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Items: 1 to 50 of 86

1.

Sustained transgene expression from sleeping beauty DNA transposons containing a core fragment of the HNRPA2B1-CBX3 ubiquitous chromatin opening element (UCOE).

Skipper KA, Hollensen AK, Antoniou MN, Mikkelsen JG.

BMC Biotechnol. 2019 Nov 9;19(1):75. doi: 10.1186/s12896-019-0570-2.

2.

MicroRNA-155 controls vincristine sensitivity and predicts superior clinical outcome in diffuse large B-cell lymphoma.

Due H, Schönherz AA, Ryø L, Primo MN, Jespersen DS, Thomsen EA, Roug AS, Xiao M, Tan X, Pang Y, Young KH, Bøgsted M, Mikkelsen JG, Dybkær K.

Blood Adv. 2019 Apr 9;3(7):1185-1196. doi: 10.1182/bloodadvances.2018029660.

3.

CRISPR-Based Lentiviral Knockout Libraries for Functional Genomic Screening and Identification of Phenotype-Related Genes.

Thomsen EA, Mikkelsen JG.

Methods Mol Biol. 2019;1961:343-357. doi: 10.1007/978-1-4939-9170-9_21.

PMID:
30912056
4.

Toward In Vivo Gene Therapy Using CRISPR.

Skipper KA, Mikkelsen JG.

Methods Mol Biol. 2019;1961:293-306. doi: 10.1007/978-1-4939-9170-9_18.

PMID:
30912053
5.

Production and Validation of Lentiviral Vectors for CRISPR/Cas9 Delivery.

Ryø LB, Thomsen EA, Mikkelsen JG.

Methods Mol Biol. 2019;1961:93-109. doi: 10.1007/978-1-4939-9170-9_7.

PMID:
30912042
6.

Suppression of Choroidal Neovascularization by AAV-Based Dual-Acting Antiangiogenic Gene Therapy.

Askou AL, Alsing S, Benckendorff JNE, Holmgaard A, Mikkelsen JG, Aagaard L, Bek T, Corydon TJ.

Mol Ther Nucleic Acids. 2019 Jun 7;16:38-50. doi: 10.1016/j.omtn.2019.01.012. Epub 2019 Feb 2.

7.

Dominant-negative SERPING1 variants cause intracellular retention of C1 inhibitor in hereditary angioedema.

Haslund D, Ryø LB, Seidelin Majidi S, Rose I, Skipper KA, Fryland T, Bohn AB, Koch C, Thomsen MK, Palarasah Y, Corydon TJ, Bygum A, Nejsum LN, Mikkelsen JG.

J Clin Invest. 2019 Jan 2;129(1):388-405. doi: 10.1172/JCI98869. Epub 2018 Dec 10.

8.

Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs.

Hollensen AK, Andersen S, Hjorth K, Bak RO, Hansen TB, Kjems J, Aagaard L, Damgaard CK, Mikkelsen JG.

Mol Ther Nucleic Acids. 2018 Dec 7;13:365-375. doi: 10.1016/j.omtn.2018.09.009. Epub 2018 Sep 21.

9.

Improved Lentiviral Gene Delivery to Mouse Liver by Hydrodynamic Vector Injection through Tail Vein.

Dalsgaard T, Cecchi CR, Askou AL, Bak RO, Andersen PO, Hougaard D, Jensen TG, Dagnæs-Hansen F, Mikkelsen JG, Corydon TJ, Aagaard L.

Mol Ther Nucleic Acids. 2018 Sep 7;12:672-683. doi: 10.1016/j.omtn.2018.07.005. Epub 2018 Aug 6.

10.

Viral delivery of genome-modifying proteins for cellular reprogramming.

Mikkelsen JG.

Curr Opin Genet Dev. 2018 Oct;52:92-99. doi: 10.1016/j.gde.2018.06.005. Epub 2018 Jun 19. Review.

PMID:
29929184
11.

Time-Restricted PiggyBac DNA Transposition by Transposase Protein Delivery Using Lentivirus-Derived Nanoparticles.

Skipper KA, Nielsen MG, Andersen S, Ryø LB, Bak RO, Mikkelsen JG.

Mol Ther Nucleic Acids. 2018 Jun 1;11:253-262. doi: 10.1016/j.omtn.2018.02.006. Epub 2018 Mar 30.

12.

Defective RNA sensing by RIG-I in severe influenza virus infection.

Jørgensen SE, Christiansen M, Ryø LB, Gad HH, Gjedsted J, Staeheli P, Mikkelsen JG, Storgaard M, Hartmann R, Mogensen TH.

Clin Exp Immunol. 2018 Jun;192(3):366-376. doi: 10.1111/cei.13120. Epub 2018 Mar 24.

13.

In Vivo Knockout of the Vegfa Gene by Lentiviral Delivery of CRISPR/Cas9 in Mouse Retinal Pigment Epithelium Cells.

Holmgaard A, Askou AL, Benckendorff JNE, Thomsen EA, Cai Y, Bek T, Mikkelsen JG, Corydon TJ.

Mol Ther Nucleic Acids. 2017 Dec 15;9:89-99. doi: 10.1016/j.omtn.2017.08.016. Epub 2017 Sep 21.

14.

Suppression of Choroidal Neovascularization in Mice by Subretinal Delivery of Multigenic Lentiviral Vectors Encoding Anti-Angiogenic MicroRNAs.

Askou AL, Benckendorff JNE, Holmgaard A, Storm T, Aagaard L, Bek T, Mikkelsen JG, Corydon TJ.

Hum Gene Ther Methods. 2017 Aug;28(4):222-233. doi: 10.1089/hgtb.2017.079.

PMID:
28817343
15.

Inborn errors in RNA polymerase III underlie severe varicella zoster virus infections.

Ogunjimi B, Zhang SY, Sørensen KB, Skipper KA, Carter-Timofte M, Kerner G, Luecke S, Prabakaran T, Cai Y, Meester J, Bartholomeus E, Bolar NA, Vandeweyer G, Claes C, Sillis Y, Lorenzo L, Fiorenza RA, Boucherit S, Dielman C, Heynderickx S, Elias G, Kurotova A, Auwera AV, Verstraete L, Lagae L, Verhelst H, Jansen A, Ramet J, Suls A, Smits E, Ceulemans B, Van Laer L, Plat Wilson G, Kreth J, Picard C, Von Bernuth H, Fluss J, Chabrier S, Abel L, Mortier G, Fribourg S, Mikkelsen JG, Casanova JL, Paludan SR, Mogensen TH.

J Clin Invest. 2017 Sep 1;127(9):3543-3556. doi: 10.1172/JCI92280. Epub 2017 Aug 7.

16.

Suppression of choroidal neovascularization in mice by subretinal delivery of multigenic lentiviral vectors encoding anti-angiogenic microRNAs.

Askou AL, Benckendorff JNE, Holmgaard A, Storm T, Aagaard L, Bek T, Mikkelsen JG, Corydon TJ.

Hum Gene Ther Methods. 2017 Jul 27. doi: 10.1089/hum.2017.079. [Epub ahead of print]

PMID:
28750559
17.

Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1.

Staunstrup NH, Stenderup K, Mortensen S, Primo MN, Rosada C, Steiniche T, Liu Y, Li R, Schmidt M, Purup S, Dagnæs-Hansen F, Schrøder LD, Svensson L, Petersen TK, Callesen H, Bolund L, Mikkelsen JG.

Dis Model Mech. 2017 Jul 1;10(7):869-880. doi: 10.1242/dmm.028662.

18.

Improved microRNA suppression by WPRE-linked tough decoy microRNA sponges.

Hollensen AK, Thomsen R, Bak RO, Petersen CC, Ermegaard ER, Aagaard L, Damgaard CK, Mikkelsen JG.

RNA. 2017 Aug;23(8):1247-1258. doi: 10.1261/rna.061192.117. Epub 2017 May 9.

19.

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.

Jønsson KL, Laustsen A, Krapp C, Skipper KA, Thavachelvam K, Hotter D, Egedal JH, Kjolby M, Mohammadi P, Prabakaran T, Sørensen LK, Sun C, Jensen SB, Holm CK, Lebbink RJ, Johannsen M, Nyegaard M, Mikkelsen JG, Kirchhoff F, Paludan SR, Jakobsen MR.

Nat Commun. 2017 Feb 10;8:14391. doi: 10.1038/ncomms14391.

20.

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection.

Thomsen MK, Nandakumar R, Stadler D, Malo A, Valls RM, Wang F, Reinert LS, Dagnaes-Hansen F, Hollensen AK, Mikkelsen JG, Protzer U, Paludan SR.

Hepatology. 2016 Sep;64(3):746-59. doi: 10.1002/hep.28685. Epub 2016 Jul 26.

PMID:
27312012
21.

Targeted, homology-driven gene insertion in stem cells by ZFN-loaded 'all-in-one' lentiviral vectors.

Cai Y, Laustsen A, Zhou Y, Sun C, Anderson MV, Li S, Uldbjerg N, Luo Y, Jakobsen MR, Mikkelsen JG.

Elife. 2016 Jun 9;5. pii: e12213. doi: 10.7554/eLife.12213.

22.

Lentiviral Delivery of Proteins for Genome Engineering.

Cai Y, Mikkelsen JG.

Curr Gene Ther. 2016;16(3):194-206. Review.

PMID:
27228988
23.

Lentivirus pre-packed with Cas9 protein for safer gene editing.

Choi JG, Dang Y, Abraham S, Ma H, Zhang J, Guo H, Cai Y, Mikkelsen JG, Wu H, Shankar P, Manjunath N.

Gene Ther. 2016 Jul;23(7):627-33. doi: 10.1038/gt.2016.27. Epub 2016 Apr 7.

PMID:
27052803
24.

Anti-Apoptotic Effects of Lentiviral Vector Transduction Promote Increased Rituximab Tolerance in Cancerous B-Cells.

Ranjbar B, Krogh LB, Laursen MB, Primo MN, Marques SC, Dybkær K, Mikkelsen JG.

PLoS One. 2016 Apr 5;11(4):e0153069. doi: 10.1371/journal.pone.0153069. eCollection 2016.

25.

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, Paludan SR.

Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680.

26.

High miR-34a expression improves response to doxorubicin in diffuse large B-cell lymphoma.

Marques SC, Ranjbar B, Laursen MB, Falgreen S, Bilgrau AE, Bødker JS, Jørgensen LK, Primo MN, Schmitz A, Ettrup MS, Johnsen HE, Bøgsted M, Mikkelsen JG, Dybkær K.

Exp Hematol. 2016 Apr;44(4):238-46.e2. doi: 10.1016/j.exphem.2015.12.007. Epub 2016 Feb 17.

PMID:
26854484
27.

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

Andersen LL, Mørk N, Reinert LS, Kofod-Olsen E, Narita R, Jørgensen SE, Skipper KA, Höning K, Gad HH, Østergaard L, Ørntoft TF, Hornung V, Paludan SR, Mikkelsen JG, Fujita T, Christiansen M, Hartmann R, Mogensen TH.

J Exp Med. 2015 Aug 24;212(9):1371-9. doi: 10.1084/jem.20142274. Epub 2015 Jul 27.

28.

Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin.

Jakobsen M, Askou AL, Stenderup K, Rosada C, Dagnæs-Hansen F, Jensen TG, Corydon TJ, Mikkelsen JG, Aagaard L.

Hum Gene Ther Methods. 2015 Aug;26(4):123-33. doi: 10.1089/hgtb.2014.135.

29.

Delivering the Goods for Genome Engineering and Editing.

Skipper KA, Mikkelsen JG.

Hum Gene Ther. 2015 Aug;26(8):486-97. doi: 10.1089/hum.2015.063. Review.

PMID:
26101789
30.

Overexpression of microRNA-155 increases IL-21 mediated STAT3 signaling and IL-21 production in systemic lupus erythematosus.

Rasmussen TK, Andersen T, Bak RO, Yiu G, Sørensen CM, Stengaard-Pedersen K, Mikkelsen JG, Utz PJ, Holm CK, Deleuran B.

Arthritis Res Ther. 2015 Jun 9;17:154. doi: 10.1186/s13075-015-0660-z.

31.

Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors.

Askou AL, Aagaard L, Kostic C, Arsenijevic Y, Hollensen AK, Bek T, Jensen TG, Mikkelsen JG, Corydon TJ.

Mol Ther Methods Clin Dev. 2015 Jan 28;2:14064. doi: 10.1038/mtm.2014.64. eCollection 2015.

32.

Driving DNA transposition by lentiviral protein transduction.

Cai Y, Mikkelsen JG.

Mob Genet Elements. 2014 Jun 23;4:e29591. eCollection 2014.

33.

Targeted genome editing by lentiviral protein transduction of zinc-finger and TAL-effector nucleases.

Cai Y, Bak RO, Mikkelsen JG.

Elife. 2014 Apr 24;3:e01911. doi: 10.7554/eLife.01911.

34.

Induction of atherosclerosis in mice and hamsters without germline genetic engineering.

Bjørklund MM, Hollensen AK, Hagensen MK, Dagnaes-Hansen F, Christoffersen C, Mikkelsen JG, Bentzon JF.

Circ Res. 2014 May 23;114(11):1684-9. doi: 10.1161/CIRCRESAHA.114.302937. Epub 2014 Mar 27.

PMID:
24677271
35.

miRNA sponges: soaking up miRNAs for regulation of gene expression.

Bak RO, Mikkelsen JG.

Wiley Interdiscip Rev RNA. 2014 May-Jun;5(3):317-33. doi: 10.1002/wrna.1213. Epub 2013 Dec 23. Review.

PMID:
24375960
36.

DNA transposon-based gene vehicles - scenes from an evolutionary drive.

Skipper KA, Andersen PR, Sharma N, Mikkelsen JG.

J Biomed Sci. 2013 Dec 9;20:92. doi: 10.1186/1423-0127-20-92. Review.

37.

DNA transposition by protein transduction of the piggyBac transposase from lentiviral Gag precursors.

Cai Y, Bak RO, Krogh LB, Staunstrup NH, Moldt B, Corydon TJ, Schrøder LD, Mikkelsen JG.

Nucleic Acids Res. 2014 Feb;42(4):e28. doi: 10.1093/nar/gkt1163. Epub 2013 Nov 21.

38.

IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication.

Jakobsen MR, Bak RO, Andersen A, Berg RK, Jensen SB, Tengchuan J, Laustsen A, Hansen K, Ostergaard L, Fitzgerald KA, Xiao TS, Mikkelsen JG, Mogensen TH, Paludan SR.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):E4571-80. doi: 10.1073/pnas.1311669110. Epub 2013 Oct 23. Erratum in: Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19651. Jin, Tengchuan [corrected to Tengchuan, Jin].

39.

Managing microRNAs with vector-encoded decoy-type inhibitors.

Bak RO, Hollensen AK, Mikkelsen JG.

Mol Ther. 2013 Aug;21(8):1478-85. doi: 10.1038/mt.2013.113. Epub 2013 Jun 11. Review.

40.

Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B.

Kofod-Olsen E, Møller JM, Schleimann MH, Bundgaard B, Bak RO, Øster B, Mikkelsen JG, Hupp T, Höllsberg P.

PLoS One. 2013;8(3):e59223. doi: 10.1371/journal.pone.0059223. Epub 2013 Mar 26.

41.

A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin.

Staunstrup NH, Bak RO, Cai Y, Svensson L, Petersen TK, Rosada C, Stenderup K, Bolund L, Mikkelsen JG.

Exp Dermatol. 2013 Mar;22(3):178-83. doi: 10.1111/exd.12091.

PMID:
23489420
42.

Efficient sleeping beauty DNA transposition from DNA minicircles.

Sharma N, Cai Y, Bak RO, Jakobsen MR, Schrøder LD, Mikkelsen JG.

Mol Ther Nucleic Acids. 2013 Feb 26;2:e74. doi: 10.1038/mtna.2013.1.

43.

Suppression of microRNAs by dual-targeting and clustered Tough Decoy inhibitors.

Hollensen AK, Bak RO, Haslund D, Mikkelsen JG.

RNA Biol. 2013 Mar;10(3):406-14. doi: 10.4161/rna.23543. Epub 2013 Jan 16.

44.

Epigenetic marking and repression of porcine endogenous retroviruses.

Wolf G, Nielsen AL, Mikkelsen JG, Pedersen FS.

J Gen Virol. 2013 May;94(Pt 5):960-70. doi: 10.1099/vir.0.049288-0. Epub 2013 Jan 16.

PMID:
23324470
45.

Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant.

Al-Mashhadi RH, Sørensen CB, Kragh PM, Christoffersen C, Mortensen MB, Tolbod LP, Thim T, Du Y, Li J, Liu Y, Moldt B, Schmidt M, Vajta G, Larsen T, Purup S, Bolund L, Nielsen LB, Callesen H, Falk E, Mikkelsen JG, Bentzon JF.

Sci Transl Med. 2013 Jan 2;5(166):166ra1. doi: 10.1126/scitranslmed.3004853.

46.

Potent microRNA suppression by RNA Pol II-transcribed 'Tough Decoy' inhibitors.

Bak RO, Hollensen AK, Primo MN, Sørensen CD, Mikkelsen JG.

RNA. 2013 Feb;19(2):280-93. doi: 10.1261/rna.034850.112. Epub 2012 Dec 18.

47.

Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT).

Jakobsen JE, Johansen MG, Schmidt M, Dagnæs-Hansen F, Dam K, Gunnarsson A, Liu Y, Kragh PM, Li R, Holm IE, Callesen H, Mikkelsen JG, Nielsen AL, Jørgensen AL.

Transgenic Res. 2013 Aug;22(4):709-23. doi: 10.1007/s11248-012-9671-6. Epub 2012 Oct 31.

48.

The impact of cHS4 insulators on DNA transposon vector mobilization and silencing in retinal pigment epithelium cells.

Sharma N, Hollensen AK, Bak RO, Staunstrup NH, Schrøder LD, Mikkelsen JG.

PLoS One. 2012;7(10):e48421. doi: 10.1371/journal.pone.0048421. Epub 2012 Oct 26.

49.

Reduction of choroidal neovascularization in mice by adeno-associated virus-delivered anti-vascular endothelial growth factor short hairpin RNA.

Askou AL, Pournaras JA, Pihlmann M, Svalgaard JD, Arsenijevic Y, Kostic C, Bek T, Dagnaes-Hansen F, Mikkelsen JG, Jensen TG, Corydon TJ.

J Gene Med. 2012 Nov;14(11):632-41. doi: 10.1002/jgm.2678.

PMID:
23080553
50.

Regulation of pro-inflammatory cytokines TNFα and IL24 by microRNA-203 in primary keratinocytes.

Primo MN, Bak RO, Schibler B, Mikkelsen JG.

Cytokine. 2012 Dec;60(3):741-8. doi: 10.1016/j.cyto.2012.07.031. Epub 2012 Aug 20.

PMID:
22917968

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