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Items: 1 to 50 of 65

1.

A Novel Peptide Restricts Ethanol Modulation of the BK Channel In Vitro and In Vivo.

Scott LL, Iyer S, Philpo AE, Avalos MN, Wu NS, Shi T, Prakash BA, Nguyen TT, Mihic SJ, Aldrich RW, Pierce JT.

J Pharmacol Exp Ther. 2018 Nov;367(2):282-290. doi: 10.1124/jpet.118.251918. Epub 2018 Aug 29.

PMID:
30158242
2.

An intersubunit electrostatic interaction in the GABAA receptor facilitates its responses to benzodiazepines.

Pflanz NC, Daszkowski AW, Cornelison GL, Trudell JR, Mihic SJ.

J Biol Chem. 2018 May 25;293(21):8264-8274. doi: 10.1074/jbc.RA118.002128. Epub 2018 Apr 5.

PMID:
29622679
3.

Single Channel Analysis of Isoflurane and Ethanol Enhancement of Taurine-Activated Glycine Receptors.

Kirson D, Todorovic J, Mihic SJ.

J Pharmacol Exp Ther. 2018 Jan;364(1):70-76. doi: 10.1124/jpet.117.243840. Epub 2017 Nov 8.

PMID:
29118035
4.

A novel BK channel-targeted peptide suppresses sound evoked activity in the mouse inferior colliculus.

Scott LL, Brecht EJ, Philpo A, Iyer S, Wu NS, Mihic SJ, Aldrich RW, Pierce J, Walton JP.

Sci Rep. 2017 Feb 14;7:42433. doi: 10.1038/srep42433.

5.

Interactions between Zinc and Allosteric Modulators of the Glycine Receptor.

Cornelison GL, Daszkowski AW, Pflanz NC, Mihic SJ.

J Pharmacol Exp Ther. 2017 Apr;361(1):1-8. doi: 10.1124/jpet.116.239152. Epub 2017 Jan 13.

6.

Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor.

Welsh BT, Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ.

Brain Res. 2017 Feb 15;1657:148-155. doi: 10.1016/j.brainres.2016.11.024. Epub 2016 Dec 5.

7.

Identification and characterization of heptapeptide modulators of the glycine receptor.

Cornelison GL, Pflanz NC, Tipps ME, Mihic SJ.

Eur J Pharmacol. 2016 Jun 5;780:252-9. doi: 10.1016/j.ejphar.2016.03.058. Epub 2016 Mar 31.

8.

Allosteric modulation of the glycine receptor activated by agonists differing in efficacy.

Farley NM, Mihic SJ.

Brain Res. 2015 May 5;1606:95-101. doi: 10.1016/j.brainres.2015.02.024. Epub 2015 Feb 24.

9.

Contaminating levels of zinc found in commonly-used labware and buffers affect glycine receptor currents.

Cornelison GL, Mihic SJ.

Brain Res Bull. 2014 Jan;100:1-5. doi: 10.1016/j.brainresbull.2013.10.012. Epub 2013 Oct 28.

10.

Physiological concentrations of zinc reduce taurine-activated GlyR responses to drugs of abuse.

Kirson D, Cornelison GL, Philpo AE, Todorovic J, Mihic SJ.

Neuropharmacology. 2013 Dec;75:286-94. doi: 10.1016/j.neuropharm.2013.07.025. Epub 2013 Aug 21.

11.

Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA.

Anesthesiology. 2012 Oct;117(4):765-71.

12.

Positive allosteric modulators differentially affect full versus partial agonist activation of the glycine receptor.

Kirson D, Todorovic J, Mihic SJ.

J Pharmacol Exp Ther. 2012 Jul;342(1):61-70. doi: 10.1124/jpet.112.191486. Epub 2012 Apr 3.

13.

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.

14.

Ethanol enhances taurine-activated glycine receptor function.

Welsh BT, Kirson D, Allen HM, Mihic SJ.

Alcohol Clin Exp Res. 2010 Sep 1;34(9):1634-9. doi: 10.1111/j.1530-0277.2010.01249.x. Epub 2010 Jun 25.

15.

Identification of novel specific allosteric modulators of the glycine receptor using phage display.

Tipps ME, Lawshe JE, Ellington AD, Mihic SJ.

J Biol Chem. 2010 Jul 23;285(30):22840-5. doi: 10.1074/jbc.M110.130815. Epub 2010 May 25.

16.

Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.

Todorovic J, Welsh BT, Bertaccini EJ, Trudell JR, Mihic SJ.

Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7987-92. doi: 10.1073/pnas.1001845107. Epub 2010 Apr 12.

17.

Zinc enhances ethanol modulation of the alpha1 glycine receptor.

McCracken LM, Trudell JR, Goldstein BE, Harris RA, Mihic SJ.

Neuropharmacology. 2010 Mar;58(3):676-81. doi: 10.1016/j.neuropharm.2009.11.001. Epub 2009 Nov 11.

18.

Single-channel analysis of ethanol enhancement of glycine receptor function.

Welsh BT, Goldstein BE, Mihic SJ.

J Pharmacol Exp Ther. 2009 Jul;330(1):198-205. doi: 10.1124/jpet.109.154344. Epub 2009 Apr 20.

19.

Ethanol's molecular targets.

Harris RA, Trudell JR, Mihic SJ.

Sci Signal. 2008 Jul 15;1(28):re7. doi: 10.1126/scisignal.128re7. Review.

20.

Effects of a mutation in the TM2-TM3 linker region of the glycine receptor alpha1 subunit on gating and allosteric modulation.

Dupre ML, Broyles JM, Mihic SJ.

Brain Res. 2007 Jun 4;1152:1-9. Epub 2007 Mar 15.

PMID:
17434460
21.

Occupancy of a single anesthetic binding pocket is sufficient to enhance glycine receptor function.

Roberts MT, Phelan R, Erlichman BS, Pillai RN, Ma L, Lopreato GF, Mihic SJ.

J Biol Chem. 2006 Feb 10;281(6):3305-11. Epub 2005 Dec 16.

22.

Multiple sites of ethanol action in alpha1 and alpha2 glycine receptors suggested by sensitivity to pressure antagonism.

Davies DL, Crawford DK, Trudell JR, Mihic SJ, Alkana RL.

J Neurochem. 2004 Jun;89(5):1175-85.

23.

Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug.

Harris RA, Mihic SJ.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):2-3. Epub 2003 Dec 26. No abstract available.

24.

Amino acids in transmembrane domain two influence anesthetic enhancement of serotonin-3A receptor function.

Lopreato GF, Banerjee P, Mihic SJ.

Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):45-51.

PMID:
14559353
25.

Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant.

Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA.

J Neurosci. 2003 Sep 3;23(22):8051-9.

26.

Ethanol potentiation of glycine receptors expressed in Xenopus oocytes antagonized by increased atmospheric pressure.

Davies DL, Trudell JR, Mihic SJ, Crawford DK, Alkana RL.

Alcohol Clin Exp Res. 2003 May;27(5):743-55.

PMID:
12766618
27.

Inhaled drugs of abuse enhance serotonin-3 receptor function.

Lopreato GF, Phelan R, Borghese CM, Beckstead MJ, Mihic SJ.

Drug Alcohol Depend. 2003 May 1;70(1):11-5.

PMID:
12681521
28.

Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.

Beckstead MJ, Phelan R, Trudell JR, Bianchini MJ, Mihic SJ.

J Neurochem. 2002 Sep;82(6):1343-51.

29.
30.

Luciferase as a model for the site of inhaled anesthetic action.

Zhang Y, Stabernack CR, Dutton R, Sonner J, Trudell JR, Mihic SJ, Yamakura T, Harris RA, Gong D, Eger EI 2nd.

Anesth Analg. 2001 Nov;93(5):1246-52.

PMID:
11682406
31.

Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1.

Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL, Bowden DW.

Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99.

PMID:
11592815
32.

Antagonism of inhalant and volatile anesthetic enhancement of glycine receptor function.

Beckstead MJ, Phelan R, Mihic SJ.

J Biol Chem. 2001 Jul 6;276(27):24959-64. Epub 2001 May 9.

33.

Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.

Ueno S, Lin A, Nikolaeva N, Trudell JR, Mihic SJ, Harris RA, Harrison NL.

Br J Pharmacol. 2000 Sep;131(2):296-302.

34.

Glycine and gamma-aminobutyric acid(A) receptor function is enhanced by inhaled drugs of abuse.

Beckstead MJ, Weiner JL, Eger EI 2nd, Gong DH, Mihic SJ.

Mol Pharmacol. 2000 Jun;57(6):1199-205.

35.
36.

Acute effects of ethanol on GABAA and glycine receptor function.

Mihic SJ.

Neurochem Int. 1999 Aug;35(2):115-23. Review. No abstract available.

PMID:
10405995
37.

Alcohol and benzodiazepines: recent mechanistic studies.

Harris RA, Mihic SJ, Valenzuela CF.

Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):155-64. Review. No abstract available.

PMID:
9716937
38.

Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?

Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL, Harris RA.

Proc Natl Acad Sci U S A. 1998 May 26;95(11):6504-9.

39.

Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267.

Ye Q, Koltchine VV, Mihic SJ, Mascia MP, Wick MJ, Finn SE, Harrison NL, Harris RA.

J Biol Chem. 1998 Feb 6;273(6):3314-9.

40.

Selective actions of a detergent on ligand-gated ion channels expressed in Xenopus oocytes.

Machu TK, Mihic SJ, Dildy-Mayfield JE.

J Pharmacol Exp Ther. 1998 Jan;284(1):32-6.

41.

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL.

Nature. 1997 Sep 25;389(6649):385-9.

PMID:
9311780
42.

Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptors expressed in mammalian cells and Xenopus oocytes.

Harris RA, Mihic SJ, Brozowski S, Hadingham K, Whiting PJ.

Alcohol Clin Exp Res. 1997 May;21(3):444-51.

PMID:
9161604
43.

GABA and the GABAA receptor.

Mihic SJ, Harris RA.

Alcohol Health Res World. 1997;21(2):127-31. Review.

PMID:
15704348
44.

A single amino acid determines differences in ethanol actions on strychnine-sensitive glycine receptors.

Mascia MP, Mihic SJ, Valenzuela CF, Schofield PR, Harris RA.

Mol Pharmacol. 1996 Aug;50(2):402-6.

PMID:
8700149
45.

Actions of long chain alcohols on GABAA and glutamate receptors: relation to in vivo effects.

Dildy-Mayfield JE, Mihic SJ, Liu Y, Deitrich RA, Harris RA.

Br J Pharmacol. 1996 May;118(2):378-84.

46.

Robotic automation of Xenopus oocyte bath perfusion.

Mihic SJ, Harris RA.

Biotechniques. 1996 May;20(5):802-4. No abstract available.

47.

Inhibition of rho1 receptor GABAergic currents by alcohols and volatile anesthetics.

Mihic SJ, Harris RA.

J Pharmacol Exp Ther. 1996 Apr;277(1):411-6.

PMID:
8613949
48.

Actions of anesthetics on ligand-gated ion channels: role of receptor subunit composition.

Harris RA, Mihic SJ, Dildy-Mayfield JE, Machu TK.

FASEB J. 1995 Nov;9(14):1454-62. Review.

PMID:
7589987
49.

Pharmacology of recombinant GABAA receptors.

Mihic SJ, Sanna E, Whiting PJ, Harris RA.

Adv Biochem Psychopharmacol. 1995;48:17-40. Review. No abstract available.

PMID:
7653324
50.

A single amino acid of the human gamma-aminobutyric acid type A receptor gamma 2 subunit determines benzodiazepine efficacy.

Mihic SJ, Whiting PJ, Klein RL, Wafford KA, Harris RA.

J Biol Chem. 1994 Dec 30;269(52):32768-73.

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