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Response to Comment on "A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands".

Faridi P, Li C, Ramarathinam SH, Illing PT, Mifsud NA, Ayala R, Song J, Gearing LJ, Croft NP, Purcell AW.

Sci Immunol. 2019 Aug 16;4(38). pii: eaaw8457. doi: 10.1126/sciimmunol.aaw8457.


Downregulation of MHC Class I Expression by Influenza A and B Viruses.

Koutsakos M, McWilliam HEG, Aktepe TE, Fritzlar S, Illing PT, Mifsud NA, Purcell AW, Rockman S, Reading PC, Vivian JP, Rossjohn J, Brooks AG, Mackenzie JM, Mintern JD, Villadangos JA, Nguyen THO, Kedzierska K.

Front Immunol. 2019 May 29;10:1158. doi: 10.3389/fimmu.2019.01158. eCollection 2019.


Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames.

Zanker DJ, Oveissi S, Tscharke DC, Duan M, Wan S, Zhang X, Xiao K, Mifsud NA, Gibbs J, Izzard L, Dlugolenski D, Faou P, Laurie KL, Vigneron N, Barr IG, Stambas J, Van den Eynde BJ, Bennink JR, Yewdell JW, Chen W.

J Immunol. 2019 Jun 15;202(12):3370-3380. doi: 10.4049/jimmunol.1900070. Epub 2019 May 15.


HLA-associated antiepileptic drug-induced cutaneous adverse reactions.

Mullan KA, Anderson A, Illing PT, Kwan P, Purcell AW, Mifsud NA.

HLA. 2019 Jun;93(6):417-435. doi: 10.1111/tan.13530. Epub 2019 Apr 9. Review.


Human CD8+ T cell cross-reactivity across influenza A, B and C viruses.

Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, Eltahla AA, Clemens EB, Sant S, Chua BY, Wong CY, Allen EK, Teng D, Dash P, Boyd DF, Grzelak L, Zeng W, Hurt AC, Barr I, Rockman S, Jackson DC, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Wakim LM, Rossjohn J, Vijaykrishna D, Luciani F, Thomas PG, Gras S, Purcell AW, Kedzierska K.

Nat Immunol. 2019 May;20(5):613-625. doi: 10.1038/s41590-019-0320-6. Epub 2019 Feb 18.


HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome.

Illing PT, Pymm P, Croft NP, Hilton HG, Jojic V, Han AS, Mendoza JL, Mifsud NA, Dudek NL, McCluskey J, Parham P, Rossjohn J, Vivian JP, Purcell AW.

Nat Commun. 2018 Nov 8;9(1):4693. doi: 10.1038/s41467-018-07109-w.


A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands.

Faridi P, Li C, Ramarathinam SH, Vivian JP, Illing PT, Mifsud NA, Ayala R, Song J, Gearing LJ, Hertzog PJ, Ternette N, Rossjohn J, Croft NP, Purcell AW.

Sci Immunol. 2018 Oct 12;3(28). pii: eaar3947. doi: 10.1126/sciimmunol.aar3947.


Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses.

Rowntree LC, Nguyen THO, Halim H, Purcell AW, Rossjohn J, Gras S, Kotsimbos TC, Mifsud NA.

J Immunol. 2018 Jun 15;200(12):3993-4003. doi: 10.4049/jimmunol.1800010. Epub 2018 May 7.


Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics.

Ramarathinam SH, Gras S, Alcantara S, Yeung AWS, Mifsud NA, Sonza S, Illing PT, Glaros EN, Center RJ, Thomas SR, Kent SJ, Ternette N, Purcell DFJ, Rossjohn J, Purcell AW.

Proteomics. 2018 Jun;18(12):e1700253. doi: 10.1002/pmic.201700253. Epub 2018 Apr 10.


Allotype specific interactions of drugs and HLA molecules in hypersensitivity reactions.

Illing PT, Mifsud NA, Purcell AW.

Curr Opin Immunol. 2016 Oct;42:31-40. doi: 10.1016/j.coi.2016.05.003. Epub 2016 Jun 2. Review.


Maintenance of the EBV-specific CD8+ TCRαβ repertoire in immunosuppressed lung transplant recipients.

Nguyen TH, Bird NL, Grant EJ, Miles JJ, Thomas PG, Kotsimbos TC, Mifsud NA, Kedzierska K.

Immunol Cell Biol. 2017 Jan;95(1):77-86. doi: 10.1038/icb.2016.71. Epub 2016 Oct 4.


Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation.

Rowntree LC, Nguyen TH, Gras S, Kotsimbos TC, Mifsud NA.

Curr Opin Organ Transplant. 2016 Feb;21(1):29-39. doi: 10.1097/MOT.0000000000000264. Review.


The Presence of HLA-E-Restricted, CMV-Specific CD8+ T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection.

Sullivan LC, Westall GP, Widjaja JM, Mifsud NA, Nguyen TH, Meehan AC, Kotsimbos TC, Brooks AG.

PLoS One. 2015 Aug 24;10(8):e0135972. doi: 10.1371/journal.pone.0135972. eCollection 2015.


Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin.

Borg RJ, Samson AL, Au AE, Scholzen A, Fuchsberger M, Kong YY, Freeman R, Mifsud NA, Plebanski M, Medcalf RL.

PLoS One. 2015 Jul 1;10(7):e0131216. doi: 10.1371/journal.pone.0131216. eCollection 2015.


The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.

Hardy CL, King SJ, Mifsud NA, Hedger MP, Phillips DJ, Mackay F, de Kretser DM, Wilson JW, Rolland JM, O'Hehir RE.

Immunol Cell Biol. 2015 Jul;93(6):567-74. doi: 10.1038/icb.2015.7. Epub 2015 Mar 10.


The oral iron chelator deferasirox inhibits NF-κB mediated gene expression without impacting on proximal activation: implications for myelodysplasia and aplastic anaemia.

Banerjee A, Mifsud NA, Bird R, Forsyth C, Szer J, Tam C, Kellner S, Grigg A, Motum P, Bentley M, Opat S, Grigoriadis G.

Br J Haematol. 2015 Feb;168(4):576-82. doi: 10.1111/bjh.13151. Epub 2014 Oct 1.


Recognition of distinct cross-reactive virus-specific CD8+ T cells reveals a unique TCR signature in a clinical setting.

Nguyen TH, Rowntree LC, Pellicci DG, Bird NL, Handel A, Kjer-Nielsen L, Kedzierska K, Kotsimbos TC, Mifsud NA.

J Immunol. 2014 Jun 1;192(11):5039-49. doi: 10.4049/jimmunol.1303147. Epub 2014 Apr 28.


Endogenous-peptide-dependent alloreactivity: new scientific insights and clinical implications.

D'Orsogna LJ, Nguyen TH, Claas FH, Witt C, Mifsud NA.

Tissue Antigens. 2013 Jun;81(6):399-407. doi: 10.1111/tan.12115. Review.


Human leucocyte antigen-defined microchimerism early post-transplant does not predict for stable lung allograft function.

Rowntree LC, Bayliss J, Nguyen TH, Kotsimbos TC, Mifsud NA.

Clin Exp Immunol. 2013 Jun;172(3):483-9. doi: 10.1111/cei.12075.


Impact of commonly used transplant immunosuppressive drugs on human NK cell function is dependent upon stimulation condition.

Meehan AC, Mifsud NA, Nguyen TH, Levvey BJ, Snell GI, Kotsimbos TC, Westall GP.

PLoS One. 2013;8(3):e60144. doi: 10.1371/journal.pone.0060144. Epub 2013 Mar 21.


Clara cells and injury post lung transplantation: an evolving story.

Bourdin A, Mifsud NA, Chanez B, Chanez P, Snell G, Kotsimbos TC.

Am J Transplant. 2013 May;13(5):1370. doi: 10.1111/ajt.12184. Epub 2013 Mar 6. No abstract available.


Cross-reactive anti-viral T cells increase prior to an episode of viral reactivation post human lung transplantation.

Nguyen TH, Westall GP, Bull TE, Meehan AC, Mifsud NA, Kotsimbos TC.

PLoS One. 2013;8(2):e56042. doi: 10.1371/journal.pone.0056042. Epub 2013 Feb 6.


A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen.

Zhao RY, Mifsud NA, Xiao K, Chan KF, Oveissi S, Jackson HM, Dimopoulos N, Guillaume P, Knights AJ, Lowen T, Robson NC, Russell SE, Scotet E, Davis ID, Maraskovsky E, Cebon J, Luescher IF, Chen W.

PLoS One. 2012;7(9):e44707. doi: 10.1371/journal.pone.0044707. Epub 2012 Sep 6.


Donor clara cell secretory protein polymorphism is a risk factor for bronchiolitis obliterans syndrome after lung transplantation.

Bourdin A, Mifsud NA, Chanez B, McLean C, Chanez P, Snell G, Kotsimbos TC.

Transplantation. 2012 Sep 27;94(6):652-8.


Detection and characterisation of alloreactive T cells.

Bharadwaj M, Mifsud NA, McCluskey J.

Methods Mol Biol. 2012;882:309-37. doi: 10.1007/978-1-61779-842-9_18.


High levels of mannose-binding lectin are associated with poor outcomes after lung transplantation.

Carroll KE, Dean MM, Heatley SL, Meehan AC, Mifsud NA, Kotsimbos TC, Snell GI, Westall GP.

Transplantation. 2011 May 15;91(9):1044-9. doi: 10.1097/TP.0b013e318212c7d6.


Quantitative and functional diversity of cross-reactive EBV-specific CD8+ T cells in a longitudinal study cohort of lung transplant recipients.

Mifsud NA, Nguyen TH, Tait BD, Kotsimbos TC.

Transplantation. 2010 Dec 27;90(12):1439-49. doi: 10.1097/TP.0b013e3181ff4ff3.


Influenza A infection enhances cross-priming of CD8+ T cells to cell-associated antigens in a TLR7- and type I IFN-dependent fashion.

Wei J, Waithman J, Lata R, Mifsud NA, Cebon J, Kay T, Smyth MJ, Sadler AJ, Chen W.

J Immunol. 2010 Nov 15;185(10):6013-22. doi: 10.4049/jimmunol.1002129. Epub 2010 Oct 18.


Respiratory epithelium: an unlikely reservoir for latent human polyomavirus infection but a likely portal of entry.

Keating DT, Michaelides A, Mifsud NA, Bowden S, Kotsimbos TC.

Transplantation. 2010 Mar 15;89(5):634-5. doi: 10.1097/TP.0b013e3181c7f255. No abstract available.


Cross-presentation of HCMV chimeric protein enables generation and measurement of polyclonal T cells.

Nguyen TH, Sullivan LC, Kotsimbos TC, Schwarer AP, Mifsud NA.

Immunol Cell Biol. 2010 Aug;88(6):676-84. doi: 10.1038/icb.2010.20. Epub 2010 Mar 2.


Natural killer cell activation in the lung allograft early posttransplantation.

Meehan AC, Sullivan LC, Mifsud NA, Brooks AG, Snell GI, Kotsimbos TC, Westall GP.

Transplantation. 2010 Mar 27;89(6):756-63. doi: 10.1097/TP.0b013e3181cab17f.


Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantation.

Van der Meulen J, Mifsud NA, Abud D, Paul E, Varney MD, Lewin SR, Cameron PU, Kotsimbos TC.

Clin Immunol. 2009 Nov;133(2):179-83. doi: 10.1016/j.clim.2009.07.012. Epub 2009 Aug 19.


Linking CMV serostatus to episodes of CMV reactivation following lung transplantation by measuring CMV-specific CD8+ T-cell immunity.

Westall GP, Mifsud NA, Kotsimbos T.

Am J Transplant. 2008 Aug;8(8):1749-54. doi: 10.1111/j.1600-6143.2008.02294.x. Epub 2008 Jun 28.


Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.

Chessman D, Kostenko L, Lethborg T, Purcell AW, Williamson NA, Chen Z, Kjer-Nielsen L, Mifsud NA, Tait BD, Holdsworth R, Almeida CA, Nolan D, Macdonald WA, Archbold JK, Kellerher AD, Marriott D, Mallal S, Bharadwaj M, Rossjohn J, McCluskey J.

Immunity. 2008 Jun;28(6):822-32. doi: 10.1016/j.immuni.2008.04.020. Erratum in: Immunity. 2008 Jul;29(1):165.


Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity.

Nguyen TH, Mifsud NA, Stewart LA, Rose MJ, Etto TL, Williamson NA, Purcell AW, Kotsimbos T, Schwarer AP.

Protein Expr Purif. 2008 Sep;61(1):22-30. doi: 10.1016/j.pep.2008.05.001. Epub 2008 May 14.


Cell-mediated rejection results in allograft loss after liver cell transplantation.

Allen KJ, Mifsud NA, Williamson R, Bertolino P, Hardikar W.

Liver Transpl. 2008 May;14(5):688-94. doi: 10.1002/lt.21443.


Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity.

Mifsud NA, Purcell AW, Chen W, Holdsworth R, Tait BD, McCluskey J.

Am J Transplant. 2008 Jan;8(1):121-32. Epub 2007 Dec 18.


Striking immunodominance hierarchy of naturally occurring CD8+ and CD4+ T cell responses to tumor antigen NY-ESO-1.

Jackson H, Dimopoulos N, Mifsud NA, Tai TY, Chen Q, Svobodova S, Browning J, Luescher I, Stockert L, Old LJ, Davis ID, Cebon J, Chen W.

J Immunol. 2006 May 15;176(10):5908-17.


Serologic and molecular investigations of a chimera.

Mifsud NA, Haddad AP, Hart CF, Holdsworth R, Condon JA, Swain M, Sparrow RL.

Immunohematology. 1999;15(3):100-4.


Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion.

Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Bharadwaj M, Chang L, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J.

J Exp Med. 2004 Jul 5;200(1):13-24. Epub 2004 Jun 28.


Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant.

Chen Q, Jackson H, Parente P, Luke T, Rizkalla M, Tai TY, Zhu HC, Mifsud NA, Dimopoulos N, Masterman KA, Hopkins W, Goldie H, Maraskovsky E, Green S, Miloradovic L, McCluskey J, Old LJ, Davis ID, Cebon J, Chen W.

Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9363-8. Epub 2004 Jun 14.


Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely LK, Beddoe T, Mifsud NA, Purcell AW, Brooks AG, McCluskey J, Rossjohn J.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7675-80. Epub 2004 May 10.


A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition.

Macdonald WA, Purcell AW, Mifsud NA, Ely LK, Williams DS, Chang L, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu L, Rossjohn J, McCluskey J.

J Exp Med. 2003 Sep 1;198(5):679-91. Epub 2003 Aug 25.


Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design.

Purcell AW, Zeng W, Mifsud NA, Ely LK, Macdonald WA, Jackson DC.

J Pept Sci. 2003 May;9(5):255-81. Review.


A novel cis-AB variant allele arising from a nucleotide substitution A796C in the B transferase gene.

Mifsud NA, Watt JM, Condon JA, Haddad AP, Sparrow RL.

Transfusion. 2000 Oct;40(10):1276-7. No abstract available.


Expression of surfactant protein mRNA in normal and neoplastic lung of B6C3F1 mice as demonstrated by in situ hybridization.

Pilling AM, Mifsud NA, Jones SA, Endersby-Wood HJ, Turton JA.

Vet Pathol. 1999 Jan;36(1):57-63.


Use of the polymerase chain reaction-sequence specific oligonucleotide technique for the detection of the K1/K2 polymorphism of the Kell blood group system.

Mifsud NA, Haddad AP, Sparrow RL, Condon JA.

Blood. 1997 Jun 15;89(12):4662-3. No abstract available.


ABO genotyping by polymerase chain reaction-restriction fragment length polymorphism.

Mifsud NA, Haddad AP, Condon JA, Sparrow RL.

Immunohematology. 1996;12(4):143-8. Erratum in: Immunohematology. 1997;13(1): 24.


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