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Items: 1 to 50 of 69

1.

Intracellular binding is an important determinant of the avid hepatic uptake of the high clearance drug omeprazole.

Sewell RB, Brook CW, Mihaly GW, Morgan DJ, Smallwood RA.

Biochem Pharmacol. 1994 Aug 17;48(4):846-9.

PMID:
8080458
2.

Quinine impairs quinidine clearance in rat perfused liver.

Mihaly GW, Scott H, Hyman MK, Morgan DJ, Smallwood RA.

J Pharm Pharmacol. 1993 Mar;45(3):215-7.

PMID:
8097780
3.

Malaria infection impairs glucuronidation and biliary excretion by the isolated perfused rat liver.

Murdoch RT, Ghabrial H, Mihaly GW, Morgan DJ, Smallwood RA.

Xenobiotica. 1991 Dec;21(12):1571-82.

PMID:
1785204
4.

Disposition of the diastereoisomers quinine and quinidine in the ovine fetus.

Czuba MA, Morgan DJ, Ching MS, Mihaly GW, Ghabrial H, Hardy KJ, Smallwood RA.

J Pharm Sci. 1991 May;80(5):445-8.

PMID:
1880724
5.

Oral bioavailability of omeprazole before and after chronic therapy in patients with duodenal ulcer.

Ching MS, Mihaly GW, Angus PW, Morgan DJ, Devenish-Meares S, Yeomans ND, Smallwood RA.

Br J Clin Pharmacol. 1991 Feb;31(2):166-70.

6.

Ontogeny of fetal renal organic cation excretion: a study with cimetidine and ranitidine during the latter half of gestation in the pregnant ewe.

Czuba MA, Morgan DJ, Ching MS, Mihaly GW, Hardy KJ, Smallwood RA.

J Pharmacol Exp Ther. 1990 Dec;255(3):1177-82.

PMID:
2262900
7.

Oxygen dependence of omeprazole clearance and sulfone and sulfide metabolite formation in the isolated perfused rat liver.

Angus PW, Mihaly GW, Morgan DJ, Smallwood RA.

J Pharmacol Exp Ther. 1989 Sep;250(3):1043-7.

PMID:
2778708
8.

Oxygen dependence of salbutamol elimination by the isolated perfused rat liver.

Angus PW, Mihaly GW, Morgan DJ, Smallwood RA.

Biochem Pharmacol. 1989 May 1;38(9):1443-9.

PMID:
2719719
9.

Influence of maternal plasma protein binding on fetal unbound plasma concentration of propranolol in the pregnant ewe.

Morgan DJ, Mihaly GW, Czuba MA, Ching MS, Hardy KJ, Smallwood RA.

J Pharm Sci. 1988 Oct;77(10):835-7.

PMID:
3236224
10.

Effect of a protein binding change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction.

Smallwood RH, Mihaly GW, Smallwood RA, Morgan DJ.

J Pharmacokinet Biopharm. 1988 Oct;16(5):529-42.

PMID:
3199317
11.

Effects of gestational age on the disposition of propranolol in pregnant sheep.

Czuba MA, Mihaly GW, Ching MS, Morgan DJ, Hardy KJ, Smallwood RA.

J Pharmacol Exp Ther. 1988 Oct;247(1):279-82.

PMID:
3171976
12.

Mechanism of triamterene transfer across the human placenta.

Ching MS, Czuba MA, Mihaly GW, Morgan DJ, Hyman KM, Paull JD, Smallwood RA.

J Pharmacol Exp Ther. 1988 Sep;246(3):1093-7.

PMID:
3418511
13.
14.

Lack of linear correlation between hepatic ligand uptake rate and unbound ligand concentration does not necessarily imply receptor-mediated uptake.

Smallwood RH, Morgan DJ, Mihaly GW, Smallwood RA.

J Pharmacokinet Biopharm. 1988 Aug;16(4):397-411.

PMID:
2848119
15.

Propranolol elimination as described by the venous equilibrium model using flow perturbations in the isolated perfused rat liver.

Smallwood RH, Mihaly GW, Smallwood RA, Morgan DJ.

J Pharm Sci. 1988 Apr;77(4):330-3.

PMID:
3379592
16.

Synergistic effects of hypoxia and fasting on harmol elimination in the isolated perfused rat liver.

Angus PW, Mihaly GW, Morgan DJ, Smallwood RA.

Biochem Pharmacol. 1988 Apr 1;37(7):1207-12.

PMID:
3355595
17.

Differences in the binding of quinine and quinidine to plasma proteins.

Mihaly GW, Ching MS, Klejn MB, Paull J, Smallwood RA.

Br J Clin Pharmacol. 1987 Dec;24(6):769-74.

18.

Decreased hepatic elimination of pyrimethamine during malaria infection. Studies in the isolated perfused rat liver.

Mihaly GW, Date NM, Veenendaal JR, Newman KT, Smallwood RA.

Biochem Pharmacol. 1987 Sep 1;36(17):2827-9.

PMID:
3307789
19.

The pharmacokinetics of (+)- and (-)-primaquine in the isolated perfused rat liver preparation.

Ward SA, Mihaly GW, Nicholl DD, Breckenridge AM, Edwards G.

Biochem Pharmacol. 1987 Jul 1;36(13):2238-9. No abstract available.

PMID:
3606640
20.

Low clearance of cimetidine across the human placenta.

Ching MS, Mihaly GW, Morgan DJ, Date NM, Hardy KJ, Smallwood RA.

J Pharmacol Exp Ther. 1987 Jun;241(3):1006-9.

PMID:
3598898
21.

High-performance liquid chromatographic analysis of quinine and its diastereoisomer quinidine.

Mihaly GW, Hyman KM, Smallwood RA, Hardy KJ.

J Chromatogr. 1987 Mar 20;415(1):177-82. No abstract available.

PMID:
3584354
22.

Hypoxia impairs conjugation and elimination of harmol in the isolated perfused rat liver.

Angus PW, Mihaly GW, Morgan DJ, Smallwood RA.

J Pharmacol Exp Ther. 1987 Mar;240(3):931-6.

PMID:
3559985
23.

The effect of malaria infection on primaquine elimination in the isolated perfused rat liver.

Mihaly GW, Date NM, Ireton HJ, Smallwood RA.

Biochem Pharmacol. 1987 Jan 15;36(2):225-8.

PMID:
3814168
24.

The effectiveness of ranitidine in reducing gastric acid-secretion decreases with continued therapy.

Prichard PJ, Jones DB, Yeomans ND, Mihaly GW, Smallwood RA, Louis WJ.

Br J Clin Pharmacol. 1986 Dec;22(6):663-8.

25.

High-performance liquid chromatographic analysis of harmol and its conjugated metabolites after enzyme hydrolysis in biological fluids.

Ching MS, Mihaly GW, Angus PW, Anderson JD, Smallwood RA.

J Chromatogr. 1986 Jul 11;380(1):190-5. No abstract available.

PMID:
3745384
26.

The disposition of pyrimethamine base and pyrimethamine pamoate in the mouse: effect of route of administration.

Coleman MD, Mihaly GW, Edwards G, Howells RE, Breckenridge AM.

Biopharm Drug Dispos. 1986 Mar-Apr;7(2):173-82.

PMID:
3708123
27.

Placental transfer of omeprazole in maternal and fetal sheep.

Ching MS, Morgan DJ, Mihaly GW, Hardy KJ, Smallwood RA.

Dev Pharmacol Ther. 1986;9(5):323-31.

PMID:
3780367
28.

The sustained release of pyrimethamine base or pyrimethamine pamoate from a biodegradable injectable depot preparation in mice.

Coleman MD, Mihaly GW, Ward SA, Edwards G, Howells RE, Breckenridge AM.

J Pharm Pharmacol. 1985 Dec;37(12):878-83.

PMID:
2868095
29.

Fetal exposure to cimetidine following chronic administration to pregnant sheep.

Ching MS, Jones DB, Morgan DJ, Mihaly GW, Hardy KJ, Smallwood RA.

Res Commun Chem Pathol Pharmacol. 1985 Oct;50(1):139-42.

PMID:
4081307
30.

The disposition of primaquine in the isolated perfused rat liver. Effect of dose size.

Ward SA, Mihaly GW, Nicholl DD, Edwards G, Breckenridge AM.

Drug Metab Dispos. 1985 Jul-Aug;13(4):425-9.

PMID:
2863105
31.

The disposition of pyrimethamine in the isolated perfused rat liver.

Coleman MD, Mihaly GW, Ward SA, Edwards G, Howells RE, Breckenridge AM.

Biochem Pharmacol. 1985 Jun 15;34(12):2193-7.

PMID:
4004937
32.

Pharmacokinetics of primaquine in man. II. Comparison of acute vs chronic dosage in Thai subjects.

Ward SA, Mihaly GW, Edwards G, Looareesuwan S, Phillips RE, Chanthavanich P, Warrell DA, Orme ML, Breckenridge AM.

Br J Clin Pharmacol. 1985 Jun;19(6):751-5.

33.

Pharmacokinetics of primaquine in man. I. Studies of the absolute bioavailability and effects of dose size.

Mihaly GW, Ward SA, Edwards G, Nicholl DD, Orme ML, Breckenridge AM.

Br J Clin Pharmacol. 1985 Jun;19(6):745-50.

34.

Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver.

Webster LK, Jones DB, Mihaly GW, Morgan DJ, Smallwood RA.

Biochem Pharmacol. 1985 Apr 15;34(8):1239-45.

PMID:
3994745
35.

Pyrimethamine pharmacokinetics and its tissue localization in mice: effect of dose size.

Coleman MD, Mihaly GW, Edwards G, Ward SA, Howells RE, Breckenridge AM.

J Pharm Pharmacol. 1985 Mar;37(3):170-4.

PMID:
2858563
36.

The effects of primaquine stereoisomers and metabolites on drug metabolism in the isolated perfused rat liver and in vitro rat liver microsomes.

Mihaly GW, Ward SA, Nicholl DD, Edwards G, Breckenridge AM.

Biochem Pharmacol. 1985 Feb 1;34(3):331-6.

PMID:
3970715
37.

High-performance liquid chromatographic analysis of amodiaquine in human plasma.

Mihaly GW, Nicholl DD, Edwards G, Ward SA, Orme ML, Warrell DA, Breckenridge AM.

J Chromatogr. 1985 Jan 11;337(1):166-71. No abstract available.

PMID:
3980649
38.

Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage.

Prichard PJ, Yeomans ND, Mihaly GW, Jones DB, Buckle PJ, Smallwood RA, Louis WJ.

Gastroenterology. 1985 Jan;88(1 Pt 1):64-9.

PMID:
3880557
39.

The effect of some benzimidazoles on the disposition of antipyrine and tolbutamide from the rat isolated perfused liver.

Ward SA, Mihaly GW, Tjia JF, Back DJ.

J Pharm Pharmacol. 1985 Jan;37(1):62-4.

PMID:
2858532
40.

Liquid chromatographic analysis of cimetidine with procainamide as internal standard.

Ching MS, Mihaly GW, Jones DB, Smallwood RA.

J Pharm Sci. 1984 Jul;73(7):1015. No abstract available.

PMID:
6470945
41.

Effect of omeprazole and polyethylene glycol-400 on antipyrine elimination by the isolated perfused rat liver.

Webster LK, Jones DB, Mihaly GW, Smallwood RA.

J Pharm Pharmacol. 1984 Jul;36(7):470-2.

PMID:
6146695
42.

High-performance liquid chromatographic method for the determination of pyrimethamine and its 3-N-oxide metabolite in biological fluids.

Coleman MD, Edwards G, Mihaly GW, Howells RE, Breckenridge AM.

J Chromatogr. 1984 Jun 8;308:363-9. No abstract available.

PMID:
6746829
43.

Differential effects of hypoxia on the disposition of propranolol and sodium taurocholate by the isolated perfused rat liver.

Jones DB, Mihaly GW, Smallwood RA, Webster LK, Morgan DJ, Madsen NP.

Hepatology. 1984 May-Jun;4(3):461-6.

PMID:
6724514
44.
45.

Effect of increased bile flow and bile acid secretion on the hepatic elimination of sodium valproate in the cat.

Marshall AW, Mihaly GW, Smallwood RA, Hanson RG, Vajda FJ, Phillips J, Baldas J.

Clin Exp Pharmacol Physiol. 1984 May-Jun;11(3):309-17.

PMID:
6430616
46.

Pharmacokinetics of primaquine in man: identification of the carboxylic acid derivative as a major plasma metabolite.

Mihaly GW, Ward SA, Edwards G, Orme ML, Breckenridge AM.

Br J Clin Pharmacol. 1984 Apr;17(4):441-6.

47.

Pharmacokinetic studies of cimetidine and ranitidine before and after treatment in peptic ulcer patients.

Mihaly GW, Jones DB, Anderson JA, Smallwood RA, Louis WJ.

Br J Clin Pharmacol. 1984 Jan;17(1):109-11. No abstract available.

48.

Effect of cimetidine and ranitidine on carbamazepine and sodium valproate pharmacokinetics.

Webster LK, Mihaly GW, Jones DB, Smallwood RA, Phillips JA, Vajda FJ.

Eur J Clin Pharmacol. 1984;27(3):341-3.

PMID:
6096154
49.

Simultaneous high-performance liquid chromatographic analysis of omeprazole and its sulphone and sulphide metabolites in human plasma and urine.

Mihaly GW, Prichard PJ, Smallwood RA, Yeomans ND, Louis WJ.

J Chromatogr. 1983 Dec 9;278(2):311-9.

PMID:
6668312
50.

Effect of daily oral omeprazole on 24 hour intragastric acidity.

Prichard PJ, Yeomans ND, Mihaly GW, Jones DB, Smallwood RA, Louis WJ.

Br Med J (Clin Res Ed). 1983 Nov 5;287(6402):1378-9. No abstract available.

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