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Items: 1 to 50 of 105

1.

The Hepatic Microenvironment and TRAIL-R2 Impact Outgrowth of Liver Metastases in Pancreatic Cancer after Surgical Resection.

Miarka L, Hauser C, Helm O, Holdhof D, Beckinger S, Egberts JH, Gundlach JP, Lenk L, Rahn S, Mikulits W, Trauzold A, Sebens S.

Cancers (Basel). 2019 May 29;11(6). pii: E745. doi: 10.3390/cancers11060745.

2.

c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial-Mesenchymal Transition and Regulates Cell Phenotypic Switch.

Almalé L, García-Álvaro M, Martínez-Palacián A, García-Bravo M, Lazcanoiturburu N, Addante A, Roncero C, Sanz J, de la O López M, Bragado P, Mikulits W, Factor VM, Thorgeirsson SS, Casal JI, Segovia JC, Rial E, Fabregat I, Herrera B, Sánchez A.

Stem Cells. 2019 Aug;37(8):1108-1118. doi: 10.1002/stem.3038. Epub 2019 Jun 18.

PMID:
31108004
3.

LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.

Morén A, Bellomo C, Tsubakihara Y, Kardassis D, Mikulits W, Heldin CH, Moustakas A.

Oncogenesis. 2019 May 16;8(6):36. doi: 10.1038/s41389-019-0140-4.

4.

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells.

Fabian A, Stegner S, Miarka L, Zimmermann J, Lenk L, Rahn S, Buttlar J, Viol F, Knaack H, Esser D, Schäuble S, Großmann P, Marinos G, Häsler R, Mikulits W, Saur D, Kaleta C, Schäfer H, Sebens S.

Cancer Lett. 2019 Jul 1;453:95-106. doi: 10.1016/j.canlet.2019.03.039. Epub 2019 Mar 28.

PMID:
30930235
5.

Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma.

Kinslechner K, Schütz B, Pistek M, Rapolter P, Weitzenböck HP, Hundsberger H, Mikulits W, Grillari J, Röhrl C, Hengstschläger M, Stangl H, Mikula M.

Int J Mol Sci. 2019 Mar 1;20(5). pii: E1063. doi: 10.3390/ijms20051063.

6.

Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics.

Holstein E, Binder M, Mikulits W.

Int J Mol Sci. 2018 Dec 18;19(12). pii: E4111. doi: 10.3390/ijms19124111. Review.

7.

Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells.

Knaack H, Lenk L, Philipp LM, Miarka L, Rahn S, Viol F, Hauser C, Egberts JH, Gundlach JP, Will O, Tiwari S, Mikulits W, Schumacher U, Hengstler JG, Sebens S.

Oncotarget. 2018 Aug 3;9(60):31771-31786. doi: 10.18632/oncotarget.25884. eCollection 2018 Aug 3.

8.

Transforming Growth Factor-β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma.

Haider C, Hnat J, Wagner R, Huber H, Timelthaler G, Grubinger M, Coulouarn C, Schreiner W, Schlangen K, Sieghart W, Peck-Radosavljevic M, Mikulits W.

Hepatology. 2019 Jan;69(1):222-236. doi: 10.1002/hep.30166. Epub 2018 Dec 20.

9.

Dynamics of CRISPR/Cas9-mediated genomic editing of the AXL locus in hepatocellular carcinoma cells.

Scharf I, Bierbaumer L, Huber H, Wittmann P, Haider C, Pirker C, Berger W, Mikulits W.

Oncol Lett. 2018 Feb;15(2):2441-2450. doi: 10.3892/ol.2017.7605. Epub 2017 Dec 13.

10.

The hepatic microenvironment essentially determines tumor cell dormancy and metastatic outgrowth of pancreatic ductal adenocarcinoma.

Lenk L, Pein M, Will O, Gomez B, Viol F, Hauser C, Egberts JH, Gundlach JP, Helm O, Tiwari S, Weiskirchen R, Rose-John S, Röcken C, Mikulits W, Wenzel P, Schneider G, Saur D, Schäfer H, Sebens S.

Oncoimmunology. 2017 Oct 26;7(1):e1368603. doi: 10.1080/2162402X.2017.1368603. eCollection 2017.

11.

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.

Cell Death Differ. 2018 May;25(5):885-903. doi: 10.1038/s41418-017-0021-3. Epub 2017 Dec 11.

12.

Use of HuH6 and other human-derived hepatoma lines for the detection of genotoxins: a new hope for laboratory animals?

Waldherr M, Mišík M, Ferk F, Tomc J, Žegura B, Filipič M, Mikulits W, Mai S, Haas O, Huber WW, Haslinger E, Knasmüller S.

Arch Toxicol. 2018 Feb;92(2):921-934. doi: 10.1007/s00204-017-2109-4. Epub 2017 Dec 7.

13.

The non-invasive serum biomarker soluble Axl accurately detects advanced liver fibrosis and cirrhosis.

Staufer K, Dengler M, Huber H, Marculescu R, Stauber R, Lackner C, Dienes HP, Kivaranovic D, Schachner C, Zeitlinger M, Wulkersdorfer B, Rauch P, Prager G, Trauner M, Mikulits W.

Cell Death Dis. 2017 Oct 26;8(10):e3135. doi: 10.1038/cddis.2017.554.

14.

Transforming Growth Factor-β Drives the Transendothelial Migration of Hepatocellular Carcinoma Cells.

Koudelkova P, Costina V, Weber G, Dooley S, Findeisen P, Winter P, Agarwal R, Schlangen K, Mikulits W.

Int J Mol Sci. 2017 Oct 10;18(10). pii: E2119. doi: 10.3390/ijms18102119.

15.

Malignant Phenotypes in Metastatic Melanoma are Governed by SR-BI and its Association with Glycosylation and STAT5 Activation.

Kinslechner K, Schörghofer D, Schütz B, Vallianou M, Wingelhofer B, Mikulits W, Röhrl C, Hengstschläger M, Moriggl R, Stangl H, Mikula M.

Mol Cancer Res. 2018 Jan;16(1):135-146. doi: 10.1158/1541-7786.MCR-17-0292. Epub 2017 Oct 3.

16.

The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma.

Govaere O, Petz M, Wouters J, Vandewynckel YP, Scott EJ, Topal B, Nevens F, Verslype C, Anstee QM, Van Vlierberghe H, Mikulits W, Roskams T.

Oncogene. 2017 Nov 23;36(47):6605-6616. doi: 10.1038/onc.2017.260. Epub 2017 Aug 7.

17.

Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis.

Dengler M, Staufer K, Huber H, Stauber R, Bantel H, Weiss KH, Starlinger P, Pock H, Klöters-Plachky P, Gotthardt DN, Rauch P, Lackner C, Stift J, Brostjan C, Gruenberger T, Kumada T, Toyoda H, Tada T, Weiss TS, Trauner M, Mikulits W.

Oncotarget. 2017 Jul 11;8(28):46234-46248. doi: 10.18632/oncotarget.17598.

18.

Transforming growth factor-β-induced plasticity causes a migratory stemness phenotype in hepatocellular carcinoma.

Malfettone A, Soukupova J, Bertran E, Crosas-Molist E, Lastra R, Fernando J, Koudelkova P, Rani B, Fabra Á, Serrano T, Ramos E, Mikulits W, Giannelli G, Fabregat I.

Cancer Lett. 2017 Apr 28;392:39-50. doi: 10.1016/j.canlet.2017.01.037. Epub 2017 Feb 2.

PMID:
28161507
19.

Accurate Determination of Soluble Axl by Enzyme-Linked Immunosorbent Assay.

Dengler M, Huber H, Müller CJ, Zellmer A, Rauch P, Mikulits W.

Assay Drug Dev Technol. 2016 Nov;14(9):543-550. Epub 2016 Nov 2.

PMID:
27805424
20.

Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice.

Themanns M, Mueller KM, Kessler SM, Golob-Schwarzl N, Mohr T, Kaltenecker D, Bourgeais J, Paier-Pourani J, Friedbichler K, Schneller D, Schlederer M, Zebedin-Brandl E, Terracciano LM, Han X, Kenner L, Wagner KU, Mikulits W, Kozlov AV, Heim MH, Gouilleux F, Haybaeck J, Moriggl R.

Sci Rep. 2016 Oct 7;6:34719. doi: 10.1038/srep34719.

21.

Epithelial to mesenchymal transition-related proteins ZEB1, β-catenin, and β-tubulin-III in idiopathic pulmonary fibrosis.

Chilosi M, Caliò A, Rossi A, Gilioli E, Pedica F, Montagna L, Pedron S, Confalonieri M, Doglioni C, Ziesche R, Grubinger M, Mikulits W, Poletti V.

Mod Pathol. 2017 Jan;30(1):26-38. doi: 10.1038/modpathol.2016.147. Epub 2016 Sep 2.

22.

Accuracy of novel diagnostic biomarkers for hepatocellular carcinoma: An update for clinicians (Review).

Reichl P, Mikulits W.

Oncol Rep. 2016 Aug;36(2):613-25. doi: 10.3892/or.2016.4842. Epub 2016 Jun 1. Review.

23.

Role of epithelial to mesenchymal transition in hepatocellular carcinoma.

Giannelli G, Koudelkova P, Dituri F, Mikulits W.

J Hepatol. 2016 Oct;65(4):798-808. doi: 10.1016/j.jhep.2016.05.007. Epub 2016 May 17. Review.

PMID:
27212245
24.

Cyclin-dependent kinase 5 stabilizes hypoxia-inducible factor-1α: a novel approach for inhibiting angiogenesis in hepatocellular carcinoma.

Herzog J, Ehrlich SM, Pfitzer L, Liebl J, Fröhlich T, Arnold GJ, Mikulits W, Haider C, Vollmar AM, Zahler S.

Oncotarget. 2016 May 10;7(19):27108-21. doi: 10.18632/oncotarget.8342.

25.

The rationale for targeting TGF-β in chronic liver diseases.

Giannelli G, Mikulits W, Dooley S, Fabregat I, Moustakas A, ten Dijke P, Portincasa P, Winter P, Janssen R, Leporatti S, Herrera B, Sanchez A.

Eur J Clin Invest. 2016 Apr;46(4):349-61. doi: 10.1111/eci.12596. Epub 2016 Mar 12. Review.

PMID:
26823073
26.

Laminin-332 sustains chemoresistance and quiescence as part of the human hepatic cancer stem cell niche.

Govaere O, Wouters J, Petz M, Vandewynckel YP, Van den Eynde K, Van den Broeck A, Verhulst S, Dollé L, Gremeaux L, Ceulemans A, Nevens F, van Grunsven LA, Topal B, Vankelecom H, Giannelli G, Van Vlierberghe H, Mikulits W, Komuta M, Roskams T.

J Hepatol. 2016 Mar;64(3):609-17. doi: 10.1016/j.jhep.2015.11.011. Epub 2015 Nov 17.

27.

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells.

Wittmann P, Grubinger M, Gröger C, Huber H, Sieghart W, Peck-Radosavljevic M, Mikulits W.

BMC Cancer. 2015 Nov 16;15:909. doi: 10.1186/s12885-015-1919-0.

28.

Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF.

Koudelkova P, Weber G, Mikulits W.

PLoS One. 2015 Nov 3;10(11):e0142134. doi: 10.1371/journal.pone.0142134. eCollection 2015.

29.

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.

Nat Commun. 2015 Oct 26;6:8802. doi: 10.1038/ncomms9802. No abstract available.

PMID:
26499136
30.

STAT3 regulated ARF expression suppresses prostate cancer metastasis.

Pencik J, Schlederer M, Gruber W, Unger C, Walker SM, Chalaris A, Marié IJ, Hassler MR, Javaheri T, Aksoy O, Blayney JK, Prutsch N, Skucha A, Herac M, Krämer OH, Mazal P, Grebien F, Egger G, Poli V, Mikulits W, Eferl R, Esterbauer H, Kennedy R, Fend F, Scharpf M, Braun M, Perner S, Levy DE, Malcolm T, Turner SD, Haitel A, Susani M, Moazzami A, Rose-John S, Aberger F, Merkel O, Moriggl R, Culig Z, Dolznig H, Kenner L.

Nat Commun. 2015 Jul 22;6:7736. doi: 10.1038/ncomms8736. Erratum in: Nat Commun. 2015;6:8802.

31.

Multicenter analysis of soluble Axl reveals diagnostic value for very early stage hepatocellular carcinoma.

Reichl P, Fang M, Starlinger P, Staufer K, Nenutil R, Muller P, Greplova K, Valik D, Dooley S, Brostjan C, Gruenberger T, Shen J, Man K, Trauner M, Yu J, Gao CF, Mikulits W.

Int J Cancer. 2015 Jul 15;137(2):385-394. doi: 10.1002/ijc.29394. Epub 2015 Jan 13.

32.

Axl activates autocrine transforming growth factor-β signaling in hepatocellular carcinoma.

Reichl P, Dengler M, van Zijl F, Huber H, Führlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W.

Hepatology. 2015 Mar;61(3):930-41. doi: 10.1002/hep.27492. Epub 2015 Jan 28.

33.

Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis.

Stiedl P, McMahon R, Blaas L, Stanek V, Svinka J, Grabner B, Zollner G, Kessler SM, Claudel T, Müller M, Mikulits W, Bilban M, Esterbauer H, Eferl R, Haybaeck J, Trauner M, Casanova E.

Hepatology. 2015 Feb;61(2):613-26. doi: 10.1002/hep.27408.

34.

STAT3 in hepatocellular carcinoma: new perspectives.

Svinka J, Mikulits W, Eferl R.

Hepat Oncol. 2014 Jan;1(1):107-120. doi: 10.2217/hep.13.7. Epub 2013 Dec 20. Review.

35.

Inhibition of tumour spheroid-induced prometastatic intravasation gates in the lymph endothelial cell barrier by carbamazepine: drug testing in a 3D model.

Teichmann M, Kretschy N, Kopf S, Jarukamjorn K, Atanasov AG, Viola K, Giessrigl B, Saiko P, Szekeres T, Mikulits W, Dirsch VM, Huttary N, Krieger S, Jäger W, Grusch M, Dolznig H, Krupitza G.

Arch Toxicol. 2014 Mar;88(3):691-9. doi: 10.1007/s00204-013-1183-5. Epub 2013 Dec 19.

PMID:
24352538
36.

The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences.

Carbonnelle D, Vignard V, Sehedic D, Moreau-Aubry A, Florenceau L, Charpentier M, Mikulits W, Labarriere N, Lang F.

PLoS One. 2013 Sep 25;8(9):e75233. doi: 10.1371/journal.pone.0075233. eCollection 2013.

37.

Novel inhibitors of cyclin-dependent kinases combat hepatocellular carcinoma without inducing chemoresistance.

Haider C, Grubinger M, Řezníčková E, Weiss TS, Rotheneder H, Miklos W, Berger W, Jorda R, Zatloukal M, Gucky T, Strnad M, Kryštof V, Mikulits W.

Mol Cancer Ther. 2013 Oct;12(10):1947-57. doi: 10.1158/1535-7163.MCT-13-0263. Epub 2013 Aug 12.

38.

In vitro characterisation of the anti-intravasative properties of the marine product heteronemin.

Kopf S, Viola K, Atanasov AG, Jarukamjorn K, Rarova L, Kretschy N, Teichmann M, Vonach C, Saiko P, Giessrigl B, Huttary N, Raab I, Krieger S, Schumacher M, Diederich M, Strnad M, de Martin R, Szekeres T, Jäger W, Dirsch VM, Mikulits W, Grusch M, Dolznig H, Krupitza G.

Arch Toxicol. 2013 Oct;87(10):1851-61. doi: 10.1007/s00204-013-1045-1. Epub 2013 Mar 30.

PMID:
23543012
39.

Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis.

Viola K, Kopf S, Rarova L, Jarukamjorn K, Kretschy N, Teichmann M, Vonach C, Atanasov AG, Giessrigl B, Huttary N, Raab I, Krieger S, Strnad M, de Martin R, Saiko P, Szekeres T, Knasmüller S, Dirsch VM, Jäger W, Grusch M, Dolznig H, Mikulits W, Krupitza G.

Arch Toxicol. 2013 Jul;87(7):1301-12. doi: 10.1007/s00204-013-1028-2. Epub 2013 Mar 17.

PMID:
23503627
40.

In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen.

Kretschy N, Teichmann M, Kopf S, Atanasov AG, Saiko P, Vonach C, Viola K, Giessrigl B, Huttary N, Raab I, Krieger S, Jäger W, Szekeres T, Nijman SM, Mikulits W, Dirsch VM, Dolznig H, Grusch M, Krupitza G.

Br J Cancer. 2013 Feb 19;108(3):570-8. doi: 10.1038/bjc.2012.580. Epub 2013 Jan 8.

41.

Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression.

Gröger CJ, Grubinger M, Waldhör T, Vierlinger K, Mikulits W.

PLoS One. 2012;7(12):e51136. doi: 10.1371/journal.pone.0051136. Epub 2012 Dec 10.

42.

Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion.

Viola K, Kopf S, Huttary N, Vonach C, Kretschy N, Teichmann M, Giessrigl B, Raab I, Stary S, Krieger S, Keller T, Bauer S, Hantusch B, Szekeres T, de Martin R, Jäger W, Mikulits W, Dolznig H, Krupitza G, Grusch M.

Br J Cancer. 2013 Feb 19;108(3):564-9. doi: 10.1038/bjc.2012.485. Epub 2012 Oct 23.

43.

NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development.

Sancho P, Mainez J, Crosas-Molist E, Roncero C, Fernández-Rodriguez CM, Pinedo F, Huber H, Eferl R, Mikulits W, Fabregat I.

PLoS One. 2012;7(9):e45285. doi: 10.1371/journal.pone.0045285. Epub 2012 Sep 26.

44.

PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition.

Petz M, Them NC, Huber H, Mikulits W.

Nucleic Acids Res. 2012 Oct;40(19):9738-49. doi: 10.1093/nar/gks760. Epub 2012 Aug 16.

45.

TGF-β in epithelial to mesenchymal transition and metastasis of liver carcinoma.

Reichl P, Haider C, Grubinger M, Mikulits W.

Curr Pharm Des. 2012;18(27):4135-47. Review.

PMID:
22630087
46.

M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.

Puxbaum V, Nimmerfall E, Bäuerl C, Taub N, Blaas PM, Wieser J, Mikula M, Mikulits W, Ng KM, Yeoh GC, Mach L.

J Hepatol. 2012 Aug;57(2):337-43. doi: 10.1016/j.jhep.2012.03.026. Epub 2012 Apr 17.

47.

La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition.

Petz M, Them N, Huber H, Beug H, Mikulits W.

Nucleic Acids Res. 2012 Jan;40(1):290-302. doi: 10.1093/nar/gkr717. Epub 2011 Sep 6.

48.

NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells.

Vonach C, Viola K, Giessrigl B, Huttary N, Raab I, Kalt R, Krieger S, Vo TP, Madlener S, Bauer S, Marian B, Hämmerle M, Kretschy N, Teichmann M, Hantusch B, Stary S, Unger C, Seelinger M, Eger A, Mader R, Jäger W, Schmidt W, Grusch M, Dolznig H, Mikulits W, Krupitza G.

Br J Cancer. 2011 Jul 12;105(2):263-71. doi: 10.1038/bjc.2011.194. Epub 2011 May 31.

49.

Initial steps of metastasis: cell invasion and endothelial transmigration.

van Zijl F, Krupitza G, Mikulits W.

Mutat Res. 2011 Jul-Oct;728(1-2):23-34. doi: 10.1016/j.mrrev.2011.05.002. Epub 2011 May 12. Review.

50.

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.

Kerjaschki D, Bago-Horvath Z, Rudas M, Sexl V, Schneckenleithner C, Wolbank S, Bartel G, Krieger S, Kalt R, Hantusch B, Keller T, Nagy-Bojarszky K, Huttary N, Raab I, Lackner K, Krautgasser K, Schachner H, Kaserer K, Rezar S, Madlener S, Vonach C, Davidovits A, Nosaka H, Hämmerle M, Viola K, Dolznig H, Schreiber M, Nader A, Mikulits W, Gnant M, Hirakawa S, Detmar M, Alitalo K, Nijman S, Offner F, Maier TJ, Steinhilber D, Krupitza G.

J Clin Invest. 2011 May;121(5):2000-12. doi: 10.1172/JCI44751. Epub 2011 Apr 11.

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