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Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.

Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H.

Pancreas. 2019 Feb 8. doi: 10.1097/MPA.0000000000001253. [Epub ahead of print]


HIV-induced neuroinflammation: impact of PAR1 and PAR2 processing by Furin.

Sachan V, Lodge R, Mihara K, Hamelin J, Power C, Gelman BB, Hollenberg MD, Cohen ÉA, Seidah NG.

Cell Death Differ. 2019 Jan 25. doi: 10.1038/s41418-018-0264-7. [Epub ahead of print]


[Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies].

Masudo C, Ogawa Y, Yamashita N, Mihara K.

Yakugaku Zasshi. 2019;139(1):113-122. doi: 10.1248/yakushi.18-00156. Japanese.


Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign".

Ueno H, Norose K, Kamimura T, Mihara K, Yamasaki F, Hikosaka K, J Amatya V, Takeshima Y, Kurisu K, Maruyama H.

Intern Med. 2018 Dec 18. doi: 10.2169/internalmedicine.1156-18. [Epub ahead of print]


Antitumor effect of palmitic acid-conjugated DsiRNA for colon cancer in a mouse subcutaneous tumor model.

Kubo T, Nishimura Y, Hatori Y, Akagi R, Mihara K, Yanagihara K, Seyama T.

Chem Biol Drug Des. 2018 Dec 17. doi: 10.1111/cbdd.13454. [Epub ahead of print]


Establishment of a novel cell line from a rare human duodenal poorly differentiated neuroendocrine carcinoma.

Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H.

Oncotarget. 2018 Nov 23;9(92):36503-36514. doi: 10.18632/oncotarget.26367. eCollection 2018 Nov 23.


Basic Procedures for Detection and Cytotoxicity of Chimeric Antigen Receptors.

Mihara K, Yoshida T, Bhattacharyya J.

Methods Mol Biol. 2019;1904:299-306. doi: 10.1007/978-1-4939-8958-4_13.


Relationship Between UGT1A4 and UGT2B7 Polymorphisms and the Steady-State Plasma Concentrations of Lamotrigine in Patients With Treatment-Resistant Depressive Disorder Receiving Lamotrigine as Augmentation Therapy.

Suzuki T, Mihara K, Nagai G, Kagawa S, Nakamura A, Nemoto K, Kondo T.

Ther Drug Monit. 2019 Feb;41(1):86-90. doi: 10.1097/FTD.0000000000000577.


Life-threatening giant esophageal neurofibroma with severe tracheal stenosis: a case report.

Booka E, Kitano M, Nakano Y, Mihara K, Nishiya S, Nishiyama R, Shibutani S, Egawa T, Nagashima A.

Surg Case Rep. 2018 Sep 3;4(1):107. doi: 10.1186/s40792-018-0517-1.


Syntheses, Structures, and Antimicrobial Activities of Gold(I)- and Copper(I)- N-Heterocyclic Carbene (NHC) Complexes Derived from Basket-Shaped Dinuclear Ag(I)-NHC Complex.

Nomiya K, Morozumi S, Yanagawa Y, Hasegawa M, Kurose K, Taguchi K, Sakamoto R, Mihara K, Kasuga NC.

Inorg Chem. 2018 Sep 17;57(18):11322-11332. doi: 10.1021/acs.inorgchem.8b00011. Epub 2018 Aug 31.


Non-clinical evaluation of JR-051 as a biosimilar to agalsidase beta for the treatment of Fabry disease.

Morimoto H, Ito Y, Yoden E, Horie M, Tanaka N, Komurasaki Y, Yamamoto R, Mihara K, Minami K, Hirato T.

Mol Genet Metab. 2018 Sep;125(1-2):153-160. doi: 10.1016/j.ymgme.2018.07.009. Epub 2018 Jul 23.


Efficacy and safety of obinutuzumab in patients with previously untreated follicular lymphoma: a subgroup analysis of patients enrolled in Japan in the randomized phase III GALLIUM trial.

Ohmachi K, Tobinai K, Kinoshita T, Ishikawa T, Hatake K, Ichikawa S, Ohmine K, Kamitsuji Y, Choi I, Chou T, Tsukasaki K, Kumagai K, Taniwaki M, Uchida T, Kikukawa Y, Kubo K, Mihara K, Tsukamoto N, Izutsu K, Yoshida I, Ishida F, Usui N, Iida S, Murayama T, Ueda E, Kuriki H, Ando K.

Int J Hematol. 2018 Nov;108(5):499-509. doi: 10.1007/s12185-018-2497-0. Epub 2018 Jul 19.


A Partial Response at Week 4 Can Predict Subsequent Outcome during Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder: A Preliminary Study.

Nagai G, Mihara K, Kagawa S, Nakamura A, Suzuki T, Nemoto K, Kondo T.

Neuropsychobiology. 2017;76(4):187-192. doi: 10.1159/000489967. Epub 2018 Jun 29.


Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation.

Eftekhari R, de Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD.

Biol Chem. 2018 Sep 25;399(9):1023-1039. doi: 10.1515/hsz-2018-0001.


Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.


Eremophilanes from Ligularia hookeri Collected in China and Structural Revision of 3β-Acyloxyfuranoeremophilan-15,6-olide.

Saito Y, Shiosaki Y, Fujiwara M, Mihara K, Nakamizo H, Otose K, Okamoto Y, Nakashima K, Hanai R, Kuroda C, Gong X, Matsuo Y, Tanaka T, Tori M.

Chem Pharm Bull (Tokyo). 2018;66(6):668-673. doi: 10.1248/cpb.c18-00191.


Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.


MicroRNAs Associated with Epithelial-Mesenchymal Transition Can Be Targeted to Inhibit Peritoneal Dissemination of Human Scirrhous Gastric Cancers.

Takei Y, Shen G, Morita-Kondo A, Hara T, Mihara K, Yanagihara K.

Pathobiology. 2018;85(4):232-246. doi: 10.1159/000488801. Epub 2018 May 30.


Orthodontic-Surgical Approach for Treating Skeletal Class III Malocclusion With Severe Maxillary Deficiency in Isolated Cleft Palate.

Nakatsugawa K, Kurosaka H, Mihara K, Tanaka S, Aikawa T, Kogo M, Yamashiro T.

Cleft Palate Craniofac J. 2019 Mar;56(3):400-407. doi: 10.1177/1055665618777573. Epub 2018 May 22.


Laparoscopic total gastrectomy for remnant gastric cancer: A single-institution experience.

Booka E, Kaihara M, Mihara K, Nishiya S, Handa K, Ito Y, Shibutani S, Egawa T, Nagashima A.

Asian J Endosc Surg. 2019 Jan;12(1):58-63. doi: 10.1111/ases.12495. Epub 2018 May 10.


Investigation of safety and efficacy of the new more thermostable formulation of Flolan (epoprostenol) in Japanese patients with pulmonary arterial hypertension (PAH)-An open-label, single-arm study.

Mihara K, Ogawa A, Matsubara H, Terao T, Ichikawa Y.

PLoS One. 2018 Apr 2;13(4):e0195195. doi: 10.1371/journal.pone.0195195. eCollection 2018.


Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.


Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics.

Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A.

Cell Metab. 2018 Mar 6;27(3):657-666.e5. doi: 10.1016/j.cmet.2018.01.011. Epub 2018 Feb 22.


Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma.

Tari A, Kitadai Y, Mouri R, Takigawa H, Asaoku H, Mihara K, Takata K, Fujihara M, Yoshino T, Koga T, Fujimori S, Tanaka S, Chayama K.

J Gastroenterol Hepatol. 2018 Aug;33(8):1461-1468. doi: 10.1111/jgh.14100. Epub 2018 Mar 25.


Both Serum Brain-Derived Neurotrophic Factor and Interleukin-6 Levels Are Not Associated with Therapeutic Response to Lamotrigine Augmentation Therapy in Treatment-Resistant Depressive Disorder.

Kagawa S, Mihara K, Suzuki T, Nagai G, Nakamura A, Nemoto K, Kondo T.

Neuropsychobiology. 2017;75(3):145-150. doi: 10.1159/000484665. Epub 2018 Jan 12.


Treatment of severe mitral regurgitation caused by lesions in both leaflets using multiple mitral valve plasty techniques in a small dog.

Yokoyama S, Kanemoto I, Mihara K, Ando T, Kawase K, Sahashi Y, Iguchi K.

Open Vet J. 2017;7(4):328-331. doi: 10.4314/ovj.v7i4.7. Epub 2017 Nov 23.


A Benzoyl Peroxide/Diphenyl Diselenide Binary System for Functionalization of Alkynes Leading to Alkenyl and Alkynyl Selenides.

Kodama S, Saeki T, Mihara K, Higashimae S, Kawaguchi SI, Sonoda M, Nomoto A, Ogawa A.

J Org Chem. 2017 Dec 1;82(23):12477-12484. doi: 10.1021/acs.joc.7b02276. Epub 2017 Nov 17.


Telomere length as a potential biomarker of coronary artery disease.

Bhattacharyya J, Mihara K, Bhattacharjee D, Mukherjee M.

Indian J Med Res. 2017 Jun;145(6):730-737. doi: 10.4103/0971-5916.216974. Review.


Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Jöhren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F.

Mol Pharmacol. 2017 Nov;92(5):519-532. doi: 10.1124/mol.117.109017. Epub 2017 Aug 25.


Engineering of the cytochrome P450 monooxygenase system for benzyl maltol hydroxylation.

Kozono I, Mihara K, Minagawa K, Hibi M, Ogawa J.

Appl Microbiol Biotechnol. 2017 Sep;101(17):6651-6658. doi: 10.1007/s00253-017-8414-2. Epub 2017 Jul 20.


Safety of human papillomavirus vaccines in healthy young women: a meta-analysis of 24 controlled studies.

Ogawa Y, Takei H, Ogawa R, Mihara K.

J Pharm Health Care Sci. 2017 Jul 11;3:18. doi: 10.1186/s40780-017-0087-6. eCollection 2017.


Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.

Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, Oka T, Mihara K, Ishihara N.

Nat Cell Biol. 2017 Jul;19(7):856-863. doi: 10.1038/ncb3560. Epub 2017 Jun 19.


T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells.

Mihara K, Yoshida T, Takei Y, Sasaki N, Takihara Y, Kuroda J, Ichinohe T.

J Hematol Oncol. 2017 Jun 8;10(1):116. doi: 10.1186/s13045-017-0488-x.


Cell-free mitochondrial fusion assay detected by specific protease reaction revealed Ca2+ as regulator of mitofusin-dependent mitochondrial fusion.

Ishihara N, Maeda M, Ban T, Mihara K.

J Biochem. 2017 Oct 1;162(4):287-294. doi: 10.1093/jb/mvx029.


PARL paves the way to apoptosis.

Ishihara N, Mihara K.

Nat Cell Biol. 2017 Mar 31;19(4):263-265. doi: 10.1038/ncb3504.


Three-dimensional analysis of somatic mitochondrial dynamics in fission-deficient injured motor neurons using FIB/SEM.

Tamada H, Kiryu-Seo S, Hosokawa H, Ohta K, Ishihara N, Nomura M, Mihara K, Nakamura KI, Kiyama H.

J Comp Neurol. 2017 Aug 1;525(11):2535-2548. doi: 10.1002/cne.24213. Epub 2017 Apr 21.


Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.


Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.


All-trans retinoic acid enhances cytotoxic effect of T cells with an anti-CD38 chimeric antigen receptor in acute myeloid leukemia.

Yoshida T, Mihara K, Takei Y, Yanagihara K, Kubo T, Bhattacharyya J, Imai C, Mino T, Takihara Y, Ichinohe T.

Clin Transl Immunology. 2016 Dec 9;5(12):e116. doi: 10.1038/cti.2016.73. eCollection 2016 Dec.


Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy.

Yamashita SI, Jin X, Furukawa K, Hamasaki M, Nezu A, Otera H, Saigusa T, Yoshimori T, Sakai Y, Mihara K, Kanki T.

J Cell Biol. 2016 Dec 5;215(5):649-665. Epub 2016 Nov 30.


Seeing Wisely.

Wheeler DJ, Mihara K, Chiovaro J.

J Gen Intern Med. 2017 Feb;32(2):139. doi: 10.1007/s11606-016-3933-6. No abstract available.


Prediction of an Optimal Dose of Aripiprazole in the Treatment of Schizophrenia From Plasma Concentrations of Aripiprazole Plus Its Active Metabolite Dehydroaripiprazole at Week 1.

Nagai G, Mihara K, Nakamura A, Nemoto K, Kagawa S, Suzuki T, Kondo T.

Ther Drug Monit. 2017 Feb;39(1):62-65. doi: 10.1097/FTD.0000000000000358.


Omphalolith: An Umbilical Concretion to Recognize.

Mihara K.

J Gen Intern Med. 2016 Nov;31(11):1396. doi: 10.1007/s11606-016-3708-0. Epub 2016 Apr 25. No abstract available.


Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence.

Gillrie MR, Renaux B, Russell-Goldman E, Avril M, Brazier AJ, Mihara K, Di Cera E, Milner DA Jr, Hollenberg MD, Smith JD, Ho M.

MBio. 2016 Sep 13;7(5). pii: e01120-16. doi: 10.1128/mBio.01120-16.


Reduced immune response to polymeric micelles coating sialic acids.

Ohmae M, Kojima M, Mihara K, Yamazaki Y, Hara I, Hara E, Kimura S.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4976-4982. doi: 10.1016/j.bmcl.2016.09.004. Epub 2016 Sep 4.


Predictors of the therapeutic effect of sivelestat in patients with acute lung injury associated with systemic inflammatory response syndrome.

Ozawa T, Mihara K, Yasuno N.

J Pharm Health Care Sci. 2016 Aug 24;2(1):19. doi: 10.1186/s40780-016-0051-x. eCollection 2016.


Mitochondrial fission is an acute and adaptive response in injured motor neurons.

Kiryu-Seo S, Tamada H, Kato Y, Yasuda K, Ishihara N, Nomura M, Mihara K, Kiyama H.

Sci Rep. 2016 Jun 20;6:28331. doi: 10.1038/srep28331.


Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.

Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N, Fromm SJ, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg MD, Ungefroren H.

Oncotarget. 2016 Jul 5;7(27):41095-41109. doi: 10.18632/oncotarget.9600.


[Local Control of Advanced Breast Cancer with Mohs Paste and Systemic Therapy].

Nishiya S, Doi M, Oikawa A, Kawaura A, Mihara K, Ono S, Handa K, Ito Y, Shibutani S, Egawa T, Nagashima A.

Gan To Kagaku Ryoho. 2016 Apr;43(4):443-5. Japanese.


All-trans retinoic acid and interferon-α increase CD38 expression on adult T-cell leukemia cells and sensitize them to T cells bearing anti-CD38 chimeric antigen receptors.

Mihara K, Yoshida T, Ishida S, Takei Y, Kitanaka A, Shimoda K, Morishita K, Takihara Y, Ichinohe T.

Blood Cancer J. 2016 May 13;6:e421. doi: 10.1038/bcj.2016.30. No abstract available.

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