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Items: 48

1.

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D.

Cell Chem Biol. 2019 Jun 20;26(6):781-791.e6. doi: 10.1016/j.chembiol.2019.02.013. Epub 2019 Mar 28.

PMID:
30930162
2.

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.

Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosere N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Jha RK, Kumar P, Freundlich JS, Brodin P, Aínsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S.

Tuberculosis (Edinb). 2018 Sep;112:98-109. doi: 10.1016/j.tube.2018.08.004. Epub 2018 Aug 11.

PMID:
30205975
3.

Copper-related toxicity in replicating and dormant Mycobacterium tuberculosis caused by 1-hydroxy-5-R-pyridine-2(1H)-thiones.

Salina EG, Huszár S, Zemanová J, Keruchenko J, Riabova O, Kazakova E, Grigorov A, Azhikina T, Kaprelyants A, Mikušová K, Makarov V.

Metallomics. 2018 Jul 18;10(7):992-1002. doi: 10.1039/c8mt00067k.

PMID:
29946601
4.

New lipophilic isoniazid derivatives and their 1,3,4-oxadiazole analogues: Synthesis, antimycobacterial activity and investigation of their mechanism of action.

Vosátka R, Krátký M, Švarcová M, Janoušek J, Stolaříková J, Madacki J, Huszár S, Mikušová K, Korduláková J, Trejtnar F, Vinšová J.

Eur J Med Chem. 2018 May 10;151:824-835. doi: 10.1016/j.ejmech.2018.04.017. Epub 2018 Apr 10.

PMID:
29679902
5.

A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK.

Chiarelli LR, Mori G, Orena BS, Esposito M, Lane T, de Jesus Lopes Ribeiro AL, Degiacomi G, Zemanová J, Szádocka S, Huszár S, Palčeková Z, Manfredi M, Gosetti F, Lelièvre J, Ballell L, Kazakova E, Makarov V, Marengo E, Mikusova K, Cole ST, Riccardi G, Ekins S, Pasca MR.

Sci Rep. 2018 Feb 16;8(1):3187. doi: 10.1038/s41598-018-21614-4.

6.

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis.

Huszár S, Singh V, Polčicová A, Baráth P, Barrio MB, Lagrange S, Leblanc V, Nacy CA, Mizrahi V, Mikušová K.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01310-17. doi: 10.1128/AAC.01310-17. Print 2017 Nov.

7.

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors.

Esposito M, Szadocka S, Degiacomi G, Orena BS, Mori G, Piano V, Boldrin F, Zemanová J, Huszár S, Barros D, Ekins S, Lelièvre J, Manganelli R, Mattevi A, Pasca MR, Riccardi G, Ballell L, Mikušová K, Chiarelli LR.

ACS Infect Dis. 2017 Jun 9;3(6):428-437. doi: 10.1021/acsinfecdis.7b00006. Epub 2017 May 11.

PMID:
28475832
8.

Identification of aminopyrimidine-sulfonamides as potent modulators of Wag31-mediated cell elongation in mycobacteria.

Singh V, Dhar N, Pató J, Kolly GS, Korduláková J, Forbak M, Evans JC, Székely R, Rybniker J, Palčeková Z, Zemanová J, Santi I, Signorino-Gelo F, Rodrigues L, Vocat A, Covarrubias AS, Rengifo MG, Johnsson K, Mowbray S, Buechler J, Delorme V, Brodin P, Knott GW, Aínsa JA, Warner DF, Kéri G, Mikušová K, McKinney JD, Cole ST, Mizrahi V, Hartkoorn RC.

Mol Microbiol. 2017 Jan;103(1):13-25. doi: 10.1111/mmi.13535. Epub 2016 Oct 29.

9.

Learning from the past for TB drug discovery in the future.

Mikušová K, Ekins S.

Drug Discov Today. 2017 Mar;22(3):534-545. doi: 10.1016/j.drudis.2016.09.025. Epub 2016 Oct 4. Review.

10.

Assembling of the Mycobacterium tuberculosis Cell Wall Core.

Grzegorzewicz AE, de Sousa-d'Auria C, McNeil MR, Huc-Claustre E, Jones V, Petit C, Angala SK, Zemanová J, Wang Q, Belardinelli JM, Gao Q, Ishizaki Y, Mikušová K, Brennan PJ, Ronning DR, Chami M, Houssin C, Jackson M.

J Biol Chem. 2016 Sep 2;291(36):18867-79. doi: 10.1074/jbc.M116.739227. Epub 2016 Jul 14.

11.

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043.

Tiwari R, Miller PA, Chiarelli LR, Mori G, Šarkan M, Centárová I, Cho S, Mikušová K, Franzblau SG, Oliver AG, Miller MJ.

ACS Med Chem Lett. 2016 Jan 4;7(3):266-70. doi: 10.1021/acsmedchemlett.5b00424. eCollection 2016 Mar 10.

12.

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.

Albesa-Jové D, Svetlíková Z, Tersa M, Sancho-Vaello E, Carreras-González A, Bonnet P, Arrasate P, Eguskiza A, Angala SK, Cifuente JO, Korduláková J, Jackson M, Mikušová K, Guerin ME.

Nat Commun. 2016 Mar 11;7:10906. doi: 10.1038/ncomms10906.

13.

Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis.

Karabanovich G, Zemanová J, Smutný T, Székely R, Šarkan M, Centárová I, Vocat A, Pávková I, Čonka P, Němeček J, Stolaříková J, Vejsová M, Vávrová K, Klimešová V, Hrabálek A, Pávek P, Cole ST, Mikušová K, Roh J.

J Med Chem. 2016 Mar 24;59(6):2362-80. doi: 10.1021/acs.jmedchem.5b00608. Epub 2016 Mar 15.

PMID:
26948407
14.

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis.

Kolly GS, Mukherjee R, Kilacsková E, Abriata LA, Raccaud M, Blaško J, Sala C, Dal Peraro M, Mikušová K, Cole ST.

J Bacteriol. 2015 Dec;197(23):3686-97. doi: 10.1128/JB.00628-15. Epub 2015 Sep 14.

15.

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

Mori G, Chiarelli LR, Esposito M, Makarov V, Bellinzoni M, Hartkoorn RC, Degiacomi G, Boldrin F, Ekins S, de Jesus Lopes Ribeiro AL, Marino LB, Centárová I, Svetlíková Z, Blaško J, Kazakova E, Lepioshkin A, Barilone N, Zanoni G, Porta A, Fondi M, Fani R, Baulard AR, Mikušová K, Alzari PM, Manganelli R, de Carvalho LP, Riccardi G, Cole ST, Pasca MR.

Chem Biol. 2015 Jul 23;22(7):917-27. doi: 10.1016/j.chembiol.2015.05.016. Epub 2015 Jun 18.

16.

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis.

Makarov V, Neres J, Hartkoorn RC, Ryabova OB, Kazakova E, Šarkan M, Huszár S, Piton J, Kolly GS, Vocat A, Conroy TM, Mikušová K, Cole ST.

Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52. doi: 10.1128/AAC.00778-15. Epub 2015 May 18.

17.

DprE1 Is a Vulnerable Tuberculosis Drug Target Due to Its Cell Wall Localization.

Brecik M, Centárová I, Mukherjee R, Kolly GS, Huszár S, Bobovská A, Kilacsková E, Mokošová V, Svetlíková Z, Šarkan M, Neres J, Korduláková J, Cole ST, Mikušová K.

ACS Chem Biol. 2015 Jul 17;10(7):1631-6. doi: 10.1021/acschembio.5b00237. Epub 2015 Apr 29.

PMID:
25906160
18.

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library.

Sipos A, Pató J, Székely R, Hartkoorn RC, Kékesi L, Őrfi L, Szántai-Kis C, Mikušová K, Svetlíková Z, Korduláková J, Nagaraja V, Godbole AA, Bush N, Collin F, Maxwell A, Cole ST, Kéri G.

Tuberculosis (Edinb). 2015 Jun;95 Suppl 1:S200-6. doi: 10.1016/j.tube.2015.02.028. Epub 2015 Feb 28.

PMID:
25801335
19.

The complex mechanism of antimycobacterial action of 5-fluorouracil.

Singh V, Brecik M, Mukherjee R, Evans JC, Svetlíková Z, Blaško J, Surade S, Blackburn J, Warner DF, Mikušová K, Mizrahi V.

Chem Biol. 2015 Jan 22;22(1):63-75. doi: 10.1016/j.chembiol.2014.11.006. Epub 2014 Dec 24.

20.

The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo.

Boldrin F, Ventura M, Degiacomi G, Ravishankar S, Sala C, Svetlikova Z, Ambady A, Dhar N, Kordulakova J, Zhang M, Serafini A, Vishwas KG, Kolly GS, Kumar N, Palù G, Guerin ME, Mikusova K, Cole ST, Manganelli R.

J Bacteriol. 2014 Oct;196(19):3441-51. doi: 10.1128/JB.01346-13. Epub 2014 Jul 21. Erratum in: J Bacteriol. 2014 Dec;196(23):4197. Vishwas, V G [Corrected to Vishwas, K G].

21.

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid--monoacylated phosphatidylinositol dimannoside.

Svetlíková Z, Baráth P, Jackson M, Korduláková J, Mikušová K.

Protein Expr Purif. 2014 Aug;100:33-9. doi: 10.1016/j.pep.2014.04.014. Epub 2014 May 6.

22.

An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition.

Ang ML, Zainul Rahim SZ, Shui G, Dianiškova P, Madacki J, Lin W, Koh VH, Martinez Gomez JM, Sudarkodi S, Bendt A, Wenk M, Mikušová K, Korduláková J, Pethe K, Alonso S.

Infect Immun. 2014 May;82(5):1850-9. doi: 10.1128/IAI.01332-13. Epub 2014 Feb 24. Erratum in: Infect Immun. 2015 Feb;83(2):846. Siti, Zarina Zainul Rahim [corrected to Zainul Rahim, Siti Zarina].

23.

DprE1--from the discovery to the promising tuberculosis drug target.

Mikusová K, Makarov V, Neres J.

Curr Pharm Des. 2014;20(27):4379-403. Review.

PMID:
24245764
24.

Identification of a small molecule with activity against drug-resistant and persistent tuberculosis.

Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, Mdluli KE, Franzblau S, Chatterjee AK, Johnsson K, Mikusova K, Besra GS, Fütterer K, Robbins SH, Barnes SW, Walker JR, Jacobs WR Jr, Schultz PG.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2510-7. doi: 10.1073/pnas.1309171110. Epub 2013 Jun 17. Erratum in: Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15848. Robbins, Scott H [added]; Barnes, S Whitney [added]; Walker, John R [added]; Johnson, Kai [corrected to Johnsson, Kai].

25.

A small multidrug resistance-like transporter involved in the arabinosylation of arabinogalactan and lipoarabinomannan in mycobacteria.

Larrouy-Maumus G, Škovierová H, Dhouib R, Angala SK, Zuberogoitia S, Pham H, Villela AD, Mikušová K, Noguera A, Gilleron M, Valentínová L, Korduláková J, Brennan PJ, Puzo G, Nigou J, Jackson M.

J Biol Chem. 2012 Nov 16;287(47):39933-41. doi: 10.1074/jbc.M112.400986. Epub 2012 Oct 4.

26.

Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase DprE1.

Trefzer C, Škovierová H, Buroni S, Bobovská A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikušová K, Johnsson K.

J Am Chem Soc. 2012 Jan 18;134(2):912-5. doi: 10.1021/ja211042r. Epub 2011 Dec 21.

PMID:
22188377
27.

Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster.

Dianišková P, Korduláková J, Skovierová H, Kaur D, Jackson M, Brennan PJ, Mikušová K.

Gen Physiol Biophys. 2011 Sep;30(3):239-50. doi: 10.4149/gpb_2011_03_239.

28.

Synthesis of 1,2,3-triazolo-linked octyl (1→6)-α-D-oligomannosides and their evaluation in mycobacterial mannosyltransferase assay.

Poláková M, Belánová M, Mikusová K, Lattová E, Perreault H.

Bioconjug Chem. 2011 Feb 16;22(2):289-98. doi: 10.1021/bc100421g. Epub 2011 Jan 20.

PMID:
21250655
29.

Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis.

Peltier P, Beláňová M, Dianišková P, Zhou R, Zheng RB, Pearcey JA, Joe M, Brennan PJ, Nugier-Chauvin C, Ferrières V, Lowary TL, Daniellou R, Mikušová K.

Chem Biol. 2010 Dec 22;17(12):1356-66. doi: 10.1016/j.chembiol.2010.10.014.

30.

Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis.

Skovierová H, Larrouy-Maumus G, Pham H, Belanová M, Barilone N, Dasgupta A, Mikusová K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M.

J Biol Chem. 2010 Dec 31;285(53):41348-55. doi: 10.1074/jbc.M110.188110. Epub 2010 Oct 28.

31.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G.

Mol Microbiol. 2010 Sep;77(5):1172-85. doi: 10.1111/j.1365-2958.2010.07277.x.

32.

Synthesis of alkyl and cycloalkyl alpha-d-mannopyranosides and derivatives thereof and their evaluation in the mycobacterial mannosyltransferase assay.

Poláková M, Belánová M, Petrus L, Mikusová K.

Carbohydr Res. 2010 Jul 2;345(10):1339-47. doi: 10.1016/j.carres.2010.03.011. Epub 2010 Mar 15.

PMID:
20363467
33.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST.

Science. 2009 May 8;324(5928):801-4. doi: 10.1126/science.1171583. Epub 2009 Mar 19.

34.

Galactosyl transferases in mycobacterial cell wall synthesis.

Belánová M, Dianisková P, Brennan PJ, Completo GC, Rose NL, Lowary TL, Mikusová K.

J Bacteriol. 2008 Feb;190(3):1141-5. Epub 2007 Nov 30.

35.

Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria.

Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM.

J Biol Chem. 2007 Jul 13;282(28):20705-14. Epub 2007 May 16.

36.

Identification of promoters recognized by RNA polymerase containing Mycobacterium tuberculosis stress-response sigma factor sigma(F).

Homerova D, Surdova K, Mikusova K, Kormanec J.

Arch Microbiol. 2007 Mar;187(3):185-97. Epub 2006 Nov 7.

PMID:
17089148
37.

Identification of a novel galactosyl transferase involved in biosynthesis of the mycobacterial cell wall.

Mikusová K, Belánová M, Korduláková J, Honda K, McNeil MR, Mahapatra S, Crick DC, Brennan PJ.

J Bacteriol. 2006 Sep;188(18):6592-8.

38.

Decaprenylphosphoryl arabinofuranose, the donor of the D-arabinofuranosyl residues of mycobacterial arabinan, is formed via a two-step epimerization of decaprenylphosphoryl ribose.

Mikusová K, Huang H, Yagi T, Holsters M, Vereecke D, D'Haeze W, Scherman MS, Brennan PJ, McNeil MR, Crick DC.

J Bacteriol. 2005 Dec;187(23):8020-5.

39.

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species.

Korduláková J, Gilleron M, Puzo G, Brennan PJ, Gicquel B, Mikusová K, Jackson M.

J Biol Chem. 2003 Sep 19;278(38):36285-95. Epub 2003 Jul 8.

40.

Polymerization of mycobacterial arabinogalactan and ligation to peptidoglycan.

Yagi T, Mahapatra S, Mikusova K, Crick DC, Brennan PJ.

J Biol Chem. 2003 Jul 18;278(29):26497-504. Epub 2003 Apr 28.

41.

Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria.

Korduláková J, Gilleron M, Mikusova K, Puzo G, Brennan PJ, Gicquel B, Jackson M.

J Biol Chem. 2002 Aug 30;277(35):31335-44. Epub 2002 Jun 14.

42.

Biosynthesis of the galactan component of the mycobacterial cell wall.

Mikusová K, Yagi T, Stern R, McNeil MR, Besra GS, Crick DC, Brennan PJ.

J Biol Chem. 2000 Oct 27;275(43):33890-7.

43.

Interaction of human mannose-binding protein with Mycobacterium avium.

Polotsky VY, Belisle JT, Mikusova K, Ezekowitz RA, Joiner KA.

J Infect Dis. 1997 May;175(5):1159-68.

PMID:
9129080
44.

Truncated structural variants of lipoarabinomannan in ethambutol drug-resistant strains of Mycobacterium smegmatis. Inhibition of arabinan biosynthesis by ethambutol.

Khoo KH, Douglas E, Azadi P, Inamine JM, Besra GS, Mikusová K, Brennan PJ, Chatterjee D.

J Biol Chem. 1996 Nov 8;271(45):28682-90.

45.

The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol.

Belanger AE, Besra GS, Ford ME, Mikusová K, Belisle JT, Brennan PJ, Inamine JM.

Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11919-24.

46.

Biosynthesis of the linkage region of the mycobacterial cell wall.

Mikusová K, Mikus M, Besra GS, Hancock I, Brennan PJ.

J Biol Chem. 1996 Mar 29;271(13):7820-8.

47.

Biogenesis of the mycobacterial cell wall and the site of action of ethambutol.

Mikusová K, Slayden RA, Besra GS, Brennan PJ.

Antimicrob Agents Chemother. 1995 Nov;39(11):2484-9.

48.

Recognition of multiple effects of ethambutol on metabolism of mycobacterial cell envelope.

Deng L, Mikusová K, Robuck KG, Scherman M, Brennan PJ, McNeil MR.

Antimicrob Agents Chemother. 1995 Mar;39(3):694-701.

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