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Items: 41

1.

Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: effects on activity and drug response.

Tolledo EC, Miksys S, Gonzalez FJ, Tyndale RF.

Br J Pharmacol. 2019 Oct 24. doi: 10.1111/bph.14884. [Epub ahead of print]

PMID:
31648367
2.

Rat brain CYP2D activity alters in vivo central oxycodone metabolism, levels and resulting analgesia.

McMillan DM, Miksys S, Tyndale RF.

Addict Biol. 2019 Mar;24(2):228-238. doi: 10.1111/adb.12590. Epub 2017 Dec 21.

PMID:
29266563
3.

Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.

Miksys S, Wadji FB, Tolledo EC, Remington G, Nobrega JN, Tyndale RF.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Aug 1;78:140-148. doi: 10.1016/j.pnpbp.2017.04.030. Epub 2017 Apr 26.

PMID:
28454738
4.

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.

Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, Binder EB, Dannlowski U, Ingelman-Sundberg M.

Mol Psychiatry. 2017 Aug;22(8):1224. doi: 10.1038/mp.2017.93. Epub 2017 Apr 18.

PMID:
28416806
5.

Elevated CYP2C19 expression is associated with depressive symptoms and hippocampal homeostasis impairment.

Jukić MM, Opel N, Ström J, Carrillo-Roa T, Miksys S, Novalen M, Renblom A, Sim SC, Peñas-Lledó EM, Courtet P, Llerena A, Baune BT, de Quervain DJ, Papassotiropoulos A, Tyndale RF, Binder EB, Dannlowski U, Ingelman-Sundberg M.

Mol Psychiatry. 2017 Aug;22(8):1155-1163. doi: 10.1038/mp.2016.204. Epub 2016 Nov 29. Erratum in: Mol Psychiatry. 2017 Aug;22(8):1224.

PMID:
27895323
6.

Effect of Brain CYP2B Inhibition on Brain Nicotine Levels and Nicotine Self-Administration.

Garcia KL, Coen K, Miksys S, Lê AD, Tyndale RF.

Neuropsychopharmacology. 2015 Jul;40(8):1910-8. doi: 10.1038/npp.2015.40. Epub 2015 Feb 5.

7.

Nicotine pharmacokinetics in rats is altered as a function of age, impacting the interpretation of animal model data.

Craig EL, Zhao B, Cui JZ, Novalen M, Miksys S, Tyndale RF.

Drug Metab Dispos. 2014 Sep;42(9):1447-55. doi: 10.1124/dmd.114.058719. Epub 2014 Jun 30.

8.

Ethanol self-administration and nicotine treatment increase brain levels of CYP2D in African green monkeys.

Miller RT, Miksys S, Hoffmann E, Tyndale RF.

Br J Pharmacol. 2014 Jun;171(12):3077-88. doi: 10.1111/bph.12652.

9.

Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys.

Ferguson CS, Miksys S, Palmour RM, Tyndale RF.

Neuropharmacology. 2013 Sep;72:74-81. doi: 10.1016/j.neuropharm.2013.04.022. Epub 2013 Apr 29.

PMID:
23639433
10.

Potential role of CYP2D6 in the central nervous system.

Cheng J, Zhen Y, Miksys S, Beyoğlu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ.

Xenobiotica. 2013 Nov;43(11):973-84. doi: 10.3109/00498254.2013.791410. Epub 2013 Apr 25.

11.

Nicotine kinetics in zebra finches in vivo and in vitro.

Miksys S, Cappendijk SL, Perry WM, Zhao B, Tyndale RF.

Drug Metab Dispos. 2013 Jun;41(6):1240-6. doi: 10.1124/dmd.112.050765. Epub 2013 Mar 25.

PMID:
23530019
12.

Cytochrome P450-mediated drug metabolism in the brain.

Miksys S, Tyndale RF.

J Psychiatry Neurosci. 2013 May;38(3):152-63. doi: 10.1503/jpn.120133. Review.

13.

Differential effects of nicotine treatment and ethanol self-administration on CYP2A6, CYP2B6 and nicotine pharmacokinetics in African green monkeys.

Ferguson CS, Miksys S, Palmour RM, Tyndale RF.

J Pharmacol Exp Ther. 2012 Dec;343(3):628-37. doi: 10.1124/jpet.112.198564. Epub 2012 Aug 30.

PMID:
22935730
14.

Developmental hippocampal neuroplasticity in a model of nicotine replacement therapy during pregnancy and breastfeeding.

Mahar I, Bagot RC, Davoli MA, Miksys S, Tyndale RF, Walker CD, Maheu M, Huang SH, Wong TP, Mechawar N.

PLoS One. 2012;7(5):e37219. doi: 10.1371/journal.pone.0037219. Epub 2012 May 15.

15.

Twenty-first-century neuroscience: the potential for innovative therapies for brain disorders.

Miksys SL, Uhl K, Tyndale RF.

Clin Pharmacol Ther. 2012 Feb;91(2):153-7. doi: 10.1038/clpt.2011.310. No abstract available.

PMID:
22261679
16.

The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients.

Mann A, Miksys SL, Gaedigk A, Kish SJ, Mash DC, Tyndale RF.

Neurobiol Aging. 2012 Sep;33(9):2160-71. doi: 10.1016/j.neurobiolaging.2011.08.014. Epub 2011 Sep 29.

PMID:
21958961
17.

Independent and combined effects of ethanol self-administration and nicotine treatment on hepatic CYP2E1 in African green monkeys.

Ferguson CS, Miksys S, Palmour R, Tyndale RF.

Drug Metab Dispos. 2011 Dec;39(12):2233-41. doi: 10.1124/dmd.111.040378. Epub 2011 Aug 25.

PMID:
21868470
18.

Neurodegenerative diseases: a growing challenge.

Miksys SL, Tyndale RF.

Clin Pharmacol Ther. 2010 Oct;88(4):427-30. doi: 10.1038/clpt.2010.198. No abstract available.

PMID:
20856233
19.

Rat brain CYP2B induction by nicotine is persistent and does not involve nicotinic acetylcholine receptors.

Khokhar JY, Miksys SL, Tyndale RF.

Brain Res. 2010 Aug 12;1348:1-9. doi: 10.1016/j.brainres.2010.06.035. Epub 2010 Jun 20.

PMID:
20599831
20.

Brain and disease: the long path to discovery and treatment.

Miksys SL, Tyndale RF.

Clin Pharmacol Ther. 2009 Oct;86(4):343-6. doi: 10.1038/clpt.2009.168. No abstract available.

21.

Differential induction of ethanol-metabolizing CYP2E1 and nicotine-metabolizing CYP2B1/2 in rat liver by chronic nicotine treatment and voluntary ethanol intake.

Yue J, Khokhar J, Miksys S, Tyndale RF.

Eur J Pharmacol. 2009 May 1;609(1-3):88-95. doi: 10.1016/j.ejphar.2009.03.015. Epub 2009 Mar 13.

22.

Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment.

Mann A, Miksys S, Lee A, Mash DC, Tyndale RF.

Neuropharmacology. 2008 Dec;55(7):1147-55. doi: 10.1016/j.neuropharm.2008.07.017. Epub 2008 Jul 19.

23.

Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition.

Miksys S, Tyndale RF.

Neuropsychopharmacology. 2009 Feb;34(3):634-40. doi: 10.1038/npp.2008.110. Epub 2008 Jul 30.

24.
25.

Nicotine induces brain CYP enzymes: relevance to Parkinson's disease.

Miksys S, Tyndale RF.

J Neural Transm Suppl. 2006;(70):177-80. Review.

PMID:
17017527
26.

Phenobarbital increases monkey in vivo nicotine disposition and induces liver and brain CYP2B6 protein.

Lee AM, Miksys S, Tyndale RF.

Br J Pharmacol. 2006 Jul;148(6):786-94. Epub 2006 Jun 5.

27.

CYP2B6 is expressed in African Green monkey brain and is induced by chronic nicotine treatment.

Lee AM, Miksys S, Palmour R, Tyndale RF.

Neuropharmacology. 2006 Mar;50(4):441-50. Epub 2005 Nov 23.

PMID:
16309716
28.

Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model.

Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF.

Drug Metab Dispos. 2005 Oct;33(10):1495-502. Epub 2005 Jul 20.

PMID:
16033950
29.

The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics.

Miksys S, Tyndale RF.

Drug Metab Rev. 2004 May;36(2):313-33. Review.

PMID:
15237857
30.

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF.

Neuropharmacology. 2003 Jul;45(1):122-32.

PMID:
12814665
31.

Rat hepatic CYP2E1 is induced by very low nicotine doses: an investigation of induction, time course, dose response, and mechanism.

Micu AL, Miksys S, Sellers EM, Koop DR, Tyndale RF.

J Pharmacol Exp Ther. 2003 Sep;306(3):941-7. Epub 2003 May 15.

PMID:
12750430
32.

Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics.

Howard LA, Miksys S, Hoffmann E, Mash D, Tyndale RF.

Br J Pharmacol. 2003 Apr;138(7):1376-86.

33.

Drug-metabolizing cytochrome P450s in the brain.

Miksys SL, Tyndale RF.

J Psychiatry Neurosci. 2002 Nov;27(6):406-15. Review.

34.

Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics.

Miksys S, Rao Y, Hoffmann E, Mash DC, Tyndale RF.

J Neurochem. 2002 Sep;82(6):1376-87.

35.

Regional and cellular distribution of CYP2D subfamily members in rat brain.

Miksys S, Rao Y, Sellers EM, Kwan M, Mendis D, Tyndale RF.

Xenobiotica. 2000 Jun;30(6):547-64.

PMID:
10923858
36.

Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment.

Miksys S, Hoffmann E, Tyndale RF.

Biochem Pharmacol. 2000 Jun 15;59(12):1501-11.

PMID:
10799646
37.

Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.

Tyndale RF, Li Y, Li NY, Messina E, Miksys S, Sellers EM.

Drug Metab Dispos. 1999 Aug;27(8):924-30.

PMID:
10421620
38.

The distribution of a CRF-like diuretic peptide in the blood-feeding bug Rhodnius prolixus.

Te Brugge VA, Miksys SM, Coast GM, Schooley DA, Orchard I.

J Exp Biol. 1999 Aug;202(Pt 15):2017-27.

39.

Localization and neurohemal release of FMRFamide-related peptides in the stick insect Carausius morosus.

Miksys S, Lange AB, Orchard I, Wong V.

Peptides. 1997;18(1):27-40.

PMID:
9114449
41.

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