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Items: 1 to 50 of 587

1.

RAC1B Suppresses TGF-β-Dependent Chemokinesis and Growth Inhibition through an Autoregulatory Feed-Forward Loop Involving PAR2 and ALK5.

Otterbein H, Mihara K, Hollenberg MD, Lehnert H, Witte D, Ungefroren H.

Cancers (Basel). 2019 Aug 20;11(8). pii: E1211. doi: 10.3390/cancers11081211.

2.

The impact of epidural catheter insertion level on pain control after esophagectomy for esophageal cancer.

Booka E, Nakano Y, Mihara K, Nishiya S, Nishiyama R, Shibutani S, Sato T, Egawa T.

Esophagus. 2019 Jun 20. doi: 10.1007/s10388-019-00682-z. [Epub ahead of print]

PMID:
31222678
3.

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation.

Pulakazhi Venu VK, Saifeddine M, Mihara K, Tsai YC, Nieves K, Alston L, Mani S, McCoy KD, Hollenberg MD, Hirota SA.

Am J Physiol Endocrinol Metab. 2019 Aug 1;317(2):E350-E361. doi: 10.1152/ajpendo.00572.2018. Epub 2019 Jun 18.

PMID:
31211619
4.

[A Case of Giant Hematogenous Left Quadricep Muscle Metastasis of Hepatocellular Carcinoma].

Nakano Y, Booka E, Mihara K, Nishiyama R, Nishiya S, Shibutani S, Egawa T.

Gan To Kagaku Ryoho. 2019 May;46(5):925-928. Japanese.

PMID:
31189817
5.

RAC1B Suppresses TGF-β1-Dependent Cell Migration in Pancreatic Carcinoma Cells through Inhibition of the TGF-β Type I Receptor ALK5.

Ungefroren H, Otterbein H, Fiedler C, Mihara K, Hollenberg MD, Gieseler F, Lehnert H, Witte D.

Cancers (Basel). 2019 May 17;11(5). pii: E691. doi: 10.3390/cancers11050691.

6.

Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line.

Yanagihara K, Kubo T, Iino Y, Mihara K, Morimoto C, Seyama T, Kuwata T, Ochiai A, Yokozaki H.

Oncotarget. 2019 Mar 29;10(25):2435-2450. doi: 10.18632/oncotarget.26764. eCollection 2019 Mar 29.

7.

Laparoscopic completion gastrectomy in elderly patients with remnant gastric cancer: a case series.

Kaihara M, Matsuda S, Booka E, Saida F, Takashima J, Kasai H, Mihara K, Nagashima A, Egawa T.

Surg Case Rep. 2019 Apr 17;5(1):63. doi: 10.1186/s40792-019-0610-0.

8.

Urate Bulla: a Rare Manifestation of Gout.

Ehlers PF, Mihara K.

J Gen Intern Med. 2019 Jun;34(6):1069-1070. doi: 10.1007/s11606-019-04864-4. Epub 2019 Mar 18. No abstract available.

PMID:
30887441
9.

Differences in Warfarin Pharmacodynamics and Predictors of Response Among Three Racial Populations.

Ohara M, Suzuki Y, Shinohara S, Gong IY, Schmerk CL, Tirona RG, Schwarz UI, Wen MS, Lee MTM, Mihara K, Nutescu EA, Perera MA, Cavallari LH, Kim RB, Takahashi H.

Clin Pharmacokinet. 2019 Aug;58(8):1077-1089. doi: 10.1007/s40262-019-00745-5.

PMID:
30815847
10.

Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.

Gillard P, Tamura T, Kuroki H, Morikawa Y, Moerman L, Parra J, Kitamura Y, Mihara K, Okamasa A.

Hum Vaccin Immunother. 2019;15(4):800-808. doi: 10.1080/21645515.2018.1564441. Epub 2019 Feb 20.

11.

Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.

Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H.

Pancreas. 2019 Mar;48(3):315-322. doi: 10.1097/MPA.0000000000001253.

12.

HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG.

Cell Death Differ. 2019 Oct;26(10):1942-1954. doi: 10.1038/s41418-018-0264-7. Epub 2019 Jan 25.

PMID:
30683917
13.

[Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies].

Masudo C, Ogawa Y, Yamashita N, Mihara K.

Yakugaku Zasshi. 2019;139(1):113-122. doi: 10.1248/yakushi.18-00156. Japanese.

14.

Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign".

Ueno H, Norose K, Kamimura T, Mihara K, Yamasaki F, Hikosaka K, J Amatya V, Takeshima Y, Kurisu K, Maruyama H.

Intern Med. 2019 Apr 15;58(8):1157-1162. doi: 10.2169/internalmedicine.1156-18. Epub 2018 Dec 18.

15.

Antitumor effect of palmitic acid-conjugated DsiRNA for colon cancer in a mouse subcutaneous tumor model.

Kubo T, Nishimura Y, Hatori Y, Akagi R, Mihara K, Yanagihara K, Seyama T.

Chem Biol Drug Des. 2019 Apr;93(4):570-581. doi: 10.1111/cbdd.13454. Epub 2019 Jan 11.

PMID:
30560565
16.

Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma.

Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H.

Oncotarget. 2018 Nov 23;9(92):36503-36514. doi: 10.18632/oncotarget.26367. eCollection 2018 Nov 23.

17.

Basic Procedures for Detection and Cytotoxicity of Chimeric Antigen Receptors.

Mihara K, Yoshida T, Bhattacharyya J.

Methods Mol Biol. 2019;1904:299-306. doi: 10.1007/978-1-4939-8958-4_13.

PMID:
30539476
18.

Relationship Between UGT1A4 and UGT2B7 Polymorphisms and the Steady-State Plasma Concentrations of Lamotrigine in Patients With Treatment-Resistant Depressive Disorder Receiving Lamotrigine as Augmentation Therapy.

Suzuki T, Mihara K, Nagai G, Kagawa S, Nakamura A, Nemoto K, Kondo T.

Ther Drug Monit. 2019 Feb;41(1):86-90. doi: 10.1097/FTD.0000000000000577.

PMID:
30489548
19.

Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report.

Booka E, Kitano M, Nakano Y, Mihara K, Nishiya S, Nishiyama R, Shibutani S, Egawa T, Nagashima A.

Surg Case Rep. 2018 Sep 3;4(1):107. doi: 10.1186/s40792-018-0517-1.

20.

Syntheses, Structures, and Antimicrobial Activities of Gold(I)- and Copper(I)- N-Heterocyclic Carbene (NHC) Complexes Derived from Basket-Shaped Dinuclear Ag(I)-NHC Complex.

Nomiya K, Morozumi S, Yanagawa Y, Hasegawa M, Kurose K, Taguchi K, Sakamoto R, Mihara K, Kasuga NC.

Inorg Chem. 2018 Sep 17;57(18):11322-11332. doi: 10.1021/acs.inorgchem.8b00011. Epub 2018 Aug 31.

PMID:
30168718
21.

Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease.

Morimoto H, Ito Y, Yoden E, Horie M, Tanaka N, Komurasaki Y, Yamamoto R, Mihara K, Minami K, Hirato T.

Mol Genet Metab. 2018 Sep;125(1-2):153-160. doi: 10.1016/j.ymgme.2018.07.009. Epub 2018 Jul 23.

22.

Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan in the randomized phase III GALLIUM trial.

Ohmachi K, Tobinai K, Kinoshita T, Ishikawa T, Hatake K, Ichikawa S, Ohmine K, Kamitsuji Y, Choi I, Chou T, Tsukasaki K, Kumagai K, Taniwaki M, Uchida T, Kikukawa Y, Kubo K, Mihara K, Tsukamoto N, Izutsu K, Yoshida I, Ishida F, Usui N, Iida S, Murayama T, Ueda E, Kuriki H, Ando K.

Int J Hematol. 2018 Nov;108(5):499-509. doi: 10.1007/s12185-018-2497-0. Epub 2018 Jul 19.

PMID:
30027429
23.

A Partial Response at Week 4 Can Predict Subsequent Outcome during Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder: A Preliminary Study.

Nagai G, Mihara K, Kagawa S, Nakamura A, Suzuki T, Nemoto K, Kondo T.

Neuropsychobiology. 2017;76(4):187-192. doi: 10.1159/000489967. Epub 2018 Jun 29.

PMID:
29961057
24.

Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation.

Eftekhari R, de Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD.

Biol Chem. 2018 Sep 25;399(9):1023-1039. doi: 10.1515/hsz-2018-0001.

PMID:
29924723
25.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.

PMID:
29908295
26.

Eremophilanes from Ligularia hookeri Collected in China and Structural Revision of 3β-Acyloxyfuranoeremophilan-15,6-olide.

Saito Y, Shiosaki Y, Fujiwara M, Mihara K, Nakamizo H, Otose K, Okamoto Y, Nakashima K, Hanai R, Kuroda C, Gong X, Matsuo Y, Tanaka T, Tori M.

Chem Pharm Bull (Tokyo). 2018;66(6):668-673. doi: 10.1248/cpb.c18-00191.

27.

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.

PMID:
29860464
28.

MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers.

Takei Y, Shen G, Morita-Kondo A, Hara T, Mihara K, Yanagihara K.

Pathobiology. 2018;85(4):232-246. doi: 10.1159/000488801. Epub 2018 May 30.

29.

Orthodontic-Surgical Approach for Treating Skeletal Class III Malocclusion With Severe Maxillary Deficiency in Isolated Cleft Palate.

Nakatsugawa K, Kurosaka H, Mihara K, Tanaka S, Aikawa T, Kogo M, Yamashiro T.

Cleft Palate Craniofac J. 2019 Mar;56(3):400-407. doi: 10.1177/1055665618777573. Epub 2018 May 22.

PMID:
29787302
30.

Laparoscopic total gastrectomy for remnant gastric cancer: A single-institution experience.

Booka E, Kaihara M, Mihara K, Nishiya S, Handa K, Ito Y, Shibutani S, Egawa T, Nagashima A.

Asian J Endosc Surg. 2019 Jan;12(1):58-63. doi: 10.1111/ases.12495. Epub 2018 May 10.

PMID:
29745474
31.

Investigation of safety and efficacy of the new more thermostable formulation of Flolan (epoprostenol) in Japanese patients with pulmonary arterial hypertension (PAH)-An open-label, single-arm study.

Mihara K, Ogawa A, Matsubara H, Terao T, Ichikawa Y.

PLoS One. 2018 Apr 2;13(4):e0195195. doi: 10.1371/journal.pone.0195195. eCollection 2018.

32.

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.

33.

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics.

Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A.

Cell Metab. 2018 Mar 6;27(3):657-666.e5. doi: 10.1016/j.cmet.2018.01.011. Epub 2018 Feb 22.

34.

Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma.

Tari A, Kitadai Y, Mouri R, Takigawa H, Asaoku H, Mihara K, Takata K, Fujihara M, Yoshino T, Koga T, Fujimori S, Tanaka S, Chayama K.

J Gastroenterol Hepatol. 2018 Aug;33(8):1461-1468. doi: 10.1111/jgh.14100. Epub 2018 Mar 25.

PMID:
29377265
35.

Both Serum Brain-Derived Neurotrophic Factor and Interleukin-6 Levels Are Not Associated with Therapeutic Response to Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder.

Kagawa S, Mihara K, Suzuki T, Nagai G, Nakamura A, Nemoto K, Kondo T.

Neuropsychobiology. 2017;75(3):145-150. doi: 10.1159/000484665. Epub 2018 Jan 12.

PMID:
29332095
36.

Treatment of severe mitral regurgitation caused by lesions in both leaflets using multiple mitral valve plasty techniques in a small dog.

Yokoyama S, Kanemoto I, Mihara K, Ando T, Kawase K, Sahashi Y, Iguchi K.

Open Vet J. 2017;7(4):328-331. doi: 10.4314/ovj.v7i4.7. Epub 2017 Nov 23.

37.

A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides.

Kodama S, Saeki T, Mihara K, Higashimae S, Kawaguchi SI, Sonoda M, Nomoto A, Ogawa A.

J Org Chem. 2017 Dec 1;82(23):12477-12484. doi: 10.1021/acs.joc.7b02276. Epub 2017 Nov 17.

PMID:
29094942
38.

Telomere length as a potential biomarker of coronary artery disease.

Bhattacharyya J, Mihara K, Bhattacharjee D, Mukherjee M.

Indian J Med Res. 2017 Jun;145(6):730-737. doi: 10.4103/0971-5916.216974. Review.

39.

Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Jöhren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F.

Mol Pharmacol. 2017 Nov;92(5):519-532. doi: 10.1124/mol.117.109017. Epub 2017 Aug 25.

PMID:
28842394
40.

Engineering of the cytochrome P450 monooxygenase system for benzyl maltol hydroxylation.

Kozono I, Mihara K, Minagawa K, Hibi M, Ogawa J.

Appl Microbiol Biotechnol. 2017 Sep;101(17):6651-6658. doi: 10.1007/s00253-017-8414-2. Epub 2017 Jul 20.

PMID:
28730410
41.

Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies.

Ogawa Y, Takei H, Ogawa R, Mihara K.

J Pharm Health Care Sci. 2017 Jul 11;3:18. doi: 10.1186/s40780-017-0087-6. eCollection 2017.

42.

Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.

Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, Oka T, Mihara K, Ishihara N.

Nat Cell Biol. 2017 Jul;19(7):856-863. doi: 10.1038/ncb3560. Epub 2017 Jun 19.

PMID:
28628083
43.

T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells.

Mihara K, Yoshida T, Takei Y, Sasaki N, Takihara Y, Kuroda J, Ichinohe T.

J Hematol Oncol. 2017 Jun 8;10(1):116. doi: 10.1186/s13045-017-0488-x.

44.

Cell-free mitochondrial fusion assay detected by specific protease reaction revealed Ca2+ as regulator of mitofusin-dependent mitochondrial fusion.

Ishihara N, Maeda M, Ban T, Mihara K.

J Biochem. 2017 Oct 1;162(4):287-294. doi: 10.1093/jb/mvx029.

PMID:
28460043
45.

PARL paves the way to apoptosis.

Ishihara N, Mihara K.

Nat Cell Biol. 2017 Mar 31;19(4):263-265. doi: 10.1038/ncb3504.

PMID:
28361942
46.

Three-dimensional analysis of somatic mitochondrial dynamics in fission-deficient injured motor neurons using FIB/SEM.

Tamada H, Kiryu-Seo S, Hosokawa H, Ohta K, Ishihara N, Nomura M, Mihara K, Nakamura KI, Kiyama H.

J Comp Neurol. 2017 Aug 1;525(11):2535-2548. doi: 10.1002/cne.24213. Epub 2017 Apr 21.

PMID:
28324645
47.

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.

48.

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.

PMID:
28126849
49.

All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia.

Yoshida T, Mihara K, Takei Y, Yanagihara K, Kubo T, Bhattacharyya J, Imai C, Mino T, Takihara Y, Ichinohe T.

Clin Transl Immunology. 2016 Dec 9;5(12):e116. doi: 10.1038/cti.2016.73. eCollection 2016 Dec.

50.

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy.

Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T.

J Cell Biol. 2016 Dec 5;215(5):649-665. Epub 2016 Nov 30.

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