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Items: 35

1.

Generation of Fibrodysplasia ossificans progressiva and control integration free iPSC lines from periodontal ligament fibroblasts.

Sanchez-Duffhues G, Mikkers H, de Jong D, Szuhai K, de Vries TJ, Freund C, Bravenboer N, van Es RJJ, Netelenbos JC, Goumans MJ, Eekhoff EMW, Ten Dijke P.

Stem Cell Res. 2019 Dec;41:101639. doi: 10.1016/j.scr.2019.101639. Epub 2019 Nov 5.

2.

De novo generation of a functional human thymus from induced pluripotent stem cells.

Chhatta AR, Cordes M, Hanegraaf MAJ, Vloemans S, Cupedo T, Cornelissen JJ, Carlotti F, Salvatori D, Pike-Overzet K, Fibbe WE, Hoeben RC, Mikkers HMM, Staal FJT.

J Allergy Clin Immunol. 2019 Nov;144(5):1416-1419.e7. doi: 10.1016/j.jaci.2019.05.042. Epub 2019 Jul 16. No abstract available.

PMID:
31323248
3.

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J.

Stem Cell Reports. 2019 May 14;12(5):906-919. doi: 10.1016/j.stemcr.2019.03.002. Epub 2019 Apr 4.

4.

Generation of 3 human induced pluripotent stem cell lines LUMCi005-A, B and C from a Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type patient.

Daoutsali E, Buijsen RAM, van de Pas S, Jong A', Mikkers H, Brands T, Eussen B, de Klein A, van der Graaf LM, Pepers BA, Freund C, Terwindt GM, Orlova VV, van Roon-Mom WMC.

Stem Cell Res. 2019 Jan;34:101359. doi: 10.1016/j.scr.2018.101359. Epub 2018 Dec 14.

5.

Allele-specific repression of Sox2 through the long non-coding RNA Sox2ot.

Messemaker TC, van Leeuwen SM, van den Berg PR, 't Jong AEJ, Palstra RJ, Hoeben RC, Semrau S, Mikkers HMM.

Sci Rep. 2018 Jan 10;8(1):386. doi: 10.1038/s41598-017-18649-4.

6.

Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays.

Quinn PM, Buck TM, Ohonin C, Mikkers HMM, Wijnholds J.

Methods Mol Biol. 2018;1715:261-273. doi: 10.1007/978-1-4939-7522-8_19.

PMID:
29188520
7.

Antisense Long Non-Coding RNAs Are Deregulated in Skin Tissue of Patients with Systemic Sclerosis.

Messemaker TC, Chadli L, Cai G, Goelela VS, Boonstra M, Dorjée AL, Andersen SN, Mikkers HMM, van 't Hof P, Mei H, Distler O, Draisma HHM, Johnson ME, Orzechowski NM, Simms RW, Toes REM, Aarbiou J, Huizinga TW, Whitfield ML, DeGroot J, de Vries-Bouwstra J, Kurreeman F.

J Invest Dermatol. 2018 Apr;138(4):826-835. doi: 10.1016/j.jid.2017.09.053. Epub 2017 Nov 24.

8.

In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting.

Chen X, Janssen JM, Liu J, Maggio I, 't Jong AEJ, Mikkers HMM, Gonçalves MAFV.

Nat Commun. 2017 Sep 22;8(1):657. doi: 10.1038/s41467-017-00687-1.

9.

Axin2-mTurquoise2: A novel reporter mouse model for the detection of canonical Wnt signalling.

de Roo JJD, Breukel C, Chhatta AR, Linssen MM, Vloemans SA, Salvatori D, Mikkers HMM, Verbeek SJ, Staal FJT.

Genesis. 2017 Oct;55(10). doi: 10.1002/dvg.23068. Epub 2017 Sep 19.

PMID:
28875532
10.

Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients.

Messemaker TC, Mikkers HMM, Huizinga TW, Toes REM, van der Helm-van Mil AHM, Kurreeman F.

Genes Immun. 2017 Sep;18(3):191-196. doi: 10.1038/gene.2017.20. Epub 2017 Aug 10.

PMID:
28794503
11.

Caught in a Wnt storm: Complexities of Wnt signaling in hematopoiesis.

Staal FJ, Chhatta A, Mikkers H.

Exp Hematol. 2016 Jun;44(6):451-7. doi: 10.1016/j.exphem.2016.03.004. Epub 2016 Mar 23. Review.

PMID:
27016274
12.

A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels.

Messemaker TC, Frank-Bertoncelj M, Marques RB, Adriaans A, Bakker AM, Daha N, Gay S, Huizinga TW, Toes RE, Mikkers HM, Kurreeman F.

Genes Immun. 2016 Mar;17(2):85-92. doi: 10.1038/gene.2015.54. Epub 2015 Dec 17.

PMID:
26673966
13.

Comment on "Functional Analysis of a Complement Polymorphism (rs17611) Associated with Rheumatoid Arthritis".

Messemaker T, Toes RE, Mikkers HM, Kurreeman F.

J Immunol. 2015 Jul 1;195(1):3-4. doi: 10.4049/jimmunol.1500822. No abstract available.

14.

Cell replacement therapies: is it time to reprogram?

Mikkers HM, Freund C, Mummery CL, Hoeben RC.

Hum Gene Ther. 2014 Oct;25(10):866-74. doi: 10.1089/hum.2014.097. Epub 2014 Sep 17. Review. Erratum in: Hum Gene Ther. 2014 Dec;25(12):1061.

15.

Polycistronic lentivirus induced pluripotent stem cells from skin biopsies after long term storage, blood outgrowth endothelial cells and cells from milk teeth.

Dambrot C, van de Pas S, van Zijl L, Brändl B, Wang JW, Schalij MJ, Hoeben RC, Atsma DE, Mikkers HM, Mummery CL, Freund C.

Differentiation. 2013 Feb;85(3):101-9. doi: 10.1016/j.diff.2013.01.001. Epub 2013 May 7.

PMID:
23665895
16.

Reconsidering pluripotency tests: do we still need teratoma assays?

Buta C, David R, Dressel R, Emgård M, Fuchs C, Gross U, Healy L, Hescheler J, Kolar R, Martin U, Mikkers H, Müller FJ, Schneider RK, Seiler AE, Spielmann H, Weitzer G.

Stem Cell Res. 2013 Jul;11(1):552-62. doi: 10.1016/j.scr.2013.03.001. Epub 2013 Mar 26. Review.

17.

Prospects and challenges of induced pluripotent stem cells as a source of hematopoietic stem cells.

van Bekkum DW, Mikkers HM.

Ann N Y Acad Sci. 2012 Aug;1266:179-88. doi: 10.1111/j.1749-6632.2012.06629.x. Review.

PMID:
22901269
18.

Induced pluripotent stem cells and severe combined immunodeficiency: merely disease modeling or potentially a novel cure?

Mikkers H, Pike-Overzet K, Staal FJ.

Pediatr Res. 2012 Apr;71(4 Pt 2):427-32. doi: 10.1038/pr.2011.65. Epub 2012 Feb 8. Review.

PMID:
22430378
19.

[Stem cells: therapeutic applications and experimental techniques].

Mikkers HM, Hoeben RC.

Ned Tijdschr Geneeskd. 2011;155(47):A3565. Review. Dutch.

PMID:
22129808
20.

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications.

Staal FJ, Baum C, Cowan C, Dzierzak E, Hacein-Bey-Abina S, Karlsson S, Lapidot T, Lemischka I, Mendez-Ferrer S, Mikkers H, Moore K, Moreno E, Mummery CL, Robin C, Suda T, Van Pel M, Vanden Brink G, Zwaginga JJ, Fibbe WE.

Leukemia. 2011 Jul;25(7):1095-102. doi: 10.1038/leu.2011.52. Epub 2011 Apr 29. Review.

PMID:
21527933
21.

Differentiation of induced pluripotent stem cells into functional oligodendrocytes.

Czepiel M, Balasubramaniyan V, Schaafsma W, Stancic M, Mikkers H, Huisman C, Boddeke E, Copray S.

Glia. 2011 Jun;59(6):882-92. doi: 10.1002/glia.21159. Epub 2011 Mar 24.

PMID:
21438010
22.

Long non-coding RNAs: Guardians of development.

van Leeuwen S, Mikkers H.

Differentiation. 2010 Nov-Dec;80(4-5):175-83. doi: 10.1016/j.diff.2010.07.003. Epub 2010 Aug 11. Review.

PMID:
20705382
23.

Tumors originating from induced pluripotent stem cells and methods for their prevention.

Duinsbergen D, Salvatori D, Eriksson M, Mikkers H.

Ann N Y Acad Sci. 2009 Sep;1176:197-204. doi: 10.1111/j.1749-6632.2009.04563.x.

PMID:
19796248
24.

A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites.

Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M, Berns A, Adams DJ.

Nat Protoc. 2009;4(5):789-98. doi: 10.1038/nprot.2009.64. Epub 2009 Apr 30.

25.

Induced pluripotency with endogenous and inducible genes.

Duinsbergen D, Eriksson M, 't Hoen PA, Frisén J, Mikkers H.

Exp Cell Res. 2008 Oct 15;314(17):3255-63. doi: 10.1016/j.yexcr.2008.06.024. Epub 2008 Jul 9.

PMID:
18656469
26.

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation.

Barnabé-Heider F, Meletis K, Eriksson M, Bergmann O, Sabelström H, Harvey MA, Mikkers H, Frisén J.

Nat Methods. 2008 Feb;5(2):189-96. doi: 10.1038/nmeth.1174. Epub 2008 Jan 20.

PMID:
18204459
27.

Deconstructing stemness.

Mikkers H, Frisén J.

EMBO J. 2005 Aug 3;24(15):2715-9. Epub 2005 Jul 21. Review.

28.

Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.

Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J, Berns A.

Mol Cell Biol. 2004 Jul;24(13):6104-15.

29.

Retroviral insertional mutagenesis: tagging cancer pathways.

Mikkers H, Berns A.

Adv Cancer Res. 2003;88:53-99. Review.

PMID:
12665053
30.
31.

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.

Mikkers H, Allen J, Knipscheer P, Romeijn L, Hart A, Vink E, Berns A.

Nat Genet. 2002 Sep;32(1):153-9. Epub 2002 Aug 19. Erratum in: Nat Genet 2002 Nov;32(3):459. Romeyn Lieke [corrected to Romeijn Like]. Nat Genet 2002 Oct;32(2):331.

PMID:
12185366
32.

Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP.

Konietzko U, Kauselmann G, Scafidi J, Staubli U, Mikkers H, Berns A, Schweizer M, Waltereit R, Kuhl D.

EMBO J. 1999 Jun 15;18(12):3359-69.

33.

Identification and characterization of collaborating oncogenes in compound mutant mice.

Berns A, Mikkers H, Krimpenfort P, Allen J, Scheijen B, Jonkers J.

Cancer Res. 1999 Apr 1;59(7 Suppl):1773s-1777s.

PMID:
10197595
35.

Insulin-induced tyrosine dephosphorylation of paxillin and focal adhesion kinase requires active phosphotyrosine phosphatase 1D.

Ouwens DM, Mikkers HM, van der Zon GC, Stein-Gerlach M, Ullrich A, Maassen JA.

Biochem J. 1996 Sep 1;318 ( Pt 2):609-14.

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