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Rapid susceptibility testing of multi-drug resistant Escherichia coli and Klebsiella by glucose metabolization monitoring.

Kittel M, Findeisen P, Ghebremedhin B, Miethke T, Grundt A, Ahmad-Nejad P, Neumaier M.

Clin Chem Lab Med. 2019 Jul 26;57(8):1271-1279. doi: 10.1515/cclm-2018-1178.


Direct MS-Based Bacterial Identification of Blood Cultures. Comparison of an In-House TritonX-Protocol with Bruker-Sepsityper?

Kittel M, Greulich A, Findeisen P, Haselmann V, Burrer A, Willem C, Miethke T, Ahmad-Nejad P, Neumaier M.

Clin Lab. 2018 Oct 31;64(11). doi: 10.7754/Clin.Lab.2018.180522. No abstract available.


Course of colonization by multidrug-resistant organisms after allogeneic hematopoietic cell transplantation.

Heidenreich D, Kreil S, Jawhar M, Müller N, Nolte F, Becker KP, Miethke T, Hofmann WK, Klein SA.

Ann Hematol. 2018 Dec;97(12):2501-2508. doi: 10.1007/s00277-018-3475-6. Epub 2018 Aug 18.


Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients.

Postina P, Skladny J, Boch T, Cornely OA, Hamprecht A, Rath PM, Steinmann J, Bader O, Miethke T, Dietz A, Merker N, Hofmann WK, Buchheidt D, Spiess B.

Front Microbiol. 2018 Mar 27;9:555. doi: 10.3389/fmicb.2018.00555. eCollection 2018.


The inventory as a core element in the further development of the science curriculum in the Mannheim Reformed Curriculum of Medicine.

Eckel J, Schüttpelz-Brauns K, Miethke T, Rolletschek A, Fritz HM.

GMS J Med Educ. 2017 May 15;34(2):Doc22. doi: 10.3205/zma001099. eCollection 2017.


Vaccination with the polymorphic membrane protein A reduces Chlamydia muridarum induced genital tract pathology.

Müller T, Becker E, Stallmann S, Waldhuber A, Römmler-Dreher F, Albrecht S, Mohr F, Hegemann JH, Miethke T.

Vaccine. 2017 May 15;35(21):2801-2810. doi: 10.1016/j.vaccine.2017.04.017. Epub 2017 Apr 14.


Phosphotransferase systems in Enterococcus faecalis OG1RF enhance anti-stress capacity in vitro and in vivo.

Peng Z, Ehrmann MA, Waldhuber A, Niemeyer C, Miethke T, Frick JS, Xiong T, Vogel RF.

Res Microbiol. 2017 Jul - Aug;168(6):558-566. doi: 10.1016/j.resmic.2017.03.003. Epub 2017 Mar 29.


Immunity to uropathogens: the emerging roles of inflammasomes.

Hamilton C, Tan L, Miethke T, Anand PK.

Nat Rev Urol. 2017 May;14(5):284-295. doi: 10.1038/nrurol.2017.25. Epub 2017 Mar 7. Review.


Multidrug-resistant organisms in allogeneic hematopoietic cell transplantation.

Heidenreich D, Kreil S, Nolte F, Hofmann WK, Miethke T, Klein SA.

Eur J Haematol. 2017 May;98(5):485-492. doi: 10.1111/ejh.12859. Epub 2017 Mar 3.


Molecular Basis of Acute Cystitis Reveals Susceptibility Genes and Immunotherapeutic Targets.

Ambite I, Puthia M, Nagy K, Cafaro C, Nadeem A, Butler DS, Rydström G, Filenko NA, Wullt B, Miethke T, Svanborg C.

PLoS Pathog. 2016 Oct 12;12(10):e1005848. doi: 10.1371/journal.ppat.1005848. eCollection 2016 Oct.


Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation.

Waldhuber A, Puthia M, Wieser A, Cirl C, Dürr S, Neumann-Pfeifer S, Albrecht S, Römmler F, Müller T, Zheng Y, Schubert S, Groß O, Svanborg C, Miethke T.

J Clin Invest. 2016 Jul 1;126(7):2425-36. doi: 10.1172/JCI81916. Epub 2016 May 23.


A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Waldhuber A, Snyder GA, Römmler F, Cirl C, Müller T, Xiao TS, Svanborg C, Miethke T.

Pathogens. 2016 Feb 29;5(1). pii: E25. doi: 10.3390/pathogens5010025.


Direct comparison of galactomannan performance in concurrent serum and bronchoalveolar lavage samples in immunocompromised patients at risk for invasive pulmonary aspergillosis.

Boch T, Buchheidt D, Spiess B, Miethke T, Hofmann WK, Reinwald M.

Mycoses. 2016 Feb;59(2):80-5. doi: 10.1111/myc.12434. Epub 2015 Dec 2.


Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS.

Burrer A, Findeisen P, Jäger E, Ghebremedhin B, Grundt A, Ahmad-Nejad P, Miethke T, Neumaier M.

Int J Med Microbiol. 2015 Dec;305(8):860-4. doi: 10.1016/j.ijmm.2015.08.004. Epub 2015 Aug 19.


Guanine-modified inhibitory oligonucleotides efficiently impair TLR7- and TLR9-mediated immune responses of human immune cells.

Römmler F, Hammel M, Waldhuber A, Müller T, Jurk M, Uhlmann E, Wagner H, Vollmer J, Miethke T.

PLoS One. 2015 Feb 19;10(2):e0116703. doi: 10.1371/journal.pone.0116703. eCollection 2015.


Granzyme A produces bioactive IL-1β through a nonapoptotic inflammasome-independent pathway.

Hildebrand D, Bode KA, Rieß D, Cerny D, Waldhuber A, Römmler F, Strack J, Korten S, Orth JH, Miethke T, Heeg K, Kubatzky KF.

Cell Rep. 2014 Nov 6;9(3):910-7. doi: 10.1016/j.celrep.2014.10.003. Epub 2014 Oct 30.


Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013.

Spiess B, Postina P, Reinwald M, Cornely OA, Hamprecht A, Hoenigl M, Lass-Flörl C, Rath PM, Steinmann J, Miethke T, Lauten M, Will S, Merker N, Hofmann WK, Buchheidt D.

PLoS One. 2014 Jul 29;9(7):e103113. doi: 10.1371/journal.pone.0103113. eCollection 2014.


Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.

Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L.

Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24.


Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry.

Snyder GA, Deredge D, Waldhuber A, Fresquez T, Wilkins DZ, Smith PT, Durr S, Cirl C, Jiang J, Jennings W, Luchetti T, Snyder N, Sundberg EJ, Wintrode P, Miethke T, Xiao TS.

J Biol Chem. 2014 Jan 10;289(2):669-79. doi: 10.1074/jbc.M113.523407. Epub 2013 Nov 25.


Guanine modification of inhibitory oligonucleotides potentiates their suppressive function.

Römmler F, Jurk M, Uhlmann E, Hammel M, Waldhuber A, Pfeiffer L, Wagner H, Vollmer J, Miethke T.

J Immunol. 2013 Sep 15;191(6):3240-53. doi: 10.4049/jimmunol.1300706. Epub 2013 Aug 21.


Acute osteomyelitis of the humerus mimicking malignancy: Streptococcus pneumoniae as exceptional pathogen in an immunocompetent adult.

Prodinger PM, Pilge H, Banke IJ, Bürklein D, Gradinger R, Miethke T, Holzapfel BM.

BMC Infect Dis. 2013 Jun 5;13:266. doi: 10.1186/1471-2334-13-266.


Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli.

Snyder GA, Cirl C, Jiang J, Chen K, Waldhuber A, Smith P, Römmler F, Snyder N, Fresquez T, Dürr S, Tjandra N, Miethke T, Xiao TS.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6985-90. doi: 10.1073/pnas.1215770110. Epub 2013 Apr 8.


Rapid detection of ampicillin resistance in Escherichia coli by quantitative mass spectrometry.

Grundt A, Findeisen P, Miethke T, Jäger E, Ahmad-Nejad P, Neumaier M.

J Clin Microbiol. 2012 May;50(5):1727-9. doi: 10.1128/JCM.00047-12. Epub 2012 Feb 8.


Toll-like receptors 2 and 4 regulate the frequency of IFNγ-producing CD4+ T-cells during pulmonary infection with Chlamydia pneumoniae.

Wantia N, Rodriguez N, Cirl C, Ertl T, Dürr S, Layland LE, Wagner H, Miethke T.

PLoS One. 2011;6(11):e26101. doi: 10.1371/journal.pone.0026101. Epub 2011 Nov 9.


Chemokine response induced by Chlamydia trachomatis in prostate derived CD45+ and CD45- cells.

Mackern Oberti JP, Breser ML, Nuñez N, Maccioni M, Rodríguez N, Wantia N, Ertl T, Miethke T, Rivero VE.

Reproduction. 2011 Sep;142(3):427-37. doi: 10.1530/REP-11-0163. Epub 2011 Jul 5.


[Antibiotic prophylaxis in primary and revision hip arthroplasty: what is the evidence?].

Gradl G, Horn C, Postl LK, Miethke T, Gollwitzer H.

Orthopade. 2011 Jun;40(6):520-7. doi: 10.1007/s00132-011-1755-0. Review. German.


[Increasing therapeutic challenges through multi-resistant bacteria in the hospital].

Miethke T.

Zentralbl Chir. 2012 Jun;137(3):279-83. doi: 10.1055/s-0031-1271348. Epub 2011 Feb 28. Review. German.


Innate immunity in the male genital tract: Chlamydia trachomatis induces keratinocyte-derived chemokine production in prostate, seminal vesicle and epididymis/vas deferens primary cultures.

Mackern-Oberti JP, Maccioni M, Breser ML, Eley A, Miethke T, Rivero VE.

J Med Microbiol. 2011 Mar;60(Pt 3):307-16. doi: 10.1099/jmm.0.024877-0. Epub 2010 Nov 25.


Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence.

Yadav M, Zhang J, Fischer H, Huang W, Lutay N, Cirl C, Lum J, Miethke T, Svanborg C.

PLoS Pathog. 2010 Sep 23;6(9):e1001120. doi: 10.1371/journal.ppat.1001120.


Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.

Rodriguez N, Dietrich H, Mossbrugger I, Weintz G, Scheller J, Hammer M, Quintanilla-Martinez L, Rose-John S, Miethke T, Lang R.

J Leukoc Biol. 2010 Sep;88(3):579-87. doi: 10.1189/jlb.0210083. Epub 2010 May 18.


Microbial Toll/interleukin 1 receptor proteins: a new class of virulence factors.

Cirl C, Miethke T.

Int J Med Microbiol. 2010 Aug;300(6):396-401. doi: 10.1016/j.ijmm.2010.04.001. Epub 2010 May 6. Review.


Chlamydophila pneumoniae downregulates MHC-class II expression by two cell type-specific mechanisms.

Peschel G, Kernschmidt L, Cirl C, Wantia N, Ertl T, Dürr S, Wagner H, Miethke T, Rodríguez N.

Mol Microbiol. 2010 May;76(3):648-61. doi: 10.1111/j.1365-2958.2010.07114.x. Epub 2010 Mar 10.


Development of novel implant abutments using the shape memory alloy nitinol: preliminary results.

Pautke C, Kolk A, Brokate M, Wehrstedt JC, Kneissl F, Miethke T, Steinhauser E, Horch HH, Deppe H.

Int J Oral Maxillofac Implants. 2009 May-Jun;24(3):477-83.


High hydrostatic pressure for disinfection of bone grafts and biomaterials: an experimental study.

Gollwitzer H, Mittelmeier W, Brendle M, Weber P, Miethke T, Hofmann GO, Gerdesmeyer L, Schauwecker J, Diehl P.

Open Orthop J. 2009 Jan 29;3:1-7. doi: 10.2174/1874325000903010001.


Effectiveness of ozone against endodontopathogenic microorganisms in a root canal biofilm model.

Huth KC, Quirling M, Maier S, Kamereck K, Alkhayer M, Paschos E, Welsch U, Miethke T, Brand K, Hickel R.

Int Endod J. 2009 Jan;42(1):3-13. doi: 10.1111/j.1365-2591.2008.01460.x.


Management of facial necrotizing fasciitis.

Schurr C, Burghartz M, Miethke T, Kesting M, Hoang N, Staudenmaier R.

Eur Arch Otorhinolaryngol. 2009 Mar;266(3):325-31. doi: 10.1007/s00405-008-0870-y. Epub 2008 Nov 29.


Induction of iNOS by Chlamydophila pneumoniae requires MyD88-dependent activation of JNK.

Rodriguez N, Lang R, Wantia N, Cirl C, Ertl T, Dürr S, Wagner H, Miethke T.

J Leukoc Biol. 2008 Dec;84(6):1585-93. doi: 10.1189/jlb.0508304. Epub 2008 Sep 17.


[Extracorporeal high hydrostatic pressure as a new technology for the disinfection of infected bone specimens]].

Weber P, Diehl P, Hofmann GO, Miethke T, Schmitt-Sody M, Mittelmeier W, Gradinger R, Gollwitzer H.

Biomed Tech (Berl). 2008 Aug;53(4):190-8. doi: 10.1515/BMT.2008.027. German.


Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins.

Cirl C, Wieser A, Yadav M, Duerr S, Schubert S, Fischer H, Stappert D, Wantia N, Rodriguez N, Wagner H, Svanborg C, Miethke T.

Nat Med. 2008 Apr;14(4):399-406. doi: 10.1038/nm1734. Epub 2008 Mar 9.


[Molecular diagnosis of mycobacterial infections].

Fend F, Langer R, Hann von Weyhern CW, Schulz S, Miethke T.

Verh Dtsch Ges Pathol. 2007;91:135-9. German.


MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae.

Rodríguez N, Mages J, Dietrich H, Wantia N, Wagner H, Lang R, Miethke T.

Physiol Genomics. 2007 Jul 18;30(2):134-45. Epub 2007 Mar 20.


Effect of 308-nm excimer laser light on peri-implantitis-associated bacteria: an in vitro investigation.

Deppe H, Horch HH, Schrödl V, Haczek C, Miethke T.

Lasers Med Sci. 2007 Nov;22(4):223-7. Epub 2007 Feb 21.


Mycobacterium monacense sp. nov.

Reischl U, Melzl H, Kroppenstedt RM, Miethke T, Naumann L, Mariottini A, Mazzarelli G, Tortoli E.

Int J Syst Evol Microbiol. 2006 Nov;56(Pt 11):2575-8.


Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae.

Rodriguez N, Wantia N, Fend F, Dürr S, Wagner H, Miethke T.

Eur J Immunol. 2006 May;36(5):1145-55.


EMMPRIN (CD 147) is a central activator of extracellular matrix degradation by Chlamydia pneumoniae-infected monocytes. Implications for plaque rupture.

Schmidt R, Redecke V, Breitfeld Y, Wantia N, Miethke T, Massberg S, Fischel S, Neumann FJ, Schömig A, May AE.

Thromb Haemost. 2006 Jan;95(1):151-8.


Development of a real-time PCR assay for rapid identification of methicillin-resistant Staphylococcus aureus from clinical samples.

Hagen RM, Seegmüller I, Navai J, Kappstein I, Lehn N, Miethke T.

Int J Med Microbiol. 2005 Jun;295(2):77-86.


Polymorphonuclear neutrophils improve replication of Chlamydia pneumoniae in vivo upon MyD88-dependent attraction.

Rodriguez N, Fend F, Jennen L, Schiemann M, Wantia N, Prazeres da Costa CU, Dürr S, Heinzmann U, Wagner H, Miethke T.

J Immunol. 2005 Apr 15;174(8):4836-44.


Species identification of mycobacteria in paraffin-embedded tissues: frequent detection of nontuberculous mycobacteria.

Schulz S, Cabras AD, Kremer M, Weirich G, Miethke T, Bösmüller HC, Höfler H, Werner M, Fend F.

Mod Pathol. 2005 Feb;18(2):274-82.


Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivo.

Da Costa CU, Wantia N, Kirschning CJ, Busch DH, Rodriguez N, Wagner H, Miethke T.

Eur J Immunol. 2004 Oct;34(10):2874-84.


Sensitivity of the BacT/ALERT FA-medium for detection of Pseudomonas aeruginosa in pre-incubated blood cultures and its temperature-dependence.

Seegmüller I, Eschenbach U, Kamereck K, Miethke T.

J Med Microbiol. 2004 Sep;53(Pt 9):869-74.


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