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Items: 17

1.

VMXi: a fully automated, fully remote, high-flux in situ macromolecular crystallography beamline.

Sanchez-Weatherby J, Sandy J, Mikolajek H, Lobley CMC, Mazzorana M, Kelly J, Preece G, Littlewood R, Sørensen TLM.

J Synchrotron Radiat. 2019 Jan 1;26(Pt 1):291-301. doi: 10.1107/S1600577518015114. Epub 2019 Jan 1.

2.

The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.

Papakyriakou A, Reeves E, Beton M, Mikolajek H, Douglas L, Cooper G, Elliott T, Werner JM, James E.

J Biol Chem. 2018 May 18;293(20):7538-7548. doi: 10.1074/jbc.RA117.000313. Epub 2018 Mar 29.

3.

Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival.

Xie J, Mikolajek H, Pigott CR, Hooper KJ, Mellows T, Moore CE, Mohammed H, Werner JM, Thomas GJ, Proud CG.

Mol Cell Biol. 2015 May;35(10):1805-24. doi: 10.1128/MCB.00012-15. Epub 2015 Mar 16.

4.

Elongation Factor 2 Kinase Is Regulated by Proline Hydroxylation and Protects Cells during Hypoxia.

Moore CE, Mikolajek H, Regufe da Mota S, Wang X, Kenney JW, Werner JM, Proud CG.

Mol Cell Biol. 2015 May;35(10):1788-804. doi: 10.1128/MCB.01457-14. Epub 2015 Mar 9.

5.

Characterization of recombinantly expressed matrilin VWA domains.

Becker AK, Mikolajek H, Werner JM, Paulsson M, Wagener R.

Protein Expr Purif. 2015 Mar;107:20-8. doi: 10.1016/j.pep.2014.11.005. Epub 2014 Nov 21.

6.

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator.

Phippen CW, Mikolajek H, Schlaefli HG, Keevil CW, Webb JS, Tews I.

FEBS Lett. 2014 Dec 20;588(24):4631-6. doi: 10.1016/j.febslet.2014.11.002. Epub 2014 Nov 11.

7.

A conserved loop in the catalytic domain of eukaryotic elongation factor 2 kinase plays a key role in its substrate specificity.

Moore CE, Regufe da Mota S, Mikolajek H, Proud CG.

Mol Cell Biol. 2014 Jun;34(12):2294-307. doi: 10.1128/MCB.00388-14. Epub 2014 Apr 14.

8.

A structure of a collagen VI VWA domain displays N and C termini at opposite sides of the protein.

Becker AK, Mikolajek H, Paulsson M, Wagener R, Werner JM.

Structure. 2014 Feb 4;22(2):199-208. doi: 10.1016/j.str.2013.06.028. Epub 2013 Dec 12.

9.

Insights into the mechanism of pyrrole polymerization catalysed by porphobilinogen deaminase: high-resolution X-ray studies of the Arabidopsis thaliana enzyme.

Roberts A, Gill R, Hussey RJ, Mikolajek H, Erskine PT, Cooper JB, Wood SP, Chrystal EJ, Shoolingin-Jordan PM.

Acta Crystallogr D Biol Crystallogr. 2013 Mar;69(Pt 3):471-85. doi: 10.1107/S0907444912052134. Epub 2013 Feb 16.

PMID:
23519422
10.

2β-deoxy-Kdo is an inhibitor of the Arabidopsis thaliana CMP-2-Keto-3-deoxymanno-octulosonic acid synthetase, the enzyme required for activation of Kdo prior to incorporation into rhamnogalacturonan II.

Smyth KM, Mikolajek H, Werner JM, Marchant A.

Mol Plant. 2013 May;6(3):981-4. doi: 10.1093/mp/sst011. Epub 2013 Jan 18. No abstract available.

11.

Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana.

Roberts A, Gill R, Hussey RJ, Mikolajek H, Erskine PT, Cooper JB, Wood SP, Chrystal EJ, Shoolingin-Jordan PM.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1491-3. doi: 10.1107/S1744309112042212. Epub 2012 Nov 14.

12.

Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.

Pigott CR, Mikolajek H, Moore CE, Finn SJ, Phippen CW, Werner JM, Proud CG.

Biochem J. 2012 Feb 15;442(1):105-18. doi: 10.1042/BJ20111536.

13.

Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component.

Mikolajek H, Kolstoe SE, Pye VE, Mangione P, Pepys MB, Wood SP.

J Mol Recognit. 2011 Mar-Apr;24(2):371-7. doi: 10.1002/jmr.1090.

PMID:
21360619
14.

Structure and function of the l-threonine dehydrogenase (TkTDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.

Bowyer A, Mikolajek H, Stuart JW, Wood SP, Jamil F, Rashid N, Akhtar M, Cooper JB.

J Struct Biol. 2009 Nov;168(2):294-304. doi: 10.1016/j.jsb.2009.07.011. Epub 2009 Jul 16.

PMID:
19616102
15.

Crystallization and preliminary X-ray diffraction analysis of L-threonine dehydrogenase (TDH) from the hyperthermophilic archaeon Thermococcus kodakaraensis.

Bowyer A, Mikolajek H, Wright JN, Coker A, Erskine PT, Cooper JB, Bashir Q, Rashid N, Jamil F, Akhtar M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1;64(Pt 9):828-30. doi: 10.1107/S1744309108025384. Epub 2008 Aug 20.

16.

High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei.

Erskine PT, Knight MJ, Ruaux A, Mikolajek H, Wong Fat Sang N, Withers J, Gill R, Wood SP, Wood M, Fox GC, Cooper JB.

J Mol Biol. 2006 Oct 13;363(1):125-36. Epub 2006 Aug 1.

PMID:
16950399
17.

Crystallization and preliminary X-ray diffraction analysis of BipD, a virulence factor from Burkholderia pseudomallei.

Knight MJ, Ruaux A, Mikolajek H, Erskine PT, Gill R, Wood SP, Wood M, Cooper JB.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt 8):761-4. Epub 2006 Jul 24.

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