara J, Marti-Bonmati E, Lopez-Perez FJ, Garcia-Montanes S, Sanfeliu J, Saval-Victoria AC, Cortijo J.

Curr Eye Res. 2016 Jul;41(7):890-6. doi: 10.3109/02713683.2015.1082187. Epub 2015 Nov 10.


Roflumilast Prevents the Metabolic Effects of Bleomycin-Induced Fibrosis in a Murine Model.

Milara J, Morcillo E, Monleon D, Tenor H, Cortijo J.

PLoS One. 2015 Jul 20;10(7):e0133453. doi: 10.1371/journal.pone.0133453. eCollection 2015.


PEG-Interferon-α ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study.

Milara J, Outeda-Macias M, Aumente-Rubio MD, Más-Serrano P, Aldaz A, Calvo MV, García-Simón MS, Martin-Barbero M, Padullés-Zamora N, Schoenenberger JA, Saavedra-Aldrich M, Tévar-Alfonso E, Saval A, Pastor-Clerigues A, García M, Margusino-Framiñan L, Montero-Alvarez JL, Merino E, Herrero JI, Beunza M, Conesa-Zamora P, Gimenez-Manzorro A, Comas-Sugrañes D, Cano-Marron M, Jiménez-Mutiloa E, Díaz-Ruíz P, Cortijo J.

Farm Hosp. 2015 Jan 1;39(1):29-43. doi: 10.7399/fh.2015.39.1.8547.


Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist.

Milara J, Morell A, Ballester B, Sanz C, Freire J, Qian X, Alonso-Garcia M, Morcillo E, Cortijo J.

Respir Res. 2015 Feb 5;16:12. doi: 10.1186/s12931-015-0179-5.


Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease.

Pastor-Clerigues A, Marti-Bonmati E, Milara J, Almudever P, Cortijo J.

PLoS One. 2014 Dec 12;9(12):e115404. doi: 10.1371/journal.pone.0115404. eCollection 2014.


Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro.

Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, Sanz C, Cortijo J.

COPD. 2015 Jun;12(3):320-31. doi: 10.3109/15412555.2014.948995. Epub 2014 Sep 10.


Mucin 1 downregulation associates with corticosteroid resistance in chronic rhinosinusitis with nasal polyps.

Milara J, Peiró T, Armengot M, Frias S, Morell A, Serrano A, Cortijo J.

J Allergy Clin Immunol. 2015 Feb;135(2):470-6. doi: 10.1016/j.jaci.2014.07.011. Epub 2014 Aug 23.


Roflumilast N-oxide reverses corticosteroid resistance in neutrophils from patients with chronic obstructive pulmonary disease.

Milara J, Lluch J, Almudever P, Freire J, Xiaozhong Q, Cortijo J.

J Allergy Clin Immunol. 2014 Aug;134(2):314-22. doi: 10.1016/j.jaci.2014.02.001. Epub 2014 Mar 15.


Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD.

Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, Cortijo J.

Pulm Pharmacol Ther. 2014 Aug;28(2):138-48. doi: 10.1016/j.pupt.2014.02.001. Epub 2014 Feb 11.


Authors' response to: epithelial mesenchymal transition (EMT) in small airways of COPD patient.

Milara J, Peiró T, Serrano A, Cortijo J.

Thorax. 2013 Aug;68(8):784. doi: 10.1136/thoraxjnl-2013-203484. Epub 2013 Mar 26. No abstract available.


Bafetinib inhibits functional responses of human eosinophils in vitro.

Milara J, Martinez-Losa M, Sanz C, Almudéver P, Peiró T, Serrano A, Morcillo EJ, Zaragozá C, Cortijo J.

Eur J Pharmacol. 2013 Sep 5;715(1-3):172-80. doi: 10.1016/j.ejphar.2013.05.025. Epub 2013 Jun 6.


Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis.

Almudéver P, Milara J, De Diego A, Serrano-Mollar A, Xaubet A, Perez-Vizcaino F, Cogolludo A, Cortijo J.

Thorax. 2013 Oct;68(10):938-48. doi: 10.1136/thoraxjnl-2013-203408. Epub 2013 Jun 5.


Effects of long-term azithromycin therapy on airway oxidative stress markers in non-cystic fibrosis bronchiectasis.

Diego AD, Milara J, Martinez-Moragón E, Palop M, León M, Cortijo J.

Respirology. 2013 Oct;18(7):1056-62. doi: 10.1111/resp.12130.


Study of USH1 splicing variants through minigenes and transcript analysis from nasal epithelial cells.

Aparisi MJ, García-García G, Aller E, Sequedo MD, Martínez-Fernández de la Cámara C, Rodrigo R, Armengot M, Cortijo J, Milara J, Díaz-LLopis M, Jaijo T, Millán JM.

PLoS One. 2013;8(2):e57506. doi: 10.1371/journal.pone.0057506. Epub 2013 Feb 25.


Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke.

Milara J, Peiró T, Serrano A, Cortijo J.

Thorax. 2013 May;68(5):410-20. doi: 10.1136/thoraxjnl-2012-201761. Epub 2013 Jan 7.


Phosphodiesterase-4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress.

Ortiz JL, Milara J, Lluch J, De Diego A, Sanz C, Cortijo J.

Allergy. 2013 Jan;68(1):64-73. doi: 10.1111/all.12055. Epub 2012 Nov 5.


Aclidinium inhibits cigarette smoke-induced lung fibroblast-to-myofibroblast transition.

Milara J, Serrano A, Peiró T, Artigues E, Gavaldà A, Miralpeix M, Morcillo EJ, Cortijo J.

Eur Respir J. 2013 Jun;41(6):1264-74. doi: 10.1183/09031936.00017712. Epub 2012 Sep 27.


Tobacco, inflammation, and respiratory tract cancer.

Milara J, Cortijo J.

Curr Pharm Des. 2012;18(26):3901-38. Review.


Nasal ciliary beat frequency and beat pattern in retinal ciliopathies.

Armengot M, Salom D, Diaz-Llopis M, Millan JM, Milara J, Mata M, Cortijo J.

Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2076-9. doi: 10.1167/iovs.11-8666.


Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitro.

Milara J, Armengot M, Bañuls P, Tenor H, Beume R, Artigues E, Cortijo J.

Br J Pharmacol. 2012 Aug;166(8):2243-62. doi: 10.1111/j.1476-5381.2012.01929.x.


Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition.

Milara J, Navarro R, Juan G, Peiró T, Serrano A, Ramón M, Morcillo E, Cortijo J.

Thorax. 2012 Feb;67(2):147-56. doi: 10.1136/thoraxjnl-2011-200026. Epub 2011 Nov 21.


Neutrophil activation in severe, early-onset COPD patients versus healthy non-smoker subjects in vitro: effects of antioxidant therapy.

Milara J, Juan G, Peiró T, Serrano A, Cortijo J.

Respiration. 2012;83(2):147-58. doi: 10.1159/000332834. Epub 2011 Nov 17.


Aclidinium inhibits human lung fibroblast to myofibroblast transition.

Milara J, Serrano A, Peiró T, Gavaldà A, Miralpeix M, Morcillo EJ, Cortijo J.

Thorax. 2012 Mar;67(3):229-37. doi: 10.1136/thoraxjnl-2011-200376. Epub 2011 Sep 28.


Development and validation of a method of cilia motility analysis for the early diagnosis of primary ciliary dyskinesia.

Armengot M, Bonet M, Carda C, Gómez MJ, Milara J, Mata M, Cortijo J.

Acta Otorrinolaringol Esp. 2012 Jan-Feb;63(1):1-8. doi: 10.1016/j.otorri.2011.07.001. Epub 2011 Sep 9. English, Spanish.


Bosentan inhibits cigarette smoke-induced endothelin receptor expression in pulmonary arteries.

Milara J, Gabarda E, Juan G, Ortiz JL, Guijarro R, Martorell M, Morcillo EJ, Cortijo J.

Eur Respir J. 2012 Apr;39(4):927-38. doi: 10.1183/09031936.00021411. Epub 2011 Aug 4.


Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers.

Dalli E, Vallés J, Cosín-Sales J, Santos MT, Moscardó A, Milara J, Sotillo JF.

Thromb Res. 2011 Oct;128(4):398-400. doi: 10.1016/j.thromres.2011.06.006. Epub 2011 Jul 6. No abstract available.


Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages.

Milara J, Navarro A, Almudéver P, Lluch J, Morcillo EJ, Cortijo J.

Clin Exp Allergy. 2011 Apr;41(4):535-46. doi: 10.1111/j.1365-2222.2011.03715.x.


Crataegus laevigata decreases neutrophil elastase and has hypolipidemic effect: a randomized, double-blind, placebo-controlled trial.

Dalli E, Colomer E, Tormos MC, Cosín-Sales J, Milara J, Esteban E, Sáez G.

Phytomedicine. 2011 Jun 15;18(8-9):769-75. doi: 10.1016/j.phymed.2010.11.011. Epub 2011 Jan 15.


Cigarette smoke exposure up-regulates endothelin receptor B in human pulmonary artery endothelial cells: molecular and functional consequences.

Milara J, Ortiz JL, Juan G, Guijarro R, Almudever P, Martorell M, Morcillo EJ, Cortijo J.

Br J Pharmacol. 2010 Dec;161(7):1599-615. doi: 10.1111/j.1476-5381.2010.00979.x.


Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia.

Milara J, Armengot M, Mata M, Morcillo EJ, Cortijo J.

Am J Rhinol Allergy. 2010 May-Jun;24(3):181-5. doi: 10.2500/ajra.2010.24.3468.


Cilia motility and structure in primary and secondary ciliary dyskinesia.

Armengot M, Milara J, Mata M, Carda C, Cortijo J.

Am J Rhinol Allergy. 2010 May-Jun;24(3):175-80. doi: 10.2500/ajra.2010.24.3448.


Aclidinium inhibits cholinergic and tobacco smoke-induced MUC5AC in human airways.

Cortijo J, Mata M, Milara J, Donet E, Gavaldà A, Miralpeix M, Morcillo EJ.

Eur Respir J. 2011 Feb;37(2):244-54. doi: 10.1183/09031936.00182009. Epub 2010 Jun 4.

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