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Items: 1 to 50 of 345

1.

DNA methylation regulates CHRNA7 transcription and can be modulated by valproate.

Dyrvig M, Mikkelsen JD, Lichota J.

Neurosci Lett. 2019 Jun 21;704:145-152. doi: 10.1016/j.neulet.2019.04.015. Epub 2019 Apr 8.

PMID:
30974230
2.

Analysis of gonadotrophin-releasing hormone-1 and kisspeptin neuronal systems in the nonphotoregulated seasonally breeding eastern rock elephant-shrew (Elephantulus myurus).

Medger K, Bennett NC, Chimimba CT, Oosthuizen MK, Mikkelsen JD, Coen CW.

J Comp Neurol. 2018 Oct 15;526(15):2388-2405. doi: 10.1002/cne.24498. Epub 2018 Sep 19.

PMID:
30004584
3.

Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons.

Runegaard AH, Sørensen AT, Fitzpatrick CM, Jørgensen SH, Petersen AV, Hansen NW, Weikop P, Andreasen JT, Mikkelsen JD, Perrier JF, Woldbye D, Rickhag M, Wortwein G, Gether U.

eNeuro. 2018 Jun 18;5(3). pii: ENEURO.0345-17.2018. doi: 10.1523/ENEURO.0345-17.2018. eCollection 2018 May-Jun.

4.

Loop Protein Engineering for Improved Transglycosylation Activity of a β-N-Acetylhexosaminidase.

Jamek SB, Muschiol J, Holck J, Zeuner B, Busk PK, Mikkelsen JD, Meyer AS.

Chembiochem. 2018 Sep 4;19(17):1858-1865. doi: 10.1002/cbic.201800181. Epub 2018 Jul 18.

PMID:
29911342
5.

Substrate specificity and transfucosylation activity of GH29 α-l-fucosidases for enzymatic production of human milk oligosaccharides.

Zeuner B, Muschiol J, Holck J, Lezyk M, Gedde MR, Jers C, Mikkelsen JD, Meyer AS.

N Biotechnol. 2018 Mar 25;41:34-45. doi: 10.1016/j.nbt.2017.12.002. Epub 2017 Dec 6.

PMID:
29221760
6.

The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans Using In Vivo 123I-CLINDE SPECT Imaging: A Test-Retest Study.

Feng L, Jensen P, Thomsen G, Dyssegaard A, Svarer C, Knudsen LV, Møller K, Thomsen C, Mikkelsen JD, Guilloteau D, Knudsen GM, Pinborg LH.

J Nucl Med. 2017 Jun;58(6):989-995. doi: 10.2967/jnumed.116.183202. Epub 2016 Nov 10.

7.

Characterization of two novel bacterial type A exo-chitobiose hydrolases having C-terminal 5/12-type carbohydrate-binding modules.

Jamek SB, Nyffenegger C, Muschiol J, Holck J, Meyer AS, Mikkelsen JD.

Appl Microbiol Biotechnol. 2017 Jun;101(11):4533-4546. doi: 10.1007/s00253-017-8198-4. Epub 2017 Mar 9.

PMID:
28280871
8.

Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity.

Nyffenegger C, Nordvang RT, Jers C, Meyer AS, Mikkelsen JD.

PLoS One. 2017 Feb 3;12(2):e0171585. doi: 10.1371/journal.pone.0171585. eCollection 2017.

9.

Perinatal nicotine treatment induces transient increases in NACHO protein levels in the rat frontal cortex.

Wichern F, Jensen MM, Christensen DZ, Mikkelsen JD, Gondré-Lewis MC, Thomsen MS.

Neuroscience. 2017 Mar 27;346:278-283. doi: 10.1016/j.neuroscience.2017.01.026. Epub 2017 Jan 25.

10.

Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters.

Henningsen JB, Ancel C, Mikkelsen JD, Gauer F, Simonneaux V.

Endocrinology. 2017 Mar 1;158(3):652-663. doi: 10.1210/en.2016-1689.

PMID:
27983867
11.

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions.

Hervig ME, Thomsen MS, Kalló I, Mikkelsen JD.

Neuroscience. 2016 Oct 15;334:13-25. doi: 10.1016/j.neuroscience.2016.07.028. Epub 2016 Jul 29.

PMID:
27476436
12.

Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.

Blomster LV, Strøbaek D, Hougaard C, Klein J, Pinborg LH, Mikkelsen JD, Christophersen P.

Glia. 2016 Dec;64(12):2065-2078. doi: 10.1002/glia.23040. Epub 2016 Jul 29.

PMID:
27470924
13.

Positive allosteric modulators of the α7 nicotinic acetylcholine receptor potentiate glutamate release in the prefrontal cortex of freely-moving rats.

Bortz DM, Upton BA, Mikkelsen JD, Bruno JP.

Neuropharmacology. 2016 Dec;111:78-91. doi: 10.1016/j.neuropharm.2016.08.033. Epub 2016 Aug 26.

PMID:
27569994
14.

Lynx1 and Aβ1-42 bind competitively to multiple nicotinic acetylcholine receptor subtypes.

Thomsen MS, Arvaniti M, Jensen MM, Shulepko MA, Dolgikh DA, Pinborg LH, Härtig W, Lyukmanova EN, Mikkelsen JD.

Neurobiol Aging. 2016 Oct;46:13-21. doi: 10.1016/j.neurobiolaging.2016.06.009. Epub 2016 Jun 17.

15.

The pan-Kv7 (KCNQ) Channel Opener Retigabine Inhibits Striatal Excitability by Direct Action on Striatal Neurons In Vivo.

Hansen HH, Weikop P, Mikkelsen MD, Rode F, Mikkelsen JD.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):46-51. doi: 10.1111/bcpt.12636. Epub 2016 Aug 23.

16.

It All Starts with a Sandwich: Identification of Sialidases with Trans-Glycosylation Activity.

Nordvang RT, Nyffenegger C, Holck J, Jers C, Zeuner B, Sundekilde UK, Meyer AS, Mikkelsen JD.

PLoS One. 2016 Jul 1;11(7):e0158434. doi: 10.1371/journal.pone.0158434. eCollection 2016.

17.

Functional interaction between Lypd6 and nicotinic acetylcholine receptors.

Arvaniti M, Jensen MM, Soni N, Wang H, Klein AB, Thiriet N, Pinborg LH, Muldoon PP, Wienecke J, Imad Damaj M, Kohlmeier KA, Gondré-Lewis MC, Mikkelsen JD, Thomsen MS.

J Neurochem. 2016 Sep;138(6):806-20. doi: 10.1111/jnc.13718. Epub 2016 Aug 15.

18.

Rapid quantification of casein in skim milk using Fourier transform infrared spectroscopy, enzymatic perturbation, and multiway partial least squares regression: Monitoring chymosin at work.

Baum A, Hansen PW, Nørgaard L, Sørensen J, Mikkelsen JD.

J Dairy Sci. 2016 Aug;99(8):6071-6079. doi: 10.3168/jds.2016-10947. Epub 2016 Jun 2.

19.

Characterization of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, in rat partial and full nigral 6-hydroxydopamine lesion models of Parkinson's disease.

Hansen HH, Fabricius K, Barkholt P, Mikkelsen JD, Jelsing J, Pyke C, Knudsen LB, Vrang N.

Brain Res. 2016 Sep 1;1646:354-365. doi: 10.1016/j.brainres.2016.05.038. Epub 2016 May 24.

PMID:
27233809
20.

Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain.

Wu J, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL.

Trends Pharmacol Sci. 2016 Jul;37(7):562-574. doi: 10.1016/j.tips.2016.03.005. Epub 2016 May 11. Review.

21.

Changes in Binding of [(123)I]CLINDE, a High-Affinity Translocator Protein 18 kDa (TSPO) Selective Radioligand in a Rat Model of Traumatic Brain Injury.

Donat CK, Gaber K, Meixensberger J, Brust P, Pinborg LH, Hansen HH, Mikkelsen JD.

Neuromolecular Med. 2016 Jun;18(2):158-69. doi: 10.1007/s12017-016-8385-y. Epub 2016 Mar 11.

PMID:
26969181
22.

Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.

Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP.

PLoS One. 2016 Feb 23;11(2):e0149733. doi: 10.1371/journal.pone.0149733. eCollection 2016.

23.

Thermostable β-galactosidases for the synthesis of human milk oligosaccharides.

Zeuner B, Nyffenegger C, Mikkelsen JD, Meyer AS.

N Biotechnol. 2016 May 25;33(3):355-60. doi: 10.1016/j.nbt.2016.01.003. Epub 2016 Jan 21.

PMID:
26802542
24.

Novel α-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides.

Lezyk M, Jers C, Kjaerulff L, Gotfredsen CH, Mikkelsen MD, Mikkelsen JD.

PLoS One. 2016 Jan 22;11(1):e0147438. doi: 10.1371/journal.pone.0147438. eCollection 2016.

25.

Quantitative enzymatic production of sialylated galactooligosaccharides with an engineered sialidase from Trypanosoma rangeli.

Zeuner B, Holck J, Perna V, Mikkelsen JD, Meyer AS.

Enzyme Microb Technol. 2016 Jan;82:42-50. doi: 10.1016/j.enzmictec.2015.08.010. Epub 2015 Aug 21.

PMID:
26672447
26.

Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster.

Henningsen JB, Poirel VJ, Mikkelsen JD, Tsutsui K, Simonneaux V, Gauer F.

J Comp Neurol. 2016 Jun 15;524(9):1825-38. doi: 10.1002/cne.23924. Epub 2015 Dec 3.

PMID:
26518222
27.

Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice.

Salaga M, Blomster LV, Piechota-Polańczyk A, Zielińska M, Jacenik D, Cygankiewicz AI, Krajewska WM, Mikkelsen JD, Fichna J.

J Pharmacol Exp Ther. 2016 Jan;356(1):157-69. doi: 10.1124/jpet.115.228205. Epub 2015 Oct 13.

PMID:
26462538
28.

Association Study of CHRNA7 Promoter Variants with Sensory and Sensorimotor Gating in Schizophrenia Patients and Healthy Controls: A Danish Case-Control Study.

Bertelsen B, Oranje B, Melchior L, Fagerlund B, Werge TM, Mikkelsen JD, Tümer Z, Glenthøj BY.

Neuromolecular Med. 2015 Dec;17(4):423-30. doi: 10.1007/s12017-015-8371-9. Epub 2015 Sep 16.

PMID:
26376812
29.

Automated N-glycan profiling of a mutant Trypanosoma rangeli sialidase expressed in Pichia pastoris, using tandem mass spectrometry and bioinformatics.

Li H, Rasmussen MI, Larsen MR, Guo Y, Jers C, Palmisano G, Mikkelsen JD, Kirpekar F.

Glycobiology. 2015 Dec;25(12):1350-61. doi: 10.1093/glycob/cwv063. Epub 2015 Aug 24.

PMID:
26306636
30.

Rhamnogalacturonan I modifying enzymes: an update.

Silva IR, Jers C, Meyer AS, Mikkelsen JD.

N Biotechnol. 2016 Jan 25;33(1):41-54. doi: 10.1016/j.nbt.2015.07.008. Epub 2015 Aug 5. Review.

PMID:
26255130
31.

Modulating the regioselectivity of a Pasteurella multocida sialyltransferase for biocatalytic production of 3'- and 6'-sialyllactose.

Guo Y, Jers C, Meyer AS, Li H, Kirpekar F, Mikkelsen JD.

Enzyme Microb Technol. 2015 Oct;78:54-62. doi: 10.1016/j.enzmictec.2015.06.012. Epub 2015 Jun 20.

PMID:
26215345
32.

TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging.

Jensen P, Feng L, Law I, Svarer C, Knudsen GM, Mikkelsen JD, de Nijs R, Larsen VA, Dyssegaard A, Thomsen G, Fischer W, Guilloteau D, Pinborg LH.

J Nucl Med. 2015 Sep;56(9):1386-90. doi: 10.2967/jnumed.115.158998. Epub 2015 Jul 16.

33.

Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression.

Jorgensen A, Magnusson P, Hanson LG, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen JD, Fink-Jensen A, Knudsen GM, Paulson OB, Bolwig TG, Jorgensen MB.

Acta Psychiatr Scand. 2016 Feb;133(2):154-164. doi: 10.1111/acps.12462. Epub 2015 Jul 3.

PMID:
26138003
34.

α7 and β2 Nicotinic Acetylcholine Receptor Subunits Form Heteromeric Receptor Complexes that Are Expressed in the Human Cortex and Display Distinct Pharmacological Properties.

Thomsen MS, Zwart R, Ursu D, Jensen MM, Pinborg LH, Gilmour G, Wu J, Sher E, Mikkelsen JD.

PLoS One. 2015 Jun 18;10(6):e0130572. doi: 10.1371/journal.pone.0130572. eCollection 2015.

35.

Role of Serotonin Transporter Changes in Depressive Responses to Sex-Steroid Hormone Manipulation: A Positron Emission Tomography Study.

Frokjaer VG, Pinborg A, Holst KK, Overgaard A, Henningsson S, Heede M, Larsen EC, Jensen PS, Agn M, Nielsen AP, Stenbæk DS, da Cunha-Bang S, Lehel S, Siebner HR, Mikkelsen JD, Svarer C, Knudsen GM.

Biol Psychiatry. 2015 Oct 15;78(8):534-43. doi: 10.1016/j.biopsych.2015.04.015. Epub 2015 Apr 27.

PMID:
26004162
36.

High plasma triglyceride levels strongly correlate with low kisspeptin in the arcuate nucleus of male rats.

Overgaard A, Axel AM, Lie ME, Hansen HH, Mikkelsen JD.

Endocr Regul. 2015 Apr;49(2):51-7.

PMID:
25960005
37.

Radiosynthesis and in vitro validation of (3)H-NS14492 as a novel high affinity alpha7 nicotinic receptor radioligand.

Magnussen JH, Ettrup A, Donat CK, Peters D, Pedersen MH, Knudsen GM, Mikkelsen JD.

Eur J Pharmacol. 2015 Sep 5;762:35-41. doi: 10.1016/j.ejphar.2015.04.036. Epub 2015 May 1.

PMID:
25941084
38.

Backbone structures in human milk oligosaccharides: trans-glycosylation by metagenomic β-N-acetylhexosaminidases.

Nyffenegger C, Nordvang RT, Zeuner B, Łężyk M, Difilippo E, Logtenberg MJ, Schols HA, Meyer AS, Mikkelsen JD.

Appl Microbiol Biotechnol. 2015 Oct;99(19):7997-8009. doi: 10.1007/s00253-015-6550-0. Epub 2015 Apr 7.

PMID:
25843303
39.

Prostate stem cell antigen interacts with nicotinic acetylcholine receptors and is affected in Alzheimer's disease.

Jensen MM, Arvaniti M, Mikkelsen JD, Michalski D, Pinborg LH, Härtig W, Thomsen MS.

Neurobiol Aging. 2015 Apr;36(4):1629-1638. doi: 10.1016/j.neurobiolaging.2015.01.001. Epub 2015 Jan 7.

PMID:
25680266
40.

Mutants of Micromonospora viridifaciens sialidase have highly variable activities on natural and non-natural substrates.

Jers C, Guo Y, Kepp KP, Mikkelsen JD.

Protein Eng Des Sel. 2015 Feb;28(2):37-44. doi: 10.1093/protein/gzu054. Epub 2015 Jan 7.

PMID:
25573534
41.

Can laccases catalyze bond cleavage in lignin?

Munk L, Sitarz AK, Kalyani DC, Mikkelsen JD, Meyer AS.

Biotechnol Adv. 2015 Jan-Feb;33(1):13-24. doi: 10.1016/j.biotechadv.2014.12.008. Epub 2015 Jan 3. Review.

PMID:
25560931
42.

Thermostability enhancement of an endo-1,4-β-galactanase from Talaromyces stipitatus by site-directed mutagenesis.

Larsen DM, Nyffenegger C, Swiniarska MM, Thygesen A, Strube ML, Meyer AS, Mikkelsen JD.

Appl Microbiol Biotechnol. 2015 May;99(10):4245-53. doi: 10.1007/s00253-014-6244-z. Epub 2014 Dec 2.

PMID:
25434812
43.

Targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors for developing effective antipsychotics: synthesis, biological characterization, and behavioral studies.

Brindisi M, Butini S, Franceschini S, Brogi S, Trotta F, Ros S, Cagnotto A, Salmona M, Casagni A, Andreassi M, Saponara S, Gorelli B, Weikop P, Mikkelsen JD, Scheel-Kruger J, Sandager-Nielsen K, Novellino E, Campiani G, Gemma S.

J Med Chem. 2014 Nov 26;57(22):9578-97. doi: 10.1021/jm501119j. Epub 2014 Nov 7.

PMID:
25343529
44.

BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels.

Fisher PM, Holst KK, Adamsen D, Klein AB, Frokjaer VG, Jensen PS, Svarer C, Gillings N, Baare WF, Mikkelsen JD, Knudsen GM.

Hum Brain Mapp. 2015 Jan;36(1):313-23. doi: 10.1002/hbm.22630. Epub 2014 Sep 13.

PMID:
25220079
45.

Methods for improving enzymatic trans-glycosylation for synthesis of human milk oligosaccharide biomimetics.

Zeuner B, Jers C, Mikkelsen JD, Meyer AS.

J Agric Food Chem. 2014 Oct 8;62(40):9615-31. doi: 10.1021/jf502619p. Epub 2014 Sep 23. Review.

PMID:
25208138
46.

Structure, functionality and tuning up of laccases for lignocellulose and other industrial applications.

Sitarz AK, Mikkelsen JD, Meyer AS.

Crit Rev Biotechnol. 2016;36(1):70-86. doi: 10.3109/07388551.2014.949617. Epub 2015 Sep 14. Review.

PMID:
25198436
47.

Changes in RFamide-related peptide-1 (RFRP-1)-immunoreactivity during postnatal development and the estrous cycle.

Jørgensen SR, Andersen MD, Overgaard A, Mikkelsen JD.

Endocrinology. 2014 Nov;155(11):4402-10. doi: 10.1210/en.2014-1274. Epub 2014 Aug 21.

PMID:
25144921
48.

Disparate changes in kisspeptin and neurokinin B expression in the arcuate nucleus after sex steroid manipulation reveal differential regulation of the two KNDy peptides in rats.

Overgaard A, Ruiz-Pino F, Castellano JM, Tena-Sempere M, Mikkelsen JD.

Endocrinology. 2014 Oct;155(10):3945-55. doi: 10.1210/en.2014-1200. Epub 2014 Jul 22.

PMID:
25051440
49.

Association of the CHRNA7 promoter variant -86T with Tourette syndrome and comorbid obsessive-compulsive disorder.

Bertelsen B, Melchior L, Groth C, Mol Debes N, Skov L, Holst KK, Fagerlund B, Mikkelsen JD, Tümer Z.

Psychiatry Res. 2014 Nov 30;219(3):710-1. doi: 10.1016/j.psychres.2014.06.032. Epub 2014 Jun 28. No abstract available.

PMID:
25024057
50.

Characterization of an extensin-modifying metalloprotease: N-terminal processing and substrate cleavage pattern of Pectobacterium carotovorum Prt1.

Feng T, Nyffenegger C, Højrup P, Vidal-Melgosa S, Yan KP, Fangel JU, Meyer AS, Kirpekar F, Willats WG, Mikkelsen JD.

Appl Microbiol Biotechnol. 2014 Dec;98(24):10077-89. doi: 10.1007/s00253-014-5877-2. Epub 2014 Jun 20.

PMID:
24946865

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