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Items: 1 to 50 of 57

1.

Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes.

Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D.

Nat Commun. 2018 Sep 7;9(1):3634. doi: 10.1038/s41467-018-05573-y.

2.

Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells.

Grace CS, Mikkola HKA, Dou DR, Calvanese V, Ronn RE, Purton LE.

Exp Hematol. 2018 Sep;65:1-16. doi: 10.1016/j.exphem.2018.06.287. Epub 2018 Jul 4. Review.

PMID:
29981365
3.

Genetic Regulation of Fibroblast Activation and Proliferation in Cardiac Fibrosis.

Park S, Ranjbarvaziri S, Lay FD, Zhao P, Miller MJ, Dhaliwal JS, Huertas-Vazquez A, Wu X, Qiao R, Soffer JM, Rau C, Wang Y, Mikkola HKA, Lusis AJ, Ardehali R.

Circulation. 2018 Sep 18;138(12):1224-1235. doi: 10.1161/CIRCULATIONAHA.118.035420.

4.

Analysis of cardiomyocyte clonal expansion during mouse heart development and injury.

Sereti KI, Nguyen NB, Kamran P, Zhao P, Ranjbarvaziri S, Park S, Sabri S, Engel JL, Sung K, Kulkarni RP, Ding Y, Hsiai TK, Plath K, Ernst J, Sahoo D, Mikkola HKA, Iruela-Arispe ML, Ardehali R.

Nat Commun. 2018 Feb 21;9(1):754. doi: 10.1038/s41467-018-02891-z.

5.

Hepatic Leukemia Factor Maintains Quiescence of Hematopoietic Stem Cells and Protects the Stem Cell Pool during Regeneration.

Komorowska K, Doyle A, Wahlestedt M, Subramaniam A, Debnath S, Chen J, Soneji S, Van Handel B, Mikkola HKA, Miharada K, Bryder D, Larsson J, Magnusson M.

Cell Rep. 2017 Dec 19;21(12):3514-3523. doi: 10.1016/j.celrep.2017.11.084.

6.

LYVE1 Marks the Divergence of Yolk Sac Definitive Hemogenic Endothelium from the Primitive Erythroid Lineage.

Lee LK, Ghorbanian Y, Wang W, Wang Y, Kim YJ, Weissman IL, Inlay MA, Mikkola HKA.

Cell Rep. 2016 Nov 22;17(9):2286-2298. doi: 10.1016/j.celrep.2016.10.080.

7.

Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros.

Ng ES, Azzola L, Bruveris FF, Calvanese V, Phipson B, Vlahos K, Hirst C, Jokubaitis VJ, Yu QC, Maksimovic J, Liebscher S, Januar V, Zhang Z, Williams B, Conscience A, Durnall J, Jackson S, Costa M, Elliott D, Haylock DN, Nilsson SK, Saffery R, Schenke-Layland K, Oshlack A, Mikkola HK, Stanley EG, Elefanty AG.

Nat Biotechnol. 2016 Nov;34(11):1168-1179. doi: 10.1038/nbt.3702. Epub 2016 Oct 17.

PMID:
27748754
8.

MEF2C protects bone marrow B-lymphoid progenitors during stress haematopoiesis.

Wang W, Org T, Montel-Hagen A, Pioli PD, Duan D, Israely E, Malkin D, Su T, Flach J, Kurdistani SK, Schiestl RH, Mikkola HK.

Nat Commun. 2016 Aug 10;7:12376. doi: 10.1038/ncomms12376.

9.

Critical requirement of VEGF-C in transition to fetal erythropoiesis.

Fang S, Nurmi H, Heinolainen K, Chen S, Salminen E, Saharinen P, Mikkola HK, Alitalo K.

Blood. 2016 Aug 4;128(5):710-20. doi: 10.1182/blood-2015-12-687970. Epub 2016 Jun 24.

PMID:
27343251
10.

Medial HOXA genes demarcate haematopoietic stem cell fate during human development.

Dou DR, Calvanese V, Sierra MI, Nguyen AT, Minasian A, Saarikoski P, Sasidharan R, Ramirez CM, Zack JA, Crooks GM, Galic Z, Mikkola HK.

Nat Cell Biol. 2016 Jun;18(6):595-606. doi: 10.1038/ncb3354. Epub 2016 May 16.

11.

Tracking HSC Origin: From Bench to Placenta.

Calvanese V, Mikkola HK.

Dev Cell. 2016 Mar 7;36(5):479-80. doi: 10.1016/j.devcel.2016.02.022.

12.

GLI2 inhibition abrogates human leukemia stem cell dormancy.

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH.

J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.

13.

Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence.

Org T, Duan D, Ferrari R, Montel-Hagen A, Van Handel B, Kerényi MA, Sasidharan R, Rubbi L, Fujiwara Y, Pellegrini M, Orkin SH, Kurdistani SK, Mikkola HK.

EMBO J. 2015 Mar 12;34(6):759-77. doi: 10.15252/embj.201490542. Epub 2015 Jan 6.

14.

GPI-80 defines self-renewal ability in hematopoietic stem cells during human development.

Prashad SL, Calvanese V, Yao CY, Kaiser J, Wang Y, Sasidharan R, Crooks G, Magnusson M, Mikkola HK.

Cell Stem Cell. 2015 Jan 8;16(1):80-7. doi: 10.1016/j.stem.2014.10.020. Epub 2014 Nov 13.

15.

The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.

Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P.

Cell Rep. 2014 May 22;7(4):1239-47. doi: 10.1016/j.celrep.2014.04.015. Epub 2014 May 9.

16.

Sex hormone drives blood stem cell reproduction.

Calvanese V, Lee LK, Mikkola HK.

EMBO J. 2014 Mar 18;33(6):534-5. doi: 10.1002/embj.201487976. Epub 2014 Feb 20.

17.

Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.

Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML.

Cell. 2014 Jan 30;156(3):549-62. doi: 10.1016/j.cell.2013.12.025.

18.

c-Met-dependent multipotent labyrinth trophoblast progenitors establish placental exchange interface.

Ueno M, Lee LK, Chhabra A, Kim YJ, Sasidharan R, Van Handel B, Wang Y, Kamata M, Kamran P, Sereti KI, Ardehali R, Jiang M, Mikkola HK.

Dev Cell. 2013 Nov 25;27(4):373-86. doi: 10.1016/j.devcel.2013.10.019.

19.

Selective suppression of endothelial cytokine production by progesterone receptor.

Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML.

Vascul Pharmacol. 2013 Jul-Aug;59(1-2):36-43. doi: 10.1016/j.vph.2013.06.001. Epub 2013 Jun 6.

20.

Haemogenic endocardium contributes to transient definitive haematopoiesis.

Nakano H, Liu X, Arshi A, Nakashima Y, van Handel B, Sasidharan R, Harmon AW, Shin JH, Schwartz RJ, Conway SJ, Harvey RP, Pashmforoush M, Mikkola HK, Nakano A.

Nat Commun. 2013;4:1564. doi: 10.1038/ncomms2569.

21.

Expansion on stromal cells preserves the undifferentiated state of human hematopoietic stem cells despite compromised reconstitution ability.

Magnusson M, Sierra MI, Sasidharan R, Prashad SL, Romero M, Saarikoski P, Van Handel B, Huang A, Li X, Mikkola HK.

PLoS One. 2013;8(1):e53912. doi: 10.1371/journal.pone.0053912. Epub 2013 Jan 16.

22.

Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo.

Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B.

J Virol. 2013 Feb;87(4):2094-108. doi: 10.1128/JVI.02032-12. Epub 2012 Nov 28. Erratum in: J Virol. 2013 Apr;87(8):4794.

23.

Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells.

Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR.

PLoS One. 2012;7(10):e45603. doi: 10.1371/journal.pone.0045603. Epub 2012 Oct 9. Erratum in: PLoS One. 2012; 7(10): 10.1371/annotation/649fb8ef-a4c7-4ee7-b382-e1657b9aa07e.

24.

Combinatorial assembly of developmental stage-specific enhancers controls gene expression programs during human erythropoiesis.

Xu J, Shao Z, Glass K, Bauer DE, Pinello L, Van Handel B, Hou S, Stamatoyannopoulos JA, Mikkola HK, Yuan GC, Orkin SH.

Dev Cell. 2012 Oct 16;23(4):796-811. doi: 10.1016/j.devcel.2012.09.003. Epub 2012 Oct 4.

25.

Dynamic distribution of linker histone H1.5 in cellular differentiation.

Li JY, Patterson M, Mikkola HK, Lowry WE, Kurdistani SK.

PLoS Genet. 2012;8(8):e1002879. doi: 10.1371/journal.pgen.1002879. Epub 2012 Aug 30.

26.

Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin.

Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM.

Nat Immunol. 2012 Oct;13(10):963-71. doi: 10.1038/ni.2405. Epub 2012 Sep 2.

27.

Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium.

Van Handel B, Montel-Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd CJ, Schredelseker J, Wang Y, Hunter S, Org T, Zhou J, Li X, Pellegrini M, Chen JN, Orkin SH, Kurdistani SK, Evans SM, Nakano A, Mikkola HK.

Cell. 2012 Aug 3;150(3):590-605. doi: 10.1016/j.cell.2012.06.026.

28.

Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling.

Chhabra A, Lechner AJ, Ueno M, Acharya A, Van Handel B, Wang Y, Iruela-Arispe ML, Tallquist MD, Mikkola HK.

Dev Cell. 2012 Mar 13;22(3):651-9. doi: 10.1016/j.devcel.2011.12.022. Epub 2012 Mar 1.

29.

The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo.

Hyde BB, Liesa M, Elorza AA, Qiu W, Haigh SE, Richey L, Mikkola HK, Schlaeger TM, Shirihai OS.

Cell Death Differ. 2012 Jul;19(7):1117-26. doi: 10.1038/cdd.2011.195. Epub 2012 Jan 13.

30.

Defining the nature of human pluripotent stem cell progeny.

Patterson M, Chan DN, Ha I, Case D, Cui Y, Van Handel B, Mikkola HK, Lowry WE.

Cell Res. 2012 Jan;22(1):178-93. doi: 10.1038/cr.2011.133. Epub 2011 Aug 16.

31.

Return to youth with Sox17.

Chhabra A, Mikkola HK.

Genes Dev. 2011 Aug 1;25(15):1557-62. doi: 10.1101/gad.17328611.

32.

Recapitulation of the embryonic cardiovascular progenitor cell niche.

Schenke-Layland K, Nsair A, Van Handel B, Angelis E, Gluck JM, Votteler M, Goldhaber JI, Mikkola HK, Kahn M, Maclellan WR.

Biomaterials. 2011 Apr;32(11):2748-56. doi: 10.1016/j.biomaterials.2010.12.046. Epub 2011 Jan 22.

33.

Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells.

Huang X, Gschweng E, Van Handel B, Cheng D, Mikkola HK, Witte ON.

Blood. 2011 Feb 17;117(7):2157-65. doi: 10.1182/blood-2010-08-302711. Epub 2010 Dec 16.

34.

Hematopoietic stem cell development in the placenta.

Gekas C, Rhodes KE, Van Handel B, Chhabra A, Ueno M, Mikkola HK.

Int J Dev Biol. 2010;54(6-7):1089-98. doi: 10.1387/ijdb.103070cg. Review.

35.

The first trimester human placenta is a site for terminal maturation of primitive erythroid cells.

Van Handel B, Prashad SL, Hassanzadeh-Kiabi N, Huang A, Magnusson M, Atanassova B, Chen A, Hamalainen EI, Mikkola HK.

Blood. 2010 Oct 28;116(17):3321-30. doi: 10.1182/blood-2010-04-279489. Epub 2010 Jul 13.

36.

Placenta as a newly identified source of hematopoietic stem cells.

Lee LK, Ueno M, Van Handel B, Mikkola HK.

Curr Opin Hematol. 2010 Jul;17(4):313-8. doi: 10.1097/MOH.0b013e328339f295. Review.

37.

Targeting leukemia stem cells.

Mikkola HK, Radu CG, Witte ON.

Nat Biotechnol. 2010 Mar;28(3):237-8. doi: 10.1038/nbt0310-237. No abstract available.

PMID:
20212485
38.

DNA methylation is a guardian of stem cell self-renewal and multipotency.

Gereige LM, Mikkola HK.

Nat Genet. 2009 Nov;41(11):1164-6. doi: 10.1038/ng1109-1164. No abstract available.

PMID:
19862008
39.

Derivation of primordial germ cells from human embryonic and induced pluripotent stem cells is significantly improved by coculture with human fetal gonadal cells.

Park TS, Galic Z, Conway AE, Lindgren A, van Handel BJ, Magnusson M, Richter L, Teitell MA, Mikkola HK, Lowry WE, Plath K, Clark AT.

Stem Cells. 2009 Apr;27(4):783-95. doi: 10.1002/stem.13.

40.

Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis.

Gekas C, Rhodes KE, Gereige LM, Helgadottir H, Ferrari R, Kurdistani SK, Montecino-Rodriguez E, Bassel-Duby R, Olson E, Krivtsov AV, Armstrong S, Orkin SH, Pellegrini M, Mikkola HK.

Blood. 2009 Apr 9;113(15):3461-71. doi: 10.1182/blood-2008-07-167577. Epub 2009 Feb 11.

41.

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH.

Science. 2008 Dec 19;322(5909):1839-42. doi: 10.1126/science.1165409. Epub 2008 Dec 4.

42.

Isolation and visualization of mouse placental hematopoietic stem cells.

Gekas C, Rhodes KE, Mikkola HK.

Curr Protoc Stem Cell Biol. 2008 Aug;Chapter 2:Unit 2A.8.1-2A.8.14. doi: 10.1002/9780470151808.sc02a08s6.

PMID:
18729047
43.

UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis.

Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS.

J Biol Chem. 2008 Nov 7;283(45):30461-70. doi: 10.1074/jbc.M805400200. Epub 2008 Aug 7.

44.

Reprogrammed mouse fibroblasts differentiate into cells of the cardiovascular and hematopoietic lineages.

Schenke-Layland K, Rhodes KE, Angelis E, Butylkova Y, Heydarkhan-Hagvall S, Gekas C, Zhang R, Goldhaber JI, Mikkola HK, Plath K, MacLellan WR.

Stem Cells. 2008 Jun;26(6):1537-46. doi: 10.1634/stemcells.2008-0033. Epub 2008 May 1.

45.

Hematopoietic stem cells in transit--where's the niche?

Magnusson M, Mikkola HK.

Cell Stem Cell. 2008 Apr 10;2(4):302-4. doi: 10.1016/j.stem.2008.03.017.

46.

The emergence of hematopoietic stem cells is initiated in the placental vasculature in the absence of circulation.

Rhodes KE, Gekas C, Wang Y, Lux CT, Francis CS, Chan DN, Conway S, Orkin SH, Yoder MC, Mikkola HK.

Cell Stem Cell. 2008 Mar 6;2(3):252-63. doi: 10.1016/j.stem.2008.01.001.

47.

The hematopoietic stem cell and its niche: a comparative view.

Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U.

Genes Dev. 2007 Dec 1;21(23):3044-60. Review.

48.

Collagen IV induces trophoectoderm differentiation of mouse embryonic stem cells.

Schenke-Layland K, Angelis E, Rhodes KE, Heydarkhan-Hagvall S, Mikkola HK, Maclellan WR.

Stem Cells. 2007 Jun;25(6):1529-38. Epub 2007 Mar 15.

49.

The journey of developing hematopoietic stem cells.

Mikkola HK, Orkin SH.

Development. 2006 Oct;133(19):3733-44. Review.

50.

Transcriptional activators, repressors, and epigenetic modifiers controlling hematopoietic stem cell development.

Teitell MA, Mikkola HK.

Pediatr Res. 2006 Apr;59(4 Pt 2):33R-9R. Review.

PMID:
16549546

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