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Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting.

Edwards K, Hanquet G, Black S, Mignot E, Jankosky C, Shimabukuro T, Miller E, Nohynek H, Neels P.

Biologicals. 2019 May 23. pii: S1045-1056(19)30047-8. doi: 10.1016/j.biologicals.2019.05.005. [Epub ahead of print]


Response to "H1N1 hemagglutinin-specific HLA-DQ6-restricted CD4+ T cells can be readily detected in narcolepsy type 1 patients and healthy controls".

Mignot E, Ambati A, Luo G.

J Neuroimmunol. 2019 Aug 15;333:476959. doi: 10.1016/j.jneuroim.2019.04.019. Epub 2019 May 1. No abstract available.


Physical activity, sleep and cardiovascular health data for 50,000 individuals from the MyHeart Counts Study.

Hershman SG, Bot BM, Shcherbina A, Doerr M, Moayedi Y, Pavlovic A, Waggott D, Cho MK, Rosenberger ME, Haskell WL, Myers J, Champagne MA, Mignot E, Salvi D, Landray M, Tarassenko L, Harrington RA, Yeung AC, McConnell MV, Ashley EA.

Sci Data. 2019 Apr 11;6(1):24. doi: 10.1038/s41597-019-0016-7.


The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW.

Science. 2019 Apr 12;364(6436). pii: eaau8650. doi: 10.1126/science.aau8650.


DOSED: A deep learning approach to detect multiple sleep micro-events in EEG signal.

Chambon S, Thorey V, Arnal PJ, Mignot E, Gramfort A.

J Neurosci Methods. 2019 Jun 1;321:64-78. doi: 10.1016/j.jneumeth.2019.03.017. Epub 2019 Apr 1.


Knowledge Gaps in the Perioperative Management of Adults With Narcolepsy: A Call for Further Research.

Hershner S, Dauvilliers Y, Chung F, Singh M, Wong J, Gali B, Kakkar R, Mignot E, Thorpy M, Auckley D.

Anesth Analg. 2019 Jul;129(1):204-211. doi: 10.1213/ANE.0000000000004088.


Non-invasive machine learning estimation of effort differentiates sleep-disordered breathing pathology.

Hanif U, Schneider LD, Trap L, Leary EB, Moore H, Guilleminault C, Jennum P, Sorensen HBD, Mignot EJM.

Physiol Meas. 2019 Feb 26;40(2):025008. doi: 10.1088/1361-6579/ab0559.


HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy.

Sakai N, Matsumura M, Lin L, Mignot E, Nishino S.

Sci Rep. 2019 Jan 24;9(1):477. doi: 10.1038/s41598-018-36942-8.


Autoimmunity to hypocretin and molecular mimicry to flu in type 1 narcolepsy.

Luo G, Ambati A, Lin L, Bonvalet M, Partinen M, Ji X, Maecker HT, Mignot EJ.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12323-E12332. doi: 10.1073/pnas.1818150116. Epub 2018 Dec 12.


Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy.

Stephansen JB, Olesen AN, Olsen M, Ambati A, Leary EB, Moore HE, Carrillo O, Lin L, Han F, Yan H, Sun YL, Dauvilliers Y, Scholz S, Barateau L, Hogl B, Stefani A, Hong SC, Kim TW, Pizza F, Plazzi G, Vandi S, Antelmi E, Perrin D, Kuna ST, Schweitzer PK, Kushida C, Peppard PE, Sorensen HBD, Jennum P, Mignot E.

Nat Commun. 2018 Dec 6;9(1):5229. doi: 10.1038/s41467-018-07229-3.


Deep residual networks for automatic sleep stage classification of raw polysomnographic waveforms.

Olesen AN, Jennum P, Peppard P, Mignot E, Sorensen HBD.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513080.


Periodic limb movements in sleep: Prevalence and associated sleepiness in the Wisconsin Sleep Cohort.

Leary EB, Moore HE 4th, Schneider LD, Finn LA, Peppard PE, Mignot E.

Clin Neurophysiol. 2018 Nov;129(11):2306-2314. doi: 10.1016/j.clinph.2018.08.022. Epub 2018 Sep 6.


Treatment of paediatric narcolepsy with sodium oxybate: a double-blind, placebo-controlled, randomised-withdrawal multicentre study and open-label investigation.

Plazzi G, Ruoff C, Lecendreux M, Dauvilliers Y, Rosen CL, Black J, Parvataneni R, Guinta D, Wang YG, Mignot E.

Lancet Child Adolesc Health. 2018 Jul;2(7):483-494. doi: 10.1016/S2352-4642(18)30133-0. Epub 2018 May 21.


Genetic variants in the HLA class II region associated with risk of cutaneous squamous cell carcinoma.

Wang W, Ollila HM, Whittemore AS, Demehri S, Ioannidis NM, Jorgenson E, Mignot E, Asgari MM.

Cancer Immunol Immunother. 2018 Jul;67(7):1123-1133. doi: 10.1007/s00262-018-2168-2. Epub 2018 May 12.


A comparative study of methods for automatic detection of rapid eye movement abnormal muscular activity in narcolepsy.

Olesen AN, Cesari M, Christensen JAE, Sorensen HBD, Mignot E, Jennum P.

Sleep Med. 2018 Apr;44:97-105. doi: 10.1016/j.sleep.2017.11.1141. Epub 2017 Dec 21.


Flow cytometry analysis of T-cell subsets in cerebrospinal fluid of narcolepsy type 1 patients with long-lasting disease.

Moresco M, Lecciso M, Ocadlikova D, Filardi M, Melzi S, Kornum BR, Antelmi E, Pizza F, Mignot E, Curti A, Plazzi G.

Sleep Med. 2018 Apr;44:53-60. doi: 10.1016/j.sleep.2017.11.1150. Epub 2018 Jan 3.


Increased EEG Theta Spectral Power in Sleep in Myotonic Dystrophy Type 1.

Cheung J, Ruoff C, Moore H, Hagerman KA, Perez J, Sakamuri S, Warby SC, Mignot E, Day J, Sampson J.

J Clin Sleep Med. 2018 Feb 15;14(2):229-235. doi: 10.5664/jcsm.6940.


Multiplex family with GAD65-Abs neurologic syndromes.

Belbezier A, Joubert B, Montero-Martin G, Fernandez-Vina M, Fabien N, Rogemond V, Mignot E, Honnorat J.

Neurol Neuroimmunol Neuroinflamm. 2017 Dec 5;5(1):e416. doi: 10.1212/NXI.0000000000000416. eCollection 2018 Jan.


Automatic, electrocardiographic-based detection of autonomic arousals and their association with cortical arousals, leg movements, and respiratory events in sleep.

Olsen M, Schneider LD, Cheung J, Peppard PE, Jennum PJ, Mignot E, Sorensen HBD.

Sleep. 2018 Mar 1;41(3). doi: 10.1093/sleep/zsy006.


Complex HLA association in paraneoplastic cerebellar ataxia with anti-Yo antibodies.

Hillary RP, Ollila HM, Lin L, Desestret V, Rogemond V, Picard G, Small M, Arnulf I, Dauvilliers Y, Honnorat J, Mignot E.

J Neuroimmunol. 2018 Feb 15;315:28-32. doi: 10.1016/j.jneuroim.2017.12.012. Epub 2017 Dec 18.


Absence of anti-hypocretin receptor 2 autoantibodies in post pandemrix narcolepsy cases.

Luo G, Lin L, Jacob L, Bonvalet M, Ambati A, Plazzi G, Pizza F, Leib R, Adams CM, Partinen M, Mignot EJ.

PLoS One. 2017 Dec 8;12(12):e0187305. doi: 10.1371/journal.pone.0187305. eCollection 2017. Erratum in: PLoS One. 2019 Mar 28;14(3):e0214340.


The MSLT is Repeatable in Narcolepsy Type 1 But Not Narcolepsy Type 2: A Retrospective Patient Study.

Ruoff C, Pizza F, Trotti LM, Sonka K, Vandi S, Cheung J, Pinto S, Einen M, Simakajornboon N, Han F, Peppard P, Nevsimalova S, Plazzi G, Rye D, Mignot E.

J Clin Sleep Med. 2018 Jan 15;14(1):65-74. doi: 10.5664/jcsm.6882.


Breathing Disturbances Without Hypoxia Are Associated With Objective Sleepiness in Sleep Apnea.

Koch H, Schneider LD, Finn LA, Leary EB, Peppard PE, Hagen E, Sorensen HBD, Jennum P, Mignot E.

Sleep. 2017 Nov 1;40(11). doi: 10.1093/sleep/zsx152.


Autoimmunity in narcolepsy.

Bonvalet M, Ollila HM, Ambati A, Mignot E.

Curr Opin Pulm Med. 2017 Nov;23(6):522-529. doi: 10.1097/MCP.0000000000000426. Review.


Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels.

Ju YS, Ooms SJ, Sutphen C, Macauley SL, Zangrilli MA, Jerome G, Fagan AM, Mignot E, Zempel JM, Claassen JAHR, Holtzman DM.

Brain. 2017 Aug 1;140(8):2104-2111. doi: 10.1093/brain/awx148.


Diagnosis and Management of Narcolepsy.

Schneider L, Mignot E.

Semin Neurol. 2017 Aug;37(4):446-460. doi: 10.1055/s-0037-1605554. Epub 2017 Aug 24. Review. No abstract available.


Diagnostic value of sleep stage dissociation as visualized on a 2-dimensional sleep state space in human narcolepsy.

Olsen AV, Stephansen J, Leary E, Peppard PE, Sheungshul H, Jennum PJ, Sorensen H, Mignot E.

J Neurosci Methods. 2017 Apr 15;282:9-19. doi: 10.1016/j.jneumeth.2017.02.004. Epub 2017 Feb 20.


Analysis of Hypoxic and Hypercapnic Ventilatory Response in Healthy Volunteers.

Goldberg S, Ollila HM, Lin L, Sharifi H, Rico T, Andlauer O, Aran A, Bloomrosen E, Faraco J, Fang H, Mignot E.

PLoS One. 2017 Jan 3;12(1):e0168930. doi: 10.1371/journal.pone.0168930. eCollection 2017.


Feasibility of Obtaining Measures of Lifestyle From a Smartphone App: The MyHeart Counts Cardiovascular Health Study.

McConnell MV, Shcherbina A, Pavlovic A, Homburger JR, Goldfeder RL, Waggot D, Cho MK, Rosenberger ME, Haskell WL, Myers J, Champagne MA, Mignot E, Landray M, Tarassenko L, Harrington RA, Yeung AC, Ashley EA.

JAMA Cardiol. 2017 Jan 1;2(1):67-76. doi: 10.1001/jamacardio.2016.4395.


Longitudinal associations of hypersomnolence and depression in the Wisconsin Sleep Cohort Study.

Plante DT, Finn LA, Hagen EW, Mignot E, Peppard PE.

J Affect Disord. 2017 Jan 1;207:197-202. doi: 10.1016/j.jad.2016.08.039. Epub 2016 Oct 3.


Histoire de la narcolepsie de 1877 à 1980 émergence d'une nouvelle entité Clinique.

Jacob L, Mignot E.

Hist Sci Med. 2016 Jan-Mar;50(1):69-74. French. No abstract available.


Familial Kleine-Levin Syndrome: A Specific Entity?

Nguyen QT, Groos E, Leclair-Visonneau L, Monaca-Charley C, Rico T, Farber N, Mignot E, Arnulf I.

Sleep. 2016 Aug 1;39(8):1535-42. doi: 10.5665/sleep.6014.


Effect of liraglutide 3.0 mg in individuals with obesity and moderate or severe obstructive sleep apnea: the SCALE Sleep Apnea randomized clinical trial.

Blackman A, Foster GD, Zammit G, Rosenberg R, Aronne L, Wadden T, Claudius B, Jensen CB, Mignot E.

Int J Obes (Lond). 2016 Aug;40(8):1310-9. doi: 10.1038/ijo.2016.52. Epub 2016 Mar 23.


Disrupted Sleep in Narcolepsy: Exploring the Integrity of Galanin Neurons in the Ventrolateral Preoptic Area.

Gavrilov YV, Ellison BA, Yamamoto M, Reddy H, Haybaeck J, Mignot E, Baumann CR, Scammell TE, Valko PO.

Sleep. 2016 May 1;39(5):1059-62. doi: 10.5665/sleep.5754.


Subjective and Objective Measures of Hypersomnolence Demonstrate Divergent Associations with Depression among Participants in the Wisconsin Sleep Cohort Study.

Plante DT, Finn LA, Hagen EW, Mignot E, Peppard PE.

J Clin Sleep Med. 2016 Apr 15;12(4):571-8. doi: 10.5664/jcsm.5694.


Urban domestic wastewater: how to reduce individual injection?

Polomé P, Mignot E, Nasri A, Lipeme Kouyi G, Campan L, Hooge C, Rivière N.

Water Sci Technol. 2016;73(1):144-52. doi: 10.2166/wst.2015.473.


The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients.

Christensen JA, Munk EG, Peppard PE, Young T, Mignot E, Sorensen HB, Jennum P.

Sleep Med. 2015 Dec;16(12):1516-27. doi: 10.1016/j.sleep.2015.09.005. Epub 2015 Sep 15.


Association of low ferritin with PLM in the Wisconsin Sleep Cohort.

Li J, Moore H 4th, Lin L, Young T, Finn L, Peppard PE, Mignot E.

Sleep Med. 2015 Nov;16(11):1413-1418. doi: 10.1016/j.sleep.2015.05.015. Epub 2015 Jun 18.


Correction: Design and Validation of a Periodic Leg Movement Detector.

Moore H 4th, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E.

PLoS One. 2015 Sep 10;10(9):e0138205. doi: 10.1371/journal.pone.0138205. eCollection 2015.


Sleep-stage transitions during polysomnographic recordings as diagnostic features of type 1 narcolepsy.

Christensen JA, Carrillo O, Leary EB, Peppard PE, Young T, Sorensen HB, Jennum P, Mignot E.

Sleep Med. 2015 Dec;16(12):1558-66. doi: 10.1016/j.sleep.2015.06.007. Epub 2015 Jul 7.


Narcolepsy in African Americans.

Kawai M, O'Hara R, Einen M, Lin L, Mignot E.

Sleep. 2015 Nov 1;38(11):1673-81. doi: 10.5665/sleep.5140.


Serum cytokine levels in Kleine-Levin syndrome.

Kornum BR, Rico T, Lin L, Huang YS, Arnulf I, Jennum P, Mignot E.

Sleep Med. 2015 Aug;16(8):961-5. doi: 10.1016/j.sleep.2015.02.540. Epub 2015 May 15.


Sleep spindle alterations in patients with Parkinson's disease.

Christensen JA, Nikolic M, Warby SC, Koch H, Zoetmulder M, Frandsen R, Moghadam KK, Sorensen HB, Mignot E, Jennum PJ.

Front Hum Neurosci. 2015 May 1;9:233. doi: 10.3389/fnhum.2015.00233. eCollection 2015.


Erratum to: History of narcolepsy at Stanford University.

Mignot EJ.

Immunol Res. 2015 Jun;62(2):253. doi: 10.1007/s12026-015-8656-y. No abstract available.


Nocturnal Sleep Dynamics Identify Narcolepsy Type 1.

Pizza F, Vandi S, Iloti M, Franceschini C, Liguori R, Mignot E, Plazzi G.

Sleep. 2015 Aug 1;38(8):1277-84. doi: 10.5665/sleep.4908.


Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset.

Kornum BR, Pizza F, Knudsen S, Plazzi G, Jennum P, Mignot E.

Brain Behav Immun. 2015 Oct;49:54-8. doi: 10.1016/j.bbi.2015.03.004. Epub 2015 Mar 11.


EIF3G is associated with narcolepsy across ethnicities.

Holm A, Lin L, Faraco J, Mostafavi S, Battle A, Zhu X, Levinson DF, Han F, Gammeltoft S, Jennum P, Mignot E, Kornum BR.

Eur J Hum Genet. 2015 Nov;23(11):1573-80. doi: 10.1038/ejhg.2015.4. Epub 2015 Feb 11.


HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy.

Ollila HM, Ravel JM, Han F, Faraco J, Lin L, Zheng X, Plazzi G, Dauvilliers Y, Pizza F, Hong SC, Jennum P, Knudsen S, Kornum BR, Dong XS, Yan H, Hong H, Coquillard C, Mahlios J, Jolanki O, Einen M, Arnulf I, Högl B, Frauscher B, Crowe C, Partinen M, Huang YS, Bourgin P, Vaarala O, Désautels A, Montplaisir J, Mack SJ, Mindrinos M, Fernandez-Vina M, Mignot E.

Am J Hum Genet. 2015 Jan 8;96(1):136-46. doi: 10.1016/j.ajhg.2014.12.010. Erratum in: Am J Hum Genet. 2015 May 7;96(5):852. Lavault, Sophie [removed]; Arnulf, Isabelle [added].


Design and validation of a periodic leg movement detector.

Moore H 4th, Leary E, Lee SY, Carrillo O, Stubbs R, Peppard P, Young T, Widrow B, Mignot E.

PLoS One. 2014 Dec 9;9(12):e114565. doi: 10.1371/journal.pone.0114565. eCollection 2014. Erratum in: PLoS One. 2015;10(9):e0138205.


Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

Gottlieb DJ, Hek K, Chen TH, Watson NF, Eiriksdottir G, Byrne EM, Cornelis M, Warby SC, Bandinelli S, Cherkas L, Evans DS, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Stafford JM, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert R, Ferrucci L, Fülöp T, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen M, Kao L, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici M, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector TD, Teumer A, Uitterlinden AG, Vohl MC, Widen E, Willemsen G, Young T, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O'Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H.

Mol Psychiatry. 2015 Oct;20(10):1232-9. doi: 10.1038/mp.2014.133. Epub 2014 Dec 2.

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