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Items: 1 to 50 of 193

1.

Secondary Organic Aerosol Formation from Healthy and Aphid-Stressed Scots Pine Emissions.

Faiola CL, Pullinen I, Buchholz A, Khalaj F, Ylisirniö A, Kari E, Miettinen P, Holopainen JK, Kivimäenpää M, Schobesberger S, Yli-Juuti T, Virtanen A.

ACS Earth Space Chem. 2019 Sep 19;3(9):1756-1772. doi: 10.1021/acsearthspacechem.9b00118. Epub 2019 Aug 14.

2.

Constitutional delay of puberty versus congenital hypogonadotropic hypogonadism: Genetics, management and updates.

Raivio T, Miettinen PJ.

Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101316. doi: 10.1016/j.beem.2019.101316. Epub 2019 Sep 5. Review.

3.

Progressive age-dependent motor impairment in human tau P301S overexpressing mice.

Koivisto H, Ytebrouck E, Carmans S, Naderi R, Miettinen PO, Roucourt B, Tanila H.

Behav Brain Res. 2019 Dec 30;376:112158. doi: 10.1016/j.bbr.2019.112158. Epub 2019 Aug 20.

PMID:
31442549
4.

Treatment of gonadotropin deficiency during the first year of life: long-term observation and outcome in five boys.

Kohva E, Huopio H, Hietamäki J, Hero M, Miettinen PJ, Raivio T.

Hum Reprod. 2019 May 1;34(5):863-871. doi: 10.1093/humrep/dez040.

5.

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.

Leinonen H, Koivisto H, Lipponen HR, Matilainen A, Salo AM, Dimova EY, Hämäläinen E, Stavén S, Miettinen P, Myllyharju J, Koivunen P, Tanila H.

Neuropharmacology. 2019 Jul 15;153:63-72. doi: 10.1016/j.neuropharm.2019.04.023. Epub 2019 Apr 25.

PMID:
31029587
6.

Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial.

Varimo T, Huopio H, Kariola L, Tenhola S, Voutilainen R, Toppari J, Toiviainen-Salo S, Hämäläinen E, Pulkkinen MA, Lääperi M, Tarkkanen A, Vaaralahti K, Miettinen PJ, Hero M, Raivio T.

Lancet Child Adolesc Health. 2019 Feb;3(2):109-120. doi: 10.1016/S2352-4642(18)30377-8. Epub 2019 Jan 4.

PMID:
30612946
7.

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism.

Kohva E, Huopio H, Hero M, Miettinen PJ, Vaaralahti K, Sidoroff V, Toppari J, Raivio T.

J Endocr Soc. 2018 Oct 15;2(12):1345-1356. doi: 10.1210/js.2018-00225. eCollection 2018 Dec 1.

8.

The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome.

Huttunen H, Hero M, Lääperi M, Känsäkoski J, Swan H, Hirsch JA, Miettinen PJ, Raivio T.

Front Endocrinol (Lausanne). 2018 Apr 24;9:194. doi: 10.3389/fendo.2018.00194. eCollection 2018.

9.

Disorders of sex development: timing of diagnosis and management in a single large tertiary center.

Kohva E, Miettinen PJ, Taskinen S, Hero M, Tarkkanen A, Raivio T.

Endocr Connect. 2018 Apr;7(4):595-603. doi: 10.1530/EC-18-0070. Epub 2018 Mar 26.

10.

Terpene Composition Complexity Controls Secondary Organic Aerosol Yields from Scots Pine Volatile Emissions.

Faiola CL, Buchholz A, Kari E, Yli-Pirilä P, Holopainen JK, Kivimäenpää M, Miettinen P, Worsnop DR, Lehtinen KEJ, Guenther AB, Virtanen A.

Sci Rep. 2018 Feb 14;8(1):3053. doi: 10.1038/s41598-018-21045-1.

11.

GnRH receptor gene mutations in adolescents and young adults presenting with signs of partial gonadotropin deficiency.

Hietamäki J, Hero M, Holopainen E, Känsäkoski J, Vaaralahti K, Iivonen AP, Miettinen PJ, Raivio T.

PLoS One. 2017 Nov 28;12(11):e0188750. doi: 10.1371/journal.pone.0188750. eCollection 2017.

12.

Heterozygous RFX6 protein truncating variants are associated with MODY with reduced penetrance.

Patel KA, Kettunen J, Laakso M, Stančáková A, Laver TW, Colclough K, Johnson MB, Abramowicz M, Groop L, Miettinen PJ, Shepherd MH, Flanagan SE, Ellard S, Inagaki N, Hattersley AT, Tuomi T, Cnop M, Weedon MN.

Nat Commun. 2017 Oct 12;8(1):888. doi: 10.1038/s41467-017-00895-9.

13.

Precocious Puberty or Premature Thelarche: Analysis of a Large Patient Series in a Single Tertiary Center with Special Emphasis on 6- to 8-Year-Old Girls.

Varimo T, Huttunen H, Miettinen PJ, Kariola L, Hietamäki J, Tarkkanen A, Hero M, Raivio T.

Front Endocrinol (Lausanne). 2017 Aug 23;8:213. doi: 10.3389/fendo.2017.00213. eCollection 2017.

14.

Non-specific abdominal pain remains as the most common reason for acute abdomen: 26-year retrospective audit in one emergency unit.

Fagerström A, Paajanen P, Saarelainen H, Ahonen-Siirtola M, Ukkonen M, Miettinen P, Paajanen H.

Scand J Gastroenterol. 2017 Oct;52(10):1072-1077. doi: 10.1080/00365521.2017.1342140. Epub 2017 Jun 28.

PMID:
28657380
15.

Biliary Anomalies in Patients With HNF1B Diabetes.

Kettunen JLT, Parviainen H, Miettinen PJ, Färkkilä M, Tamminen M, Salonen P, Lantto E, Tuomi T.

J Clin Endocrinol Metab. 2017 Jun 1;102(6):2075-2082. doi: 10.1210/jc.2017-00061.

PMID:
28324003
16.

A randomised clinical trial of routine versus selective CT imaging in acute abdomen: Impact of patient age on treatment costs and hospital resource use.

Lehtimäki TT, Valtonen H, Miettinen P, Juvonen P, Paajanen H, Vanninen R.

Eur J Radiol. 2017 Feb;87:1-7. doi: 10.1016/j.ejrad.2016.11.031. Epub 2016 Nov 28.

PMID:
28065368
17.
18.

Global atmospheric particle formation from CERN CLOUD measurements.

Dunne EM, Gordon H, Kürten A, Almeida J, Duplissy J, Williamson C, Ortega IK, Pringle KJ, Adamov A, Baltensperger U, Barmet P, Benduhn F, Bianchi F, Breitenlechner M, Clarke A, Curtius J, Dommen J, Donahue NM, Ehrhart S, Flagan RC, Franchin A, Guida R, Hakala J, Hansel A, Heinritzi M, Jokinen T, Kangasluoma J, Kirkby J, Kulmala M, Kupc A, Lawler MJ, Lehtipalo K, Makhmutov V, Mann G, Mathot S, Merikanto J, Miettinen P, Nenes A, Onnela A, Rap A, Reddington CL, Riccobono F, Richards NA, Rissanen MP, Rondo L, Sarnela N, Schobesberger S, Sengupta K, Simon M, Sipilä M, Smith JN, Stozkhov Y, Tomé A, Tröstl J, Wagner PE, Wimmer D, Winkler PM, Worsnop DR, Carslaw KS.

Science. 2016 Dec 2;354(6316):1119-1124. Epub 2016 Oct 27.

19.

Fundus Photography as a Screening Method for Diabetic Retinopathy in Children With Type 1 Diabetes: Outcome of the Initial Photography.

Gräsbeck TC, Gräsbeck SV, Miettinen PJ, Summanen PA.

Am J Ophthalmol. 2016 Sep;169:227-234. doi: 10.1016/j.ajo.2016.06.037. Epub 2016 Jul 2.

PMID:
27381713
20.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort.

Löf C, Patyra K, Kuulasmaa T, Vangipurapu J, Undeutsch H, Jaeschke H, Pajunen T, Kero A, Krude H, Biebermann H, Kleinau G, Kühnen P, Rantakari K, Miettinen P, Kirjavainen T, Pursiheimo JP, Mustila T, Jääskeläinen J, Ojaniemi M, Toppari J, Ignatius J, Laakso M, Kero J.

Thyroid. 2016 Sep;26(9):1215-24. doi: 10.1089/thy.2016.0016. Epub 2016 Aug 2.

21.

The role of low-volatility organic compounds in initial particle growth in the atmosphere.

Tröstl J, Chuang WK, Gordon H, Heinritzi M, Yan C, Molteni U, Ahlm L, Frege C, Bianchi F, Wagner R, Simon M, Lehtipalo K, Williamson C, Craven JS, Duplissy J, Adamov A, Almeida J, Bernhammer AK, Breitenlechner M, Brilke S, Dias A, Ehrhart S, Flagan RC, Franchin A, Fuchs C, Guida R, Gysel M, Hansel A, Hoyle CR, Jokinen T, Junninen H, Kangasluoma J, Keskinen H, Kim J, Krapf M, Kürten A, Laaksonen A, Lawler M, Leiminger M, Mathot S, Möhler O, Nieminen T, Onnela A, Petäjä T, Piel FM, Miettinen P, Rissanen MP, Rondo L, Sarnela N, Schobesberger S, Sengupta K, Sipilä M, Smith JN, Steiner G, Tomè A, Virtanen A, Wagner AC, Weingartner E, Wimmer D, Winkler PM, Ye P, Carslaw KS, Curtius J, Dommen J, Kirkby J, Kulmala M, Riipinen I, Worsnop DR, Donahue NM, Baltensperger U.

Nature. 2016 May 26;533(7604):527-31. doi: 10.1038/nature18271.

22.

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population.

Huopio H, Miettinen PJ, Ilonen J, Nykänen P, Veijola R, Keskinen P, Näntö-Salonen K, Vangipurapu J, Raivo J, Stančáková A, Männistö J, Kuulasmaa T, Knip M, Otonkoski T, Laakso M.

J Clin Endocrinol Metab. 2016 Aug;101(8):3018-26. doi: 10.1210/jc.2015-4296. Epub 2016 May 11.

PMID:
27167055
23.

Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty.

Varimo T, Dunkel L, Vaaralahti K, Miettinen PJ, Hero M, Raivio T.

Eur J Endocrinol. 2016 Jun;174(6):785-90. doi: 10.1530/EJE-15-1193. Epub 2016 Mar 29.

PMID:
27025240
24.

Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease.

Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H, Davis S.

J Alzheimers Dis. 2016;51(4):1157-73. doi: 10.3233/JAD-150926.

PMID:
26923018
25.

Childhood growth in boys with congenital hypogonadotropic hypogonadism.

Varimo T, Hero M, Laitinen EM, Miettinen PJ, Tommiska J, Känsäkoski J, Juul A, Raivio T.

Pediatr Res. 2016 May;79(5):705-9. doi: 10.1038/pr.2015.278. Epub 2015 Dec 31.

PMID:
26720605
26.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.

Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.

PMID:
26563932
27.

Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease.

Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H.

Dement Geriatr Cogn Disord. 2015;40(5-6):243-55. doi: 10.1159/000435948. Epub 2015 Aug 18.

PMID:
26305064
28.

Opposing effects of APP/PS1 and TrkB.T1 genotypes on midbrain dopamine neurons and stimulated dopamine release in vivo.

Kärkkäinen E, Yavich L, Miettinen PO, Tanila H.

Brain Res. 2015 Oct 5;1622:452-65. doi: 10.1016/j.brainres.2015.07.006. Epub 2015 Jul 11.

PMID:
26168899
29.

Early-onset diabetic E1-DN mice develop albuminuria and glomerular injury typical of diabetic nephropathy.

Hyvönen ME, Dumont V, Tienari J, Lehtonen E, Ustinov J, Havana M, Jalanko H, Otonkoski T, Miettinen PJ, Lehtonen S.

Biomed Res Int. 2015;2015:102969. doi: 10.1155/2015/102969. Epub 2015 Apr 27.

30.

Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice.

Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H.

Behav Brain Res. 2014 Dec 15;275:15-26. doi: 10.1016/j.bbr.2014.08.050. Epub 2014 Sep 1.

PMID:
25192639
31.

Effect of omeprazole dose, nonsteroidal anti-inflammatory agents, and smoking on repair mechanisms in acute peptic ulcer bleeding.

Rantanen T, Udd M, Honkanen T, Miettinen P, Kärjä V, Rantanen L, Julkunen R, Mustonen H, Paavonen T, Oksala N.

Dig Dis Sci. 2014 Nov;59(11):2666-74. doi: 10.1007/s10620-014-3242-z. Epub 2014 Aug 20.

PMID:
25138901
32.

Innate BDNF expression is associated with ethanol intake in alcohol-preferring AA and alcohol-avoiding ANA rats.

Raivio N, Miettinen P, Kiianmaa K.

Brain Res. 2014 Sep 4;1579:74-83. doi: 10.1016/j.brainres.2014.07.006. Epub 2014 Jul 18.

PMID:
25044407
33.

Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland.

Ilves I, Fagerström A, Herzig KH, Juvonen P, Miettinen P, Paajanen H.

World J Gastroenterol. 2014 Apr 14;20(14):4037-42. doi: 10.3748/wjg.v20.i14.4037.

34.

The need for surgery in acute abdominal pain: a randomized study of abdominal computed tomography.

Juvonen P, Lehtimäki T, Eskelinen M, Ilves I, Vanninen R, Miettinen P, Paajanen H.

In Vivo. 2014 May-Jun;28(3):305-9.

PMID:
24815831
35.

High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status.

Takalo M, Haapasalo A, Martiskainen H, Kurkinen KM, Koivisto H, Miettinen P, Khandelwal VK, Kemppainen S, Kaminska D, Mäkinen P, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M.

J Nutr Biochem. 2014 Jun;25(6):634-41. doi: 10.1016/j.jnutbio.2014.02.003. Epub 2014 Mar 12.

PMID:
24746833
36.

Long-term outcome of patients with acute non-specific abdominal pain compared to acute appendicitis: prospective symptom audit after two decades.

Fagerström A, Miettinen P, Valtola J, Juvonen P, Tarvainen R, Ilves I, Paajanen H.

Acta Chir Belg. 2014 Jan-Feb;114(1):46-51.

PMID:
24720138
37.

EGFR signaling promotes β-cell proliferation and survivin expression during pregnancy.

Hakonen E, Ustinov J, Palgi J, Miettinen PJ, Otonkoski T.

PLoS One. 2014 Apr 2;9(4):e93651. doi: 10.1371/journal.pone.0093651. eCollection 2014.

38.
39.

In vivo activation of the PI3K-Akt pathway in mouse beta cells by the EGFR mutation L858R protects against diabetes.

Hakonen E, Ustinov J, Eizirik DL, Sariola H, Miettinen PJ, Otonkoski T.

Diabetologia. 2014 May;57(5):970-9. doi: 10.1007/s00125-014-3175-2. Epub 2014 Feb 4.

PMID:
24493201
40.

Special lipid-based diets alleviate cognitive deficits in the APPswe/PS1dE9 transgenic mouse model of Alzheimer's disease independent of brain amyloid deposition.

Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, Lütjohann D D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Janáky T, Broersen LM, Hartmann T, Tanila H.

J Nutr Biochem. 2014 Feb;25(2):157-69. doi: 10.1016/j.jnutbio.2013.09.015. Epub 2013 Nov 6.

PMID:
24445040
41.

Characteristic changes in microbial community composition and expression of innate immune genes in acute appendicitis.

Arlt A, Bharti R, Ilves I, Häsler R, Miettinen P, Paajanen H, Brunke G, Ellrichmann M, Rehman A, Hauser C, Egberts JH, Ott SJ, Schreiber S, Rosenstiel P, Herzig KH.

Innate Immun. 2015 Jan;21(1):30-41. doi: 10.1177/1753425913515033. Epub 2013 Dec 11.

PMID:
24336024
42.

Adipose tissue INSR splicing in humans associates with fasting insulin level and is regulated by weight loss.

Kaminska D, Hämäläinen M, Cederberg H, Käkelä P, Venesmaa S, Miettinen P, Ilves I, Herzig KH, Kolehmainen M, Karhunen L, Kuusisto J, Gylling H, Laakso M, Pihlajamäki J.

Diabetologia. 2014 Feb;57(2):347-51. doi: 10.1007/s00125-013-3097-4. Epub 2013 Nov 7.

PMID:
24196191
43.

Use of electronic health records for automated screening of growth disorders in primary care.

Sankilampi U, Saari A, Laine T, Miettinen PJ, Dunkel L.

JAMA. 2013 Sep 11;310(10):1071-2. doi: 10.1001/jama.2013.218793. No abstract available.

PMID:
24026604
44.

Outpatient antibiotic use and the incidence of acute appendicitis in Finland: a nationwide study from 1990-2008.

Ilves I, Miettinen P, Huovinen P, Herzig KH, Alajääski J, Salminen P, Paajanen H.

Surg Infect (Larchmt). 2013 Aug;14(4):352-6. doi: 10.1089/sur.2012.069. Epub 2013 Jul 16.

45.

The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer's disease.

Rantamäki T, Kemppainen S, Autio H, Stavén S, Koivisto H, Kojima M, Antila H, Miettinen PO, Kärkkäinen E, Karpova N, Vesa L, Lindemann L, Hoener MC, Tanila H, Castrén E.

PLoS One. 2013 Jul 3;8(7):e68722. doi: 10.1371/journal.pone.0068722. Print 2013.

46.

Thyroid cancer and co-occurring RET mutations in Hirschsprung disease.

Virtanen VB, Pukkala E, Kivisaari R, Salo PP, Koivusalo A, Arola J, Miettinen PJ, Rintala RJ, Perola M, Pakarinen MP.

Endocr Relat Cancer. 2013 Jul 12;20(4):595-602. doi: 10.1530/ERC-13-0082. Print 2013 Aug.

PMID:
23744765
47.

Impact of routine contrast-enhanced CT on costs and use of hospital resources in patients with acute abdomen. Results of a randomised clinical trial.

Lehtimäki T, Juvonen P, Valtonen H, Miettinen P, Paajanen H, Vanninen R.

Eur Radiol. 2013 Sep;23(9):2538-45. doi: 10.1007/s00330-013-2848-4. Epub 2013 May 29.

PMID:
23715771
48.

Aerosol chemical composition in cloud events by high resolution time-of-flight aerosol mass spectrometry.

Hao L, Romakkaniemi S, Kortelainen A, Jaatinen A, Portin H, Miettinen P, Komppula M, Leskinen A, Virtanen A, Smith JN, Sueper D, Worsnop DR, Lehtinen KE, Laaksonen A.

Environ Sci Technol. 2013 Mar 19;47(6):2645-53. doi: 10.1021/es302889w. Epub 2013 Feb 28.

PMID:
23419193
49.

[MODY diabetes--a monogenic developmental and functional disturbance of pancreatic beta cells].

Miettinen PJ, Tuomi T.

Duodecim. 2012;128(19):1989-98. Review. Finnish.

PMID:
23155750
50.

Gender identity and gender role orientation in female assigned patients with disorders of sex development.

Mattila AK, Fagerholm R, Santtila P, Miettinen PJ, Taskinen S.

J Urol. 2012 Nov;188(5):1930-4. doi: 10.1016/j.juro.2012.07.018. Epub 2012 Sep 20.

PMID:
22999536

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