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Items: 20


K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis.

Oliveira H, Mendes A, Fraga AG, Ferreira A, Pimenta AI, Mil-Homens D, Fialho AM, Pedrosa J, Azeredo J.

Appl Environ Microbiol. 2019 Aug 14;85(17). pii: e00934-19. doi: 10.1128/AEM.00934-19. Print 2019 Sep 1.


The mechanism of action of pepR, a viral-derived peptide, against Staphylococcus aureus biofilms.

Pinto SN, Dias SA, Cruz AF, Mil-Homens D, Fernandes F, Valle J, Andreu D, Prieto M, Castanho MARB, Coutinho A, Veiga AS.

J Antimicrob Chemother. 2019 Sep 1;74(9):2617-2625. doi: 10.1093/jac/dkz223.


A Transcriptomics Approach To Unveiling the Mechanisms of In Vitro Evolution towards Fluconazole Resistance of a Candida glabrata Clinical Isolate.

Cavalheiro M, Costa C, Silva-Dias A, Miranda IM, Wang C, Pais P, Pinto SN, Mil-Homens D, Sato-Okamoto M, Takahashi-Nakaguchi A, Silva RM, Mira NP, Fialho AM, Chibana H, Rodrigues AG, Butler G, Teixeira MC.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e00995-18. doi: 10.1128/AAC.00995-18. Print 2019 Jan.


Stress Response Protein BolA Influences Fitness and Promotes Salmonella enterica Serovar Typhimurium Virulence.

Mil-Homens D, Barahona S, Moreira RN, Silva IJ, Pinto SN, Fialho AM, Arraiano CM.

Appl Environ Microbiol. 2018 Apr 2;84(8). pii: e02850-17. doi: 10.1128/AEM.02850-17. Print 2018 Apr 15.


A New Determinant of Candida glabrata Virulence: The Acetate Exporter CgDtr1.

Romão D, Cavalheiro M, Mil-Homens D, Santos R, Pais P, Costa C, Takahashi-Nakaguchi A, Fialho AM, Chibana H, Teixeira MC.

Front Cell Infect Microbiol. 2017 Nov 14;7:473. doi: 10.3389/fcimb.2017.00473. eCollection 2017.


Repair of Iron Centers RIC protein contributes to the virulence of Staphylococcus aureus.

Silva LO, Nobre LS, Mil-Homens D, Fialho A, Saraiva LM.

Virulence. 2018 Jan 1;9(1):312-317. doi: 10.1080/21505594.2017.1389829. Epub 2017 Dec 8.


Burkholderia cenocepacia K56-2 trimeric autotransporter adhesin BcaA binds TNFR1 and contributes to induce airway inflammation.

Mil-Homens D, Pinto SN, Matos RG, Arraiano C, Fialho AM.

Cell Microbiol. 2017 Apr;19(4). doi: 10.1111/cmi.12677. Epub 2016 Oct 27.


The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.

Santos R, Costa C, Mil-Homens D, Romão D, de Carvalho CC, Pais P, Mira NP, Fialho AM, Teixeira MC.

Cell Microbiol. 2017 May;19(5). doi: 10.1111/cmi.12686. Epub 2017 Jan 3.


Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection.

Moreira AS, Mil-Homens D, Sousa SA, Coutinho CP, Pinto-de-Oliveira A, Ramos CG, Dos Santos SC, Fialho AM, Leitão JH, Sá-Correia I.

Virulence. 2017 Aug 18;8(6):782-796. doi: 10.1080/21505594.2016.1237334. Epub 2016 Sep 21.


Fish oils against Burkholderia and Pseudomonas aeruginosa: in vitro efficacy and their therapeutic and prophylactic effects on infected Galleria mellonella larvae.

Mil-Homens D, Ferreira-Dias S, Fialho AM.

J Appl Microbiol. 2016 Jun;120(6):1509-19. doi: 10.1111/jam.13145. Epub 2016 Apr 25.


Characterization of BCAM0224, a multifunctional trimeric autotransporter from the human pathogen Burkholderia cenocepacia.

Mil-Homens D, Leça MI, Fernandes F, Pinto SN, Fialho AM.

J Bacteriol. 2014 Jun;196(11):1968-79. doi: 10.1128/JB.00061-14. Epub 2014 Mar 21.


The virulence of Salmonella enterica Serovar Typhimurium in the insect model galleria mellonella is impaired by mutations in RNase E and RNase III.

Viegas SC, Mil-Homens D, Fialho AM, Arraiano CM.

Appl Environ Microbiol. 2013 Oct;79(19):6124-33. doi: 10.1128/AEM.02044-13. Epub 2013 Aug 2.


Single-molecule atomic force microscopy unravels the binding mechanism of a Burkholderia cenocepacia trimeric autotransporter adhesin.

El-Kirat-Chatel S, Mil-Homens D, Beaussart A, Fialho AM, Dufrêne YF.

Mol Microbiol. 2013 Aug;89(4):649-59. doi: 10.1111/mmi.12301. Epub 2013 Jul 12.


A BCAM0223 mutant of Burkholderia cenocepacia is deficient in hemagglutination, serum resistance, adhesion to epithelial cells and virulence.

Mil-Homens D, Fialho AM.

PLoS One. 2012;7(7):e41747. doi: 10.1371/journal.pone.0041747. Epub 2012 Jul 25.


The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia.

Mil-Homens D, Bernardes N, Fialho AM.

FEMS Microbiol Lett. 2012 Mar;328(1):61-9. doi: 10.1111/j.1574-6968.2011.02476.x. Epub 2012 Jan 6.


Mucoid morphotype variation of Burkholderia multivorans during chronic cystic fibrosis lung infection is correlated with changes in metabolism, motility, biofilm formation and virulence.

Silva IN, Ferreira AS, Becker JD, Zlosnik JE, Speert DP, He J, Mil-Homens D, Moreira LM.

Microbiology. 2011 Nov;157(Pt 11):3124-37. doi: 10.1099/mic.0.050989-0. Epub 2011 Aug 11.


Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate.

Rocha J, Popescu AO, Borges P, Mil-Homens D, Moreira LM, Sá-Correia I, Fialho AM, Frazão C.

J Bacteriol. 2011 Aug;193(15):3978-87. doi: 10.1128/JB.01076-10. Epub 2011 May 20.


Trimeric autotransporter adhesins in members of the Burkholderia cepacia complex: a multifunctional family of proteins implicated in virulence.

Mil-Homens D, Fialho AM.

Front Cell Infect Microbiol. 2011 Dec 7;1:13. doi: 10.3389/fcimb.2011.00013. eCollection 2011. Review.


Genome-wide analysis of DNA repeats in Burkholderia cenocepacia J2315 identifies a novel adhesin-like gene unique to epidemic-associated strains of the ET-12 lineage.

Mil-Homens D, Rocha EP, Fialho AM.

Microbiology. 2010 Apr;156(Pt 4):1084-96. doi: 10.1099/mic.0.032623-0. Epub 2009 Dec 17.


The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients.

Holden MT, Seth-Smith HM, Crossman LC, Sebaihia M, Bentley SD, Cerdeño-Tárraga AM, Thomson NR, Bason N, Quail MA, Sharp S, Cherevach I, Churcher C, Goodhead I, Hauser H, Holroyd N, Mungall K, Scott P, Walker D, White B, Rose H, Iversen P, Mil-Homens D, Rocha EP, Fialho AM, Baldwin A, Dowson C, Barrell BG, Govan JR, Vandamme P, Hart CA, Mahenthiralingam E, Parkhill J.

J Bacteriol. 2009 Jan;191(1):261-77. doi: 10.1128/JB.01230-08. Epub 2008 Oct 17. Erratum in: J Bacteriol. 2009 Apr;191(8):2907.

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